PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HOXC8	0	SMAD4	9	affinity chromatography technology	Shi X (1999)	1
MSX1	0	HOXC8	0	pull down	Zhang H (1997)	1
PBX1	9	HOXC8	0	affinity chromatography technology	Kikugawa T (2006)	1
SMAD4	9	SMAD6	9	affinity chromatography technology, affinity chromatography technology	Topper JN (1997), Moren A (2005)	2
SMAD1	0	SMAD4	9	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Harada J (2003), Hanai J (1999), Lopez-Rovira T (2002), Kato Y (2002), Wang L (2011), Li L (2004), Hata A (1998), Barrios-Rodiles M (2005), Wu RY (1997), Wu RY (1997), Colland F (2004), Qiu T (2007), Yan X (2016), Zhou F (2017)	14
DLX2	0	HOXC8	0	pull down	Zhang H (1997)	1
DLX5	0	DLX2	0	pull down, pull down	Zhang H (1997), Zhang H (1997)	2
SMAD1	0	HOXC8	0	two hybrid, pull down, affinity chromatography technology	Shi X (1999), Shi X (1999), Shi X (1999)	3
DLX2	0	MSX1	0	pull down, pull down, two hybrid	Zhang H (1997), Zhang H (1997), Zhang H (1997)	3
MAPK8IP1	7	HOXC8	0	affinity chromatography technology	Huttlin EL (2017)	1
HOXC8	0	SMAD6	9	two hybrid, affinity chromatography technology, pull down	Bai S (2000), Bai S (2000), Bai S (2000)	3
SMAD1	0	SMAD6	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Topper JN (1997), Murakami G (2003), Itoh F (2001), Hata A (1998), Hata A (1998)	5
DLX5	0	MSX1	0	pull down, pull down	Zhang H (1997), Zhang H (1997)	2
DLX5	0	HOXC8	0	pull down	Zhang H (1997)	1
BTG2	0	HOXC8	0	far western blotting	Prevot D (2000)	1