PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UBE2V2	0	UBC	7	x-ray crystallography, pull down, x-ray crystallography, x-ray crystallography, pull down	McKenna S (2003), McKenna S (2003), McKenna S (2003), Lewis MJ (2006), McKenna S (2001)	5
BIRC2	1	MAP3K2	1	enzymatic study	Takeda AN (2014)	1
NOD1	3	NOD2	1	affinity chromatography technology, affinity chromatography technology	Travassos LH (2010), Travassos LH (2010)	2
UBE2V2	0	SIAH1	2	two hybrid	Markson G (2009)	1
ELAVL1	0	UBE2D3	1	affinity chromatography technology	Abdelmohsen K (2009)	1
NEK6	2	PRDX3	3	two hybrid, pull down	Vaz Meirelles G (2010), Vaz Meirelles G (2010)	2
UBE2L6	0	LONRF1	4	two hybrid, two hybrid	Markson G (2009), Rolland T (2014)	2
MDM2	2	S100A4	0	pull down	van Dieck J (2010)	1
TRAF6	0	BCL10	0	affinity chromatography technology	Bidere N (2006)	1
MDM2	2	USO1	1	affinity chromatography technology	Jacob AG (2014)	1
CASP6	0	CASP8	1	enzymatic study, enzymatic study, enzymatic study	Cowling V (2002), Guo Y (2002), Srinivasula SM (1996)	3
TRAF6	0	UBC	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Muroi M (2011), Park S (2013), Sun L (2004), Kanayama A (2004), Sakamoto H (2015), Yu J (2016), Middleton AJ (2017)	7
IRF3	4	AKT1	1	affinity chromatography technology	Joung SM (2011)	1
PTEN	24	CASP8	1	affinity chromatography technology, affinity chromatography technology	Crockett DK (2005), Crockett DK (2005)	2
CASP10	1	CASP2	1	enzymatic study	Srinivasula SM (1996)	1
CASP3	0	CASP7	1	enzymatic study	Walsh JG (2008)	1
HNRNPL	3	SCARA3	2	affinity chromatography technology	Fei T (2017)	1
USP19	1	HSPA4	3	affinity chromatography technology	Lee JG (2014)	1
NOD2	1	CASP12	1	affinity chromatography technology	LeBlanc PM (2008)	1
CASP10	1	RIPK1	2	affinity chromatography technology	Chaudhary PM (2000)	1
ELAVL1	0	GMCL1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	90378	0	affinity chromatography technology	Abdelmohsen K (2009)	1
UBE2I	0	TAB2	5	enzymatic study	Wang X (2014)	1
XIAP	0	NEK6	2	two hybrid	Rolland T (2014)	1
RIPK4	0	AIFM1	1	affinity chromatography technology	Rodriguez J (2016)	1
BIRC5	1	CASP3	0	pull down, enzymatic study, pull down	Tamm I (1998), Shin S (2001), Shin S (2001)	3
RIPK2	0	CASP12	1	affinity chromatography technology, affinity chromatography technology	LeBlanc PM (2008), LeBlanc PM (2008)	2
BRCA1	7	CASP9	6	affinity chromatography technology	Martin SA (2005)	1
CASP8	1	CRYAB	0	affinity chromatography technology	Lee JS (2012)	1
TRAF6	0	HSPA4	3	affinity chromatography technology, enzymatic study, affinity chromatography technology	Chen H (2006), Pridgeon JW (2004), Chen H (2006)	3
ELAVL1	0	DIABLO	2	affinity chromatography technology	Abdelmohsen K (2009)	1
CCT2	1	CASP7	1	pull down, affinity chromatography technology	Lin YF (2012), Lin YF (2012)	2
UBE2D4	0	TRAF6	0	two hybrid	Markson G (2009)	1
CASP8	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chaudhary PM (2000), Oshima S (2009), Bertrand MJ (2008), Knox PG (2011), Kim S (2010), Cheung HH (2009), Tenev T (2011), Tenev T (2011), Mahul-Mellier AL (2011), Legarda-Addison D (2009), Biton S (2011), Bellail AC (2012), Bellail AC (2012), Lee EW (2012), Rebe C (2007), Feoktistova M (2012), Puliyappadamba VT (2013), Wu P (2014), Wu P (2014), Feoktistova M (2011), Selmi T (2015), Yamaguchi N (2015), Moquin DM (2013), Ranjan K (2016), Zinngrebe J (2016), Nakazawa S (2016), Zheng M (2016)	27
USP11	3	UBC	7	enzymatic study, pull down, pull down	Faesen AC (2011), Zhang X (2017), Kwasna D (2018)	3
CDK1	0	UBE2I	0	enzymatic study, affinity chromatography technology	Tomasi ML (2012), Tomasi ML (2012)	2
TRIM32	2	UBE2E2	1	two hybrid, two hybrid	Napolitano LM (2011), Napolitano LM (2011)	2
RIPK1	2	BIRC2	1	affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Bertrand MJ (2008), Bertrand MJ (2008), Xu M (2009), Dynek JN (2010), Dynek JN (2010), Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011), Puliyappadamba VT (2013), Fu J (2016), Vu NT (2016), Vu NT (2016)	12
SEPT4	2	SIAH1	2	affinity chromatography technology	Garrison JB (2011)	1
MAP3K7	2	TAB2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cheung PC (2004), Cheung PC (2004), Takaesu G (2000), Takaesu G (2001), Ishitani T (2003), Ishitani T (2003), Ea CK (2006), Broglie P (2010), Liu XY (2008), Li S (2011), Li S (2011), Jiang Z (2003), Mendoza H (2008), Ear T (2010), Criollo A (2011), Kim SY (2012), Jiang Z (2002), Jiang Z (2002), Hong S (2007), Shibuya H (1996), Minoda Y (2009), Li M (2010), Scholz R (2010), Kim SI (2009), Yong Kim S (2013), Liu R (2014), Wang J (2015), Moon G (2015), Wade EM (2016), Min Y (2016), Zhang J (2017)	31
EGFR	5	AKT1	1	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
TOLLIP	3	TRAF6	0	affinity chromatography technology	Lee JY (2009)	1
DIABLO	2	BIRC5	1	affinity chromatography technology, pull down, affinity chromatography technology, pull down, fluorescent resonance energy transfe, pull down, affinity chromatography technology, pull down	Song Z (2003), Song Z (2003), McNeish IA (2005), Pavlyukov MS (2011), Pavlyukov MS (2011), Guvenc H (2013), Song Z (2004), Song Z (2004)	8
HNRNPC	0	UBE2I	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
UBE2I	0	TRAF6	0	enzymatic study, enzymatic study	Li Y (2013), Pham LV (2008)	2
UBE2D2	0	STUB1	4	pull down, pull down, biochemical, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down	Demand J (2001), Soss SE (2011), Shimura H (2004), Esser C (2005), Kalia LV (2011), Xie P (2009), Grelle G (2006), Westhoff B (2005), Hatakeyama S (2004), Dolan PJ (2010), Tsukahara F (2010), Chen Z (2013), Dreiseidler M (2012), Zhang H (2015), Liu X (2017), Liu X (2017), Blessing NA (2017)	17
BRCA1	7	XIAP	0	affinity chromatography technology, pull down	Martin SA (2005), Martin SA (2005)	2
BIRC2	1	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Silke J (2005), Rajalingam K (2006), Rajalingam K (2006), Oberoi-Khanuja TK (2012), Huttlin EL (2017)	5
XIAP	0	PGAM5	4	enzymatic study, pull down, affinity chromatography technology	Zhuang M (2013), Zhuang M (2013), Zhuang M (2013)	3
XIAP	0	ARHGDIA	3	affinity chromatography technology, affinity chromatography technology	Liu J (2011), Liu J (2012)	2
E2F1	0	XIAP	0	affinity chromatography technology, affinity chromatography technology	Cartier J (2011), Cao Z (2014)	2
EGFR	5	AKT2	1	affinity chromatography technology	Tong J (2014)	1
BRCA1	7	UBE2W	0	two hybrid, x-ray crystallography, pull down, two hybrid, pull down, pull down	Christensen DE (2009), Christensen DE (2009), Christensen DE (2009), Christensen DE (2007), David Y (2011), Vittal V (2015)	6
GSK3B	1	BIRC2	1	affinity chromatography technology	Sun M (2009)	1
BRCA1	7	BLM	2	biochemical, affinity chromatography technology, affinity chromatography technology	Wang Y (2000), Acharya S (2014), Ertych N (2016)	3
UBE2N	1	SIAH1	2	two hybrid	Markson G (2009)	1
IKBKE	2	UBC	7	affinity chromatography technology, pull down, affinity chromatography technology	Rajsbaum R (2014), Paz S (2009), Bharaj P (2016)	3
BCL10	0	UBE2N	1	pull down	Zhou H (2004)	1
LRRN2	2	BIRC2	1	affinity chromatography technology	Huttlin EL (2017)	1
UBE2N	1	BIRC3	1	two hybrid, pull down, two hybrid	van Wijk SJ (2009), Wu CJ (2006), Schimmack G (2017)	3
TRAF6	0	TAB1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Takaesu G (2000), Ninomiya-Tsuji J (1999), Walsh MC (2008)	3
BLM	2	UBE2I	0	two hybrid, affinity chromatography technology	Eladad S (2005), Eladad S (2005)	2
BIRC3	1	CASP7	1	pull down, affinity chromatography technology	Roy N (1997), Eckelman BP (2006)	2
RAF1	3	BCL2	0	pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang HG (1996), Wang HG (1996), Wang HG (1996), Jin S (2005), Jin S (2005), Mazzocca A (2003)	6
XIAP	0	TAB2	5	affinity chromatography technology	Sanna MG (2002)	1
TAB1	1	TRAF2	1	affinity chromatography technology	Bouwmeester T (2004)	1
TRIM32	2	UBE2V2	0	two hybrid, two hybrid, affinity chromatography technology	Napolitano LM (2011), Napolitano LM (2011), Napolitano LM (2011)	3
CASP9	6	BIRC8	0	pull down, two hybrid, affinity chromatography technology	Richter BW (2001), Rolland T (2014), Huttlin EL (2017)	3
DYNLL2	0	DIABLO	2	affinity chromatography technology	Boldt K (2016)	1
USP5	2	UCHL3	1	biochemical	Havugimana PC (2012)	1
RIPK4	0	MAGED1	0	affinity chromatography technology	Rodriguez J (2016)	1
MUS81	1	TRAF6	0	genetic interference	Vizeacoumar FJ (2013)	1
UBC	7	TOLLIP	3	pull down, pull down, pull down, biochemical, pull down, pull down, pull down, pull down	Fenner BJ (2009), Nathan JA (2013), Mitra S (2013), Mitra S (2013), Shih SC (2003), Lu K (2014), Lu K (2014), Zhang X (2017)	8
XIAP	0	SIVA1	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Resch U (2009), Resch U (2009), Resch U (2009), Iorio-Morin C (2012)	4
UBE2D2	0	UBE2V1	0	biochemical	Havugimana PC (2012)	1
TBK1	1	XIAP	0	enzymatic study, enzymatic study	Nakhaei P (2012), Kuranaga E (2006)	2
BRCA1	7	CCT2	1	affinity chromatography technology	Ertych N (2016)	1
IKBKE	2	IRF3	4	affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study	Friedman CS (2008), Nakhaei P (2012), Bharaj P (2016), Zhang Q (2017)	4
NOTCH1	25	XIAP	0	affinity chromatography technology, affinity chromatography technology	Liu WH (2007), Liu WH (2007)	2
IKBKE	2	BIRC2	1	affinity chromatography technology, enzymatic study	Zhou AY (2013), Zhou AY (2013)	2
UBC	7	SSB	0	affinity chromatography technology	Matsumoto M (2005)	1
STUB1	4	UBE2E1	1	pull down, pull down	Soss SE (2011), Parsons JL (2009)	2
HNRNPL	3	RAPGEF2	5	affinity chromatography technology	Fei T (2017)	1
SORT1	1	USP11	3	affinity chromatography technology	Hein MY (2015)	1
XIAP	0	RIPK2	0	pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid	Bertrand MJ (2011), Damgaard RB (2012), Krieg A (2009), Krieg A (2009), Krieg A (2009), Conde C (2012), Damgaard RB (2013), Damgaard RB (2013), Rolland T (2014)	9
ELAVL1	0	PTEN	24	affinity chromatography technology	Abdelmohsen K (2009)	1
UBE2L6	0	DTX3	4	two hybrid	Markson G (2009)	1
BCL2	0	CASP8	1	affinity chromatography technology, genetic interference, two hybrid, affinity chromatography technology	Poulaki V (2001), Guo Y (2002), Zhu J (2005), Zhu J (2005)	4
UCHL3	1	ARHGDIA	3	biochemical	Wan C (2015)	1
IRF3	4	TRAF2	1	affinity chromatography technology	Liu S (2015)	1
RIPK4	0	PRDX3	3	affinity chromatography technology	Rodriguez J (2016)	1
USP11	3	PGAM5	4	affinity chromatography technology	Sowa ME (2009)	1
BIRC2	1	UBE2D1	0	affinity chromatography technology, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Hu S (2003), Dynek JN (2010), Dynek JN (2010), Xu M (2009), Phu L (2011), Oberoi TK (2012), Bertrand MJ (2011), Guicciardi ME (2014), Takeda AN (2014), Wauer T (2015), Vu NT (2016)	11
RIPK4	0	RAF1	3	affinity chromatography technology	Rodriguez J (2016)	1
TRAF2	1	UBC	7	enzymatic study, enzymatic study	Liu J (2011), Kanayama A (2004)	2
TRIM32	2	UBE2D1	0	affinity chromatography technology, pull down, pull down, pull down, pull down	Napolitano LM (2011), Zhang J (2012), Streich FC (2013), Albor A (2006), Mokhonova EI (2015)	5
TCF7L2	12	TLE3	2	pull down, affinity chromatography technology	Hanson AJ (2012), Hanson AJ (2012)	2
XIAP	0	BCL2	0	pull down, enzymatic study	Edison N (2017), Edison N (2017)	2
TRAF6	0	TBK1	1	affinity chromatography technology, affinity chromatography technology, pull down	Cai B (2017), Fang R (2017), Fang R (2017)	3
TRAF2	1	RIPK3	2	affinity chromatography technology	Yu PW (1999)	1
SEC23IP	3	XIAP	0	biochemical	Havugimana PC (2012)	1
BIRC3	1	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rajalingam K (2006), Rajalingam K (2006), Yang W (2014), Yang W (2014)	4
TBK1	1	IKBKE	2	affinity chromatography technology, pull down, affinity chromatography technology, pull down	Li S (2011), Ikeda F (2007), Liu D (2015), Liu D (2015)	4
