PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RBPJ	1	CDC27	2	affinity chromatography technology	Li X (2015)	1
FOS	0	HOXD13	0	affinity chromatography technology	Li X (2015)	1
IL13RA2	0	HOXD13	0	affinity chromatography technology	Huttlin EL (2017)	1
FOXC1	0	FOXC2	2	affinity chromatography technology, affinity chromatography technology	Li X (2015), Li X (2015)	2
GPR55	1	HOXD13	0	affinity chromatography technology	Huttlin EL (2015)	1
CDC20	1	CREBBP	29	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Turnell AS (2005), Turnell AS (2005), Townsend K (2009)	3
FOXQ1	0	HOXD13	0	affinity chromatography technology	Li X (2015)	1
CDC20	1	CDC27	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	DAngiolella V (2003), Kallio MJ (2002), Wassmann K (1998), Kramer ER (1998), Kallio M (1998), Kallio M (1998), Nilsson J (2008), Jeganathan KB (2006), Nath S (2011), Lee YJ (2008), Lara-Gonzalez P (2011), Mansfeld J (2011), Braunstein I (2007), Visconti R (2010), Ma HT (2011), Lee YJ (2008), DAngiolella V (2003), Lee SJ (2012), Fang G (1998), Fang G (1998), Wolthuis R (2008), Ban KH (2007), Ge S (2009), Tipton AR (2011), Westhorpe FG (2011), Uzunova K (2012), Kwan PS (2013), Sedgwick GG (2012), Eytan E (2013), Hyun SY (2013), Lim HJ (2013), Choi BH (2014), Fogeron ML (2013), Sackton KL (2014), Shoji S (2014), Han JS (2014), Lara-Gonzalez P (2011), Hein JB (2014), Vodermaier HC (2003), Yen AH (2010), Voets E (2015), Boekhout M (2015), Kelly A (2014), Kelly A (2014), Craney A (2016), Craney A (2016), Craney A (2016), Listovsky T (2013), Qiao R (2016), Qiao R (2016), Qiao R (2016), Qiao R (2016), Qiao R (2016), Hein JB (2016)	54
JUN	0	HOXD13	0	affinity chromatography technology	Li X (2015)	1
CREBBP	29	FOS	0	pull down, affinity chromatography technology, two hybrid	Fan S (2002), Bossis G (2005), Patel D (1999)	3
FOXD3	1	HOXD13	0	affinity chromatography technology	Li X (2015)	1
HOXD13	0	HAND2	1	affinity chromatography technology, affinity chromatography technology	Galli A (2010), Galli A (2010)	2
HERC2	9	HOXD13	0	affinity chromatography technology	Huttlin EL (2015)	1
CREB1	1	HOXD13	0	affinity chromatography technology	Li X (2015)	1
ANAPC10	0	HOXD13	0	affinity chromatography technology	Salsi V (2016)	1
NFATC1	12	HOXD13	0	affinity chromatography technology	Li X (2015)	1
FOS	0	NFATC1	12	affinity chromatography technology, affinity chromatography technology	Li X (2015), Gabriel CH (2016)	2
FOXS1	2	FOXC1	0	affinity chromatography technology	Li X (2015)	1
FOXC2	2	HOXD13	0	affinity chromatography technology	Li X (2015)	1
FOXP3	1	FOXP1	23	affinity chromatography technology, affinity chromatography technology	Li X (2015), Huttlin EL (2017)	2
FOXI2	1	HOXD13	0	affinity chromatography technology	Li X (2015)	1
FOXQ1	0	CDC27	2	affinity chromatography technology	Li X (2015)	1
ANAPC4	0	HOXD13	0	affinity chromatography technology	Salsi V (2016)	1
FOXC1	0	CREB1	1	affinity chromatography technology	Li X (2015)	1
CDC20	1	ANAPC10	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nilsson J (2008), Voets E (2015), Kelly A (2014), Craney A (2016)	4
TEAD2	2	NFATC1	12	affinity chromatography technology	Li X (2015)	1
ANAPC10	0	ANAPC4	0	biochemical, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Havugimana PC (2012), Zhang Z (2012), Chang L (2014), Vodermaier HC (2003), Chang L (2015), Yamaguchi M (2015), Wan C (2015), Voets E (2015)	8
FOXE1	2	CREB1	1	affinity chromatography technology	Li X (2015)	1
FOXA1	2	HOXD13	0	affinity chromatography technology	Li X (2015)	1
NFATC1	12	FOXP3	1	affinity chromatography technology, affinity chromatography technology	Loizou L (2011), Bettelli E (2005)	2
FOXJ2	3	FOXC1	0	affinity chromatography technology	Li X (2015)	1
HLA-DPA1	1	HOXD13	0	affinity chromatography technology	Huttlin EL (2015)	1
CREBBP	29	CDC27	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nath S (2011), Nath S (2011), Townsend K (2009)	3
