PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RNF31	3	UBE2D1	0	pull down, pull down	Nakamura M (2006), Kirisako T (2006)	2
BIRC3	1	IKBKB	1	imaging technique	Chen TC (2014)	1
TRAF6	0	BCL10	0	affinity chromatography technology	Bidere N (2006)	1
YOD1	0	RIPK1	2	enzymatic study	Mevissen TE (2013)	1
TRAF6	0	UBC	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Muroi M (2011), Park S (2013), Sun L (2004), Kanayama A (2004), Sakamoto H (2015), Yu J (2016), Middleton AJ (2017)	7
EGLN3	0	USP7	14	affinity chromatography technology	Rodriguez J (2016)	1
CD40LG	0	BIRC3	1	affinity chromatography technology	Salzmann S (2013)	1
CASP3	0	CASP7	1	enzymatic study	Walsh JG (2008)	1
NFKB1	2	TNFAIP3	3	affinity chromatography technology	Lapid D (2017)	1
NFKB1	2	REL	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Huttlin EL (2015), Li X (2015), Huttlin EL (2017)	4
TRAF3	1	DCAF7	4	affinity chromatography technology	van Zuylen WJ (2012)	1
PELI1	1	UBC	7	enzymatic study, enzymatic study	Smith H (2009), Smith H (2011)	2
CASP10	1	RIPK1	2	affinity chromatography technology	Chaudhary PM (2000)	1
BIRC5	1	CASP3	0	pull down, enzymatic study, pull down	Tamm I (1998), Shin S (2001), Shin S (2001)	3
GSK3B	1	NFKB1	2	enzymatic study	Demarchi F (2001)	1
IKBKG	0	RBCK1	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Fenner BJ (2010), Verhelst K (2012), Zak DE (2011), Niu J (2011), Fu J (2013), Tokunaga F (2011), Xia ZP (2009), Emmerich CH (2013), Abdul-Sater AA (2017), Abdul-Sater AA (2017), Bal E (2017), Bal E (2017)	12
TNFRSF1A	3	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Won M (2010), Zilberman-Rudenko J (2016), Moquin DM (2013)	3
TNFRSF1A	3	TRAF3	1	pull down	Mosialos G (1995)	1
PELI1	1	BIRC3	1	affinity chromatography technology, pull down, pull down	Jeon YK (2016), Jeon YK (2016), Jeon YK (2016)	3
CASP8	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chaudhary PM (2000), Oshima S (2009), Bertrand MJ (2008), Knox PG (2011), Kim S (2010), Cheung HH (2009), Tenev T (2011), Tenev T (2011), Mahul-Mellier AL (2011), Legarda-Addison D (2009), Biton S (2011), Bellail AC (2012), Bellail AC (2012), Lee EW (2012), Rebe C (2007), Feoktistova M (2012), Puliyappadamba VT (2013), Wu P (2014), Wu P (2014), Feoktistova M (2011), Selmi T (2015), Yamaguchi N (2015), Moquin DM (2013), Ranjan K (2016), Zinngrebe J (2016), Nakazawa S (2016), Zheng M (2016)	27
RIPK1	2	BIRC2	1	affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Bertrand MJ (2008), Bertrand MJ (2008), Xu M (2009), Dynek JN (2010), Dynek JN (2010), Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011), Puliyappadamba VT (2013), Fu J (2016), Vu NT (2016), Vu NT (2016)	12
TLR3	2	RIPK1	2	affinity chromatography technology, affinity chromatography technology	Cusson-Hermance N (2005), Zinngrebe J (2016)	2
TNFRSF1A	3	UBC	7	affinity chromatography technology	Nakazawa S (2016)	1
RNF31	3	TRAF2	1	affinity chromatography technology	Schaeffer V (2014)	1
EGLN3	0	UBR4	15	affinity chromatography technology	Rodriguez J (2016)	1
DIABLO	2	BIRC5	1	affinity chromatography technology, pull down, affinity chromatography technology, pull down, fluorescent resonance energy transfe, pull down, affinity chromatography technology, pull down	Song Z (2003), Song Z (2003), McNeish IA (2005), Pavlyukov MS (2011), Pavlyukov MS (2011), Guvenc H (2013), Song Z (2004), Song Z (2004)	8
UBE2I	0	TRAF6	0	enzymatic study, enzymatic study	Li Y (2013), Pham LV (2008)	2
UBE2D1	0	DZIP3	6	two hybrid, pull down	Markson G (2009), Kreft SG (2003)	2
BIRC2	1	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Silke J (2005), Rajalingam K (2006), Rajalingam K (2006), Oberoi-Khanuja TK (2012), Huttlin EL (2017)	5
IKBKB	1	TNFRSF1A	3	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Zhang SQ (2000), Chaudhary PM (2000), Fan YH (2011), Park KJ (2002), Guan YJ (2011), Guan YJ (2011), Guan YJ (2011), Mitsuhashi S (2008), Chen TC (2014)	9
BIRC3	1	TRAF1	0	pull down, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology	Roy N (1997), Li X (2002), Goncharov T (2013), Chen TC (2014), Greenfeld H (2015)	5
E2F1	0	XIAP	0	affinity chromatography technology, affinity chromatography technology	Cartier J (2011), Cao Z (2014)	2
BIRC3	1	BIRC3	1	enzymatic study, x-ray crystallography, enzymatic study, two hybrid, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study	Li X (2002), Mace PD (2008), Yin Q (2009), Dynek JN (2010), Dynek JN (2010), Feltham R (2011), Feltham R (2011), Schumacher FR (2013), Durcan TM (2011), Budhidarmo R (2014), Choi JS (2014), Choi JS (2014), Choi JS (2014), Fang S (2001), Bertrand MJ (2008), Suzuki S (2017)	16
GSK3B	1	BIRC2	1	affinity chromatography technology	Sun M (2009)	1
IKBKE	2	UBC	7	affinity chromatography technology, pull down, affinity chromatography technology	Rajsbaum R (2014), Paz S (2009), Bharaj P (2016)	3
BCL10	0	UBE2N	1	pull down	Zhou H (2004)	1
MAVS	1	BIRC3	1	affinity chromatography technology	Mao AP (2010)	1
UBE2N	1	BIRC3	1	two hybrid, pull down, two hybrid	van Wijk SJ (2009), Wu CJ (2006), Schimmack G (2017)	3
TRAF6	0	TAB1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Takaesu G (2000), Ninomiya-Tsuji J (1999), Walsh MC (2008)	3
BIRC2	1	RNF31	3	affinity chromatography technology, affinity chromatography technology	Goncharov T (2013), Schaeffer V (2014)	2
BIRC3	1	CASP7	1	pull down, affinity chromatography technology	Roy N (1997), Eckelman BP (2006)	2
UBXN1	0	MAVS	1	affinity chromatography technology, affinity chromatography technology	Wang P (2013), Wang P (2013)	2
IKBKE	2	TRAF3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ng MH (2011), Charoenthongtrakul S (2013), Peng Y (2014), Gu L (2017), Fang R (2017)	5
TAB1	1	TRAF2	1	affinity chromatography technology	Bouwmeester T (2004)	1
TANK	1	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Li S (2011), Goncharov T (2013)	2
UBE2D2	0	UBE2V1	0	biochemical	Havugimana PC (2012)	1
IKBKE	2	BIRC2	1	affinity chromatography technology, enzymatic study	Zhou AY (2013), Zhou AY (2013)	2
PELI1	1	UBE2D2	0	pull down	Smith H (2009)	1
IKBKE	2	TANK	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nomura F (2000), Nomura F (2000), Nomura F (2000), Gatot JS (2007), Renner F (2011), Shen RR (2012), Ryzhakov G (2007), So J (2015)	8
XIAP	0	RIPK2	0	pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid	Bertrand MJ (2011), Damgaard RB (2012), Krieg A (2009), Krieg A (2009), Krieg A (2009), Conde C (2012), Damgaard RB (2013), Damgaard RB (2013), Rolland T (2014)	9
OTUB1	0	MAVS	1	affinity chromatography technology	Li S (2010)	1
BIRC2	1	UBE2D1	0	affinity chromatography technology, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Hu S (2003), Dynek JN (2010), Dynek JN (2010), Xu M (2009), Phu L (2011), Oberoi TK (2012), Bertrand MJ (2011), Guicciardi ME (2014), Takeda AN (2014), Wauer T (2015), Vu NT (2016)	11
RIPK4	0	RAF1	3	affinity chromatography technology	Rodriguez J (2016)	1
TRAF2	1	UBC	7	enzymatic study, enzymatic study	Liu J (2011), Kanayama A (2004)	2
TRIM32	2	UBE2D1	0	affinity chromatography technology, pull down, pull down, pull down, pull down	Napolitano LM (2011), Zhang J (2012), Streich FC (2013), Albor A (2006), Mokhonova EI (2015)	5
TNFAIP3	3	TRAF1	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Song HY (1996), Song HY (1996), Heyninck K (1999), Greenfeld H (2015), Greenfeld H (2015)	5
UBC	7	LIMA1	4	pull down	Nathan JA (2013)	1
TRAF2	1	RIPK3	2	affinity chromatography technology	Yu PW (1999)	1
RBCK1	0	UBC	7	affinity chromatography technology, affinity chromatography technology, x-ray crystallography, enzymatic study, pull down, pull down, pull down, pull down, enzymatic study, pull down	Tatematsu K (2008), Yoshimoto N (2009), Sato Y (2011), Kirisako T (2006), Haas TL (2009), Yoshimoto N (2009), Sato Y (2011), Emmerich CH (2013), Emmerich CH (2013), Zhang X (2017)	10
BIRC3	1	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rajalingam K (2006), Rajalingam K (2006), Yang W (2014), Yang W (2014)	4
RNF31	3	RBCK1	0	affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, pull down	Haas TL (2009), Yagi H (2012), Yagi H (2012), Yagi H (2012), Nakamura M (2006), Tokunaga F (2012), Kirisako T (2006), Kirisako T (2006), Rivkin E (2013), Schaeffer V (2014), Tokunaga F (2011), Tokunaga F (2011), Chen Y (2015), Draber P (2015), Draber P (2015), Klein T (2015), Klein T (2015), Stieglitz B (2012), Huttlin EL (2017), Liu J (2017), Liu J (2017)	21