SCARA3	2	XIAP	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Zheng ZL (2012), Zheng ZL (2012), Zheng ZL (2012)	3
RIPK2	0	RIPK1	2	affinity chromatography technology	Damgaard RB (2012)	1
UBC	7	HAX1	1	affinity chromatography technology	Matsumoto M (2005)	1
BRCA1	7	UBE2I	0	fluorescent resonance energy transfe, enzymatic study, affinity chromatography technology, affinity chromatography technology	Morris JR (2009), Morris JR (2009), Xu J (2009), Xu J (2009)	4
USP5	2	XIAP	0	biochemical	Havugimana PC (2012)	1
UBE2V2	0	XIAP	0	two hybrid	Markson G (2009)	1
STUB1	4	UBE2L3	1	pull down	Hampe C (2006)	1
UBE2L3	1	DTX3	4	two hybrid	Markson G (2009)	1
STUB1	4	TRAF2	1	affinity chromatography technology	Jang KW (2011)	1
SIAH1	2	UBE2D1	0	two hybrid, two hybrid, pull down, pull down, pull down	Matsuzawa SI (2001), Markson G (2009), Dimitrova YN (2010), Rott R (2008), Liu QY (2008)	5
CRYAB	0	UBE2D1	0	pull down	Lin DI (2006)	1
COMMD1	1	XIAP	0	pull down, affinity chromatography technology, affinity chromatography technology	Maine GN (2009), Burstein E (2004), Burstein E (2004)	3
UBE2V1	0	UBE2V2	0	biochemical	Havugimana PC (2012)	1
HNRNPL	3	CEP170	4	affinity chromatography technology	Fei T (2017)	1
CASP10	1	CASP4	1	enzymatic study	Srinivasula SM (1996)	1
STRADB	1	CCT2	1	affinity chromatography technology	Huttlin EL (2017)	1
CASP6	0	XIAP	0	affinity chromatography technology	Lee JS (2012)	1
DYNLL1	0	DIABLO	2	affinity chromatography technology	Boldt K (2016)	1
TAB2	5	TAB1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, two hybrid, affinity chromatography technology	Bouwmeester T (2004), Cheung PC (2004), Cheung PC (2004), Takaesu G (2000), Li S (2011), Li S (2011), Mendoza H (2008), Shin MS (2009), Suzuki S (2007), Jiang Z (2002), Wang J (2011), Xia ZP (2009), Charlaftis N (2014), St-Denis N (2016)	14
UBE2V1	0	STUB1	4	pull down, pull down, pull down, biochemical, affinity chromatography technology, pull down	Zhang M (2005), Yang M (2011), Windheim M (2008), Havugimana PC (2012), Zhang M (2005), Zhang M (2005)	6
RAC1	7	LATS1	3	two hybrid	Bandyopadhyay S (2010)	1
SORT1	1	MUS81	1	affinity chromatography technology	Hein MY (2015)	1
IKBKE	2	TRAF2	1	enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Shen RR (2012), Shen RR (2012), Shen RR (2012), Zhang W (2010), Zhou AY (2013), Zhou AY (2013), So J (2015), Fang R (2017)	8
XIAP	0	SSX2IP	0	two hybrid	Rolland T (2014)	1
BAX	3	CASP3	0	biochemical	Chandra D (2004)	1
BIRC2	1	CASP10	1	affinity chromatography technology	McDonald ER (2004)	1
CASP12	1	CRYAB	0	affinity chromatography technology	Lee JS (2012)	1
STUB1	4	MAP3K7	2	affinity chromatography technology	Wang S (2013)	1
MDM2	2	UBC	7	pull down, enzymatic study, enzymatic study	Higashitsuji H (2005), Luo J (2013), Poyurovsky MV (2007)	3
XIAP	0	STUB1	4	pull down	Dogan T (2008)	1
PTEN	24	UBC	7	protein complementation assay, affinity chromatography technology	Li Y (2014), Li Y (2014)	2
UBC	7	STUB1	4	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study	Connell P (2001), Connell P (2001), Windheim M (2008), Zhang M (2005)	4
HNRNPL	3	ATP6V1A	3	affinity chromatography technology	Fei T (2017)	1
EGFR	5	XIAP	0	affinity chromatography technology	Yao Z (2017)	1
RAC1	7	BIRC2	1	affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology	Oberoi TK (2012), Oberoi TK (2012), Marivin A (2013), Woolery AR (2014), Woolery AR (2014)	5
BIRC3	1	BIRC5	1	pull down	Dohi T (2004)	1
UBE2I	0	HNRNPA1	1	biochemical	Wan C (2015)	1
BIRC3	1	CASP9	6	pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, imaging technique	Deveraux QL (1998), Deveraux QL (1998), Eckelman BP (2006), Cheung HH (2006), Wang J (2011), McDonald ER (2004), Chen TC (2014)	7
EGFR	5	SSB	0	affinity chromatography technology	Yao Z (2017)	1
UBE2D3	1	SIAH1	2	two hybrid, two hybrid, pull down, pull down, pull down	van Wijk SJ (2009), Markson G (2009), Liu M (2012), Mei Y (2007), Kim SY (2009)	5
TOLLIP	3	DIABLO	2	affinity chromatography technology	Li S (2011)	1
BIRC2	1	RIPK3	2	pull down, affinity chromatography technology, enzymatic study	Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011)	3
ELAVL1	0	SORT1	1	affinity chromatography technology	Abdelmohsen K (2009)	1
RIPK2	0	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hasegawa M (2008), Kim JY (2008), Yang Y (2007), Yang Y (2007), Windheim M (2007)	5
BIRC5	1	CASP9	6	affinity chromatography technology, imaging technique	OConnor DS (2000), Chen TC (2014)	2
ELAVL1	0	ACVR1B	1	affinity chromatography technology	Abdelmohsen K (2009)	1
BCL10	0	TRAF2	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Yoneda T (2000), Yoneda T (2000), Yoneda T (2000), Yui D (2001), Rolland T (2014)	5
BRCA1	7	HNRNPL	3	affinity chromatography technology	Ertych N (2016)	1
TRAF2	1	UBE2V2	0	pull down	Sasai M (2010)	1
CASP6	0	CRYAB	0	affinity chromatography technology	Lee JS (2012)	1
STUB1	4	UBE2E2	1	pull down, pull down	Xu Z (2008), Soss SE (2011)	2
BRCA1	7	CKAP5	2	affinity chromatography technology	Ertych N (2016)	1
EGFR	5	HSPA4	3	protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay	Deribe YL (2009), Deribe YL (2009), Citri A (2002), Tong J (2008), Kotlyar M (2015), Petschnigg J (2014)	6
KLHL2	0	TCF25	0	affinity chromatography technology	Huttlin EL (2017)	1
BMPR1B	3	TRAF6	0	affinity chromatography technology	Sorrentino A (2008)	1
TAB2	5	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Takaesu G (2000), Li S (2009), Ishitani T (2003), Hong S (2007)	4
XIAP	0	AKT1	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique	Dan HC (2004), Dan HC (2004), Pramanik KC (2013), Pramanik KC (2013), Chen TC (2014)	5
XIAP	0	CASP7	1	pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, x-ray crystallography, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Riedl SJ (2001), Roy N (1997), Deveraux QL (1997), Deveraux QL (1997), Suzuki Y (2001), Bartke T (2004), Tenev T (2005), Paulsen M (2008), Huang Y (2001), Huang Y (2001), Chai J (2001), Chai J (2001), Huang Y (2003), Huang Y (2003), Sun M (2009), Takahashi R (1998), Lee JS (2012), Lin YF (2013), Lin YF (2013), Hou Y (2017)	20
UBC	7	E2F1	0	affinity chromatography technology	Rizos H (2007)	1
TRAF2	1	XIAP	0	affinity chromatography technology	Vince JE (2009)	1
CASP7	1	ARHGDIA	3	enzymatic study	Walsh JG (2008)	1
BMPR2	1	XIAP	0	affinity chromatography technology	Liu Z (2009)	1
ELAVL1	0	CASP2	1	affinity chromatography technology	Abdelmohsen K (2009)	1
XIAP	0	RFC5	2	two hybrid	Rolland T (2014)	1
BRCA1	7	PHB2	1	affinity chromatography technology	Woods NT (2012)	1
PTEN	24	EGFR	5	affinity chromatography technology	Zheng J (2016)	1
BIRC7	0	UBE2E1	1	two hybrid	Dynek JN (2010)	1
TRAF2	1	DIABLO	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Li S (2011), Huttlin EL (2017)	3
CASP12	1	XIAP	0	affinity chromatography technology	Lee JS (2012)	1
BIRC3	1	UBE2I	0	two hybrid, two hybrid	Dynek JN (2010), Dynek JN (2010)	2
XIAP	0	ERCC3	3	two hybrid	Rolland T (2014)	1
MDM2	2	UBE2N	1	pull down	David Y (2011)	1
TRAF6	0	XIAP	0	affinity chromatography technology, two hybrid, imaging technique	Sanna MG (2002), Woodsmith J (2012), Chen TC (2014)	3
SSX2IP	0	TAB1	1	bioid	Gupta GD (2015)	1
BRCA1	7	UBE2D2	0	two hybrid, two hybrid, x-ray crystallography, pull down	Dynek JN (2010), Christensen DE (2009), Christensen DE (2009), Christensen DE (2009)	4
UBE2W	0	DTX3	4	two hybrid	Markson G (2009)	1
XIAP	0	NOD1	3	pull down	Krieg A (2009)	1
TOLLIP	3	BIRC2	1	affinity chromatography technology	Li S (2011)	1
XIAP	0	CASP10	1	two hybrid, affinity chromatography technology	Rolland T (2014), McDonald ER (2004)	2
UBE2D3	1	BIRC8	0	two hybrid	Markson G (2009)	1
AKT2	1	XIAP	0	enzymatic study	Dan HC (2004)	1
BRCA1	7	LONRF1	4	two hybrid	Woodsmith J (2012)	1
USP19	1	CDK1	0	affinity chromatography technology	Sowa ME (2009)	1
EGFR	5	MAP3K3	3	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
AKT1	1	GSK3B	1	pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Thimmaiah KN (2005), Drendall CI (2010), Connor MK (2005), Hunter MG (2004), Zhu QS (2011), Li L (2003), Nam SY (2010), Yang WL (2009), Zeng L (2013), Yang H (2005), Boehme KA (2008), Cross DA (1995), Hinton CV (2007), Kapoor GS (2004), Pitre A (2012), Guo J (2016)	16
USP11	3	SSX2IP	0	affinity chromatography technology	Sowa ME (2009)	1
IRF3	4	SORT1	1	affinity chromatography technology	Li X (2015)	1
BCL10	0	UBE2V2	0	pull down	Zhou H (2004)	1
BIRC2	1	EGFR	5	affinity chromatography technology	Puliyappadamba VT (2013)	1
BIRC2	1	UBE2L3	1	affinity chromatography technology	Hu S (2003)	1
BRCA1	7	CDK1	0	pull down	Wang H (1997)	1
UBE2J2	1	UBC	7	enzymatic study	Sheng Y (2012)	1
HSPA4	3	CRYAB	0	affinity chromatography technology	Chavez Zobel AT (2003)	1
UBE2A	0	UBE2L3	1	biochemical	Wan C (2015)	1
SORT1	1	CDK1	0	affinity chromatography technology	Hein MY (2015)	1
KLHL2	0	TRIM8	6	affinity chromatography technology	Huttlin EL (2017)	1
CLEC11A	0	XIAP	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ELAVL1	0	HNRNPC	0	affinity chromatography technology	Abdelmohsen K (2009)	1
IRF3	4	USP19	1	affinity chromatography technology	Huttlin EL (2017)	1
XIAP	0	HNRNPA1	1	affinity chromatography technology, affinity chromatography technology, unspecified method	Lewis SM (2007), Lewis SM (2007), Roy R (2014)	3
GMCL1	0	CRYAB	0	affinity chromatography technology	Huttlin EL (2017)	1
STUB1	4	TRAF6	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down	Yang M (2011), Yang M (2011), Wang S (2013), Li S (2014), Li S (2014), Li S (2014), Li S (2014)	7
GSK3B	1	MDM2	2	enzymatic study, affinity chromatography technology	Kulikov R (2005), Kulikov R (2005)	2
UBC	7	HNRNPL	3	affinity chromatography technology	Matsumoto M (2005)	1
BIRC3	1	CASP3	0	pull down, affinity chromatography technology	Roy N (1997), Rajalingam K (2006)	2
CASP7	1	CRYAB	0	affinity chromatography technology, affinity chromatography technology	Lee JS (2012), Jeong WJ (2012)	2
E2F1	0	BIRC3	1	affinity chromatography technology	Cartier J (2011)	1
MAP3K7	2	STRADB	1	affinity chromatography technology	Sanna MG (2002)	1
CDK1	0	CKAP5	2	genetic interference	Horlbeck MA (2018)	1
HTRA2	1	LATS1	3	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology	Kuninaka S (2007), Kuninaka S (2007), Kuninaka S (2007), Kuninaka S (2005), Kuninaka S (2005), Kuninaka S (2005), Chiyoda T (2012), Chiyoda T (2012)	8
HNRNPA1	1	SSB	0	affinity chromatography technology	Roy R (2014)	1
ELAVL1	0	HNRNPA1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Abdelmohsen K (2009), Close P (2012), Roy R (2014), Hein MY (2015)	4
MAGED1	0	TAB1	1	affinity chromatography technology	Kang J (2014)	1
UBE2I	0	UBE2E1	1	biochemical	Wan C (2015)	1
AFP	1	XIAP	0	affinity chromatography technology, pull down	Dudich E (2006), Dudich E (2006)	2
HNRNPL	3	TBK1	1	affinity chromatography technology	Fei T (2017)	1
UBE2D4	0	DTX3	4	two hybrid	Markson G (2009)	1
CDK1	0	HTRA2	1	enzymatic study	Plun-Favreau H (2007)	1
PFAS	3	XIAP	0	biochemical	Havugimana PC (2012)	1
CASP8	1	FAF1	1	affinity chromatography technology, affinity chromatography technology	Knox PG (2011), Caballero-Lopez MJ (2017)	2
CASP8	1	XIAP	0	genetic interference, affinity chromatography technology, affinity chromatography technology	Guo Y (2002), Lee JS (2012), McDonald ER (2004)	3
ATP6V1A	3	XIAP	0	biochemical	Havugimana PC (2012)	1
TRAF6	0	IKBKE	2	affinity chromatography technology	Fang R (2017)	1
RAC1	7	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Oberoi TK (2012), Oberoi TK (2012), Woolery AR (2014), Woolery AR (2014), Fujita M (2015)	5
BIRC3	1	HAX1	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Choi JS (2014), Choi JS (2014), Choi JS (2014), Choi JS (2014)	4
