PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TP53	0	HOXA9	0	genetic interference	Xie L (2013)	1
HOXA9	0	PLSCR1	0	two hybrid	Rual JF (2005)	1
HOXA9	0	CUL4A	2	affinity chromatography technology, pull down	Zhang Y (2003), Zhang Y (2003)	2
CUL4A	2	TP53	0	affinity chromatography technology	Banks D (2006)	1
HOXA9	0	TRIP6	2	two hybrid, affinity chromatography technology, two hybrid	Rual JF (2005), Rual JF (2005), Venkatesan K (2009)	3
HOXA9	0	PBX2	1	pull down, affinity chromatography technology	Shen WF (1999), Shen WF (1999)	2
TRIM25	5	CUL4A	2	affinity chromatography technology	Choudhury NR (2017)	1
CREBBP	29	PBX1	9	pull down	Shen WF (2001)	1
HOXA9	0	PRMT5	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bandyopadhyay S (2012), Bandyopadhyay S (2012), Bandyopadhyay S (2012)	3
MEIS1	0	PBX1	9	pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Shen WF (1999), Shanmugam K (1999), Jacobs Y (1999), Argiropoulos B (2010), Argiropoulos B (2010)	5
BCR	3	TP53	0	two hybrid, imaging technique	Stelzl U (2005), Chen TC (2014)	2
CREBBP	29	TP53	0	enzymatic study, pull down, genetic interference, pull down, enzymatic study, fluorescent resonance energy transfe, enzymatic study, affinity chromatography technology, imaging technique, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, affinity chromatography technology, unspecified method, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, enzymatic study, enzymatic study, pull down, x-ray crystallography, x-ray crystallography, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Ito A (2002), Livengood JA (2002), Livengood JA (2002), Giebler HA (2000), Tang Y (2008), Jenkins LM (2009), Shi D (2009), Zhao Y (2006), Saifudeen Z (2005), Scolnick DM (1997), Scolnick DM (1997), Gu W (1997), Gu W (1997), Matsuda S (2004), Pasqualucci L (2011), Lee SK (1999), Dai C (2011), Lee CW (2010), Ferreon JC (2009), Ruas JL (2010), Ruas JL (2010), Huang WC (2007), Huang WC (2007), Mujtaba S (2004), Mujtaba S (2004), Mujtaba S (2004), Mujtaba S (2004), Col E (2002), Jansma AL (2014), Jansma AL (2014), Krois AS (2016), Hasegawa K (2008), Huang X (2013), Huang X (2013), Piskacek M (2016)	35
HOXA9	0	SMAD4	9	affinity chromatography technology	Shi X (2001)	1
HOXA9	0	RBPMS	0	two hybrid	Rual JF (2005)	1
TRIM25	5	HOXA9	0	affinity chromatography technology	Choudhury NR (2017)	1
HOXA9	0	PBX3	4	pull down	Shen WF (1999)	1
CREBBP	29	HOXA9	0	pull down	Shen WF (2001)	1
TRIM25	5	BCR	3	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	CREBBP	29	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
TP53	0	PRMT5	3	affinity chromatography technology	Horikawa I (2014)	1
SMAD4	9	CREBBP	29	affinity chromatography technology	Yang Y (2015)	1
MEIS1	0	HOXA9	0	pull down, pull down, affinity chromatography technology	Shen WF (1997), Shen WF (1999), Shen WF (1999)	3
MEIS1	0	CREBBP	29	affinity chromatography technology	Wang Z (2010)	1
TRIM25	5	SMAD4	9	affinity chromatography technology	Choudhury NR (2017)	1
BCR	3	HOXA9	0	genetic interference	Mayotte N (2002)	1
HOXA9	0	PBX1	9	pull down	Shen WF (1999)	1
CUL4A	2	PRMT5	3	biochemical	Kristensen AR (2012)	1