TRAF1	0	RBCK1	0	affinity chromatography technology, pull down, affinity chromatography technology, pull down	Li S (2011), Li S (2011), Greenfeld H (2015), Abdul-Sater AA (2017)	4
RIPK2	0	RIPK1	2	affinity chromatography technology	Damgaard RB (2012)	1
UBC	7	HAX1	1	affinity chromatography technology	Matsumoto M (2005)	1
RCHY1	0	UBE2D1	0	pull down, pull down	Abou Zeinab R (2013), McClurg UL (2016)	2
CASP1	1	NOD2	1	affinity chromatography technology	Damiano JS (2004)	1
EGFR	5	USP9X	15	affinity chromatography technology	Foerster S (2013)	1
GLMN	2	BIRC2	1	affinity chromatography technology, pull down	Suzuki S (2017), Suzuki S (2017)	2
RIPK4	0	UBA1	1	affinity chromatography technology	Rodriguez J (2016)	1
MAVS	1	RNF31	3	affinity chromatography technology	Khan M (2016)	1
COMMD1	1	XIAP	0	pull down, affinity chromatography technology, affinity chromatography technology	Maine GN (2009), Burstein E (2004), Burstein E (2004)	3
UBC	7	IKBKB	1	pull down	Zhang X (2017)	1
USP15	4	TRAF6	0	enzymatic study	Bremm A (2010)	1
IKBKE	2	TRAF2	1	enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Shen RR (2012), Shen RR (2012), Shen RR (2012), Zhang W (2010), Zhou AY (2013), Zhou AY (2013), So J (2015), Fang R (2017)	8
BIRC2	1	CASP10	1	affinity chromatography technology	McDonald ER (2004)	1
IKBKB	1	PELI1	1	enzymatic study	Smith H (2011)	1
EGFR	5	IKBKG	0	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
OTUB1	0	TRAF3	1	affinity chromatography technology, affinity chromatography technology	Li S (2010), Peng Y (2014)	2
UBXN1	0	UBC	7	pull down, pull down, affinity chromatography technology, pull down, pull down, pull down	Wu-Baer F (2010), Fenner BJ (2009), Alexandru G (2008), LaLonde DP (2011), McNeill H (2004), Zhang X (2017)	6
TRAF1	0	DIABLO	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li S (2011), Greenfeld H (2015), Huttlin EL (2017)	3
TANK	1	TRAF6	0	affinity chromatography technology, affinity chromatography technology, pull down	Wang W (2015), Wang W (2015), Wang W (2015)	3
RIPK2	0	IKBKG	0	affinity chromatography technology, affinity chromatography technology	Inohara N (2000), Hasegawa M (2008)	2
NOD2	1	TNFAIP3	3	affinity chromatography technology	Draber P (2015)	1
EGFR	5	XIAP	0	affinity chromatography technology	Yao Z (2017)	1
CASP1	1	TRAF2	1	affinity chromatography technology	Labbe K (2011)	1
UBE2L3	1	RBCK1	0	two hybrid, pull down, pull down	Markson G (2009), Tatematsu K (2008), Kirisako T (2006)	3
IKBKB	1	TNFAIP3	3	enzymatic study, affinity chromatography technology	Zetoune FS (2001), Xiong Y (2011)	2
BIRC3	1	BIRC5	1	pull down	Dohi T (2004)	1
UBA1	1	UBE2D3	1	enzymatic study, pull down, enzymatic study, enzymatic study	Tokgoez Z (2012), Jin J (2007), Song AX (2014), Huguenin-Dezot N (2016)	4
BIRC3	1	CASP9	6	pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, imaging technique	Deveraux QL (1998), Deveraux QL (1998), Eckelman BP (2006), Cheung HH (2006), Wang J (2011), McDonald ER (2004), Chen TC (2014)	7
SPHK1	0	BIRC3	1	affinity chromatography technology, affinity chromatography technology, pull down	Harikumar KB (2014), Harikumar KB (2014), Harikumar KB (2014)	3
RIPK1	2	IKBKB	1	biochemical, pull down	Yang Y (2011), Poyet JL (2000)	2
USP7	14	RBCK1	0	two hybrid	Hayes SD (2012)	1
BIRC2	1	RIPK3	2	pull down, affinity chromatography technology, enzymatic study	Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011)	3
EGLN3	0	TAB1	1	affinity chromatography technology	Rodriguez J (2016)	1
BIRC5	1	CASP9	6	affinity chromatography technology, imaging technique	OConnor DS (2000), Chen TC (2014)	2
BCL10	0	TRAF2	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Yoneda T (2000), Yoneda T (2000), Yoneda T (2000), Yui D (2001), Rolland T (2014)	5
BIRC5	1	USP9X	15	affinity chromatography technology	Vong QP (2005)	1
TNFRSF1A	3	SUMO1	0	two hybrid, two hybrid, pull down	Liou ML (1999), Okura T (1996), Okura T (1996)	3
EGLN3	0	GLMN	2	affinity chromatography technology	Rodriguez J (2016)	1
LIMA1	4	DIABLO	2	affinity chromatography technology	Hein MY (2015)	1
XIAP	0	CASP7	1	pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, x-ray crystallography, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Riedl SJ (2001), Roy N (1997), Deveraux QL (1997), Deveraux QL (1997), Suzuki Y (2001), Bartke T (2004), Tenev T (2005), Paulsen M (2008), Huang Y (2001), Huang Y (2001), Chai J (2001), Chai J (2001), Huang Y (2003), Huang Y (2003), Sun M (2009), Takahashi R (1998), Lee JS (2012), Lin YF (2013), Lin YF (2013), Hou Y (2017)	20
UBC	7	E2F1	0	affinity chromatography technology	Rizos H (2007)	1
TRAF2	1	XIAP	0	affinity chromatography technology	Vince JE (2009)	1
TLR3	2	TRAF3	1	affinity chromatography technology	Li S (2011)	1
IKBKG	0	TRAF3	1	affinity chromatography technology	Belgnaoui SM (2012)	1
IKBKB	1	MAVS	1	enzymatic study	Liu S (2015)	1
TRAF1	0	RNF31	3	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down	Li S (2011), Li S (2011), Greenfeld H (2015), Greenfeld H (2015), Greenfeld H (2015), Abdul-Sater AA (2017)	6
NOD2	1	RBCK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Damgaard RB (2012), Damgaard RB (2013), Draber P (2015)	3
TRAF2	1	DIABLO	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Li S (2011), Huttlin EL (2017)	3
BIRC3	1	DCAF7	4	affinity chromatography technology	Goncharov T (2013)	1
BIRC2	1	UBE2Q2	4	two hybrid	Dynek JN (2010)	1
BIRC3	1	UBE2I	0	two hybrid, two hybrid	Dynek JN (2010), Dynek JN (2010)	2
TRAF6	0	XIAP	0	affinity chromatography technology, two hybrid, imaging technique	Sanna MG (2002), Woodsmith J (2012), Chen TC (2014)	3
USP7	14	HTRA2	1	two hybrid	Lim J (2006)	1
TRAF3	1	MAVS	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nakhaei P (2009), Arnaud N (2011), Paz S (2011), Wang Y (2012), Saha SK (2006), Saha SK (2006), Ng MH (2011), Johnsen IB (2009), van Zuylen WJ (2012), Belgnaoui SM (2012), Chen X (2014), Wang P (2013), Wang P (2013), Minassian A (2015), Gu L (2017), Khan M (2016), Fang R (2017), Fang R (2017)	18
USP15	4	USP7	14	enzymatic study	Loch CM (2012)	1
EGLN3	0	BIRC3	1	affinity chromatography technology	Fu J (2016)	1
UBXN1	0	USP9X	15	biochemical	Havugimana PC (2012)	1
XIAP	0	CASP10	1	two hybrid, affinity chromatography technology	Rolland T (2014), McDonald ER (2004)	2
BIRC2	1	EGFR	5	affinity chromatography technology	Puliyappadamba VT (2013)	1
BIRC2	1	UBE2L3	1	affinity chromatography technology	Hu S (2003)	1
UBE2N	1	RBCK1	0	two hybrid	Markson G (2009)	1
USP7	14	TRAF6	0	pull down, affinity chromatography technology, enzymatic study	Zapata JM (2001), Daubeuf S (2009), Bremm A (2010)	3
TRAF1	0	HTRA2	1	affinity chromatography technology	Greenfeld H (2015)	1
BIRC3	1	CASP3	0	pull down, affinity chromatography technology	Roy N (1997), Rajalingam K (2006)	2
IKBKG	0	IKBKE	2	affinity chromatography technology, affinity chromatography technology	Zhao T (2007), Zhou AY (2013)	2
E2F1	0	BIRC3	1	affinity chromatography technology	Cartier J (2011)	1
UBE2I	0	TNFRSF1A	3	two hybrid, pull down	Saltzman A (1998), Saltzman A (1998)	2
UBC	7	UBR4	15	affinity chromatography technology, pull down, affinity chromatography technology	Matsumoto M (2005), Nathan JA (2013), Bish RA (2007)	3
BIRC3	1	NFKB1	2	imaging technique	Chen TC (2014)	1
TNFAIP3	3	TRAF2	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Song HY (1996), Song HY (1996), Fries KL (1999), Yamaguchi N (2013), Rolland T (2014)	5
TNFAIP3	3	BIRC3	1	affinity chromatography technology	Yamaguchi N (2013)	1
BIRC3	1	USP7	14	affinity chromatography technology	Goncharov T (2013)	1
CASP8	1	XIAP	0	genetic interference, affinity chromatography technology, affinity chromatography technology	Guo Y (2002), Lee JS (2012), McDonald ER (2004)	3
TRAF6	0	IKBKE	2	affinity chromatography technology	Fang R (2017)	1
TRAF6	0	YOD1	0	two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Schimmack G (2017), Schimmack G (2017), Schimmack G (2017), Schimmack G (2017), Schimmack G (2017)	5
BIRC3	1	HAX1	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Choi JS (2014), Choi JS (2014), Choi JS (2014), Choi JS (2014)	4
CASP8	1	CASP7	1	enzymatic study, enzymatic study	Guo Y (2002), Srinivasula SM (1996)	2
BIRC2	1	CASP3	0	pull down, pull down, enzymatic study, enzymatic study, affinity chromatography technology	Roy N (1997), Choi YE (2009), Choi YE (2009), Clem RJ (2001), Rajalingam K (2006)	5