CASP8	1	CASP7	1	enzymatic study, enzymatic study	Guo Y (2002), Srinivasula SM (1996)	2
BIRC2	1	CASP3	0	pull down, pull down, enzymatic study, enzymatic study, affinity chromatography technology	Roy N (1997), Choi YE (2009), Choi YE (2009), Clem RJ (2001), Rajalingam K (2006)	5
BIRC3	1	RIPK2	0	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Thome M (1998), Bertrand MJ (2009), Bertrand MJ (2009), Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011)	6
CASP2	1	BCL2	0	genetic interference	Guo Y (2002)	1
BRCA1	7	SSB	0	affinity chromatography technology	Ertych N (2016)	1
TRAF2	1	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ishitani T (2003), Ishitani T (2003), Hong S (2007), Tan B (2015)	4
PHB2	1	XIAP	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CRYAB	0	BCL2	0	affinity chromatography technology, affinity chromatography technology	Launay N (2010), Launay N (2010)	2
DYNLL1	0	XIAP	0	affinity chromatography technology	Boldt K (2016)	1
TBK1	1	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Bouwmeester T (2004), Bonnard M (2000), Behrends C (2010), Li S (2011), Li S (2011), Shen RR (2012), Zhang W (2010), Huttlin EL (2017), Fang R (2017), Fang R (2017)	10
BIRC7	0	UBC	7	x-ray crystallography	Dou H (2012)	1
ADAMTS4	1	BIRC2	1	affinity chromatography technology	Huttlin EL (2017)	1
STUB1	4	UBE2W	0	pull down, pull down, enzymatic study, pull down	Soss SE (2011), Tatham MH (2013), Scaglione KM (2011), Blessing NA (2017)	4
UBE2W	0	BIRC8	0	two hybrid	Markson G (2009)	1
BIRC3	1	IKBKE	2	enzymatic study	Zhou AY (2013)	1
XIAP	0	TLE3	2	affinity chromatography technology, enzymatic study	Hanson AJ (2012), Hanson AJ (2012)	2
SRPRA	3	XIAP	0	affinity chromatography technology	Hein MY (2015)	1
USO1	1	XIAP	0	biochemical	Havugimana PC (2012)	1
BIRC3	1	CASP8	1	affinity chromatography technology, affinity chromatography technology	McDonald ER (2004), Zinngrebe J (2016)	2
CASP10	1	CASP8	1	biochemical, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Micheau O (2003), Micheau O (2003), Guo Y (2002), Srinivasula SM (1996), Srinivasula SM (1996), Sinha SK (2004), Lee EW (2012), Feoktistova M (2011)	9
TRAF6	0	CASP8	1	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Bidere N (2006), Bidere N (2006), He L (2006), He L (2006), Zinngrebe J (2016)	5
NOTCH1	25	TAB1	1	affinity chromatography technology	Yatim A (2012)	1
TBK1	1	GSK3B	1	affinity chromatography technology, affinity chromatography technology	Qin Y (2016), Qin Y (2016)	2
UBE2D4	0	XIAP	0	two hybrid	Markson G (2009)	1
HNRNPA1	1	CDC42	3	biochemical	Wan C (2015)	1
LATS1	3	PTEN	24	enzymatic study	Chiyoda T (2012)	1
CHEK1	2	BRCA1	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, genetic interference	Yarden RI (2002), Yarden RI (2002), Inoue Y (2007), Shen JP (2017)	4
TRAF6	0	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Ishitani T (2003), Takaesu G (2000), Ninomiya-Tsuji J (1999), Takaesu G (2001), Mochida Y (2000), Mochida Y (2000), Walsh MC (2008), Sorrentino A (2008), Frobose H (2006), Ishitani T (2003), Xia ZP (2009), Jiang Z (2003), Jiang Z (2003), Yamazaki K (2009), Yamazaki K (2009), Jiang Z (2002), Jiang Z (2002), Cui W (2012), Jiang Z (2003), Minoda Y (2009), Gao D (2009), Lee HJ (2012), Hirata Y (2006), Hu MM (2014), Fujikawa H (2013), Sun D (2011), Li W (2015), Lin J (2015), Lee Y (2016), Ji YX (2016), Ji YX (2016), Ji YX (2016), Ji YX (2016)	33
MAP3K2	1	STUB1	4	affinity chromatography technology, pull down, enzymatic study	Maruyama T (2010), Maruyama T (2010), Maruyama T (2010)	3
EGFR	5	RAF1	3	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
EGFR	5	RIPK1	2	affinity chromatography technology	Habib AA (2001)	1
RNPS1	1	XIAP	0	affinity chromatography technology	Hein MY (2015)	1
COMMD1	1	BIRC3	1	affinity chromatography technology	Burstein E (2004)	1
UBE2D1	0	TRAF6	0	two hybrid, pull down	Markson G (2009), Markson G (2009)	2
BIRC8	0	XIAP	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GSK3B	1	MAP3K2	1	affinity chromatography technology	Greenblatt MB (2016)	1
RIPK1	2	BIRC3	1	affinity chromatography technology, enzymatic study, enzymatic study, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study	Bertrand MJ (2008), Bertrand MJ (2008), Dynek JN (2010), Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011), Puliyappadamba VT (2013), Wu CJ (2006)	8
BIRC3	1	RIPK4	0	pull down, affinity chromatography technology, enzymatic study	Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011)	3
UBE2D1	0	TRIM8	6	two hybrid	Markson G (2009)	1
BRCA1	7	HNRNPA1	1	affinity chromatography technology	Goina E (2008)	1
TRAF2	1	TRAF6	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Li S (2011), Davies CC (2005), Relaix F (1998), Rolland T (2014), Yu H (2011), Huttlin EL (2017)	7
BRCA1	7	UBE2D3	1	two hybrid, affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, x-ray crystallography, pull down, pull down, pull down, pull down	Dynek JN (2010), Polanowska J (2006), Christensen DE (2009), Christensen DE (2009), Christensen DE (2009), Calvo V (2011), Wu-Baer F (2010), Yu X (2006), Starita LM (2005), Sato K (2012), Starita LM (2004), Wei L (2011), Wu W (2007), David Y (2011), Kentsis A (2002), Kleiman FE (2005), Zhao GY (2007), Wenzel DM (2011), Wenzel DM (2011), McGinty RK (2014), Chen A (2002), Shabbeer S (2013), Ando K (2017)	23
CASP3	0	MDM2	2	enzymatic study, enzymatic study, enzymatic study, imaging technique	Chen L (1997), Pochampally R (1998), Cheng Q (2014), Chen TC (2014)	4
XIAP	0	RIPK4	0	pull down, enzymatic study	Bertrand MJ (2011), Bertrand MJ (2011)	2
SIVA1	0	UBE2D1	0	pull down	Wang X (2013)	1
NEK6	2	DYNLL1	0	affinity chromatography technology	Ewing RM (2007)	1
EGFR	5	AIFM1	1	affinity chromatography technology	Tong J (2014)	1
AKT1	1	AKT2	1	affinity chromatography technology	Huttlin EL (2017)	1
HTRA2	1	XIAP	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, pull down, unspecified method, pull down	Hegde R (2003), Verhagen AM (2002), Hao Y (2004), Sekine K (2005), Vucic D (2002), van Loo G (2002), Seong YM (2004), Seong YM (2004), Martins LM (2002), Martins LM (2002), Suzuki Y (2001), Suzuki Y (2001), Hegde R (2002), Plun-Favreau H (2007), Singh N (2014), Singh N (2014), Singh N (2014)	17
EGFR	5	RFC5	2	affinity chromatography technology	Tong J (2014)	1
TLE3	2	AHCY	5	biochemical	Wan C (2015)	1
XIAP	0	AIFM1	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Wilkinson JC (2008), Wilkinson JC (2008), Lewis EM (2011)	3
AFP	1	PHB2	1	two hybrid	Wang J (2011)	1
BRCA1	7	UBE2E1	1	two hybrid, x-ray crystallography, pull down, two hybrid, pull down	Christensen DE (2009), Christensen DE (2009), Christensen DE (2009), Christensen DE (2007), David Y (2011)	5
TRAF6	0	STRADB	1	affinity chromatography technology	Sanna MG (2002)	1
COMMD1	1	HSPA4	3	affinity chromatography technology, affinity chromatography technology	van de Sluis B (2009), van de Sluis B (2009)	2
BAX	3	CASP8	1	biochemical	Chandra D (2004)	1
TRAF6	0	BIRC3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mao AP (2010), Goncharov T (2013), Harikumar KB (2014), Harikumar KB (2014)	4
HNRNPL	3	EGFR	5	affinity chromatography technology	Fei T (2017)	1
CASP8	1	CASP9	6	enzymatic study, genetic interference, enzymatic study	Guo Y (2002), Guo Y (2002), Srinivasula SM (1996)	3
TRAF2	1	ELAVL1	0	affinity chromatography technology	Herjan T (2013)	1
PTEN	24	NOTCH1	25	genetic interference	Vizeacoumar FJ (2013)	1
TAB2	5	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ishitani T (2003), Takaesu G (2000), Takaesu G (2000), Takaesu G (2001), Takaesu G (2001), Walsh MC (2008), Ma Q (2008), Windheim M (2008), Xia ZP (2009), Jiang Z (2003), Kanayama A (2004), Kanayama A (2004), Yokota S (2008), Jiang Z (2002), Jiang Z (2002), Jiang Z (2003), Wang J (2011), Yong Kim S (2013), Jeon J (2014), Fujikawa H (2013)	20
RIPK4	0	TCF25	0	affinity chromatography technology	Rodriguez J (2016)	1
NOD1	3	CASP8	1	affinity chromatography technology	Inohara N (1999)	1
CDC42	3	UBC	7	two hybrid	Bandyopadhyay S (2010)	1
RIPK1	2	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bertrand MJ (2008), Li H (2006), Yang Y (2011), Yang Y (2011), Yang Y (2011), Hu MM (2014)	6
RAF1	3	BIRC7	0	affinity chromatography technology, affinity chromatography technology	Oberoi-Khanuja TK (2012), Oberoi-Khanuja TK (2012)	2
XIAP	0	UBE2L3	1	affinity chromatography technology	Hu S (2003)	1
UBE2I	0	LATS1	3	enzymatic study	Mei L (2017)	1
BIRC7	0	HTRA2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vucic D (2002), Huttlin EL (2015), Huttlin EL (2017)	3
ELAVL1	0	GSPT1	3	affinity chromatography technology	Abdelmohsen K (2009)	1
CRYAB	0	BAX	3	pull down, affinity chromatography technology, affinity chromatography technology	Mao YW (2004), Mao YW (2004), Mao YW (2004)	3
TRAF6	0	NOD2	1	affinity chromatography technology	Park S (2013)	1
APAF1	8	CASP9	6	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Cho DH (2004), Li P (1997), Chu ZL (2001), Hu Y (1998), Pan G (1998), Srinivasula SM (2001), Srinivasula SM (2001), Sun M (2009), Choi H (2011), Wo L (2016), Vu NT (2016)	11
ELAVL1	0	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method	Abdelmohsen K (2009), Durie D (2011), Durie D (2011), Durie D (2011)	4
XIAP	0	UBE2E1	1	two hybrid, pull down	Dynek JN (2010), Markson G (2009)	2
XIAP	0	BIRC5	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Arora V (2007), Dohi T (2004), Dohi T (2004), Pavlyukov MS (2011)	4
BIRC2	1	CASP9	6	pull down, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, unspecified method, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Deveraux QL (1998), Deveraux QL (1998), Eckelman BP (2006), Cheung HH (2006), Kulathila R (2009), Kulathila R (2009), Vucic D (2000), Rolland T (2014), McDonald ER (2004), Chen TC (2014), Vu NT (2016), Vu NT (2016)	12
UBC	7	UBE2D3	1	affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down, pull down	Matsumoto M (2005), Vinayagam A (2011), Pruneda JN (2014), Li Y (2014), Poyurovsky MV (2007), Zhang X (2017)	6
MAP3K7	2	ERC1	0	affinity chromatography technology	Wu ZH (2010)	1
CHEK1	2	PTEN	24	genetic interference	Shen JP (2017)	1
BIRC3	1	UBE2V1	0	pull down, pull down	Bertrand MJ (2008), Wu CJ (2006)	2
BIRC3	1	UBE2D2	0	x-ray crystallography, pull down, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down	Mace PD (2008), Mace PD (2008), Dynek JN (2010), Feltham R (2011), Dou H (2012), Li X (2002), Schumacher FR (2013), Choi JS (2014), Wu CJ (2006), Fang S (2001), Hu S (2003), Suzuki S (2017)	12
APAF1	8	CASP8	1	affinity chromatography technology	Hu Y (1998)	1
XIAP	0	VPS37C	3	two hybrid	Rolland T (2014)	1
UBC	7	MAP3K7	2	pull down	Zhang X (2017)	1
BLM	2	TRIM8	6	genetic interference	Vizeacoumar FJ (2013)	1
UBE2D1	0	DTX3	4	two hybrid	Markson G (2009)	1
HNRNPL	3	HNRNPC	0	affinity chromatography technology	Fei T (2017)	1
TRIM32	2	HSPA4	3	affinity chromatography technology, pull down	Kawaguchi Y (2017), Kawaguchi Y (2017)	2
BIRC2	1	WDYHV1	0	two hybrid, affinity chromatography technology	Rolland T (2014), Huttlin EL (2017)	2
BMPR2	1	BMPR1B	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Liu F (1995), Liu F (1995), Gilboa L (2000), Gilboa L (2000)	4
CDCA4	1	XIAP	0	affinity chromatography technology, affinity chromatography technology	Li C (2015), Li C (2015)	2
BIRC2	1	UBE2L6	0	affinity chromatography technology	Hu S (2003)	1
UBC	7	TAB1	1	pull down	Zhang X (2017)	1
CDK1	0	RNPS1	1	affinity chromatography technology	Malty RH (2017)	1
XIAP	0	XAF1	1	two hybrid, affinity chromatography technology, imaging technique, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Liston P (2001), Liston P (2001), Liston P (2001), Arora V (2007), Tse MK (2012), Ju JH (2013), Ju JH (2013)	7
PTEN	24	UBE2L3	1	affinity chromatography technology	Waite KA (2003)	1
