PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HOXB9	0	ING4	1	two hybrid	Ravasi T (2010)	1
HOXB9	0	TAL1	0	two hybrid	Wang J (2011)	1
TCEAL1	3	HOXB9	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FOXC1	0	FOXC2	2	affinity chromatography technology, affinity chromatography technology	Li X (2015), Li X (2015)	2
HOXB9	0	SAT1	0	two hybrid, two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009), Rolland T (2014)	3
KRTAP4-12	2	KRTAP10-9	1	two hybrid	Rolland T (2014)	1
EGLN3	0	TRIP6	2	affinity chromatography technology	Rodriguez J (2016)	1
GOLGA2	2	HOXB9	0	two hybrid	Rolland T (2014)	1
ZNF408	0	LZTS2	4	affinity chromatography technology	Huttlin EL (2017)	1
ARIH1	3	ECT2	2	affinity chromatography technology	Huttlin EL (2017)	1
HOXB9	0	MDFI	1	two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009)	2
RBPJ	1	KAT2B	2	affinity chromatography technology, two hybrid	Kurooka H (2000), Kurooka H (2000)	2
MAPK14	0	TCEAL1	3	affinity chromatography technology	Varjosalo M (2013)	1
HOXB9	0	MYBBP1A	8	two hybrid	Ravasi T (2010)	1
MAPK14	0	KAT2B	2	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Pillai VB (2011), Pillai VB (2011), Pillai VB (2011), Pillai VB (2011)	4
FOXS1	2	FOXC1	0	affinity chromatography technology	Li X (2015)	1
KRTAP5-9	0	KRTAP10-9	1	two hybrid	Rolland T (2014)	1
FOXS1	2	HOXB9	0	affinity chromatography technology	Li X (2015)	1
HOXB9	0	PHTF1	0	two hybrid	Ravasi T (2010)	1
FOXD3	1	HOXB9	0	affinity chromatography technology	Li X (2015)	1
ARIH1	3	HOXB9	0	affinity chromatography technology	Huttlin EL (2017)	1
FOXK2	9	HOXB9	0	affinity chromatography technology	Li X (2015)	1
CKLF	0	HOXB9	0	affinity chromatography technology	Huttlin EL (2017)	1
HOXB9	0	LZTS2	4	two hybrid	Yu H (2011)	1
CREBBP	29	HOXB9	0	pull down	Shen WF (2001)	1
HOXB9	0	KRTAP10-9	1	two hybrid	Rolland T (2014)	1
NOLC1	2	HOXB9	0	affinity chromatography technology	Huttlin EL (2017)	1
HOXB9	0	HOPX	0	two hybrid	Ravasi T (2010)	1
HOXB9	0	ZNF408	0	two hybrid	Ravasi T (2010)	1
TAL1	0	KAT2B	2	affinity chromatography technology, enzymatic study, pull down, pull down	Huang S (2000), Huang S (2000), Huang S (2000), Huang S (2000)	4
MDFI	1	ZNF408	0	two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009)	2
JUN	0	HOXB9	0	affinity chromatography technology	Li X (2015)	1
TEAD2	2	FOXK2	9	affinity chromatography technology	Li X (2015)	1
ING4	1	NOLC1	2	affinity chromatography technology	Hein MY (2015)	1
SIRT1	3	JUN	0	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Gao Z (2008), Zhang R (2010), Zhang R (2010), Armour SM (2013)	4
HOXB9	0	KRTAP4-12	2	two hybrid	Rual JF (2005)	1
AHCYL2	4	JUN	0	affinity chromatography technology	Huttlin EL (2017)	1
KRTAP5-9	0	KRTAP4-12	2	two hybrid	Rolland T (2014)	1
FOXC2	2	RBPMS	0	two hybrid	Rolland T (2014)	1
ZNF408	0	KRTAP4-12	2	two hybrid	Rual JF (2005)	1
FOXA1	2	HOXB9	0	affinity chromatography technology	Li X (2015)	1
AHCYL2	4	HOXB9	0	affinity chromatography technology	Huttlin EL (2017)	1
EGLN3	0	HOXB9	0	affinity chromatography technology	Rodriguez J (2016)	1
8339	0	FOXC1	0	bioid	Lambert JP (2015)	1
RBPJ	1	HOXB9	0	affinity chromatography technology	Li X (2015)	1
ECT2	2	SIRT1	3	affinity chromatography technology	Woods NT (2012)	1
KAT2B	2	JUN	0	affinity chromatography technology	Tsai LN (2008)	1