MBTPS1	4	BIRC3	1	affinity chromatography technology, pull down, affinity chromatography technology	Harikumar KB (2014), Harikumar KB (2014), Harikumar KB (2014)	3
CASP8	1	TNFRSF1A	3	biochemical	Gajate C (2005)	1
BIRC3	1	RIPK2	0	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Thome M (1998), Bertrand MJ (2009), Bertrand MJ (2009), Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011)	6
COMMD1	1	REL	5	affinity chromatography technology	Burstein E (2005)	1
TANK	1	TRAF2	1	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, unspecified method	Bouwmeester T (2004), Rothe M (1996), Rothe M (1996), Nomura F (2000), Nomura F (2000), Pomerantz JL (1999), Behrends C (2010), Li S (2011), Li S (2011), Li C (2002), Shen RR (2012), Shen RR (2012), Wang J (2011), Huttlin EL (2017), Kim CM (2017)	15
BIRC2	1	PACS2	9	enzymatic study, affinity chromatography technology, pull down	Guicciardi ME (2014), Guicciardi ME (2014), Guicciardi ME (2014)	3
BIRC3	1	IKBKE	2	enzymatic study	Zhou AY (2013)	1
UBC	7	SUMO1	0	affinity chromatography technology	Sahin U (2014)	1
BIRC3	1	CASP8	1	affinity chromatography technology, affinity chromatography technology	McDonald ER (2004), Zinngrebe J (2016)	2
CASP10	1	CASP8	1	biochemical, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Micheau O (2003), Micheau O (2003), Guo Y (2002), Srinivasula SM (1996), Srinivasula SM (1996), Sinha SK (2004), Lee EW (2012), Feoktistova M (2011)	9
TRAF6	0	CASP8	1	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Bidere N (2006), Bidere N (2006), He L (2006), He L (2006), Zinngrebe J (2016)	5
TNFRSF1A	3	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Hsu H (1996), Hsu H (1996), Shu HB (1996), Vince JE (2009), Mahul-Mellier AL (2011), Won M (2010), Kolliputi N (2009), Park KJ (2002), Lee IT (2010), Kim WJ (2005), Zheng L (2006), Vince JE (2007), Jeon J (2014), Chen TC (2014), Lee CK (2015), Jeong M (2017)	16
TNFAIP3	3	UBC	7	x-ray crystallography, enzymatic study, pull down, pull down, x-ray crystallography, pull down, enzymatic study, enzymatic study, enzymatic study, pull down, pull down, enzymatic study, x-ray crystallography, pull down	Bosanac I (2010), Bremm A (2010), Fenner BJ (2009), Tokunaga F (2012), Tokunaga F (2012), Verhelst K (2012), Mevissen TE (2013), Komander D (2009), Evans PC (2004), Skaug B (2011), Bohgaki M (2008), Boone DL (2004), Mevissen TE (2016), Mevissen TE (2016)	14
BIRC3	1	DZIP3	6	two hybrid	Woodsmith J (2012)	1
USP15	4	YOD1	0	enzymatic study	Loch CM (2012)	1
IKBKG	0	BCL10	0	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Wu CJ (2008), Wu CJ (2008), Bhattacharyya S (2010), Stilo R (2004), Poyet JL (2001), Poyet JL (2001), Park Y (2013), Zhou H (2004), Yang YK (2016)	9
EGFR	5	RAF1	3	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
EGFR	5	RIPK1	2	affinity chromatography technology	Habib AA (2001)	1
TRAF6	0	SPHK1	0	affinity chromatography technology	Ryu J (2006)	1
MAVS	1	TRAF1	0	affinity chromatography technology	Minassian A (2015)	1
EGFR	5	TNFRSF1A	3	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
COMMD1	1	BIRC3	1	affinity chromatography technology	Burstein E (2004)	1
UBE2D1	0	TRAF6	0	two hybrid, pull down	Markson G (2009), Markson G (2009)	2
UBC	7	UBA1	1	affinity chromatography technology, unspecified method, x-ray crystallography, biochemical, affinity chromatography technology, pull down	Nicassio F (2007), Zhao B (2012), Schaefer A (2014), Schaefer A (2014), Bish RA (2007), Zhang X (2017)	6
RIPK1	2	BIRC3	1	affinity chromatography technology, enzymatic study, enzymatic study, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study	Bertrand MJ (2008), Bertrand MJ (2008), Dynek JN (2010), Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011), Puliyappadamba VT (2013), Wu CJ (2006)	8
BIRC3	1	RIPK4	0	pull down, affinity chromatography technology, enzymatic study	Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011)	3
TRAF2	1	TRAF6	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Li S (2011), Davies CC (2005), Relaix F (1998), Rolland T (2014), Yu H (2011), Huttlin EL (2017)	7
XIAP	0	RIPK4	0	pull down, enzymatic study	Bertrand MJ (2011), Bertrand MJ (2011)	2
TNFAIP3	3	UBE2N	1	pull down	Wertz IE (2004)	1
BIRC2	1	USP15	4	affinity chromatography technology	Goncharov T (2013)	1
HTRA2	1	XIAP	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, pull down, unspecified method, pull down	Hegde R (2003), Verhagen AM (2002), Hao Y (2004), Sekine K (2005), Vucic D (2002), van Loo G (2002), Seong YM (2004), Seong YM (2004), Martins LM (2002), Martins LM (2002), Suzuki Y (2001), Suzuki Y (2001), Hegde R (2002), Plun-Favreau H (2007), Singh N (2014), Singh N (2014), Singh N (2014)	17
PACS2	9	TRAF2	1	pull down	Guicciardi ME (2014)	1
BIRC3	1	WDR1	3	affinity chromatography technology	Goncharov T (2013)	1
TRAF3	1	RIPK2	0	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Cai X (2013), Cai X (2013), Cai X (2013), Cai X (2013)	4
TRAF6	0	BIRC3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mao AP (2010), Goncharov T (2013), Harikumar KB (2014), Harikumar KB (2014)	4
CASP8	1	CASP9	6	enzymatic study, genetic interference, enzymatic study	Guo Y (2002), Guo Y (2002), Srinivasula SM (1996)	3
UBA1	1	UBE2Q2	4	enzymatic study, enzymatic study	Wauer T (2015), Huguenin-Dezot N (2016)	2
UBE2D3	1	DZIP3	6	two hybrid	Markson G (2009)	1
XIAP	0	UBE2L3	1	affinity chromatography technology	Hu S (2003)	1
REL	5	BIRC3	1	affinity chromatography technology	Jin J (2015)	1
TRAF6	0	NOD2	1	affinity chromatography technology	Park S (2013)	1
BIRC2	1	USP7	14	affinity chromatography technology	Goncharov T (2013)	1
XIAP	0	BIRC5	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Arora V (2007), Dohi T (2004), Dohi T (2004), Pavlyukov MS (2011)	4
BIRC2	1	CASP9	6	pull down, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, unspecified method, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Deveraux QL (1998), Deveraux QL (1998), Eckelman BP (2006), Cheung HH (2006), Kulathila R (2009), Kulathila R (2009), Vucic D (2000), Rolland T (2014), McDonald ER (2004), Chen TC (2014), Vu NT (2016), Vu NT (2016)	12
NFKB1	2	IKBKG	0	affinity chromatography technology, pull down	Bouwmeester T (2004), Smolle M (2004)	2
UBC	7	UBE2D3	1	affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down, pull down	Matsumoto M (2005), Vinayagam A (2011), Pruneda JN (2014), Li Y (2014), Poyurovsky MV (2007), Zhang X (2017)	6
OTUB1	0	UBE2N	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Sowa ME (2009), Nakada S (2010), Nakada S (2010), Sato Y (2012), Sato Y (2012), Sato Y (2012), Wiener R (2012), Herhaus L (2013), Herhaus L (2015), Scholz CC (2016), Boldt K (2016), Weber E (2017)	12
TNFRSF1A	3	BIRC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shu HB (1996), Vince JE (2009), Vince JE (2007), Wang YB (2015)	4
TLR3	2	CASP8	1	affinity chromatography technology	Zinngrebe J (2016)	1
BIRC2	1	USP9X	15	affinity chromatography technology	Goncharov T (2013)	1
BIRC3	1	UBE2V1	0	pull down, pull down	Bertrand MJ (2008), Wu CJ (2006)	2
EGLN3	0	BIRC2	1	affinity chromatography technology	Fu J (2016)	1
BIRC3	1	UBE2D2	0	x-ray crystallography, pull down, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down	Mace PD (2008), Mace PD (2008), Dynek JN (2010), Feltham R (2011), Dou H (2012), Li X (2002), Schumacher FR (2013), Choi JS (2014), Wu CJ (2006), Fang S (2001), Hu S (2003), Suzuki S (2017)	12
MAVS	1	BIRC2	1	affinity chromatography technology	Mao AP (2010)	1
UBC	7	TAB1	1	pull down	Zhang X (2017)	1
NOD2	1	RNF31	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Damgaard RB (2012), Damgaard RB (2013), Draber P (2015)	3
UBE2N	1	DZIP3	6	two hybrid	Markson G (2009)	1
RNF31	3	UBE2D3	1	pull down, pull down, pull down	Inn KS (2011), Tokunaga F (2011), Kirisako T (2006)	3
XIAP	0	XAF1	1	two hybrid, affinity chromatography technology, imaging technique, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Liston P (2001), Liston P (2001), Liston P (2001), Arora V (2007), Tse MK (2012), Ju JH (2013), Ju JH (2013)	7
UBE2D1	0	XIAP	0	two hybrid, affinity chromatography technology, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Markson G (2009), Hu S (2003), Dynek JN (2010), Morizane Y (2005), Janzer A (2012), Liu WH (2007), Takeda AN (2014), Markson G (2009), Hao Y (2004), Hanson AJ (2012)	10
BIRC3	1	LIMA1	4	affinity chromatography technology	Nie Z (2015)	1
EGLN3	0	UBXN1	0	affinity chromatography technology	Rodriguez J (2016)	1