UBE2D2	0	CCNB1	3	enzymatic study	Tang Z (2001)	1
FAF1	1	USP11	3	affinity chromatography technology	Raman M (2015)	1
CASP8	1	CASP4	1	enzymatic study	Srinivasula SM (1996)	1
SIAH1	2	UBE2I	0	two hybrid, two hybrid	Depaux A (2007), Hu G (1997)	2
NUDCD2	2	SEC23IP	3	biochemical	Havugimana PC (2012)	1
MAP3K7	2	SIVA1	0	affinity chromatography technology	Resch U (2009)	1
SEPT4	2	BCL2	0	affinity chromatography technology, protein complementation assay, unspecified method, protein complementation assay	Edison N (2017), Edison N (2017), Edison N (2017), Edison N (2017)	4
SSX2IP	0	BRCA1	7	two hybrid	Hill SJ (2014)	1
UBE2D1	0	XIAP	0	two hybrid, affinity chromatography technology, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Markson G (2009), Hu S (2003), Dynek JN (2010), Morizane Y (2005), Janzer A (2012), Liu WH (2007), Takeda AN (2014), Markson G (2009), Hao Y (2004), Hanson AJ (2012)	10
LATS1	3	SSX2IP	0	two hybrid	Rolland T (2014)	1
NOTCH1	25	TLE3	2	two hybrid	Daakour S (2016)	1
TAB2	5	UBC	7	pull down, x-ray crystallography, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down	Kulathu Y (2009), Kulathu Y (2009), Sato Y (2009), van Wijk SJ (2012), Kanayama A (2004), Niu J (2011), van Wijk SJ (2013), Hooper C (2014), Komander D (2009), Emmerich CH (2013), Wauer T (2015), Kristariyanto YA (2015), Zhang X (2017)	13
UBE2D3	1	DTX3	4	two hybrid	Markson G (2009)	1
MAP3K3	3	RIPK1	2	affinity chromatography technology	Yang J (2001)	1
UBE2D4	0	TRIM8	6	two hybrid	Markson G (2009)	1
UBE2N	1	RIPK1	2	enzymatic study	Bohgaki M (2008)	1
BCL2	0	DYNLL1	0	affinity chromatography technology	Puthalakath H (1999)	1
BRCA1	7	ERC1	0	affinity chromatography technology	Ertych N (2016)	1
TRIM32	2	UBC	7	enzymatic study, pull down	Streich FC (2013), Zhang X (2017)	2
UBE2I	0	MDM2	2	pull down, affinity chromatography technology, enzymatic study, unspecified method	Buschmann T (2001), Buschmann T (2001), Buschmann T (2001), Buschmann T (2001)	4
ELAVL1	0	SSX2IP	0	affinity chromatography technology	Abdelmohsen K (2009)	1
NOD2	1	UBC	7	x-ray crystallography	Ver Heul AM (2013)	1
CASP10	1	CASP6	0	enzymatic study	Srinivasula SM (1996)	1
XIAP	0	MAGED1	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jordan BW (2001), Jordan BW (2001), Jordan BW (2001), Kang J (2014)	4
EGFR	5	SRPRA	3	affinity chromatography technology	Tong J (2014)	1
MDM2	2	UBE2E2	1	pull down, pull down	David Y (2011), Yamauchi T (2014)	2
UBE2V1	0	UCHL3	1	biochemical	Havugimana PC (2012)	1
CHEK1	2	BLM	2	affinity chromatography technology, imaging technique, genetic interference	Sengupta S (2004), Sengupta S (2004), Srivas R (2016)	3
HNRNPL	3	NEK6	2	affinity chromatography technology	Fei T (2017)	1
HNRNPL	3	BMPR2	1	affinity chromatography technology	Fei T (2017)	1
EGFR	5	CEP170	4	affinity chromatography technology	Yao Z (2017)	1
BRCA1	7	MAP3K3	3	two hybrid, affinity chromatography technology	Gilmore PM (2004), Gilmore PM (2004)	2
MDM2	2	XIAP	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method	Gu L (2009), Huang X (2013), Huang X (2013), Huang X (2013), Liu T (2015)	5
BIRC3	1	UBE2D3	1	affinity chromatography technology, two hybrid, pull down, pull down	Hu S (2003), Dynek JN (2010), Darding M (2011), Hu S (2003)	4
NOD2	1	BIRC3	1	affinity chromatography technology	Damgaard RB (2012)	1
AKT1	1	BCL10	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Yeh PY (2006), Yeh PY (2006), Yeh PY (2006)	3
TOLLIP	3	RAC1	7	affinity chromatography technology, affinity chromatography technology	Visvikis O (2011), Visvikis O (2011)	2
BIRC2	1	UBE2D2	0	two hybrid, pull down, pull down, pull down	Dynek JN (2010), Li X (2002), Feltham R (2011), Choi YE (2009)	4
UBE2D2	0	TRIM8	6	two hybrid, pull down	Markson G (2009), Li Q (2011)	2
UBE2D4	0	SIAH1	2	two hybrid	van Wijk SJ (2009)	1
BIRC2	1	E2F1	0	affinity chromatography technology, affinity chromatography technology	Cartier J (2011), Cartier J (2011)	2
TAB1	1	MDM2	2	affinity chromatography technology	Zhu Y (2013)	1
BIRC3	1	XAF1	1	affinity chromatography technology	Arora V (2007)	1
ELAVL1	0	CDCA4	1	affinity chromatography technology	Abdelmohsen K (2009)	1
CDK1	0	CKS1B	0	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Wolthuis R (2008), Havugimana PC (2012), Hixon ML (1998), Varjosalo M (2013), Radulovic M (2010), Rolland T (2014), So J (2015), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	11
HTRA2	1	BIRC3	1	pull down, affinity chromatography technology	Hegde R (2003), Suzuki Y (2001)	2
BIRC7	0	BIRC2	1	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Dynek JN (2010), Oberoi-Khanuja TK (2012), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	5
MUS81	1	XIAP	0	genetic interference	Vizeacoumar FJ (2013)	1
CDK1	0	XIAP	0	enzymatic study	Hou Y (2017)	1
RIPK4	0	PFAS	3	affinity chromatography technology	Rodriguez J (2016)	1
UBE2N	1	STUB1	4	pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, pull down	Zhang M (2005), Graf C (2010), Soss SE (2011), Huen MS (2008), Lim GG (2013), Taipale M (2014), Taipale M (2014), Zhu X (2014), Zhang M (2005), Zhang M (2005), Kim HT (2007), Blessing NA (2017)	12
XIAP	0	RIPK3	2	pull down	Bertrand MJ (2011)	1
BIRC2	1	UBC	7	pull down, pull down, pull down, pull down, enzymatic study	Dynek JN (2010), Gyrd-Hansen M (2008), Gyrd-Hansen M (2008), Komander D (2009), Sakamoto H (2015)	5
IKBKE	2	CCT2	1	affinity chromatography technology	So J (2015)	1
ELAVL1	0	ADAMTS4	1	affinity chromatography technology	Abdelmohsen K (2009)	1
BRCA1	7	CCNB1	3	pull down, affinity chromatography technology, enzymatic study	Wang H (1997), Shabbeer S (2013), Shabbeer S (2013)	3
UBE2V1	0	UBC	7	pull down	McKenna S (2003)	1
BIRC3	1	RIPK3	2	pull down, affinity chromatography technology, enzymatic study	Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011)	3
MDM2	2	LATS1	3	affinity chromatography technology	Matallanas D (2011)	1
CASP3	0	USO1	1	enzymatic study	Chiu R (2002)	1
PRDX3	3	XIAP	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2D2	0	UBE2L3	1	biochemical	Havugimana PC (2012)	1
AHCY	5	ATP6V1A	3	biochemical	Havugimana PC (2012)	1
UBE2A	0	HNRNPC	0	affinity chromatography technology	An H (2017)	1
TRAF6	0	CASP4	1	affinity chromatography technology	Lakshmanan U (2007)	1
BMPR1B	3	XIAP	0	affinity chromatography technology	Liu Z (2009)	1
BIRC7	0	CASP7	1	pull down	Kasof GM (2001)	1
CKAP5	2	XIAP	0	affinity chromatography technology	Hein MY (2015)	1
HNRNPL	3	XIAP	0	affinity chromatography technology	Fei T (2017)	1
CDK1	0	HSPA4	3	affinity chromatography technology	Garcia-Morales P (2007)	1
GSPT1	3	CCT2	1	biochemical	Havugimana PC (2012)	1
BCL2	0	CDK1	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Pathan N (2002), Pathan N (2001), Ling YH (1998)	3
CDC42	3	BIRC2	1	pull down, pull down, affinity chromatography technology, enzymatic study	Marivin A (2013), Marivin A (2013), Marivin A (2013), Murali A (2017)	4
DCAF12	0	BIRC2	1	affinity chromatography technology	Huttlin EL (2017)	1
UBE2N	1	XIAP	0	two hybrid, pull down	Markson G (2009), Markson G (2009)	2
BIRC3	1	TRAF2	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology	Uren AG (1996), Roy N (1997), Yoneda T (2000), Yoneda T (2000), Li X (2002), Behrends C (2010), Samuel T (2006), Vince JE (2009), Darding M (2011), Zheng C (2010), Zheng C (2010), Zheng C (2010), Zheng C (2010), Zheng C (2010), Rothe M (1995), Varfolomeev E (2006), Choudhary S (2013), Goncharov T (2013), Wang J (2011), Harikumar KB (2014), Shen RR (2012), Chen TC (2014), Akhtar N (2016)	23
STUB1	4	HSPA4	3	pull down, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down, pull down, enzymatic study, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ballinger CA (1999), Ballinger CA (1999), Ballinger CA (1999), Dai Q (2005), Tateishi Y (2004), Tateishi Y (2004), Ko HS (2009), Qian SB (2009), Kumar P (2007), Kumar P (2007), Wang L (2011), Wang L (2011), Wang L (2011), Graf C (2010), Kundrat L (2010), Matsumoto K (2011), Kundrat L (2010), Kundrat L (2010), Morishima Y (2008), Luo W (2010), Soss SE (2011), Zhou P (2003), Kalia LV (2011), Gao Y (2010), Gao Y (2010), Grelle G (2006), Rao SN (2010), Tetzlaff JE (2008), Kim SA (2005), Dai Q (2003), Zhang X (2011), Zhang X (2011), Muller P (2012), Jang KW (2011), Schuelke JP (2010), Jinwal UK (2012), Shimamoto S (2013), Shimamoto S (2013), Shimamoto S (2013), Mao RF (2013), Lee JS (2013), Lee JS (2013)	42
BIRC2	1	XAF1	1	affinity chromatography technology	Arora V (2007)	1
ELAVL1	0	CDC42	3	affinity chromatography technology	Abdelmohsen K (2009)	1
XIAP	0	CKS1B	0	two hybrid	Rolland T (2014)	1
AKT1	1	RAF1	3	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Zimmermann S (1999), Zimmermann S (1999), Wang J (2009), Wang J (2009), Ivanov AA (2017)	5
RIPK4	0	HAX1	1	affinity chromatography technology	Rodriguez J (2016)	1
BRCA1	7	UBE2N	1	two hybrid, x-ray crystallography, pull down, two hybrid, pull down	Christensen DE (2009), Christensen DE (2009), Christensen DE (2009), Christensen DE (2007), David Y (2011)	5
UBE2L6	0	ARHGDIA	3	two hybrid	Vinayagam A (2011)	1
HNRNPC	0	BRCA1	7	unspecified method	Anantha RW (2013)	1
CASP8	1	BIRC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Micheau O (2003), Feoktistova M (2012), McDonald ER (2004), Zinngrebe J (2016)	4
UBE2W	0	TRIM8	6	two hybrid	Markson G (2009)	1
DIABLO	2	BIRC3	1	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Verhagen AM (2000), Yang QH (2004), Hu S (2003), Burke SP (2010), Budhidarmo R (2014), Hu S (2003), Wo L (2016)	7
KLHL2	0	RNPS1	1	affinity chromatography technology	Huttlin EL (2017)	1
WDYHV1	0	HTRA2	1	affinity chromatography technology	Huttlin EL (2017)	1
GSK3B	1	UBE2D1	0	two hybrid	Vinayagam A (2011)	1
ELAVL1	0	ATP6V1A	3	affinity chromatography technology	Abdelmohsen K (2009)	1
TRIM32	2	UBE2D3	1	affinity chromatography technology, pull down, pull down, pull down	Napolitano LM (2011), Zhang J (2012), Streich FC (2013), Mokhonova EI (2015)	4
CASP3	0	BLM	2	enzymatic study	Freire R (2001)	1
BIRC2	1	BCL10	0	affinity chromatography technology, affinity chromatography technology	Yoneda T (2000), Hu S (2006)	2
ELAVL1	0	SMS	1	affinity chromatography technology	Abdelmohsen K (2009)	1
PTEN	24	AKT1	1	affinity chromatography technology, fluorescent resonance energy transfe	Mistafa O (2010), Ivanov AA (2017)	2
NOD2	1	BIRC2	1	affinity chromatography technology	Damgaard RB (2012)	1
AKT1	1	CHEK1	2	genetic interference	Shen JP (2017)	1
90378	0	XIAP	0	affinity chromatography technology	Hein MY (2015)	1
NOD1	3	CASP4	1	affinity chromatography technology	Inohara N (1999)	1
STUB1	4	UBE2V2	0	biochemical	Havugimana PC (2012)	1
CHEK1	2	USP11	3	genetic interference	Srivas R (2016)	1
ARHGDIA	3	RAC1	7	affinity chromatography technology, pull down, x-ray crystallography, x-ray crystallography, biochemical, two hybrid, biochemical, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Grizot S (2001), Grizot S (2001), Lian LY (2000), Gorvel JP (1998), Di-Poi N (2001), Di-Poi N (2001), Faure J (2001), Vinayagam A (2011), Yu J (2012), Sandrock K (2010), Boldt K (2016)	12
XIAP	0	HSPA4	3	affinity chromatography technology	Hegde R (2002)	1
CCNB1	3	PRDX3	3	affinity chromatography technology	Hein MY (2015)	1
UBE2D1	0	UBC	7	x-ray crystallography	Bosanac I (2010)	1
XIAP	0	TCF25	0	pull down, affinity chromatography technology	Steen H (2008), Steen H (2008)	2
CASP3	0	CASP2	1	enzymatic study, enzymatic study	Paroni G (2001), Walsh JG (2008)	2
RIPK4	0	CCT2	1	affinity chromatography technology	Rodriguez J (2016)	1
BIRC2	1	CASP2	1	pull down	Cheung HH (2006)	1
ELAVL1	0	UBE2N	1	affinity chromatography technology	Abdelmohsen K (2009)	1
S100A4	0	DYNLL1	0	affinity chromatography technology	Hein MY (2015)	1
BAX	3	CASP7	1	biochemical	Chandra D (2004)	1
