PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
APCS	2	APCS	2	x-ray crystallography	Emsley J (1994)	1
APCS	2	HES1	0	two hybrid	Vinayagam A (2011)	1
FCGR3A	0	GK	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FCGR3B	2	GK	0	affinity chromatography technology	Huttlin EL (2015)	1
FCGR3A	0	FCGR3B	2	affinity chromatography technology	Huttlin EL (2015)	1
FN1	17	APCS	2	affinity chromatography technology	Sen JW (2002)	1
GRB2	2	FN1	17	two hybrid, affinity chromatography technology	Wang J (2008), Humphries JD (2009)	2
FN1	17	CRP	0	pull down	Salonen EM (1984)	1
CRP	0	APCS	2	pull down	Christner RB (1994)	1
APCS	2	COPS5	0	two hybrid	Wang J (2011)	1
FN1	17	C4BPA	3	affinity chromatography technology	Moussavi-Harami SF (2013)	1
APCS	2	FCGR3A	0	pull down	Bharadwaj D (2001)	1
APCS	2	GK	0	two hybrid	Wang J (2011)	1
FCGR3A	0	FCGR1A	0	imaging technique	Chen TC (2014)	1
APCS	2	GOT2	0	two hybrid	Vinayagam A (2011)	1
C4BPA	3	APCS	2	biochemical, affinity chromatography technology	Garcia de Frutos P (1995), Sen JW (2002)	2
APCS	2	FCGR1A	0	pull down	Bharadwaj D (2001)	1
CALU	4	APCS	2	pull down	Vorum H (2000)	1
APCS	2	FCGR3B	2	pull down	Bharadwaj D (2001)	1
GRB2	2	APCS	2	two hybrid	Wang J (2008)	1