IKBKE	2	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology	Gao L (2011), Saitoh T (2005)	2
UBA1	1	UBE2L3	1	enzymatic study, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Tokgoez Z (2012), Ronchi VP (2012), Jin J (2007), Liu Z (2014), Nuber U (1996), Huang DT (2009), Kang D (2002), Wauer T (2015), Huguenin-Dezot N (2016)	9
UBE2N	1	RIPK1	2	enzymatic study	Bohgaki M (2008)	1
TRIM32	2	UBC	7	enzymatic study, pull down	Streich FC (2013), Zhang X (2017)	2
TRAF3	1	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Mao AP (2010), Goncharov T (2013)	2
NOD2	1	UBC	7	x-ray crystallography	Ver Heul AM (2013)	1
RNF31	3	RIPK1	2	affinity chromatography technology	Draber P (2015)	1
EGLN3	0	USP9X	15	affinity chromatography technology	Rodriguez J (2016)	1
BIRC3	1	TANK	1	affinity chromatography technology	Goncharov T (2013)	1
BIRC3	1	UBE2D3	1	affinity chromatography technology, two hybrid, pull down, pull down	Hu S (2003), Dynek JN (2010), Darding M (2011), Hu S (2003)	4
IRF5	0	MAVS	1	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
NOD2	1	BIRC3	1	affinity chromatography technology	Damgaard RB (2012)	1
TRAF6	0	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, two hybrid, enzymatic study, affinity chromatography technology, enzymatic study, two hybrid, two hybrid	Heyninck K (1999), Evans PC (2001), Lin SC (2008), Xiong Y (2011), Bremm A (2010), Kelly C (2012), Hayes SD (2012), Lin SC (2008), Garg AV (2013), Boone DL (2004), Schimmack G (2017), Schimmack G (2017)	12
BIRC2	1	UBE2D2	0	two hybrid, pull down, pull down, pull down	Dynek JN (2010), Li X (2002), Feltham R (2011), Choi YE (2009)	4
USP7	14	TRAF2	1	pull down	Zapata JM (2001)	1
MAVS	1	IKBKG	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tang ED (2010), Li S (2011), Li S (2011), Wang L (2012), Wang L (2012), Zhou Z (2014)	6
BIRC2	1	E2F1	0	affinity chromatography technology, affinity chromatography technology	Cartier J (2011), Cartier J (2011)	2
BIRC3	1	XAF1	1	affinity chromatography technology	Arora V (2007)	1
HTRA2	1	BIRC3	1	pull down, affinity chromatography technology	Hegde R (2003), Suzuki Y (2001)	2
TRAF2	1	SPHK1	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Xia P (2002), Xia P (2002), Park ES (2015), Liu H (2017), Liu H (2017)	5
RNF31	3	UBC	7	pull down, pull down, affinity chromatography technology, enzymatic study, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, pull down, enzymatic study, enzymatic study	Wauer T (2013), Fujita H (2014), Schaeffer V (2014), Tokunaga F (2011), Kirisako T (2006), Haas TL (2009), Emmerich CH (2013), Sakamoto H (2015), Lechtenberg BC (2016), Lechtenberg BC (2016), Stieglitz B (2012), Zhang X (2017), Kliza K (2017), Liu J (2017)	14
UBE2N	1	UBA1	1	affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology	Huen MS (2008), Wu PY (2003), Wauer T (2015), Boldt K (2016)	4
BIRC2	1	UBA1	1	affinity chromatography technology	Goncharov T (2013)	1
XIAP	0	RIPK3	2	pull down	Bertrand MJ (2011)	1
BIRC2	1	UBC	7	pull down, pull down, pull down, pull down, enzymatic study	Dynek JN (2010), Gyrd-Hansen M (2008), Gyrd-Hansen M (2008), Komander D (2009), Sakamoto H (2015)	5
UBE2I	0	UBXN1	0	two hybrid	Rolland T (2014)	1
TLR3	2	BIRC2	1	affinity chromatography technology	Zinngrebe J (2016)	1
CASP8	1	CASP1	1	enzymatic study	Srinivasula SM (1996)	1
UBE2V1	0	UBC	7	pull down	McKenna S (2003)	1
BIRC3	1	RIPK3	2	pull down, affinity chromatography technology, enzymatic study	Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011)	3
IKBKG	0	TRAF1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Greenfeld H (2015), Greenfeld H (2015), Abdul-Sater AA (2017)	3
UBE2D2	0	UBE2L3	1	biochemical	Havugimana PC (2012)	1
CASP10	1	CASP1	1	enzymatic study	Srinivasula SM (1996)	1
PELI1	1	UBE2N	1	pull down	Smith H (2011)	1
EGLN3	0	HAX1	1	affinity chromatography technology	Rodriguez J (2016)	1
CASP3	0	TRAF1	0	imaging technique	Chen TC (2014)	1
MAVS	1	IKBKE	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Paz S (2009), Li S (2011), Paz S (2011), Paz S (2011), Fang R (2017)	5
RNF31	3	UBE2L3	1	pull down, pull down, pull down	Kirisako T (2006), Greenfeld H (2015), Liu J (2017)	3
RNF31	3	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology	Tokunaga F (2012), Verhelst K (2012)	2
BIRC2	1	DCAF7	4	affinity chromatography technology	Goncharov T (2013)	1
UBA1	1	UBE2D2	0	enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Tokgoez Z (2012), Jin J (2007), Choi JS (2014), Huang DT (2009), Kang D (2002), Kumar B (2010), Liu X (2017), Huguenin-Dezot N (2016)	8
UBE2N	1	XIAP	0	two hybrid, pull down	Markson G (2009), Markson G (2009)	2
BIRC3	1	TRAF2	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology	Uren AG (1996), Roy N (1997), Yoneda T (2000), Yoneda T (2000), Li X (2002), Behrends C (2010), Samuel T (2006), Vince JE (2009), Darding M (2011), Zheng C (2010), Zheng C (2010), Zheng C (2010), Zheng C (2010), Zheng C (2010), Rothe M (1995), Varfolomeev E (2006), Choudhary S (2013), Goncharov T (2013), Wang J (2011), Harikumar KB (2014), Shen RR (2012), Chen TC (2014), Akhtar N (2016)	23
BIRC2	1	XAF1	1	affinity chromatography technology	Arora V (2007)	1
BIRC3	1	RCHY1	0	two hybrid	Wang J (2011)	1
RIPK4	0	HAX1	1	affinity chromatography technology	Rodriguez J (2016)	1
TNFRSF1A	3	BCL10	0	two hybrid	Costanzo A (1999)	1
CASP8	1	BIRC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Micheau O (2003), Feoktistova M (2012), McDonald ER (2004), Zinngrebe J (2016)	4
TNFRSF1A	3	IKBKG	0	affinity chromatography technology, affinity chromatography technology	Zhang SQ (2000), Nakazawa S (2016)	2
TRAF1	0	TANK	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography	Rothe M (1996), Wang J (2011), Greenfeld H (2015), Huttlin EL (2017), Kim CM (2017), Kim CM (2017)	6
DIABLO	2	BIRC3	1	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Verhagen AM (2000), Yang QH (2004), Hu S (2003), Burke SP (2010), Budhidarmo R (2014), Hu S (2003), Wo L (2016)	7
TLR3	2	BIRC3	1	affinity chromatography technology	Zinngrebe J (2016)	1
GSK3B	1	UBE2D1	0	two hybrid	Vinayagam A (2011)	1
CASP10	1	TRAF1	0	enzymatic study	Leo E (2001)	1
UBE2D3	1	OTUB1	0	two hybrid, enzymatic study, pull down, affinity chromatography technology	Rolland T (2014), Li Y (2014), Li Y (2014), Scholz CC (2016)	4
TRIM32	2	UBE2D3	1	affinity chromatography technology, pull down, pull down, pull down	Napolitano LM (2011), Zhang J (2012), Streich FC (2013), Mokhonova EI (2015)	4
BCL10	0	IKBKB	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology	Lobry C (2007), Lobry C (2007), Poyet JL (2001), Zhou H (2004), Bidere N (2009)	5
BIRC2	1	TRAF1	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Roy N (1997), Shu HB (1996), Li X (2002), Li S (2011), Mace PD (2010), Rothe M (1995), Varfolomeev E (2006), Goncharov T (2013), Wang J (2011), Greenfeld H (2015), Huttlin EL (2017)	11
USP7	14	UBE2D3	1	enzymatic study	Zhang ZM (2015)	1
TRAF2	1	IKBKB	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Devin A (2001), Li S (2009), Li S (2009), Li HY (2008), Shen RR (2012), Shen RR (2012), Zhang W (2010), Chen TC (2014), Mei ZZ (2016)	9
IKBKG	0	TRAF6	0	pull down, pull down, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Lamothe B (2008), Windheim M (2008), Lamothe B (2007), Gautheron J (2010), Gautheron J (2010), Hinz M (2010), Sebban-Benin H (2007), Zotti T (2014), Sun L (2004), Emmerich CH (2013), Zhou L (2014), Chen J (2015), Kim EK (2017), Medunjanin S (2016), Xing J (2016), Bal E (2017), Bal E (2017)	17
BIRC2	1	BCL10	0	affinity chromatography technology, affinity chromatography technology	Yoneda T (2000), Hu S (2006)	2
NOD2	1	BIRC2	1	affinity chromatography technology	Damgaard RB (2012)	1
RNF31	3	UBE2D2	0	pull down, x-ray crystallography, pull down	Kirisako T (2006), Lechtenberg BC (2016), Lechtenberg BC (2016)	3
TRAF2	1	TRAF3	1	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Li S (2011), He L (2004), He L (2004), Pullen SS (1998)	4
UBE2D1	0	UBC	7	x-ray crystallography	Bosanac I (2010)	1
YOD1	0	BIRC3	1	two hybrid	Schimmack G (2017)	1
UBXN1	0	UBR4	15	affinity chromatography technology	Alexandru G (2008)	1
BIRC3	1	CYFIP2	7	two hybrid	Wang J (2011)	1
RIPK1	2	EGLN3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fu J (2016), Fu J (2016), Rodriguez J (2016)	3
CASP7	1	CASP9	6	enzymatic study	Walsh JG (2008)	1
USP9X	15	UBC	7	unspecified method, pull down	Ernst A (2013), Kwasna D (2018)	2