FAF1	1	HSPA4	3	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical	Lee JJ (2012), Kim HJ (2005), Kim HJ (2005), Lee JJ (2013), Lee JJ (2013), Kristensen AR (2012)	6
AKT1	1	STUB1	4	affinity chromatography technology, affinity chromatography technology	Dickey CA (2008), Su CH (2011)	2
HNRNPL	3	FAF1	1	affinity chromatography technology	Fei T (2017)	1
NOD1	3	RIPK2	0	affinity chromatography technology, affinity chromatography technology, pull down	Inohara N (1999), Hirata Y (2006), Ver Heul AM (2013)	3
GSK3B	1	AKT2	1	x-ray crystallography	Yang J (2002)	1
TOLLIP	3	WDYHV1	0	two hybrid	Rolland T (2014)	1
CASP7	1	CASP9	6	enzymatic study	Walsh JG (2008)	1
ADAMTS4	1	XIAP	0	affinity chromatography technology	Huttlin EL (2017)	1
AKT1	1	PHB2	1	two hybrid, affinity chromatography technology	Sun L (2004), Sun L (2004)	2
USP5	2	TRAF6	0	enzymatic study	Bremm A (2010)	1
RIPK2	0	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	McCarthy JV (1998), LeBlanc PM (2008), Marinis JM (2011)	3
BIRC2	1	CASP7	1	pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Roy N (1997), Choi YE (2009), Choi YE (2009), Tenev T (2005), Eckelman BP (2006), Vucic D (2000)	6
UBC	7	UBE2N	1	affinity chromatography technology, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down	Matsumoto M (2005), Scheper J (2010), Wu PY (2003), McKenna S (2003), Wiener R (2012), Ye Y (2003), Bish RA (2007), Juang YC (2012), Pastushok L (2007), Singh RK (2012), McKenna S (2001), McKenna S (2001)	12
UBE2I	0	CASP2	1	two hybrid	Shirakura H (2005)	1
NOD2	1	RIPK2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ogura Y (2001), Tao M (2009), Abbott DW (2004), Abbott DW (2004), Tigno-Aranjuez JT (2010), Tigno-Aranjuez JT (2010), Damgaard RB (2012), Marinis JM (2011), Draber P (2015)	9
BRCA1	7	SEC23IP	3	affinity chromatography technology	Ertych N (2016)	1
LATS1	3	CDK1	0	two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology	Tao W (1999), Tao W (1999), Morisaki T (2002), Pefani DE (2014)	4
TBK1	1	IRF3	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, pull down, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study	Friedman CS (2008), Li S (2011), Li S (2011), Cui J (2012), Piao W (2009), Nakhaei P (2012), Ikeda F (2007), Ikeda F (2007), Ng MH (2011), Wang L (2012), Yang K (2006), Yang K (2006), Liu XY (2010), Liu S (2015), Liu S (2015), Freischmidt A (2015), Zhang Q (2017), Zhang Q (2017)	18
HTRA1	3	XIAP	0	affinity chromatography technology, pull down	He X (2012), He X (2012)	2
ARHGDIA	3	CASP8	1	biochemical	Gajate C (2005)	1
UBE2D2	0	DTX3	4	two hybrid	Markson G (2009)	1
SIAH1	2	TOLLIP	3	two hybrid	Rolland T (2014)	1
SEPT4	2	UBC	7	affinity chromatography technology	Fu RH (2017)	1
BIRC3	1	RAF1	3	pull down	Dogan T (2008)	1
ELAVL1	0	TOLLIP	3	affinity chromatography technology	Abdelmohsen K (2009)	1
KLHL2	0	90378	0	affinity chromatography technology	Huttlin EL (2017)	1
GSK3B	1	NOTCH1	25	enzymatic study, pull down	Foltz DR (2002), Foltz DR (2002)	2
EGFR	5	TAB1	1	affinity chromatography technology, two hybrid, protein complementation assay	Tong J (2008), Kotlyar M (2015), Petschnigg J (2014)	3
MAP3K3	3	XIAP	0	pull down, enzymatic study	Takeda AN (2014), Takeda AN (2014)	2
SMS	1	XIAP	0	affinity chromatography technology	Hein MY (2015)	1
RIPK2	0	TAB1	1	affinity chromatography technology	Hasegawa M (2008)	1
TRAF6	0	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Mao AP (2010), Hinz M (2010)	2
UBE2J2	1	EGFR	5	affinity chromatography technology	Chen S (2017)	1
BIRC7	0	UBE2D3	1	two hybrid	Dynek JN (2010)	1
KLHL2	0	XIAP	0	affinity chromatography technology	Huttlin EL (2017)	1
NOD2	1	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down	Kim JY (2008), Chen CM (2004), Chen CM (2004), Chen CM (2004), Chen CM (2004), Windheim M (2007)	6
RIPK2	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology	Thome M (1998), Li S (2011)	2
XIAP	0	ERC1	0	affinity chromatography technology	Wu ZH (2010)	1
LRRN2	2	TRAF2	1	affinity chromatography technology	Huttlin EL (2017)	1
XIAP	0	ACVR1B	1	imaging technique	Chen TC (2014)	1
UBE2E2	1	SIAH1	2	pull down, affinity chromatography technology, affinity chromatography technology	Kraemer OH (2008), Kraemer OH (2008), Lee JT (2008)	3
GSK3B	1	XIAP	0	affinity chromatography technology	Sun M (2009)	1
HNRNPL	3	TCF7L2	12	affinity chromatography technology	Fei T (2017)	1
CASP10	1	CASP9	6	enzymatic study	Srinivasula SM (1996)	1
MDM2	2	HSPA4	3	affinity chromatography technology	Lu TL (2010)	1
CDK1	0	E2F1	0	enzymatic study	Dynlacht BD (1997)	1
MAP3K3	3	HSPA4	3	affinity chromatography technology	Bouwmeester T (2004)	1
NOD1	3	CASP9	6	affinity chromatography technology	Inohara N (1999)	1
CEP170	4	XIAP	0	bioid	Gupta GD (2015)	1
XIAP	0	UBC	7	x-ray crystallography, pull down, pull down, pull down	Tse MK (2011), Gyrd-Hansen M (2008), Gyrd-Hansen M (2008), Nakatani Y (2012)	4
NOD1	3	CASP2	1	affinity chromatography technology	Inohara N (1999)	1
RIPK2	0	PHB2	1	affinity chromatography technology	Ewing RM (2007)	1
GSK3B	1	DYNLL1	0	affinity chromatography technology	Varjosalo M (2013)	1
HTRA2	1	DIABLO	2	far western blotting, affinity chromatography technology	Hegde R (2002), Hegde R (2002)	2
WDYHV1	0	LONRF1	4	two hybrid	Rolland T (2014)	1
MAP3K3	3	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Yamazaki K (2009), Yamazaki K (2009), Blonska M (2005), Blonska M (2005), Blonska M (2005)	5
XIAP	0	FAF1	1	two hybrid, pull down, affinity chromatography technology, imaging technique	Caballero-Lopez MJ (2017), Caballero-Lopez MJ (2017), Caballero-Lopez MJ (2017), Caballero-Lopez MJ (2017)	4
UBE2A	0	ELAVL1	0	affinity chromatography technology	An H (2017)	1
TAB1	1	CASP6	0	two hybrid	Vinayagam A (2011)	1
S100A4	0	XIAP	0	affinity chromatography technology	Hein MY (2015)	1
CASP7	1	CASP2	1	enzymatic study	Paroni G (2001)	1
USP5	2	UBC	7	pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, pull down, pull down, pull down, pull down, pull down, pull down, unspecified method, affinity chromatography technology, pull down, x-ray crystallography, pull down, pull down, pull down, enzymatic study, enzymatic study, pull down, pull down	Reyes-Turcu FE (2008), Nicassio F (2007), Zhang YH (2012), Bremm A (2010), Komander D (2009), Melandri F (1996), Sokratous K (2012), Fenner BJ (2009), Schulz S (2012), Raasi S (2005), Nathan JA (2013), Ernst A (2013), Bish RA (2007), Reyes-Turcu FE (2006), Reyes-Turcu FE (2006), Zhang YH (2012), Liu Y (2014), Scott D (2015), Flierman D (2016), Castaneda CA (2016), Zhang X (2017), Kwasna D (2018)	22
CDC42	3	TRAF2	1	affinity chromatography technology, pull down	Marivin A (2013), Marivin A (2013)	2
RAPGEF2	5	UBC	7	affinity chromatography technology	Kim TY (2014)	1
PRDX3	3	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BIRC3	1	CASP10	1	affinity chromatography technology	McDonald ER (2004)	1
BIRC5	1	CASP7	1	pull down, enzymatic study, pull down	Tamm I (1998), Shin S (2001), Shin S (2001)	3
XIAP	0	FAIM	0	affinity chromatography technology	Moubarak RS (2013)	1
UBE2D2	0	RAF1	3	enzymatic study	Demand J (2001)	1
PTEN	24	TRIM8	6	genetic interference	Vizeacoumar FJ (2013)	1
EGFR	5	CDK1	0	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay	Tong J (2008), Foerster S (2013), Kotlyar M (2015), Petschnigg J (2014)	4
RIPK2	0	TAB2	5	affinity chromatography technology	Hasegawa M (2008)	1
LATS1	3	XIAP	0	affinity chromatography technology	Kuninaka S (2005)	1
TRAF6	0	UBE2E1	1	pull down	Markson G (2009)	1
SSX2IP	0	TBK1	1	bioid	Gupta GD (2015)	1
UBE2L6	0	TRIM8	6	two hybrid	Markson G (2009)	1
BIRC7	0	UBE2I	0	two hybrid, two hybrid	Dynek JN (2010), Dynek JN (2010)	2
UBC	7	NOD1	3	pull down, x-ray crystallography	Ver Heul AM (2013), Ver Heul AM (2013)	2
UBC	7	RFC5	2	affinity chromatography technology	Matsumoto M (2005)	1
HAX1	1	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kang YJ (2010), Kang YJ (2010), Kang YJ (2010)	3
STUB1	4	UBE2D3	1	pull down, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Murata S (2001), Soss SE (2011), Page RC (2012), Parsons JL (2009), Stankiewicz M (2010), Gao XC (2011), Kundrat L (2010), Kundrat L (2010), Tsukahara F (2010), Todi SV (2010), Smith MC (2013), Ronnebaum SM (2013), Seki T (2013), Heimdal K (2014), Todi SV (2009), Yuan L (2015), Kim JH (2017), Blessing NA (2017), Pakdaman Y (2017)	19
MDM2	2	UBE2D3	1	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Yadavilli S (2009), Nie J (2010), Minsky N (2004), Wang X (2011), Sionov RV (2001), Oh W (2010), Zhu Y (2009), Latini P (2011), Jung CR (2010), David Y (2011), Ye B (2013), Cheng Q (2014), Saville MK (2004), Yamauchi T (2014), Jin M (2017)	15
NEK6	2	CDC42	3	two hybrid, pull down	Vaz Meirelles G (2010), Vaz Meirelles G (2010)	2
BRCA1	7	AHCY	5	affinity chromatography technology	Ertych N (2016)	1
BIRC2	1	HTRA2	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hegde R (2003), Hegde R (2003), Verhagen AM (2002), Suzuki Y (2001), Huttlin EL (2017)	5
AKT1	1	COMMD1	1	two hybrid, affinity chromatography technology	Wang J (2008), Ke Y (2010)	2
CLEC11A	0	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EGFR	5	S100A4	0	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
UBE2I	0	RIPK2	0	two hybrid	Rual JF (2005)	1
TRIM32	2	SEC23IP	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Boldt K (2016)	2
TAB1	1	BIRC7	0	affinity chromatography technology	Sanna MG (2002)	1
RAF1	3	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, enzymatic study, imaging technique	Dogan T (2008), Tian S (2006), Tian S (2006), Tian S (2006), Tian S (2006), Tian S (2006), Chen TC (2014)	7
MAP3K7	2	TRIM8	6	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li Q (2011), Li Q (2011), Chen L (2017), Chen L (2017), Yan FJ (2016), Yan FJ (2016)	6
ELAVL1	0	UBE2W	0	affinity chromatography technology	Abdelmohsen K (2009)	1
UBE2E1	1	DTX3	4	two hybrid	Markson G (2009)	1
XIAP	0	CASP9	6	two hybrid, far western blotting, pull down, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, unspecified method, x-ray crystallography, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique	Rual JF (2005), Davoodi J (2004), Deveraux QL (1998), Deveraux QL (1998), Richter BW (2001), Morizane Y (2005), Fu J (2003), Fu J (2003), Hao Y (2004), Varfolomeev E (2007), Vucic D (2002), Qiu XB (2005), Srinivasula SM (2001), Cheung HH (2006), Kulathila R (2009), Shiozaki EN (2003), Davoodi J (2007), Checinska A (2007), Huang Y (2003), Sun M (2009), Martin SA (2005), Lee JS (2012), Rolland T (2014), McDonald ER (2004), Chen TC (2014)	25
USP5	2	ATP6V1A	3	biochemical	Havugimana PC (2012)	1
HAX1	1	GSK3B	1	affinity chromatography technology	Huttlin EL (2015)	1
UBE2I	0	UBE2D2	0	biochemical	Wan C (2015)	1
KLHL2	0	DIABLO	2	affinity chromatography technology	Huttlin EL (2017)	1
BIRC2	1	BIRC3	1	affinity chromatography technology, affinity chromatography technology	Rajalingam K (2006), Rajalingam K (2006)	2
ELAVL1	0	SSB	0	affinity chromatography technology	Abdelmohsen K (2009)	1
BRCA1	7	E2F1	0	affinity chromatography technology	Gorski JJ (2011)	1
UBE2E1	1	BIRC8	0	two hybrid	Markson G (2009)	1
ARHGDIA	3	CDC42	3	affinity chromatography technology, biochemical, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical	Ewing RM (2007), Gorvel JP (1998), Bandyopadhyay S (2010), Vinayagam A (2011), Marivin A (2013), Marivin A (2013), Wan C (2015)	7
XAF1	1	TRAF2	1	affinity chromatography technology	Lin B (2016)	1
UBE2D2	0	XIAP	0	two hybrid, two hybrid, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, pull down, pull down	Markson G (2009), Dynek JN (2010), Nakatani Y (2012), Nakatani Y (2012), Markson G (2009), Fang S (2001), Hu S (2003), Buetow L (2015), Foglizzo M (2016), Edison N (2017)	10
