PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HOXB5	0	RCHY1	0	protein complementation assay	Bridoux L (2015)	1
HNRNPL	3	APP	1	affinity chromatography technology	Fei T (2017)	1
SUV39H1	0	PRMT6	2	two hybrid	Weimann M (2013)	1
XRCC6	3	ANKRD28	1	affinity chromatography technology	Hein MY (2015)	1
HOXC4	1	ANKRD28	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
POU2F1	5	XRCC5	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Schild-Poulter C (2001), Matheos D (2002), Schaffer A (2003)	3
LYN	2	HOXC4	1	affinity chromatography technology	Zhu J (2013)	1
HNRNPL	3	XRCC5	5	affinity chromatography technology	Fei T (2017)	1
HOXC4	1	RABGAP1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ELMOD2	0	HOXC4	1	two hybrid	Wang J (2011)	1
HOXC4	1	SUV39H1	0	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
HNRNPL	3	HOXC4	1	affinity chromatography technology	Fei T (2017)	1
HNRNPL	3	ANKHD1-EIF4EBP3	0	affinity chromatography technology	Fei T (2017)	1
HOXC4	1	NSD3	6	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
HOXC4	1	ANKRD17	10	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HOXC4	1	ANKHD1-EIF4EBP3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HNRNPL	3	NCK2	2	affinity chromatography technology	Fei T (2017)	1
RABGAP1	2	RABGAP1L	4	affinity chromatography technology	Behrends C (2010)	1
XRCC5	5	XRCC6	3	two hybrid, biochemical, two hybrid, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, enzymatic study, x-ray crystallography, affinity chromatography technology, pull down, biochemical, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology	Gell D (1999), Barlev NA (1998), Yang CR (1999), Singleton BK (1999), Song K (2000), Gell D (1999), Gell D (1999), Willis DM (2002), Willis DM (2002), Drouet J (2005), Drouet J (2005), Cohen HY (2004), Lan L (2010), Cooper MP (2000), Cooper MP (2000), Velma V (2010), Zheng Y (2011), Sucharov CC (2004), Sucharov CC (2004), Sibani S (2005), Sibani S (2005), Walker JR (2001), Nick McElhinny SA (2000), Nick McElhinny SA (2000), Sand-Dejmek J (2011), Sand-Dejmek J (2011), Sand-Dejmek J (2011), Pucci S (2009), Trougakos IP (2009), Havugimana PC (2012), Sartorius CA (2000), Sartorius CA (2000), Rivera-Calzada A (2007), Kelavkar UP (2001), Kelavkar UP (2001), Kristensen AR (2012), Kim E (2008), Wan C (2015), Hein MY (2015), Hein MY (2015), Nolens G (2009), Nolens G (2009), Nolens G (2009), Nolens G (2009), Huttlin EL (2017), Fantini D (2017)	46
HOXC4	1	PRMT5	3	two hybrid	Weimann M (2013)	1
XRCC6	3	HTT	14	pull down, two hybrid	Goehler H (2004), Goehler H (2004)	2
HOXC4	1	RABGAP1L	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HTT	14	HOXC4	1	two hybrid	Suter B (2013)	1
XRCC6	3	HOXC4	1	two hybrid, pull down, pull down, affinity chromatography technology	Schild-Poulter C (2001), Schild-Poulter C (2001), Schaffer A (2003), Schaffer A (2003)	4
HNRNPL	3	ANKRD17	10	affinity chromatography technology	Fei T (2017)	1
HOXC4	1	PRMT6	2	two hybrid	Weimann M (2013)	1
RNF32	0	APP	1	pull down, two hybrid, pull down	Olah J (2011), Soler-Lopez M (2011), Virok DP (2011)	3
HOXC4	1	RNF32	0	two hybrid	Wang J (2011)	1
HOXC4	1	NCK2	2	two hybrid	Rolland T (2014)	1
HNRNPL	3	HTT	14	affinity chromatography technology	Fei T (2017)	1
POU2F1	5	APP	1	pull down	Olah J (2011)	1
HOXC4	1	RCHY1	0	protein complementation assay	Bridoux L (2015)	1
APP	1	HOXC4	1	pull down	Virok DP (2011)	1
HOXC4	1	POU2F1	5	pull down, pull down, affinity chromatography technology	Schaffer A (2003), Schaffer A (2003), Schaffer A (2003)	3
HNRNPL	3	RABGAP1	2	affinity chromatography technology	Fei T (2017)	1
HOXC4	1	ERBIN	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HOXB5	0	HOXC4	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
XRCC5	5	HOXC4	1	affinity chromatography technology	Schaffer A (2003)	1
PRMT6	2	PRMT5	3	genetic interference	Wong AS (2016)	1
POU2F1	5	XRCC6	3	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Schild-Poulter C (2001), Schild-Poulter C (2007), Schaffer A (2003), Schaffer A (2003)	4
HOXC4	1	ANKHD1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HOXB5	0	LYN	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HNRNPL	3	ERBIN	5	affinity chromatography technology	Fei T (2017)	1