BIRC3	1	USP15	4	affinity chromatography technology	Goncharov T (2013)	1
RIPK2	0	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	McCarthy JV (1998), LeBlanc PM (2008), Marinis JM (2011)	3
BIRC2	1	CASP7	1	pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Roy N (1997), Choi YE (2009), Choi YE (2009), Tenev T (2005), Eckelman BP (2006), Vucic D (2000)	6
UBC	7	UBE2N	1	affinity chromatography technology, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down	Matsumoto M (2005), Scheper J (2010), Wu PY (2003), McKenna S (2003), Wiener R (2012), Ye Y (2003), Bish RA (2007), Juang YC (2012), Pastushok L (2007), Singh RK (2012), McKenna S (2001), McKenna S (2001)	12
NOD2	1	RIPK2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ogura Y (2001), Tao M (2009), Abbott DW (2004), Abbott DW (2004), Tigno-Aranjuez JT (2010), Tigno-Aranjuez JT (2010), Damgaard RB (2012), Marinis JM (2011), Draber P (2015)	9
OTUB1	0	UBE2D2	0	affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Nakada S (2010), Juang YC (2012), Ernst A (2013), Juang YC (2012), Huttlin EL (2015), Scholz CC (2016), Huttlin EL (2017)	8
BIRC3	1	UBR4	15	affinity chromatography technology	Goncharov T (2013)	1
RIPK2	0	RNF31	3	affinity chromatography technology	Damgaard RB (2012)	1
IKBKB	1	CASP8	1	affinity chromatography technology	Chaudhary PM (2000)	1
SEPT4	2	UBC	7	affinity chromatography technology	Fu RH (2017)	1
BIRC2	1	WDR82	3	affinity chromatography technology	Goncharov T (2013)	1
BIRC3	1	RAF1	3	pull down	Dogan T (2008)	1
EGFR	5	TAB1	1	affinity chromatography technology, two hybrid, protein complementation assay	Tong J (2008), Kotlyar M (2015), Petschnigg J (2014)	3
RIPK2	0	TAB1	1	affinity chromatography technology	Hasegawa M (2008)	1
TRAF6	0	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Mao AP (2010), Hinz M (2010)	2
RIPK2	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology	Thome M (1998), Li S (2011)	2
OTUB1	0	UBE2L3	1	affinity chromatography technology	Scholz CC (2016)	1
TRAF1	0	RIPK2	0	affinity chromatography technology	Thome M (1998)	1
GSK3B	1	XIAP	0	affinity chromatography technology	Sun M (2009)	1
CASP10	1	CASP9	6	enzymatic study	Srinivasula SM (1996)	1
XIAP	0	UBC	7	x-ray crystallography, pull down, pull down, pull down	Tse MK (2011), Gyrd-Hansen M (2008), Gyrd-Hansen M (2008), Nakatani Y (2012)	4
HTRA2	1	DIABLO	2	far western blotting, affinity chromatography technology	Hegde R (2002), Hegde R (2002)	2
TRAF1	0	UBC	7	affinity chromatography technology	Greenfeld H (2015)	1
TAB1	1	IKBKB	1	affinity chromatography technology	Neil JR (2008)	1
TNFAIP3	3	UBE2D1	0	pull down, pull down	Wertz IE (2004), Lee JH (2017)	2
REL	5	EGLN3	0	two hybrid, affinity chromatography technology	Rolland T (2014), Rodriguez J (2016)	2
BIRC3	1	CASP10	1	affinity chromatography technology	McDonald ER (2004)	1
BIRC5	1	CASP7	1	pull down, enzymatic study, pull down	Tamm I (1998), Shin S (2001), Shin S (2001)	3
UBE2D2	0	RAF1	3	enzymatic study	Demand J (2001)	1
RBCK1	0	UBE2D3	1	pull down, pull down, pull down, pull down	Zenke-Kawasaki Y (2007), Yamanaka K (2003), Inn KS (2011), Kirisako T (2006)	4
RCHY1	0	UBE2D3	1	pull down	Abou Zeinab R (2013)	1
HAX1	1	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kang YJ (2010), Kang YJ (2010), Kang YJ (2010)	3
UBE2L3	1	USP9X	15	biochemical	Havugimana PC (2012)	1
RBCK1	0	TRAF6	0	affinity chromatography technology	Tian Y (2007)	1
PELI1	1	UBE2D1	0	pull down	Smith H (2009)	1
YOD1	0	UBC	7	pull down, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study	Ernst R (2009), Mevissen TE (2013), Mevissen TE (2013), Ernst R (2009), Flierman D (2016)	5
BIRC3	1	IKBKG	0	pull down, affinity chromatography technology	Gyrd-Hansen M (2008), Goncharov T (2013)	2
BIRC2	1	HTRA2	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hegde R (2003), Hegde R (2003), Verhagen AM (2002), Suzuki Y (2001), Huttlin EL (2017)	5
PELI1	1	UBE2V1	0	pull down, pull down	Smith H (2011), Chang M (2009)	2
UBE2I	0	RIPK2	0	two hybrid	Rual JF (2005)	1
UBE2D2	0	USP9X	15	biochemical	Havugimana PC (2012)	1
RAF1	3	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, enzymatic study, imaging technique	Dogan T (2008), Tian S (2006), Tian S (2006), Tian S (2006), Tian S (2006), Tian S (2006), Chen TC (2014)	7
EGLN3	0	USP15	4	affinity chromatography technology	Rodriguez J (2016)	1
XIAP	0	CASP9	6	two hybrid, far western blotting, pull down, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, unspecified method, x-ray crystallography, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique	Rual JF (2005), Davoodi J (2004), Deveraux QL (1998), Deveraux QL (1998), Richter BW (2001), Morizane Y (2005), Fu J (2003), Fu J (2003), Hao Y (2004), Varfolomeev E (2007), Vucic D (2002), Qiu XB (2005), Srinivasula SM (2001), Cheung HH (2006), Kulathila R (2009), Shiozaki EN (2003), Davoodi J (2007), Checinska A (2007), Huang Y (2003), Sun M (2009), Martin SA (2005), Lee JS (2012), Rolland T (2014), McDonald ER (2004), Chen TC (2014)	25
HAX1	1	GSK3B	1	affinity chromatography technology	Huttlin EL (2015)	1
MAVS	1	TRAF2	1	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li S (2011), Xu LG (2005), Yu H (2011), Minassian A (2015), Khan M (2016), Fang R (2017), Fang R (2017)	7
UBE2I	0	UBE2D2	0	biochemical	Wan C (2015)	1
BIRC2	1	BIRC3	1	affinity chromatography technology, affinity chromatography technology	Rajalingam K (2006), Rajalingam K (2006)	2
XAF1	1	TRAF2	1	affinity chromatography technology	Lin B (2016)	1
TLR3	2	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yang M (2011), Jiang Z (2003), Jiang Z (2003), Cusson-Hermance N (2005), Zinngrebe J (2016)	5
OTUB1	0	UBE2D1	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Sun XX (2011), Herhaus L (2013), Li Y (2014), Scholz CC (2016)	4
UBE2D2	0	XIAP	0	two hybrid, two hybrid, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, pull down, pull down	Markson G (2009), Dynek JN (2010), Nakatani Y (2012), Nakatani Y (2012), Markson G (2009), Fang S (2001), Hu S (2003), Buetow L (2015), Foglizzo M (2016), Edison N (2017)	10
UBE2D1	0	USP9X	15	biochemical, biochemical	Havugimana PC (2012), You J (2001)	2
UBC	7	UBE2L3	1	affinity chromatography technology	Bish RA (2007)	1
BIRC2	1	RAF1	3	pull down	Dogan T (2008)	1
BIRC3	1	IRF1	0	enzymatic study, affinity chromatography technology	Harikumar KB (2014), Harikumar KB (2014)	2
IRF1	0	TRAF3	1	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
BIRC3	1	UBE2L3	1	affinity chromatography technology	Hu S (2003)	1
UBE2I	0	TRAF3	1	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Miliara S (2013), Miliara S (2013), Miliara S (2013), Miliara S (2013)	4
USP7	14	TRAF1	0	pull down	Zapata JM (2001)	1
TNFRSF1A	3	RBCK1	0	affinity chromatography technology	Nakazawa S (2016)	1
EGFR	5	TRAF2	1	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Tong J (2008), Puliyappadamba VT (2013), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	5
XIAP	0	UBE2I	0	two hybrid, two hybrid	Dynek JN (2010), Dynek JN (2010)	2
TRAF6	0	UBE2V1	0	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Deng L (2000), Lamothe B (2007), Kanayama A (2004), Shi CS (2010), Xia ZP (2009), Yang WL (2009), Murata H (2013), Ning S (2008), Sun L (2004), Lin Y (2014)	10
TRAF6	0	UBE2L3	1	pull down, pull down	Geetha T (2005), Babu JR (2005)	2
CD40LG	0	TRAF1	0	affinity chromatography technology	Salzmann S (2013)	1
RCHY1	0	UBC	7	enzymatic study	Wu G (2010)	1
NOD2	1	IKBKG	0	affinity chromatography technology	Damgaard RB (2012)	1
IRF5	0	BIRC3	1	affinity chromatography technology	Jin J (2015)	1
IKBKG	0	TNFAIP3	3	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Zhang SQ (2000), Zhang SQ (2000), Skaug B (2011), Skaug B (2011), Klinkenberg M (2001), Verhelst K (2012), Verhelst K (2012), Wang J (2011), Zilberman-Rudenko J (2016)	9
MAVS	1	RIPK2	0	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
CASP10	1	CASP7	1	enzymatic study	Srinivasula SM (1996)	1
BIRC3	1	UBE2Q2	4	two hybrid	Dynek JN (2010)	1
TRAF1	0	TRAF3	1	affinity chromatography technology, affinity chromatography technology	Pullen SS (1998), Greenfeld H (2015)	2