UBC	7	UBE2L3	1	affinity chromatography technology	Bish RA (2007)	1
MDM2	2	AKT1	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique	Lin HK (2002), Ogawara Y (2002), Zhou BP (2001), Zhou BP (2001), Kim CK (2011), Kim CK (2011), Zhu QS (2011), Milne D (2004), Deep G (2008), Deep G (2008), Chen TC (2014)	11
XIAP	0	XIAP	0	two hybrid, two hybrid, enzymatic study, affinity chromatography technology, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, x-ray crystallography	Rual JF (2005), Dynek JN (2010), Janzer A (2012), Martins LM (2002), Nakatani Y (2012), Nakatani Y (2012), Kenten JH (2005), Takeda AN (2014), Markson G (2009), Fang S (2001), Bertrand MJ (2008), Cossu F (2015), Buetow L (2015), Zumbraegel FK (2017), Gabrielsen M (2017), Gabrielsen M (2017)	16
BIRC2	1	RAF1	3	pull down	Dogan T (2008)	1
RAF1	3	HSPA4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhu J (2005), Zhu J (2005), Zhu J (2005), da Rocha Dias S (2005)	4
BIRC3	1	UBE2L3	1	affinity chromatography technology	Hu S (2003)	1
EXTL3	10	XIAP	0	affinity chromatography technology	Holley CL (2002)	1
EGFR	5	UBE2V2	0	protein complementation assay	Deribe YL (2009)	1
USP19	1	STUB1	4	affinity chromatography technology	He WT (2016)	1
UBC	7	VPS37C	3	pull down	Nathan JA (2013)	1
CDK1	0	CHEK1	2	affinity chromatography technology	Hein MY (2015)	1
UBE2D1	0	MDM2	2	two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Singh RK (2007), Poyurovsky MV (2007), Li M (2003), Yogosawa S (2003), Honda R (1997), Sun XX (2011), Singh RK (2007), Taira N (2010), Fu X (2010), Wang KS (2011), Wang X (2004), Sehat B (2008), Wawrzynow B (2007), Burch L (2004), Frazier DP (2012), Huart AS (2012), Pettersson S (2009), Gama V (2009), Demma M (2010), Chymkowitch P (2011), Yan C (2010), Yang Y (2013), Ranaweera RS (2013), Siepe D (2009), Shi D (2009), Uchiki T (2009), Grossman SR (2003), Xirodimas DP (2004), Saville MK (2004), Liu T (2015), Batuello CN (2015), Fraser JA (2015), Yamauchi T (2014), Liu D (2016), McClurg UL (2016), Landre V (2017)	36
EGFR	5	TRAF2	1	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Tong J (2008), Puliyappadamba VT (2013), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	5
DIABLO	2	BIRC7	0	affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ma L (2006), Ma L (2006), Vucic D (2002), Shiozaki EN (2003), Ma L (2006), Dou H (2012), Huttlin EL (2015), Liu GH (2015), Huttlin EL (2017)	9
XIAP	0	UBE2I	0	two hybrid, two hybrid	Dynek JN (2010), Dynek JN (2010)	2
TRAF6	0	UBE2V1	0	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Deng L (2000), Lamothe B (2007), Kanayama A (2004), Shi CS (2010), Xia ZP (2009), Yang WL (2009), Murata H (2013), Ning S (2008), Sun L (2004), Lin Y (2014)	10
TRAF6	0	UBE2L3	1	pull down, pull down	Geetha T (2005), Babu JR (2005)	2
PRSS22	0	XIAP	0	affinity chromatography technology	Huttlin EL (2015)	1
APAF1	8	XIAP	0	biochemical, affinity chromatography technology, affinity chromatography technology	Srinivasula SM (2001), Srinivasula SM (2001), Sun M (2009)	3
NOTCH1	25	TRIM32	2	affinity chromatography technology	Yatim A (2012)	1
CCNB1	3	XIAP	0	pull down	Hou Y (2017)	1
UBE2V1	0	DTX3	4	two hybrid	Markson G (2009)	1
AKT1	1	HSPA4	3	affinity chromatography technology	Doong H (2003)	1
HNRNPA1	1	HNRNPC	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Zhang S (2004), Roy R (2014), Hein MY (2015)	4
ELAVL1	0	HNRNPL	3	affinity chromatography technology	Abdelmohsen K (2009)	1
CASP10	1	CASP7	1	enzymatic study	Srinivasula SM (1996)	1
MDM2	2	E2F1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Zhang Z (2005), Zhang Z (2005), Stevens C (2008), Stevens C (2008)	4
CRYAB	0	CASP3	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Stegh AH (2008), Stegh AH (2008), Stegh AH (2008), Lee JS (2012), Jeong WJ (2012)	5
AHCY	5	XIAP	0	biochemical	Havugimana PC (2012)	1
UBE2L3	1	UBE2V2	0	biochemical	Havugimana PC (2012)	1
SCARA3	2	EXTL3	10	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MDM2	2	UBE2L3	1	pull down, pull down	Hampe C (2006), Yamauchi T (2014)	2
UBE2D4	0	BIRC8	0	two hybrid	Markson G (2009)	1
TRAF6	0	UBE2N	1	genetic interference, pull down, two hybrid, biochemical, two hybrid, x-ray crystallography, two hybrid, enzymatic study, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid, two hybrid	Deng L (2000), Deng L (2000), Markson G (2009), Yin Q (2009), Dynek JN (2010), Yin Q (2009), Yin Q (2009), Petroski MD (2007), Mercier P (2007), Lamothe B (2008), Kanayama A (2004), Murata H (2013), Ning S (2008), Markson G (2009), Lin Y (2014), Chen J (2015), Zhang J (2016), Boldt K (2016), Rezaeian AH (2017), Xing J (2016), Schimmack G (2017), Schimmack G (2017)	22
NOD2	1	XIAP	0	affinity chromatography technology, pull down	Damgaard RB (2012), Krieg A (2009)	2
UBC	7	HNRNPC	0	affinity chromatography technology	Matsumoto M (2005)	1
RIPK3	2	RIPK1	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yu PW (1999), Yu PW (1999), Li S (2011), Lee EW (2012), Petersen SL (2015), Moquin DM (2013), Moriwaki K (2016)	7
RIPK2	0	UBC	7	affinity chromatography technology	Park S (2013)	1
UBE2N	1	UBE2V1	0	biochemical, pull down, pull down, pull down, two hybrid, two hybrid, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, two hybrid, biochemical, pull down, pull down, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Deng L (2000), Deng L (2000), Zhang M (2005), Andersen PL (2005), Andersen PL (2005), Scheper J (2010), Scheper J (2010), Scheper J (2010), Wooff J (2004), Plans V (2006), Huen MS (2008), Huen MS (2008), Havugimana PC (2012), Bohgaki M (2008), Petroski MD (2007), Sawasaki T (2008), Wan C (2015), Chen J (2015), Boldt K (2016), Zhang Y (2018)	20
BLM	2	CASP8	1	affinity chromatography technology	Hein MY (2015)	1
SIAH1	2	WDYHV1	0	two hybrid	Rolland T (2014)	1
CASP8	1	CASP3	0	enzymatic study, enzymatic study, enzymatic study	Guo Y (2002), Srinivasula SM (1996), Chandra D (2004)	3
FAF1	1	UBC	7	pull down, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical	Song EJ (2005), Lee JJ (2012), Song J (2009), Song J (2009), Song J (2009), Lee JJ (2013), Lee JJ (2013), Nathan JA (2013), Baron Y (2014), Alexandru G (2008), Lee JJ (2012)	11
UBE2W	0	XIAP	0	two hybrid, two hybrid	Markson G (2009), Dynek JN (2010)	2
BIRC8	0	DIABLO	2	x-ray crystallography, affinity chromatography technology, affinity chromatography technology	Shin H (2005), Huttlin EL (2015), Huttlin EL (2017)	3
CASP8	1	CHEK1	2	genetic interference	Shen JP (2017)	1
ELAVL1	0	CASP3	0	affinity chromatography technology	Abdelmohsen K (2009)	1
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
RIPK4	0	STUB1	4	affinity chromatography technology	Rodriguez J (2016)	1
CASP10	1	CASP3	0	enzymatic study	Srinivasula SM (1996)	1
NOD2	1	RIPK1	2	affinity chromatography technology	Damgaard RB (2012)	1
BCL2	0	BAX	3	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hoetelmans RW (2004), Lin B (2004), Lin B (2004), Oltvai ZN (1993), Komatsu K (2000), Geng F (2011), Bodur C (2012), Trisciuoglio D (2013), Zhang H (2000), Diaz JL (1997), Dlugosz PJ (2006), Konopleva M (2006), Konopleva M (2006), Czabotar PE (2011)	14
STUB1	4	USP5	2	biochemical	Wan C (2015)	1
CCS	0	XIAP	0	affinity chromatography technology, affinity chromatography technology	Brady GF (2010), Brady GF (2010)	2
HTRA2	1	HAX1	1	affinity chromatography technology	Plun-Favreau H (2007)	1
BIRC2	1	RIPK4	0	pull down, affinity chromatography technology, enzymatic study	Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011)	3
USP19	1	BIRC3	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Mei Y (2011), Mei Y (2011), Mei Y (2011)	3
ELAVL1	0	STRADB	1	affinity chromatography technology	Abdelmohsen K (2009)	1
XIAP	0	SSB	0	affinity chromatography technology	Lewis SM (2007)	1
XIAP	0	IRF3	4	affinity chromatography technology	Nakhaei P (2012)	1
BAX	3	XIAP	0	affinity chromatography technology	Gogada R (2011)	1
CASP8	1	CASP2	1	enzymatic study, enzymatic study	Guo Y (2002), Srinivasula SM (1996)	2
HNRNPA1	1	PHB2	1	affinity chromatography technology, biochemical	Roy R (2014), Wan C (2015)	2
TRAF2	1	HTRA2	1	affinity chromatography technology	Behrends C (2010)	1
XIAP	0	UBE2L6	0	affinity chromatography technology	Hu S (2003)	1
TRAF2	1	CASP12	1	affinity chromatography technology	Yoneda T (2001)	1
TRIM32	2	UBE2D2	0	affinity chromatography technology, pull down, pull down	Napolitano LM (2011), Streich FC (2013), Mokhonova EI (2015)	3
BIRC2	1	PGAM5	4	enzymatic study, pull down, affinity chromatography technology	Zhuang M (2013), Zhuang M (2013), Zhuang M (2013)	3
BRCA1	7	USO1	1	affinity chromatography technology	Ertych N (2016)	1
UBC	7	BRCA1	7	pull down, enzymatic study	Sobhian B (2007), Zhao GY (2007)	2
SIVA1	0	MDM2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Du W (2009), Du W (2009), Iorio-Morin C (2012)	3
PTEN	24	UBE2I	0	affinity chromatography technology, affinity chromatography technology	Waite KA (2003), Huang J (2012)	2
WDYHV1	0	TRAF2	1	affinity chromatography technology	Huttlin EL (2017)	1
TRAF6	0	AKT1	1	enzymatic study, affinity chromatography technology, affinity chromatography technology	Yang WL (2009), Mitra S (2011), Mitra S (2011)	3
CASP9	6	CRYAB	0	affinity chromatography technology	Lee JS (2012)	1
UBE2V1	0	TRIM32	2	two hybrid, two hybrid, two hybrid, affinity chromatography technology	Markson G (2009), Napolitano LM (2011), Napolitano LM (2011), Napolitano LM (2011)	4
CASP2	1	MDM2	2	enzymatic study	Oliver TG (2011)	1
XIAP	0	BCL10	0	affinity chromatography technology	Hu S (2006)	1
CASP8	1	RIPK3	2	affinity chromatography technology	Lee EW (2012)	1
UBE2L3	1	UCHL3	1	biochemical	Havugimana PC (2012)	1
XIAP	0	HNRNPC	0	affinity chromatography technology	Lewis SM (2007)	1
MAGED1	0	BIRC8	0	two hybrid	Rolland T (2014)	1
CCT2	1	XIAP	0	pull down, affinity chromatography technology	Lin YF (2012), Lin YF (2012)	2
UBE2D3	1	TRIM8	6	two hybrid	Markson G (2009)	1
EGFR	5	BLM	2	affinity chromatography technology	Tong J (2014)	1
XIAP	0	DTX3	4	two hybrid	Woodsmith J (2012)	1
BIRC2	1	BIRC5	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Dohi T (2004), Samuel T (2005), Samuel T (2005), Jung SA (2015), Jung SA (2015), Jung SA (2015)	6
ADAMTS4	1	TRAF2	1	affinity chromatography technology	Huttlin EL (2017)	1
UBE2A	0	XIAP	0	affinity chromatography technology	Hein MY (2015)	1
TRAF2	1	SIVA1	0	affinity chromatography technology	Iorio-Morin C (2012)	1
MAGED1	0	MAP3K7	2	affinity chromatography technology, affinity chromatography technology	Kang J (2014), Kang J (2014)	2
BIRC3	1	UBE2D1	0	affinity chromatography technology, two hybrid, pull down, pull down, pull down, pull down	Hu S (2003), Dynek JN (2010), Dynek JN (2010), Bertrand MJ (2011), Hu S (2006), Guicciardi ME (2014)	6
UBE2I	0	ARHGDIA	3	enzymatic study	Kuhlmann N (2016)	1
CASP3	0	CASP6	0	enzymatic study, enzymatic study, imaging technique	Srinivasula SM (1996), Walsh JG (2008), Chen TC (2014)	3
RIPK4	0	SRPRA	3	affinity chromatography technology	Rodriguez J (2016)	1
TRAF2	1	UBE2D1	0	pull down	Alvarez SE (2010)	1
MAP3K7	2	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Sanna MG (2002), Resch U (2009), Sanna MG (2002), Sanna MG (2002)	4
BIRC3	1	TRIM32	2	affinity chromatography technology	Ryu YS (2011)	1
CDC42	3	XIAP	0	affinity chromatography technology, pull down, enzymatic study, pull down	Murali A (2017), Murali A (2017), Murali A (2017), Murali A (2017)	4
ELAVL1	0	APAF1	8	affinity chromatography technology	Abdelmohsen K (2009)	1
USP19	1	CKAP5	2	two hybrid	Velasco K (2013)	1
PTEN	24	STUB1	4	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Ahmed SF (2012), Ahmed SF (2012), Ahmed SF (2012), Yuan L (2015)	4
UCHL3	1	LONRF1	4	two hybrid	Hayes SD (2012)	1
CDC42	3	CASP3	0	imaging technique	Chen TC (2014)	1