CDC20	1	ANAPC4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Mansfeld J (2011), Mansfeld J (2011), Izawa D (2011), Ma HT (2011), Wolthuis R (2008), Sedgwick GG (2012), Zhang Z (2012), Chang L (2014), Fogeron ML (2013), Hein JB (2014), Hein JB (2014), Voets E (2015), Voets E (2015), Tipton AR (2013), Boekhout M (2015), Kelly A (2014), Craney A (2016), Craney A (2016), Sedgwick GG (2016), Qiao R (2016), Izawa D (2012), Izawa D (2012), Izawa D (2012), Izawa D (2012), Salsi V (2016)	25
FZR1	1	ANAPC10	0	unspecified method	Vodermaier HC (2003)	1
A4GNT	0	HOXD13	0	affinity chromatography technology	Huttlin EL (2015)	1
TEAD2	2	CDC27	2	affinity chromatography technology	Li X (2015)	1
FZR1	1	HOXD13	0	affinity chromatography technology	Salsi V (2016)	1
FOXE1	2	HOXD13	0	affinity chromatography technology	Li X (2015)	1
CDC27	2	ANAPC10	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Vodermaier HC (2003), Gmachl M (2000), Kraft C (2003), Lara-Gonzalez P (2011), Dube P (2005), Fehr AR (2012), Holzmann J (2011), Kurasawa Y (1999), Kurasawa Y (1999), Havugimana PC (2012), Vodermaier HC (2003), Wan C (2015), Hein MY (2015)	13
TEAD2	2	FOXK2	9	affinity chromatography technology	Li X (2015)	1
FOXP3	1	HOXD13	0	affinity chromatography technology	Li X (2015)	1
NFATC1	12	FOXK2	9	affinity chromatography technology	Gabriel CH (2016)	1
RAE1	0	HOXD13	0	affinity chromatography technology	Salsi V (2016)	1
FOXP1	23	HOXD13	0	affinity chromatography technology	Li X (2015)	1
SLC2A12	2	HOXD13	0	affinity chromatography technology	Huttlin EL (2017)	1
CDC27	2	HOXD13	0	affinity chromatography technology	Salsi V (2016)	1
FZR1	1	CDC27	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhou Y (2003), Kramer ER (1998), Farhana L (2002), Cen B (2010), Sorensen CS (2001), Binne UK (2007), Wang X (2008), Tran K (2008), Wang LY (2012), Wang LY (2012), Ban KH (2007), Lv XB (2010), Huang KT (2012), Song MS (2011), Fukushima H (2013), Lau AW (2013), Cotto-Rios XM (2011), Vodermaier HC (2003), Vodermaier HC (2003), Vodermaier HC (2003), Choi BH (2014), Jeganathan KB (2006), Fang G (1998), Sedgwick GG (2012), Kelly A (2014), Listovsky T (2013), Pavlides SC (2016), Huttlin EL (2017)	28
CREBBP	29	HOXD13	0	pull down	Shen WF (2001)	1
PLAUR	0	HOXD13	0	affinity chromatography technology	Huttlin EL (2015)	1
ANAPC4	0	FZR1	1	biochemical, biochemical, unspecified method, biochemical, affinity chromatography technology, affinity chromatography technology	Zhang Z (2012), Chang L (2014), Vodermaier HC (2003), Chang L (2015), Boekhout M (2015), Huttlin EL (2017)	6
NFATC1	12	CREB1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li X (2015), Gabriel CH (2016), Gabriel CH (2016)	3
FOXO1	2	HOXD13	0	affinity chromatography technology	Li X (2015)	1
FOXE1	2	FOXK2	9	affinity chromatography technology	Li X (2015)	1
FOXK2	9	HOXD13	0	affinity chromatography technology	Li X (2015)	1
FOS	0	JUN	0	pull down, two hybrid, pull down, x-ray crystallography, two hybrid, pull down, two hybrid, two hybrid, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, fluorescent resonance energy transfe, pull down, pull down, imaging technique, pull down, affinity chromatography technology, pull down, pull down, fluorescent resonance energy transfe, pull down, pull down, affinity chromatography technology, biochemical, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ito T (2001), Pognonec P (1997), Pognonec P (1997), Glover JN (1995), Yang X (1999), Nomura N (1993), Finkel T (1993), Finkel T (1993), Venugopal R (1998), Kumar NV (2001), Dumin E (2006), Bandyopadhyay S (2010), Asim M (2010), Asim M (2010), Srivastav RK (2011), Bossis G (2005), Bossis G (2005), Gupta K (2000), Bachmann M (2004), Reinke AW (2013), Miyagi M (2005), Subbaramaiah K (2007), Jang M (2012), Yamaguchi K (2005), Varjosalo M (2013), Miyamoto-Sato E (2010), Miyamoto-Sato E (2010), Varjosalo M (2013), Tang HY (2006), Marden NY (2005), Adler J (2010), Adler J (2010), Adler J (2010), Billiet L (2008), Huttlin EL (2015), Hein MY (2015), Li X (2015), Li X (2015), Huttlin EL (2017)	39
FZR1	1	CDC20	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Stewart S (2005), Stewart S (2005), Wang Y (2007), Wang Y (2007), Tian W (2012), Hyun SY (2013), Hyun SY (2013)	7