TRAF6	0	UBE2N	1	genetic interference, pull down, two hybrid, biochemical, two hybrid, x-ray crystallography, two hybrid, enzymatic study, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid, two hybrid	Deng L (2000), Deng L (2000), Markson G (2009), Yin Q (2009), Dynek JN (2010), Yin Q (2009), Yin Q (2009), Petroski MD (2007), Mercier P (2007), Lamothe B (2008), Kanayama A (2004), Murata H (2013), Ning S (2008), Markson G (2009), Lin Y (2014), Chen J (2015), Zhang J (2016), Boldt K (2016), Rezaeian AH (2017), Xing J (2016), Schimmack G (2017), Schimmack G (2017)	22
NOD2	1	XIAP	0	affinity chromatography technology, pull down	Damgaard RB (2012), Krieg A (2009)	2
TRAF1	0	DCAF7	4	affinity chromatography technology	Greenfeld H (2015)	1
BIRC3	1	PACS2	9	enzymatic study, affinity chromatography technology, pull down	Guicciardi ME (2014), Guicciardi ME (2014), Guicciardi ME (2014)	3
RIPK1	2	PELI1	1	affinity chromatography technology, enzymatic study	Chang M (2009), Chang M (2009)	2
RIPK3	2	RIPK1	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yu PW (1999), Yu PW (1999), Li S (2011), Lee EW (2012), Petersen SL (2015), Moquin DM (2013), Moriwaki K (2016)	7
RIPK2	0	UBC	7	affinity chromatography technology	Park S (2013)	1
UBE2N	1	UBE2V1	0	biochemical, pull down, pull down, pull down, two hybrid, two hybrid, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, two hybrid, biochemical, pull down, pull down, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Deng L (2000), Deng L (2000), Zhang M (2005), Andersen PL (2005), Andersen PL (2005), Scheper J (2010), Scheper J (2010), Scheper J (2010), Wooff J (2004), Plans V (2006), Huen MS (2008), Huen MS (2008), Havugimana PC (2012), Bohgaki M (2008), Petroski MD (2007), Sawasaki T (2008), Wan C (2015), Chen J (2015), Boldt K (2016), Zhang Y (2018)	20
CASP8	1	CASP3	0	enzymatic study, enzymatic study, enzymatic study	Guo Y (2002), Srinivasula SM (1996), Chandra D (2004)	3
BIRC3	1	RBCK1	0	affinity chromatography technology	Goncharov T (2013)	1
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
USP15	4	UBC	7	pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, pull down	Hetfeld BK (2005), Bremm A (2010), Komander D (2009), Loch CM (2012), Herhaus L (2014), Wauer T (2015), Das T (2017), Zhang X (2017), Kwasna D (2018)	9
CASP10	1	CASP3	0	enzymatic study	Srinivasula SM (1996)	1
RIPK3	2	TNFRSF1A	3	affinity chromatography technology	Yu PW (1999)	1
NOD2	1	RIPK1	2	affinity chromatography technology	Damgaard RB (2012)	1
CASP10	1	TNFRSF1A	3	biochemical, affinity chromatography technology	Gajate C (2005), Vincenz C (1997)	2
HTRA2	1	HAX1	1	affinity chromatography technology	Plun-Favreau H (2007)	1
BIRC2	1	RIPK4	0	pull down, affinity chromatography technology, enzymatic study	Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011)	3
TRAF1	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Takeuchi M (1996), Li S (2011), Li S (2011), Fries KL (1999), He L (2004), Zheng C (2010), Zheng C (2010), Relaix F (1998), Relaix F (1998), Jang HD (2001), Fotin-Mleczek M (2004), Pullen SS (1998), Wicovsky A (2009), Rothe M (1994), Rothe M (1994), Chen TC (2014), Greenfeld H (2015), Huttlin EL (2017)	19
USP19	1	BIRC3	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Mei Y (2011), Mei Y (2011), Mei Y (2011)	3
IKBKG	0	TANK	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Chariot A (2002), Chariot A (2002), Chariot A (2002), Zhang W (2010), Zhang W (2010), Zhao T (2007), Wang J (2011), Wang W (2015), Huttlin EL (2017)	9
BIRC3	1	CASP1	1	affinity chromatography technology, affinity chromatography technology	Labbe K (2011), Labbe K (2011)	2
TRAF2	1	HTRA2	1	affinity chromatography technology	Behrends C (2010)	1
TLR3	2	IKBKG	0	affinity chromatography technology	Zinngrebe J (2016)	1
TRIM32	2	UBE2D2	0	affinity chromatography technology, pull down, pull down	Napolitano LM (2011), Streich FC (2013), Mokhonova EI (2015)	3
USP15	4	OTUB1	0	enzymatic study	Loch CM (2012)	1
UBA1	1	UBE2D1	0	enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study	Tokgoez Z (2012), Jin J (2007), Kang D (2002), Wauer T (2015), Huguenin-Dezot N (2016)	5
EGLN3	0	OTUB1	0	affinity chromatography technology	Rodriguez J (2016)	1
BIRC3	1	RNF31	3	affinity chromatography technology	Goncharov T (2013)	1
UBE2V1	0	TRIM32	2	two hybrid, two hybrid, two hybrid, affinity chromatography technology	Markson G (2009), Napolitano LM (2011), Napolitano LM (2011), Napolitano LM (2011)	4
RBCK1	0	UBE2D1	0	pull down	Kirisako T (2006)	1
TNFRSF1A	3	TRAF6	0	affinity chromatography technology	Chang YL (2014)	1
BIRC2	1	WDR1	3	affinity chromatography technology	Goncharov T (2013)	1
XIAP	0	BCL10	0	affinity chromatography technology	Hu S (2006)	1
CASP8	1	RIPK3	2	affinity chromatography technology	Lee EW (2012)	1
UBE2V1	0	DZIP3	6	two hybrid	Markson G (2009)	1
BIRC2	1	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Tang ED (2003), Hinz M (2010), Hinz M (2010), Shibata Y (2012), Goncharov T (2013), Fu J (2013)	6
TRAF3	1	BIRC3	1	affinity chromatography technology, enzymatic study, affinity chromatography technology	Mao AP (2010), de Jong SJ (2013), Goncharov T (2013)	3
BIRC2	1	BIRC5	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Dohi T (2004), Samuel T (2005), Samuel T (2005), Jung SA (2015), Jung SA (2015), Jung SA (2015)	6
BIRC3	1	UBE2D1	0	affinity chromatography technology, two hybrid, pull down, pull down, pull down, pull down	Hu S (2003), Dynek JN (2010), Dynek JN (2010), Bertrand MJ (2011), Hu S (2006), Guicciardi ME (2014)	6
TNFRSF1A	3	TRAF1	0	affinity chromatography technology, pull down, affinity chromatography technology	Hsu H (1996), Mosialos G (1995), Wicovsky A (2009)	3
CASP8	1	TRAF1	0	affinity chromatography technology, enzymatic study	Micheau O (2003), Leo E (2001)	2
TRAF2	1	UBE2D1	0	pull down	Alvarez SE (2010)	1
BIRC3	1	TRIM32	2	affinity chromatography technology	Ryu YS (2011)	1
TLR3	2	RNF31	3	affinity chromatography technology	Zinngrebe J (2016)	1
USP15	4	RBCK1	0	two hybrid	Hayes SD (2012)	1
BIRC2	1	UBE2N	1	two hybrid	Schimmack G (2017)	1
TRAF2	1	GSK3B	1	affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Huttlin EL (2017)	2
BIRC3	1	TAB1	1	affinity chromatography technology	Goncharov T (2013)	1
BCL10	0	RNF31	3	affinity chromatography technology, affinity chromatography technology	Yang YK (2016), Yang YK (2016)	2
GSK3B	1	BIRC3	1	affinity chromatography technology	Sun M (2009)	1
XIAP	0	RIPK1	2	pull down	Bertrand MJ (2011)	1
BIRC3	1	WDR61	0	affinity chromatography technology	Goncharov T (2013)	1
IKBKB	1	EGLN3	0	affinity chromatography technology, pull down, affinity chromatography technology	Xue J (2010), Xue J (2010), Fu J (2013)	3
COMMD1	1	NFKB1	2	affinity chromatography technology	Burstein E (2005)	1
IKBKB	1	NFKB1	2	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, imaging technique	Heissmeyer V (2001), Heissmeyer V (1999), Beinke S (2002), Beinke S (2002), Beinke S (2002), Chen TC (2014)	6
RIPK1	2	XAF1	1	affinity chromatography technology	Lin B (2016)	1
XIAP	0	DIABLO	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, pull down, x-ray crystallography, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down	Hunter AM (2003), Davoodi J (2004), Song Z (2003), Verhagen AM (2000), Verhagen AM (2000), Verhagen AM (2000), Verhagen AM (2000), Verhagen AM (2002), Samuel T (2006), McNeish IA (2005), Yoon K (2004), Fu J (2003), Fu J (2003), Fu J (2003), Fu J (2003), Hu S (2003), Hao Y (2004), Sekine K (2005), Csomos RA (2009), Bartke T (2004), Burke SP (2010), Burke SP (2010), Vucic D (2002), Qiu XB (2005), Qiu XB (2005), Scott FL (2005), Srinivasula SM (2001), Martins LM (2002), Kulathila R (2009), Huang Y (2001), Chai J (2001), Liu Z (2001), Liu Z (2001), Gao Z (2007), Davoodi J (2007), Hegde R (2002), Krieg A (2009), Huang Y (2003), Huang Y (2003), Arnt CR (2002), Damgaard RB (2013), Lee S (2014), Hao Y (2004), Hao Y (2004), Masoumi KC (2012), Guvenc H (2013), Buetow L (2015), Wo L (2016), Huttlin EL (2017), Wu G (2001), Wu G (2001), Hou Y (2017)	52
MAVS	1	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li S (2011), Wang Y (2012), Xu LG (2005), Wang P (2013), Wang P (2013), Shi Z (2015), Shi Z (2015), Minassian A (2015), Khan M (2016), Fang R (2017), Fang R (2017)	11
EGFR	5	UBC	7	affinity chromatography technology, affinity chromatography technology	Tong J (2009), Bishop N (2002)	2
BCL10	0	USP9X	15	affinity chromatography technology	Park Y (2013)	1
TRAF2	1	UBE2V1	0	pull down	Deng L (2000)	1