UBE2V1	0	BIRC8	0	two hybrid	Markson G (2009)	1
ELAVL1	0	TRIM8	6	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	UBE2L3	1	affinity chromatography technology	Abdelmohsen K (2009)	1
GSK3B	1	HSPA4	3	enzymatic study, pull down	Muller P (2012), Kawakami F (2011)	2
BIRC2	1	UBE2N	1	two hybrid	Schimmack G (2017)	1
TRAF2	1	GSK3B	1	affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Huttlin EL (2017)	2
ELAVL1	0	BCL10	0	affinity chromatography technology	Abdelmohsen K (2009)	1
BIRC3	1	TAB1	1	affinity chromatography technology	Goncharov T (2013)	1
BIRC8	0	HTRA2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAP3K2	1	MAP3K3	3	pull down, affinity chromatography technology	Takeda AN (2014), Hein MY (2015)	2
GSK3B	1	BIRC3	1	affinity chromatography technology	Sun M (2009)	1
BMPR2	1	CRYAB	0	affinity chromatography technology	Hassel S (2004)	1
XIAP	0	RIPK1	2	pull down	Bertrand MJ (2011)	1
BAX	3	HSPA4	3	affinity chromatography technology	Guo F (2005)	1
BIRC7	0	XAF1	1	affinity chromatography technology	Arora V (2007)	1
TRAF6	0	PFAS	3	affinity chromatography technology	Ewing RM (2007)	1
CLEC11A	0	TRAF2	1	affinity chromatography technology	Huttlin EL (2015)	1
RIPK1	2	XAF1	1	affinity chromatography technology	Lin B (2016)	1
SMS	1	UCHL3	1	biochemical	Wan C (2015)	1
XIAP	0	DIABLO	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, pull down, x-ray crystallography, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down	Hunter AM (2003), Davoodi J (2004), Song Z (2003), Verhagen AM (2000), Verhagen AM (2000), Verhagen AM (2000), Verhagen AM (2000), Verhagen AM (2002), Samuel T (2006), McNeish IA (2005), Yoon K (2004), Fu J (2003), Fu J (2003), Fu J (2003), Fu J (2003), Hu S (2003), Hao Y (2004), Sekine K (2005), Csomos RA (2009), Bartke T (2004), Burke SP (2010), Burke SP (2010), Vucic D (2002), Qiu XB (2005), Qiu XB (2005), Scott FL (2005), Srinivasula SM (2001), Martins LM (2002), Kulathila R (2009), Huang Y (2001), Chai J (2001), Liu Z (2001), Liu Z (2001), Gao Z (2007), Davoodi J (2007), Hegde R (2002), Krieg A (2009), Huang Y (2003), Huang Y (2003), Arnt CR (2002), Damgaard RB (2013), Lee S (2014), Hao Y (2004), Hao Y (2004), Masoumi KC (2012), Guvenc H (2013), Buetow L (2015), Wo L (2016), Huttlin EL (2017), Wu G (2001), Wu G (2001), Hou Y (2017)	52
EGFR	5	UBC	7	affinity chromatography technology, affinity chromatography technology	Tong J (2009), Bishop N (2002)	2
E2F1	0	ERCC3	3	pull down	Pearson A (1997)	1
UBE2V1	0	TRIM8	6	two hybrid	Markson G (2009)	1
XIAP	0	CRYAB	0	affinity chromatography technology	Lee JS (2012)	1
KLHL2	0	UBE2D1	0	pull down	Takahashi D (2013)	1
MAP3K7	2	TAB1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cheung PC (2004), Cheung PC (2004), Channavajhala PL (2003), Ninomiya-Tsuji J (1999), Sakurai H (2000), Liu XY (2008), Li S (2011), Li S (2011), Ear T (2010), Singhirunnusorn P (2005), Prickett TD (2008), Kim SY (2012), Jiang Z (2002), Shibuya H (1996), Shibuya H (1996), Minoda Y (2009), Minoda Y (2009), Scholz R (2010), Scholz R (2010), Scholz R (2010), Kim SI (2009), Ge B (2003), Blonska M (2005), Kishimoto K (2000), Kishimoto K (2000), Zhu Y (2013), Liu R (2014), Chen TC (2014), Moon G (2015), Ninomiya-Tsuji J (2003), Min Y (2016), St-Denis N (2016), Zhang J (2017)	33
TRAF2	1	UBE2V1	0	pull down	Deng L (2000)	1
ELAVL1	0	UBE2E2	1	affinity chromatography technology	Abdelmohsen K (2009)	1
XIAP	0	INPP5D	2	affinity chromatography technology, two hybrid	Conde C (2012), Conde C (2012)	2
ELAVL1	0	GSK3B	1	affinity chromatography technology	Abdelmohsen K (2009)	1
RAPGEF2	5	XIAP	0	affinity chromatography technology	Hein MY (2015)	1
TRAF2	1	UBE2N	1	genetic interference, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down	Deng L (2000), Deng L (2000), Liu J (2011), Liu J (2011), Liu J (2011), Alvarez SE (2010), Sasai M (2010), Zhou AY (2013), Shen RR (2012)	9
SORT1	1	XIAP	0	affinity chromatography technology	Hein MY (2015)	1
XIAP	0	TRIM32	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Ryu YS (2011), Ryu YS (2011), Ryu YS (2011)	3
XIAP	0	LONRF1	4	two hybrid	Rolland T (2014)	1
TRIM32	2	UBE2E1	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Napolitano LM (2011), Napolitano LM (2011), Napolitano LM (2011), Locke M (2009), Albor A (2006)	5
BIRC2	1	MAP3K3	3	enzymatic study	Takeda AN (2014)	1
XIAP	0	TRIM8	6	two hybrid	Woodsmith J (2012)	1
BIRC2	1	GSPT1	3	affinity chromatography technology, pull down	Hegde R (2003), Hegde R (2003)	2
ELAVL1	0	TCF7L2	12	affinity chromatography technology	Abdelmohsen K (2009)	1
CCNB1	3	CDK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shanahan F (1999), Yang Q (2000), Pines J (1989), Kong M (2000), Amador V (2007), Paulsen MT (2006), Niida H (2005), Pereg Y (2010), Tamura D (2010), Kiviharju-af Haellstroem TM (2007), Pan ZQ (1993), Pan ZQ (1993), Pan ZQ (1993), van Zon W (2010), Desai D (1995), Vazquez-Novelle MD (2010), Smith EM (2008), Poon RY (1996), OConnor PM (1993), Fosbrink M (2009), Linares JF (2011), Varjosalo M (2013), Felzien LK (1998), Toby GG (2003), So J (2015), Huttlin EL (2015), Wan C (2015), Jenkins RH (2014), Hein MY (2015), Hein MY (2015), Voets E (2015), Lin Z (2015), Lin Z (2015), Huttlin EL (2017)	34
STUB1	4	UBE2D1	0	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Xu Z (2008), Xia T (2007), Jiang J (2001), Graf C (2010), Soss SE (2011), Pabarcus MK (2009), Wang Y (2011), Summers DW (2009), Clapp KM (2010), Wang L (2011), Ren HY (2011), Urushitani M (2004), Plechanovova A (2012), Al-Ramahi I (2006), Germano S (2006), Alberti S (2004), Peng HM (2004), Qian SB (2009), Yang M (2011), Lee H (2006), Windheim M (2008), Tsukahara F (2010), Zhou P (2003), Chymkowitch P (2011), Shimamoto S (2013), Spooner RA (2008), Zhang M (2005), Uchiki T (2009), Wang Y (2011), Wang Y (2015), Narayan V (2015), Clapp KM (2012), Kim HT (2007), McClurg UL (2016), Blessing NA (2017), Landre V (2017), Kopp Y (2017)	37
NUDCD2	2	XIAP	0	biochemical	Havugimana PC (2012)	1
E2F1	0	GSK3B	1	affinity chromatography technology	Zhou F (2008)	1
XIAP	0	CASP3	0	affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down	Suzuki Y (2001), Suzuki Y (2001), Silke J (2002), Riedl SJ (2001), Riedl SJ (2001), Roy N (1997), Deveraux QL (1997), Deveraux QL (1997), Suzuki Y (2001), Bartke T (2004), Nakhaei P (2012), Qiu XB (2005), Nomura T (2003), Paulsen M (2008), Scott FL (2005), Mufti AR (2006), Rajalingam K (2006), Dudich E (2006), Chai J (2001), Checinska A (2007), Sun M (2009), Takahashi R (1998), Conde C (2012), Walsh JG (2008), Lee JS (2012), Lin YF (2013), Huttlin EL (2015), Chen TC (2014), Huttlin EL (2017), Hou Y (2017)	30
XIAP	0	DYNLL2	0	two hybrid, affinity chromatography technology	Rual JF (2005), Boldt K (2016)	2
ARHGDIA	3	CASP10	1	biochemical	Gajate C (2005)	1
UBE2A	0	UBC	7	affinity chromatography technology	Hong JH (2015)	1
XIAP	0	STRADB	1	pull down, two hybrid	Sanna MG (2002), Sanna MG (2002)	2
CASP3	0	CASP9	6	enzymatic study, enzymatic study, enzymatic study, enzymatic study, imaging technique	Qiu XB (2005), Denault JB (2007), Srinivasula SM (2001), Walsh JG (2008), Chen TC (2014)	5
BIRC7	0	UBE2D1	0	two hybrid	Dynek JN (2010)	1
MAP3K2	1	XIAP	0	affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, pull down, enzymatic study	Winsauer G (2008), Winsauer G (2008), Takeda AN (2014), Takeda AN (2014), Takeda AN (2014), Takeda AN (2014)	6
BIRC2	1	DIABLO	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, unspecified method, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hegde R (2003), Verhagen AM (2000), Samuel T (2006), Samuel T (2006), Yang QH (2004), Hu S (2003), Hu S (2003), Csomos RA (2009), Burke SP (2010), Kulathila R (2009), Kulathila R (2009), Arnt CR (2002), Budhidarmo R (2014), Lee S (2014), Wo L (2016), Huttlin EL (2017)	16
USP19	1	BIRC2	1	affinity chromatography technology	Mei Y (2011)	1
CHEK1	2	XIAP	0	pull down, affinity chromatography technology, pull down	Galvan V (2004), Galvan V (2004), Galvan V (2004)	3
BIRC7	0	UBE2D2	0	two hybrid, pull down, x-ray crystallography, pull down	Dynek JN (2010), Dou H (2012), Dou H (2012), Ma L (2006)	4
ELAVL1	0	BIRC5	1	affinity chromatography technology	Abdelmohsen K (2009)	1
UBE2V1	0	XIAP	0	two hybrid	Markson G (2009)	1
RAC1	7	UBC	7	two hybrid	Bandyopadhyay S (2010)	1
EGFR	5	STUB1	4	protein complementation assay, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Deribe YL (2009), Wang T (2014), Wang T (2014), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014), Chung C (2016), Chung C (2016)	8
UBE2D2	0	UBC	7	x-ray crystallography, x-ray crystallography, enzymatic study, pull down, pull down	Juang YC (2012), Dou H (2012), Sheng Y (2012), Buetow L (2015), Zhang X (2017)	5
ERCC3	3	CDC42	3	pull down	Maru Y (1999)	1
CASP8	1	UBC	7	pull down	Bellail AC (2012)	1
UBE2E2	1	DTX3	4	two hybrid	Markson G (2009)	1
RIPK2	0	BIRC2	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	McCarthy JV (1998), Thome M (1998), Bertrand MJ (2009), Bertrand MJ (2009), Bertrand MJ (2009), Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011)	8
BIRC2	1	TRAF2	1	two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique, enzymatic study, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Uren AG (1996), Roy N (1997), Shu HB (1996), Yoneda T (2000), Yoneda T (2000), Li X (2002), Li X (2002), Li X (2002), Behrends C (2010), Samuel T (2006), Samuel T (2006), Samuel T (2006), Silke J (2005), Wu CJ (2005), Vince JE (2009), Csomos RA (2009), Li S (2011), Darding M (2011), Sanjo H (2010), Mace PD (2010), Choi JW (2009), Kanno Y (2010), Jang HD (2001), Rothe M (1995), Rothe M (1995), Cartier J (2011), Varfolomeev E (2006), Varfolomeev E (2006), Shen RR (2012), Shen RR (2012), Goncharov T (2013), Wang J (2011), Marivin A (2013), Shen RR (2012), Park ES (2015), Wang YB (2015), Chen TC (2014), Petersen SL (2015), Huttlin EL (2017), Akhtar N (2016)	41
BIRC2	1	UBE2V1	0	pull down	Bertrand MJ (2008)	1
BIRC7	0	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Oberoi-Khanuja TK (2012), Oberoi-Khanuja TK (2012), Huttlin EL (2015), Huttlin EL (2017)	4
UBE2V1	0	UBE2A	0	biochemical	Havugimana PC (2012)	1
PTTG1	0	XIAP	0	genetic interference	Vizeacoumar FJ (2013)	1
DYNLL2	0	RAF1	3	affinity chromatography technology	Boldt K (2016)	1
HNRNPA1	1	HNRNPL	3	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Close P (2012), Havugimana PC (2012), Roy R (2014), Hein MY (2015)	5
ELAVL1	0	DCAF12	0	affinity chromatography technology	Abdelmohsen K (2009)	1
TRAF2	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Takeuchi M (1996), Tada K (2001), Hsu H (1996), Hsu H (1996), Malinin NL (1997), Knox PG (2011), Ea CK (2006), Chang EJ (2011), Vince JE (2009), Alvarez SE (2010), Jang HD (2001), Shen RR (2012), Shen RR (2012), Puliyappadamba VT (2013), Hu MM (2014), Jeon J (2014), Rolland T (2014), Park ES (2015), Petersen SL (2015), Lin B (2016), Lin B (2016)	21
NUDCD2	2	SMS	1	biochemical	Havugimana PC (2012)	1
RAF1	3	STUB1	4	affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study	Dogan T (2008), Dogan T (2008), Alberti S (2004), Westhoff B (2005), Dreiseidler M (2012)	5
CASP12	1	CASP9	6	enzymatic study	Morishima N (2002)	1
BRCA1	7	HSPA4	3	affinity chromatography technology	Ertych N (2016)	1
DYNLL1	0	DYNLL2	0	biochemical, affinity chromatography technology	Wan C (2015), Boldt K (2016)	2
USP19	1	UBC	7	enzymatic study, pull down, pull down	Lee JG (2014), Zhang X (2017), Kwasna D (2018)	3
BMPR2	1	ACVR1B	1	two hybrid	Liu F (1995)	1
SIAH1	2	XIAP	0	affinity chromatography technology, affinity chromatography technology	Garrison JB (2011), Garrison JB (2011)	2
XIAP	0	CASP4	1	affinity chromatography technology	Silke J (2002)	1