FOXJ2	3	HOXD13	0	affinity chromatography technology	Li X (2015)	1
NFATC1	12	CREBBP	29	affinity chromatography technology	Gabriel CH (2016)	1
CARD8	3	HOXD13	0	affinity chromatography technology	Huttlin EL (2015)	1
FOXE1	2	CDC27	2	affinity chromatography technology	Li X (2015)	1
CDC27	2	ANAPC4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vodermaier HC (2003), Gmachl M (2000), Kraft C (2003), Mansfeld J (2011), Lara-Gonzalez P (2011), Mansfeld J (2011), Izawa D (2011), Ma HT (2011), Ma HT (2011), Ma HT (2011), Dube P (2005), Holzmann J (2011), Wolthuis R (2008), Havugimana PC (2012), Uzunova K (2012), Song MS (2011), Zhang Z (2012), Chang L (2014), Hein JB (2014), Vodermaier HC (2003), Vodermaier HC (2003), Vodermaier HC (2003), Tran K (2010), Chang L (2015), Yamaguchi M (2015), Wan C (2015), Hein MY (2015), Voets E (2015), Masuda K (2015), Boekhout M (2015), Craney A (2016), Qiao R (2016), Izawa D (2012), Hein JB (2016)	34
FOXB1	1	HOXD13	0	affinity chromatography technology	Li X (2015)	1
FOXG1	26	HOXD13	0	affinity chromatography technology	Li X (2015)	1
F9	0	HOXD13	0	affinity chromatography technology	Huttlin EL (2017)	1
FOXA3	0	HOXD13	0	affinity chromatography technology	Li X (2015)	1
CDC20	1	HOXD13	0	affinity chromatography technology	Salsi V (2016)	1
JUN	0	NFATC1	12	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li X (2015), Li X (2015), Gabriel CH (2016)	3
FOXA3	0	FOXP3	1	affinity chromatography technology	Li X (2015)	1
CREB1	1	JUN	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Benbrook DM (1990), Li X (2015), Li X (2015)	3
FOXS1	2	HOXD13	0	affinity chromatography technology	Li X (2015)	1
CREBBP	29	CREB1	1	affinity chromatography technology, two hybrid, pull down, x-ray crystallography, pull down, pull down, affinity chromatography technology, fluorescent resonance energy transfe, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, two hybrid, affinity chromatography technology, far western blotting, pull down, far western blotting, pull down, far western blotting, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shi Y (2004), Kim J (2005), Shimomura A (1996), Radhakrishnan I (1997), Radhakrishnan I (1997), Sano Y (1998), Sano Y (1998), Zor T (2002), Giebler HA (2000), Zhang Q (2000), Ernst P (2001), Ledo F (2002), Poon SL (2008), Best JL (2004), Best JL (2004), Chan EC (2010), Yang F (2006), Solomou EE (2001), Du K (1998), Venza I (2001), Lundblad JR (1995), Lundblad JR (1995), Arias J (1994), Chrivia JC (1993), Chrivia JC (1993), Shi Y (2004), Ramirez JA (2007), Sun HS (2003), Sun HS (2003), Wang Y (2016)	30
FOXN1	3	HOXD13	0	affinity chromatography technology	Li X (2015)	1
FOXR1	3	FOXP3	1	affinity chromatography technology	Li X (2015)	1
TEAD2	2	HOXD13	0	affinity chromatography technology	Li X (2015)	1
FOXP3	1	CDC27	2	affinity chromatography technology	Li X (2015)	1
FOXR1	3	HOXD13	0	affinity chromatography technology	Li X (2015)	1
FOXC2	2	CREB1	1	affinity chromatography technology	Li X (2015)	1
FOXC1	0	HOXD13	0	affinity chromatography technology	Li X (2015)	1
FOXA1	2	CREB1	1	affinity chromatography technology	Li X (2015)	1
RBPJ	1	NFATC1	12	affinity chromatography technology	Li X (2015)	1
FOXA1	2	FOXA3	0	affinity chromatography technology	Li X (2015)	1
FZR1	1	TEAD2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CREBBP	29	JUN	0	pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, far western blotting	Sano Y (1998), Sano Y (1998), Merika M (1998), Duyndam MC (1999), Johnson J (2007), Yamaguchi K (2005), Tsai LN (2008), Arias J (1994)	8
RBPJ	1	HOXD13	0	affinity chromatography technology	Li X (2015)	1
FOXA2	3	HOXD13	0	affinity chromatography technology	Li X (2015)	1
FOXF1	2	HOXD13	0	affinity chromatography technology	Li X (2015)	1
FOXO1	2	CREBBP	29	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nasrin N (2000), Nasrin N (2000), Kitamura YI (2005), Daitoku H (2004), Daitoku H (2004), Daitoku H (2004), Daitoku H (2004), Pramanik KC (2014), Pramanik KC (2014), Li X (2015)	10
KLK15	0	HOXD13	0	affinity chromatography technology	Huttlin EL (2015)	1