RIPK1	2	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Inohara N (2000), Li H (2006), Ea CK (2006), Dynek JN (2010), Skaug B (2011), Wagner S (2008), Wu CJ (2006), Legarda-Addison D (2009), Yang Y (2011), Bohgaki M (2008), Lucas PC (2001), Biton S (2011), Zhu G (2007), Zhu G (2007), Keusekotten K (2013), Jeon J (2014), Wu CJ (2006), Vincendeau M (2016), Baratchian M (2016), Zilberman-Rudenko J (2016), Medunjanin S (2016), Bal E (2017), Bal E (2017)	23
CASP1	1	EGFR	5	enzymatic study	Bae SS (2001)	1
BIRC3	1	SNX7	0	two hybrid	Wang J (2011)	1
SPHK1	0	MBTPS1	4	enzymatic study	Ryu J (2006)	1
TANK	1	TRAF3	1	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, affinity chromatography technology	Bouwmeester T (2004), Rothe M (1996), Gatot JS (2007), Li S (2011), Li C (2003), Li C (2002), Li C (2002), Ng MH (2011)	8
IKBKB	1	IKBKE	2	enzymatic study, affinity chromatography technology	Heilker R (1999), Zhou AY (2013)	2
TRAF2	1	UBE2N	1	genetic interference, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down	Deng L (2000), Deng L (2000), Liu J (2011), Liu J (2011), Liu J (2011), Alvarez SE (2010), Sasai M (2010), Zhou AY (2013), Shen RR (2012)	9
RIPK4	0	IKBKG	0	affinity chromatography technology	Rodriguez J (2016)	1
XIAP	0	TRIM32	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Ryu YS (2011), Ryu YS (2011), Ryu YS (2011)	3
UBE2D2	0	DZIP3	6	two hybrid, pull down	Markson G (2009), Zhou W (2008)	2
USP7	14	WDR1	3	affinity chromatography technology	Hein MY (2015)	1
E2F1	0	GSK3B	1	affinity chromatography technology	Zhou F (2008)	1
XIAP	0	CASP3	0	affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down	Suzuki Y (2001), Suzuki Y (2001), Silke J (2002), Riedl SJ (2001), Riedl SJ (2001), Roy N (1997), Deveraux QL (1997), Deveraux QL (1997), Suzuki Y (2001), Bartke T (2004), Nakhaei P (2012), Qiu XB (2005), Nomura T (2003), Paulsen M (2008), Scott FL (2005), Mufti AR (2006), Rajalingam K (2006), Dudich E (2006), Chai J (2001), Checinska A (2007), Sun M (2009), Takahashi R (1998), Conde C (2012), Walsh JG (2008), Lee JS (2012), Lin YF (2013), Huttlin EL (2015), Chen TC (2014), Huttlin EL (2017), Hou Y (2017)	30
RIPK1	2	TNFRSF1A	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim JW (2000), Duan H (1997), Hsu H (1996), Blankenship JW (2009), Newton K (2008), Varfolomeev E (2008), Fearns C (2006), Vince JE (2009), Dynek JN (2010), Kim S (2010), Cheung HH (2009), Tenev T (2011), Mahul-Mellier AL (2011), Won M (2010), Glowacka WK (2012), Fan YH (2011), Cusson-Hermance N (2005), ODonnell MA (2012), Zheng L (2006), Vince JE (2007), Mitsuhashi S (2008), Kim TW (2013), Wertz IE (2004), Liao W (2008), Wang YB (2015), Chang YL (2014), Zilberman-Rudenko J (2016), Zemirli N (2014), Moquin DM (2013), Nakazawa S (2016), Jeong M (2017), Huttlin EL (2017), Elliott PR (2016)	33
CASP3	0	CASP9	6	enzymatic study, enzymatic study, enzymatic study, enzymatic study, imaging technique	Qiu XB (2005), Denault JB (2007), Srinivasula SM (2001), Walsh JG (2008), Chen TC (2014)	5
OTUB1	0	UBC	7	enzymatic study, enzymatic study, x-ray crystallography, unspecified method, pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, enzymatic study, x-ray crystallography, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, pull down	Wang T (2009), Bremm A (2010), Juang YC (2012), Ernst A (2013), Ernst A (2013), Nakasone MA (2013), Wiener R (2013), Edelmann MJ (2009), Bish RA (2007), Mevissen TE (2013), Juang YC (2012), Herhaus L (2013), Ernst A (2013), Herhaus L (2015), Herhaus L (2015), Herhaus L (2015), Wauer T (2015), Michel MA (2015), Kristariyanto YA (2015), Scholz CC (2016), Scholz CC (2016), Altun M (2015), Flierman D (2016), Castaneda CA (2016), Zhang X (2017), Kwasna D (2018)	26
PELI1	1	UBE2I	0	two hybrid, pull down	Kim JH (2011), Kim JH (2011)	2
RIPK2	0	TNFRSF1A	3	affinity chromatography technology	McCarthy JV (1998)	1
RBCK1	0	UBE2D2	0	pull down	Kirisako T (2006)	1
UBE2L3	1	UBXN1	0	biochemical	Havugimana PC (2012)	1
TNFRSF1A	3	BIRC3	1	affinity chromatography technology, affinity chromatography technology	Blankenship JW (2009), Vince JE (2009)	2
BIRC2	1	DIABLO	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, unspecified method, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hegde R (2003), Verhagen AM (2000), Samuel T (2006), Samuel T (2006), Yang QH (2004), Hu S (2003), Hu S (2003), Csomos RA (2009), Burke SP (2010), Kulathila R (2009), Kulathila R (2009), Arnt CR (2002), Budhidarmo R (2014), Lee S (2014), Wo L (2016), Huttlin EL (2017)	16
USP19	1	BIRC2	1	affinity chromatography technology	Mei Y (2011)	1
UBC	7	IKBKG	0	pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, x-ray crystallography, pull down, unspecified method, x-ray crystallography, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Dynek JN (2010), Dynek JN (2010), Chiaravalli J (2011), Laplantine E (2009), Hubeau M (2011), Lo YC (2009), Ikeda F (2010), Cordier F (2009), Cordier F (2009), Cordier F (2009), Renner F (2011), Fenner BJ (2009), Fenner BJ (2009), Ivins FJ (2009), Rahighi S (2009), Rahighi S (2009), Zhu G (2007), Zhu G (2007), Niu J (2011), Keusekotten K (2013), van Wijk SJ (2013), Hooper C (2014), Wagner S (2008), Saul VV (2014), Gleason CE (2011), Komander D (2009), Kensche T (2012), Skaug B (2011), Ea CK (2006), Ea CK (2006), Lo YC (2009), Laplantine E (2009), Laplantine E (2009), Emmerich CH (2013), Dubosclard V (2015), Vincendeau M (2015), Vincendeau M (2016), Zhang X (2017), Fang R (2017), Kliza K (2017), Joo D (2016), Fang R (2017), Hauenstein AV (2017)	43
BIRC2	1	UBXN1	0	affinity chromatography technology, affinity chromatography technology	Wang YB (2015), Wang YB (2015)	2
UBE2V1	0	XIAP	0	two hybrid	Markson G (2009)	1
CD40LG	0	BIRC2	1	affinity chromatography technology	Salzmann S (2013)	1
RNF31	3	TNFRSF1A	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Draber P (2015), Nakazawa S (2016), Elliott PR (2016)	3
UBE2D2	0	UBC	7	x-ray crystallography, x-ray crystallography, enzymatic study, pull down, pull down	Juang YC (2012), Dou H (2012), Sheng Y (2012), Buetow L (2015), Zhang X (2017)	5
CASP8	1	UBC	7	pull down	Bellail AC (2012)	1
RIPK2	0	BIRC2	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	McCarthy JV (1998), Thome M (1998), Bertrand MJ (2009), Bertrand MJ (2009), Bertrand MJ (2009), Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011)	8
BIRC2	1	TRAF2	1	two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique, enzymatic study, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Uren AG (1996), Roy N (1997), Shu HB (1996), Yoneda T (2000), Yoneda T (2000), Li X (2002), Li X (2002), Li X (2002), Behrends C (2010), Samuel T (2006), Samuel T (2006), Samuel T (2006), Silke J (2005), Wu CJ (2005), Vince JE (2009), Csomos RA (2009), Li S (2011), Darding M (2011), Sanjo H (2010), Mace PD (2010), Choi JW (2009), Kanno Y (2010), Jang HD (2001), Rothe M (1995), Rothe M (1995), Cartier J (2011), Varfolomeev E (2006), Varfolomeev E (2006), Shen RR (2012), Shen RR (2012), Goncharov T (2013), Wang J (2011), Marivin A (2013), Shen RR (2012), Park ES (2015), Wang YB (2015), Chen TC (2014), Petersen SL (2015), Huttlin EL (2017), Akhtar N (2016)	41
BIRC2	1	UBE2V1	0	pull down	Bertrand MJ (2008)	1
CD40LG	0	TRAF2	1	affinity chromatography technology	Salzmann S (2013)	1
BIRC2	1	DZIP3	6	two hybrid	Woodsmith J (2012)	1
TRAF2	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Takeuchi M (1996), Tada K (2001), Hsu H (1996), Hsu H (1996), Malinin NL (1997), Knox PG (2011), Ea CK (2006), Chang EJ (2011), Vince JE (2009), Alvarez SE (2010), Jang HD (2001), Shen RR (2012), Shen RR (2012), Puliyappadamba VT (2013), Hu MM (2014), Jeon J (2014), Rolland T (2014), Park ES (2015), Petersen SL (2015), Lin B (2016), Lin B (2016)	21
RBCK1	0	RIPK1	2	affinity chromatography technology	Tian Y (2007)	1
LIMA1	4	WDR1	3	affinity chromatography technology	Hein MY (2015)	1
EGFR	5	UBR4	15	affinity chromatography technology	Tong J (2014)	1
BIRC3	1	UBA1	1	affinity chromatography technology	Goncharov T (2013)	1
TRAF2	1	IKBKG	0	affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tang ED (2003), Poyet JL (2000), Shen RR (2012), Shen RR (2012), Bal E (2017), Bal E (2017)	6
OTUB1	0	TRAF6	0	affinity chromatography technology, enzymatic study	Li S (2010), Bremm A (2010)	2
USP19	1	UBC	7	enzymatic study, pull down, pull down	Lee JG (2014), Zhang X (2017), Kwasna D (2018)	3
BIRC3	1	OTUB1	0	affinity chromatography technology	Goncharov T (2013)	1
BIRC2	1	TRIM32	2	affinity chromatography technology	Ryu YS (2011)	1
USP7	14	TRAF3	1	pull down	Zapata JM (2001)	1