AHCYL2	4	FOXK2	9	affinity chromatography technology	Huttlin EL (2017)	1
FOXC1	0	HOXB9	0	affinity chromatography technology	Li X (2015)	1
FOXE1	2	HOXB9	0	affinity chromatography technology	Li X (2015)	1
HOXB9	0	MID2	1	two hybrid	Rolland T (2014)	1
FOXE1	2	FOXK2	9	affinity chromatography technology	Li X (2015)	1
MAPK14	0	HOXB9	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
VTN	1	HOXB9	0	affinity chromatography technology	Huttlin EL (2017)	1
EGLN3	0	FOXC1	0	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	LZTS2	4	affinity chromatography technology	Rodriguez J (2016)	1
HOXB9	0	PNMA1	0	two hybrid	Rolland T (2014)	1
HOXB9	0	TRIP6	2	two hybrid	Rolland T (2014)	1
HOXB9	0	RBPMS	0	two hybrid	Rual JF (2005)	1
HOXB9	0	SPZ1	0	two hybrid	Ravasi T (2010)	1
KAT2B	2	PNMA1	0	two hybrid	Albers M (2005)	1
ARIH1	3	JUN	0	affinity chromatography technology	Huttlin EL (2017)	1
HOXB9	0	SIRT1	3	affinity chromatography technology, pull down	Wan J (2016), Wan J (2016)	2
NAGK	4	HOXB9	0	affinity chromatography technology	Huttlin EL (2017)	1
HOXB9	0	CALCOCO2	0	two hybrid	Rolland T (2014)	1
TEAD2	2	HOXB9	0	affinity chromatography technology	Li X (2015)	1
FOXF1	2	HOXB9	0	affinity chromatography technology	Li X (2015)	1
EGLN3	0	JUN	0	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	TCEAL1	3	affinity chromatography technology	Rodriguez J (2016)	1
CALCOCO2	0	MID2	1	two hybrid	Rolland T (2014)	1
EGLN3	0	SIRT1	3	affinity chromatography technology	Rodriguez J (2016)	1
CYP2S1	0	HOXB9	0	affinity chromatography technology	Huttlin EL (2017)	1
WASF3	3	HOXB9	0	affinity chromatography technology	Huttlin EL (2017)	1
FOXC2	2	HOXB9	0	affinity chromatography technology	Li X (2015)	1
SIRT1	3	KAT2B	2	enzymatic study, affinity chromatography technology, affinity chromatography technology	Pediconi N (2009), Pediconi N (2009), Pediconi N (2009)	3
CREBBP	29	KAT2B	2	pull down, biochemical, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Tini M (2002), Cho H (1998), Cho H (1998), Cho H (1998), Korzus E (1998), Korzus E (1998), Korzus E (1998), Yang XJ (1996), Yang XJ (1996), Yang XJ (1996)	10
HOXB9	0	SOX15	4	two hybrid	Ravasi T (2010)	1
8339	0	HOXB9	0	bioid	Lambert JP (2015)	1
HOXB9	0	BTG2	0	two hybrid, far western blotting	Prevot D (2000), Prevot D (2000)	2
GOLGA2	2	MID2	1	two hybrid	Rolland T (2014)	1
ECT2	2	HOXB9	0	affinity chromatography technology	Woods NT (2012)	1
CALCOCO2	0	ZNF408	0	two hybrid	Rual JF (2005)	1
FOXS1	2	RBPMS	0	two hybrid	Rual JF (2005)	1
RBPMS	0	LZTS2	4	two hybrid	Rual JF (2005)	1
MAPK14	0	JUN	0	enzymatic study	Thakur N (2014)	1
HOXB9	0	KRTAP5-9	0	two hybrid	Rolland T (2014)	1
HOXB9	0	BTG1	1	two hybrid, far western blotting	Prevot D (2000), Prevot D (2000)	2
EGLN3	0	ECT2	2	affinity chromatography technology	Rodriguez J (2016)	1
CREBBP	29	JUN	0	pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, far western blotting	Sano Y (1998), Sano Y (1998), Merika M (1998), Duyndam MC (1999), Johnson J (2007), Yamaguchi K (2005), Tsai LN (2008), Arias J (1994)	8
EGLN3	0	CREBBP	29	affinity chromatography technology	Rodriguez J (2016)	1
KAT2B	2	HOXB9	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Wan J (2016), Wan J (2016), Wan J (2016), Wan J (2016), Wan J (2016)	5