HNRNPL	3	UBE2E2	1	affinity chromatography technology	Fei T (2017)	1
BIRC2	1	TRIM32	2	affinity chromatography technology	Ryu YS (2011)	1
BCL2	0	UBE2I	0	affinity chromatography technology	Tomasi ML (2015)	1
UBE2L6	0	SIAH1	2	pull down	Kraemer OH (2008)	1
RIPK1	2	TAB2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ma Q (2008), Ea CK (2006), Kanayama A (2004), Kanayama A (2004)	4
BIRC3	1	UBC	7	pull down, pull down, enzymatic study	Gyrd-Hansen M (2008), Nakatani Y (2012), Sakamoto H (2015)	3
LATS1	3	RAF1	3	affinity chromatography technology	Matallanas D (2007)	1
BRCA1	7	UBE2D1	0	pull down, pull down, pull down, pull down, pull down, pull down, two hybrid, x-ray crystallography, pull down, two hybrid, pull down, pull down, pull down, pull down	Mallery DL (2002), Brzovic PS (2003), Nishikawa H (2004), Dong Y (2003), Wu-Baer F (2003), Hashizume R (2001), Christensen DE (2009), Christensen DE (2009), Christensen DE (2009), Morris JR (2006), Vandenberg CJ (2003), Morris JR (2006), Nhukeaw T (2014), Thakar A (2010)	14
TAB1	1	XIAP	0	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yamaguchi K (1999), Yamaguchi K (1999), Yamaguchi K (1999), Sanna MG (2002), Sanna MG (2002), Caballero-Lopez MJ (2017)	6
UBE2E2	1	XIAP	0	two hybrid	Markson G (2009)	1
HNRNPL	3	BMPR1B	3	affinity chromatography technology	Fei T (2017)	1
GSPT1	3	XIAP	0	affinity chromatography technology, pull down	Hegde R (2003), Hashimoto Y (2015)	2
IRF3	4	TRAF6	0	affinity chromatography technology	Liu S (2015)	1
TOLLIP	3	XIAP	0	affinity chromatography technology	Li S (2011)	1
C19orf33	0	XIAP	0	affinity chromatography technology, affinity chromatography technology	Jeon SY (2013), Jeon SY (2013)	2
CASP3	0	ARHGDIA	3	enzymatic study	Walsh JG (2008)	1
PTEN	24	UBE2D1	0	genetic interference	Vizeacoumar FJ (2013)	1
BRCA1	7	PGAM5	4	affinity chromatography technology	Hill SJ (2014)	1
DYNLL1	0	RAF1	3	affinity chromatography technology	Boldt K (2016)	1
APAF1	8	CASP4	1	affinity chromatography technology	Hu Y (1998)	1
DCAF12	0	XIAP	0	affinity chromatography technology	Huttlin EL (2017)	1
HSPA4	3	CCT2	1	biochemical	Wan C (2015)	1
NOTCH1	25	MAGED1	0	two hybrid	Daakour S (2016)	1
SEC23IP	3	HSPA4	3	biochemical	Wan C (2015)	1
UBE2D1	0	BIRC8	0	two hybrid	Markson G (2009)	1
XIAP	0	WDYHV1	0	two hybrid	Rual JF (2005)	1
HNRNPL	3	TLE3	2	affinity chromatography technology	Fei T (2017)	1
CDC42	3	SSX2IP	0	two hybrid	Wang J (2011)	1
CASP3	0	BCL2	0	enzymatic study	Liang Y (2002)	1
CASP8	1	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Micheau O (2003), Knox PG (2011), Mahul-Mellier AL (2011), Gonzalvez F (2012), Gonzalvez F (2012), Xu L (2017), Xu L (2017)	7
HNRNPL	3	UBE2J2	1	affinity chromatography technology	Fei T (2017)	1
SIAH1	2	TRIM8	6	two hybrid	Woodsmith J (2012)	1
TRIM32	2	UBE2N	1	two hybrid, affinity chromatography technology, two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Saccone V (2008), Saccone V (2008), van Wijk SJ (2009), Markson G (2009), Napolitano LM (2011), Napolitano LM (2011), Napolitano LM (2011), Boldt K (2016)	8
BIRC2	1	UBE2D3	1	affinity chromatography technology, two hybrid, pull down	Hu S (2003), Dynek JN (2010), Hu S (2003)	3
UBE2D3	1	TRAF6	0	two hybrid, enzymatic study, pull down, pull down, pull down	Markson G (2009), Petroski MD (2007), Xia ZP (2009), Markson G (2009), Wauer T (2015)	5
BIRC3	1	BCL10	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Yoneda T (2000), Hu S (2006), Yui D (2001), Hu S (2006), Hu S (2006), Hu S (2006), Hu S (2006)	7
AKT1	1	RAC1	7	enzymatic study	Kwon T (2000)	1
UCHL3	1	UBC	7	enzymatic study, enzymatic study, enzymatic study, x-ray crystallography, pull down, x-ray crystallography, pull down, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, pull down, pull down, enzymatic study, pull down, pull down	Bremm A (2010), Boudreaux D (2012), Misaghi S (2005), Misaghi S (2005), Wilkinson KD (1999), Wilkinson KD (1999), Phillips AH (2013), Larsen CN (1998), Wada H (1998), Hemelaar J (2004), Altun M (2015), Flierman D (2016), Zhang X (2017), Kwasna D (2018), Lee YC (2017), Lee YC (2017), Hanpude P (2017)	17
BLM	2	XIAP	0	genetic interference	Vizeacoumar FJ (2013)	1
NOTCH1	25	USP11	3	affinity chromatography technology	Yatim A (2012)	1
C19orf54	0	XIAP	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBC	7	CCT2	1	affinity chromatography technology	Bish RA (2007)	1
STUB1	4	UBE2D4	0	pull down	Blessing NA (2017)	1
TCF7L2	12	UBE2I	0	two hybrid, affinity chromatography technology	Wang J (2011), Hsieh YL (2013)	2
UCHL3	1	XIAP	0	biochemical	Havugimana PC (2012)	1
UBE2A	0	MDM2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lyakhovich A (2003), Chen S (2012), Chen S (2012)	3
BAX	3	CASP9	6	biochemical	Chandra D (2004)	1
GMCL1	0	XIAP	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BRCA1	7	UBE2L3	1	pull down, two hybrid, x-ray crystallography, pull down	Brzovic PS (2003), Christensen DE (2009), Christensen DE (2009), Christensen DE (2009)	4
UBE2D2	0	TRAF6	0	two hybrid, pull down	Markson G (2009), Markson G (2009)	2
UBE2L3	1	HSPA4	3	enzymatic study	Pridgeon JW (2004)	1
UBE2D2	0	BIRC8	0	two hybrid	Markson G (2009)	1
UBE2J2	1	XIAP	0	two hybrid	Markson G (2009)	1
BIRC7	0	CASP3	0	pull down, affinity chromatography technology	Kasof GM (2001), Liu GH (2013)	2
AKT1	1	TBK1	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Joung SM (2011), Joung SM (2011), Joung SM (2011)	3
RAPGEF2	5	USP11	3	affinity chromatography technology	Hein MY (2015)	1
CASP9	6	BIRC7	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Kasof GM (2001), Vucic D (2002), Vucic D (2000), Rolland T (2014)	4
BCL2	0	BRCA1	7	fluorescent resonance energy transfe, affinity chromatography technology	Laulier C (2011), Laulier C (2011)	2
MAP3K7	2	BCL10	0	affinity chromatography technology	Blonska M (2007)	1
BIRC3	1	SEPT4	2	affinity chromatography technology	Edison N (2012)	1
USP19	1	XIAP	0	affinity chromatography technology, affinity chromatography technology	Mei Y (2011), Mei Y (2011)	2
MDM2	2	UBE2D2	0	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Iyappan S (2010), Dou H (2012), Brenkman AB (2008), Fang S (2000), Szypowska AA (2011), Okamoto K (2009), Busso CS (2009), Maguire M (2008), Sehat B (2008), Uldrijan S (2007), Yang Y (2005), Jin Y (2004), Roxburgh P (2012), Shloush J (2011), Rinaldo C (2007), Cheng Q (2009), Amson R (2011), Li X (2009), David Y (2011), Sosin AM (2012), Schumacher FR (2013), Bista M (2013), Mikawa T (2014), Lohrum MA (2001), Fang S (2001), Saville MK (2004), Rodriguez MS (1999), Auger KR (2005), Wu PY (2003), Wu H (2015), Yamauchi T (2014), Nomura K (2017), Kurokawa M (2013)	33
UBE2D2	0	SIAH1	2	two hybrid, two hybrid, pull down, pull down	van Wijk SJ (2009), Markson G (2009), Szargel R (2009), Winter M (2008)	4
UBE2W	0	BIRC2	1	two hybrid	van Wijk SJ (2009)	1
HNRNPL	3	PTEN	24	affinity chromatography technology	Fei T (2017)	1
TCF7L2	12	XIAP	0	pull down, affinity chromatography technology	Hanson AJ (2012), Hanson AJ (2012)	2
BIRC3	1	EGFR	5	affinity chromatography technology	Puliyappadamba VT (2013)	1
RIPK1	2	UBC	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao L (2015), Ding Z (2015), Varfolomeev E (2015)	3
EGFR	5	TBK1	1	affinity chromatography technology	Tong J (2014)	1
CDC42	3	PRDX3	3	affinity chromatography technology	Hein MY (2015)	1
UBE2D3	1	XIAP	0	two hybrid, affinity chromatography technology, two hybrid, pull down, pull down, pull down, pull down	Markson G (2009), Hu S (2003), Dynek JN (2010), Bartke T (2004), Bornstein B (2011), Damgaard RB (2013), Markson G (2009)	7
LRRN2	2	XIAP	0	affinity chromatography technology	Huttlin EL (2017)	1
MAP3K3	3	TRAF6	0	affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Nakamura K (2010), Nakamura K (2010), Nakamura K (2010), Yamazaki K (2009), Yamazaki K (2009), Huang Q (2004), Chen TC (2014)	7
BRCA1	7	AKT1	1	pull down, affinity chromatography technology, pull down, enzymatic study, pull down	Altiok S (1999), Xiang T (2008), Xiang T (2008), Xiang T (2008), Xiang T (2011)	5
USP19	1	SIAH1	2	two hybrid, two hybrid, affinity chromatography technology, x-ray crystallography, pull down, unspecified method	Altun M (2012), Velasco K (2013), Velasco K (2013), Zhang Q (2017), Zhang Q (2017), Zhang Q (2017)	6
MDM2	2	NOTCH1	25	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Lim SO (2011), Lim SO (2011), Pettersson S (2012), Pettersson S (2012), Pettersson S (2012)	5
UBE2A	0	UCHL3	1	biochemical	Havugimana PC (2012)	1
BRCA1	7	COMMD1	1	two hybrid, affinity chromatography technology	Woods NT (2012), Woods NT (2012)	2
CASP2	1	CRYAB	0	affinity chromatography technology	Jeong WJ (2012)	1
ELAVL1	0	RNPS1	1	affinity chromatography technology	Abdelmohsen K (2009)	1
DYNLL1	0	SSX2IP	0	affinity chromatography technology	Hein MY (2015)	1
SEPT4	2	XIAP	0	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, protein complementation assay	Garrison JB (2011), Garrison JB (2011), Bornstein B (2011), Bornstein B (2011), Edison N (2012), Gottfried Y (2004), Gottfried Y (2004), Fu RH (2017), Edison N (2017), Edison N (2017), Edison N (2017)	11
PTEN	24	XIAP	0	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Van Themsche C (2009), Van Themsche C (2009), Van Themsche C (2009), Ahmed SF (2012)	4
NUDCD2	2	STUB1	4	biochemical	Havugimana PC (2012)	1
HNRNPC	0	RNPS1	1	biochemical	Havugimana PC (2012)	1
USP11	3	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Zhou Z (2017), Zhou Z (2017), Zhou Z (2017)	4
UBE2N	1	BIRC8	0	two hybrid	Markson G (2009)	1
CCNB1	3	CKS1B	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wolthuis R (2008), Hein MY (2015), Huttlin EL (2017)	3
CASP2	1	CASP9	6	genetic interference	Guo Y (2002)	1
AIFM1	1	PGAM5	4	affinity chromatography technology, affinity chromatography technology	Lenhausen AM (2016), Lenhausen AM (2016)	2
RIPK4	0	HSPA4	3	affinity chromatography technology	Rodriguez J (2016)	1
IKBKE	2	XIAP	0	enzymatic study	Nakhaei P (2012)	1
TOLLIP	3	MAGED1	0	affinity chromatography technology	Li S (2011)	1
XIAP	0	SERTAD1	0	affinity chromatography technology, affinity chromatography technology, pull down	Hong SW (2009), Li C (2015), Hu W (2017)	3
RIPK4	0	RFC5	2	affinity chromatography technology	Rodriguez J (2016)	1
CEP170	4	CCNB1	3	bioid	Gupta GD (2015)	1
UBE2V2	0	UBE2N	1	pull down, two hybrid, x-ray crystallography, two hybrid, two hybrid, two hybrid, pull down, pull down, x-ray crystallography, affinity chromatography technology, pull down, two hybrid, pull down, pull down, affinity chromatography technology, two hybrid, pull down, biochemical, x-ray crystallography, pull down, affinity chromatography technology, pull down, x-ray crystallography, biochemical, x-ray crystallography, affinity chromatography technology	Andersen PL (2005), Andersen PL (2005), Markin CJ (2010), Wooff J (2004), Wooff J (2004), Plans V (2006), Wu PY (2003), McKenna S (2003), McKenna S (2003), Zou W (2005), Takeuchi T (2005), Pastushok L (2005), Pastushok L (2005), Pastushok L (2005), Huen MS (2008), Huen MS (2008), Ye Y (2003), Havugimana PC (2012), Moraes TF (2001), Pastushok L (2007), Zou W (2005), McKenna S (2001), Hodge CD (2015), Wan C (2015), Branigan E (2015), Boldt K (2016)	26
CASP2	1	XIAP	0	genetic interference	Guo Y (2002)	1
PTTG1	0	CASP3	0	genetic interference	Vizeacoumar FJ (2013)	1
AKT1	1	NOTCH1	25	enzymatic study, two hybrid	Song J (2008), Daakour S (2016)	2
APAF1	8	HSPA4	3	affinity chromatography technology, pull down, biochemical, affinity chromatography technology	Saleh A (2000), Saleh A (2000), Saleh A (2000), Zhang Z (2012)	4
BRCA1	7	UBE2E2	1	two hybrid, x-ray crystallography, pull down, two hybrid, pull down	Christensen DE (2009), Christensen DE (2009), Christensen DE (2009), Christensen DE (2007), David Y (2011)	5