UBXN1	0	BIRC3	1	affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Wang YB (2015)	2
BIRC3	1	UBC	7	pull down, pull down, enzymatic study	Gyrd-Hansen M (2008), Nakatani Y (2012), Sakamoto H (2015)	3
UBE2D1	0	WDR1	3	biochemical	Havugimana PC (2012)	1
TAB1	1	XIAP	0	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yamaguchi K (1999), Yamaguchi K (1999), Yamaguchi K (1999), Sanna MG (2002), Sanna MG (2002), Caballero-Lopez MJ (2017)	6
PELI1	1	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jiang Z (2003), Jiang Z (2003), Choi KC (2006), Jensen LE (2003)	4
CASP7	1	TNFRSF1A	3	enzymatic study	Ethell DW (2001)	1
UBE2I	0	DZIP3	6	two hybrid	Markson G (2009)	1
BIRC3	1	SUMO1	0	two hybrid	Wang J (2011)	1
CASP8	1	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Micheau O (2003), Knox PG (2011), Mahul-Mellier AL (2011), Gonzalvez F (2012), Gonzalvez F (2012), Xu L (2017), Xu L (2017)	7
IKBKG	0	USP7	14	affinity chromatography technology, affinity chromatography technology	Daubeuf S (2009), Li T (2014)	2
TRIM32	2	UBE2N	1	two hybrid, affinity chromatography technology, two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Saccone V (2008), Saccone V (2008), van Wijk SJ (2009), Markson G (2009), Napolitano LM (2011), Napolitano LM (2011), Napolitano LM (2011), Boldt K (2016)	8
USP7	14	USP19	1	affinity chromatography technology	Sowa ME (2009)	1
BIRC2	1	UBE2D3	1	affinity chromatography technology, two hybrid, pull down	Hu S (2003), Dynek JN (2010), Hu S (2003)	3
USP7	14	UBC	7	enzymatic study, enzymatic study, unspecified method, enzymatic study, pull down	Bremm A (2010), Faesen AC (2011), Ernst A (2013), Holowaty MN (2003), Kwasna D (2018)	5
UBE2D3	1	TRAF6	0	two hybrid, enzymatic study, pull down, pull down, pull down	Markson G (2009), Petroski MD (2007), Xia ZP (2009), Markson G (2009), Wauer T (2015)	5
UBR4	15	USP9X	15	biochemical	Havugimana PC (2012)	1
BIRC3	1	BCL10	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Yoneda T (2000), Hu S (2006), Yui D (2001), Hu S (2006), Hu S (2006), Hu S (2006), Hu S (2006)	7
GLMN	2	BIRC3	1	affinity chromatography technology, pull down	Suzuki S (2017), Suzuki S (2017)	2
TRAF1	0	RIPK1	2	affinity chromatography technology, affinity chromatography technology, two hybrid	Hsu H (1996), Wicovsky A (2009), Rolland T (2014)	3
CASP1	1	RIPK2	0	affinity chromatography technology	Thome M (1998)	1
TRAF6	0	IKBKB	1	affinity chromatography technology	Bidere N (2006)	1
IKBKG	0	EGLN3	0	affinity chromatography technology, affinity chromatography technology, pull down	Fu J (2013), Fu J (2013), Fu J (2013)	3
UBE2D2	0	TRAF6	0	two hybrid, pull down	Markson G (2009), Markson G (2009)	2
RNF31	3	TRAF6	0	enzymatic study	Kliza K (2017)	1
BIRC3	1	SEPT4	2	affinity chromatography technology	Edison N (2012)	1
IKBKB	1	IKBKG	0	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, biochemical, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography, pull down, affinity chromatography technology	Chen G (2002), Chen G (2002), Chariot A (2002), Wu RC (2002), Deng L (2000), Shifera AS (2008), Fenner BJ (2010), Fenner BJ (2010), Fenner BJ (2010), Lee KY (2005), Rothwarf DM (1998), Ea CK (2006), Thurston TL (2009), Orel L (2010), Wu ZH (2010), Napolitano G (2009), Liu J (2009), Skaug B (2011), Li S (2011), Li S (2011), Kensche T (2012), Chiaravalli J (2011), Wu CJ (2006), Wu ZH (2006), Ahmad R (2007), Ahmad R (2007), Palkowitsch L (2008), Palkowitsch L (2008), Lo YC (2008), Mabb AM (2006), Baima ET (2010), Tegethoff S (2003), Tegethoff S (2003), Hai T (2006), Ammirante M (2010), Lee DF (2007), Rottenberg S (2002), Poyet JL (2000), Stilo R (2004), Marienfeld RB (2006), Marienfeld RB (2006), Strnad J (2006), Funakoshi-Tago M (2005), Ivins FJ (2009), Shibata Y (2012), Shibata Y (2012), Wu X (2007), Stehlik C (2002), Ryzhakov G (2007), Chen RA (2008), Wu ZH (2008), Mitsuhashi S (2008), Fujita H (2014), Golden MS (2013), Lee SH (2012), Cote SM (2013), Kim HJ (2014), Jackson SS (2014), Liao W (2008), Tokunaga F (2011), Criollo A (2010), Emmerich CH (2013), So J (2015), Liu D (2014), Guo B (2014), Guo B (2014), Guo B (2014), Zhou L (2014), Zhou L (2014), Hein MY (2015), Bagneris C (2015), Medunjanin S (2016), Huttlin EL (2017), Nowicka AM (2016), Rushe M (2008), Rushe M (2008), Hauenstein AV (2017), Bal E (2017)	78
USP19	1	XIAP	0	affinity chromatography technology, affinity chromatography technology	Mei Y (2011), Mei Y (2011)	2
BIRC3	1	WDR82	3	affinity chromatography technology	Goncharov T (2013)	1
TRAF3	1	RIPK1	2	affinity chromatography technology	Hsu H (1996)	1
BIRC3	1	EGFR	5	affinity chromatography technology	Puliyappadamba VT (2013)	1
RIPK1	2	UBC	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao L (2015), Ding Z (2015), Varfolomeev E (2015)	3
TRAF6	0	IRF5	0	affinity chromatography technology	Takaoka A (2005)	1
E2F1	0	NFKB1	2	pull down	Kundu M (1997)	1
UBE2D3	1	XIAP	0	two hybrid, affinity chromatography technology, two hybrid, pull down, pull down, pull down, pull down	Markson G (2009), Hu S (2003), Dynek JN (2010), Bartke T (2004), Bornstein B (2011), Damgaard RB (2013), Markson G (2009)	7
RNF31	3	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Tokunaga F (2012), Verhelst K (2012), Niu J (2011), Fujita H (2014), Tokunaga F (2011), Tokunaga F (2011), Xia ZP (2009), Fu J (2013), Emmerich CH (2013), Chen Y (2015), Bal E (2017)	11
TNFAIP3	3	RBCK1	0	affinity chromatography technology, two hybrid	Verhelst K (2012), Hayes SD (2012)	2
IKBKB	1	TRAF1	0	two hybrid, affinity chromatography technology, fluorescent resonance energy transfe, two hybrid	Sughra K (2010), Sughra K (2010), Sughra K (2010), Henkler F (2003)	4
TRAF1	0	TRAF6	0	two hybrid, two hybrid, two hybrid, affinity chromatography technology	Wang J (2011), Rolland T (2014), Yu H (2011), Huttlin EL (2017)	4
BIRC2	1	OTUB1	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Goncharov T (2013), Goncharov T (2013), Goncharov T (2013)	3
SEPT4	2	XIAP	0	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, protein complementation assay	Garrison JB (2011), Garrison JB (2011), Bornstein B (2011), Bornstein B (2011), Edison N (2012), Gottfried Y (2004), Gottfried Y (2004), Fu RH (2017), Edison N (2017), Edison N (2017), Edison N (2017)	11
UBE2I	0	SUMO1	0	affinity chromatography technology, pull down, two hybrid, two hybrid, fluorescent resonance energy transfe, pull down, two hybrid, two hybrid, pull down, pull down, two hybrid, pull down, fluorescent resonance energy transfe, pull down, two hybrid, pull down, pull down, enzymatic study, enzymatic study, biochemical, affinity chromatography technology	Ewing RM (2007), Tatham MH (2003), Minty A (2000), Shen Z (1996), Song Y (2011), Knipscheer P (2007), Boutell C (2011), Gong L (1997), Gong L (1997), Hemelaar J (2004), Hecker CM (2006), Hecker CM (2006), Martin SF (2008), Everett RD (2014), Rolland T (2014), Zilio N (2013), Carbia-Nagashima A (2007), Knipscheer P (2007), Matic I (2008), Wan C (2015), Hein MY (2015)	21
CASP3	0	TRAF3	1	enzymatic study, enzymatic study	Lee ZH (2001), Leo E (2001)	2
EGLN3	0	GSK3B	1	affinity chromatography technology	Rodriguez J (2016)	1
IKBKE	2	XIAP	0	enzymatic study	Nakhaei P (2012)	1
EGLN3	0	RAF1	3	affinity chromatography technology	Rodriguez J (2016)	1
TLR3	2	RBCK1	0	affinity chromatography technology	Zinngrebe J (2016)	1
BIRC2	1	TNFAIP3	3	affinity chromatography technology	Yamaguchi N (2013)	1
CASP8	1	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology	Oshima S (2009), Saitoh Y (2016)	2
IKBKG	0	TAB1	1	pull down	Emmerich CH (2013)	1
RCHY1	0	UBE2D2	0	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Hattori T (2007), Duan S (2007), Sheng Y (2008), Wu G (2010), Corcoran CA (2009), Abe K (2008), Shloush J (2011), Bohgaki M (2013), Abou Zeinab R (2013)	9
RIPK1	2	TNFAIP3	3	affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study	Shembade N (2009), Wertz IE (2004), Wertz IE (2004), Wertz IE (2004), Shembade N (2008), Bellail AC (2012)	6
GSK3B	1	IKBKG	0	imaging technique, enzymatic study, affinity chromatography technology, affinity chromatography technology	Chen TC (2014), Medunjanin S (2016), Medunjanin S (2016), Medunjanin S (2016)	4
EGFR	5	LIMA1	4	affinity chromatography technology	Tong J (2014)	1
BIRC2	1	UBR4	15	affinity chromatography technology	Goncharov T (2013)	1
BIRC3	1	USP9X	15	affinity chromatography technology	Goncharov T (2013)	1