PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HSF1	1	FKBP5	0	pull down	Nair SC (1996)	1
HSF4	0	HSF1	1	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
ALKBH4	2	HSF4	0	two hybrid	Bjornstad LG (2012)	1
BCL6	6	SMARCA4	19	affinity chromatography technology	Miles RR (2005)	1
MAPK1	1	HSF1	1	affinity chromatography technology, pull down	Dai R (2000), Dai R (2000)	2
HSF1	1	HSF2	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	He H (2003), He H (2003), Taipale M (2014), Taipale M (2014), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	7
CDK2AP2	0	HSF4	0	two hybrid	Vinayagam A (2011)	1
HSF4	0	SUGT1	1	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
HSF1	1	DAXX	5	two hybrid, affinity chromatography technology, pull down	Boellmann F (2004), Boellmann F (2004), Zhang J (2010)	3
ZBED8	1	HSF4	0	two hybrid	Vinayagam A (2011)	1
HSF4	0	FKBP5	0	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
HSF4	0	TARBP1	3	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
FKBP5	0	SUGT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014), Taipale M (2014), Taipale M (2014)	4
HSF4	0	RABEP1	4	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
HSF4	0	DAXX	5	affinity chromatography technology, pull down	Zhang J (2010), Zhang J (2010)	2
NUDT21	0	HSF4	0	two hybrid	Vinayagam A (2011)	1
HSF4	0	MAPK1	1	affinity chromatography technology, pull down	Hu Y (2006), Hu Y (2006)	2
HSF4	0	SMARCA4	19	affinity chromatography technology, pull down	Tu N (2006), Tu N (2006)	2
HSF4	0	DUSP26	0	two hybrid, pull down, affinity chromatography technology	Hu Y (2006), Hu Y (2006), Hu Y (2006)	3
HSF4	0	TIMM13	0	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
HSF4	0	SESTD1	1	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
HSF4	0	HSF2	2	affinity chromatography technology, affinity chromatography technology, imaging technique	Taipale M (2014), Taipale M (2014), Chen R (2011)	3
BCL6	6	HSF4	0	affinity chromatography technology	Miles RR (2005)	1
HSF4	0	MYO15A	9	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
HSF1	1	SMARCA4	19	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sullivan EK (2001), Cheng MB (2010), Zhang Y (2010)	3