PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SNCA	0	ACTA1	1	pull down	Sousa VL (2009)	1
ALDOA	0	GAPDH	0	biochemical	Wan C (2015)	1
HSPB2	1	MB	2	two hybrid	Grose JH (2015)	1
ENO1	3	FLNC	8	biochemical	Havugimana PC (2012)	1
HSPB2	1	ENO3	4	two hybrid	Grose JH (2015)	1
HSPB2	1	ABCC9	14	two hybrid	Grose JH (2015)	1
HSPB2	1	SNU13	0	two hybrid	Grose JH (2015)	1
HSPB2	1	EIF4E	1	affinity chromatography technology	Andrieu C (2010)	1
HSPB2	1	DCTN1	6	two hybrid	Grose JH (2015)	1
TATDN1	1	UBE2I	0	biochemical	Wan C (2015)	1
UBE2I	0	TRAF6	0	enzymatic study, enzymatic study	Li Y (2013), Pham LV (2008)	2
HSPB8	0	CRYAB	0	two hybrid, fluorescent resonance energy transfe	Fontaine JM (2005), Fontaine JM (2005)	2
HSPB2	1	ACTA1	1	two hybrid	Grose JH (2015)	1
CTSD	0	SNCA	0	enzymatic study	Lehri-Boufala S (2015)	1
HSPB2	1	TNNI3	0	two hybrid	Grose JH (2015)	1
HSPB2	1	A2M	8	two hybrid	Grose JH (2015)	1
HSPB2	1	NDUFA13	2	two hybrid	Grose JH (2015)	1
HSPB2	1	ACTC1	5	two hybrid	Grose JH (2015)	1
DCTN1	6	DCTN6	0	bioid, affinity chromatography technology, affinity chromatography technology	Gupta GD (2015), Huttlin EL (2017), Boldt K (2016)	3
HSPB2	1	CTSD	0	two hybrid	Grose JH (2015)	1
TGFB1I1	2	HSPB2	1	affinity chromatography technology	Desai LP (2014)	1
HNRNPD	3	UBE2I	0	two hybrid, pull down	Moraes KC (2003), Moraes KC (2003)	2
CFTR	5	ALDOA	0	affinity chromatography technology	Pankow S (2015)	1
CFTR	5	FHL2	0	affinity chromatography technology	Pankow S (2015)	1
CRYAA	0	CRYGC	0	two hybrid, two hybrid, affinity chromatography technology, two hybrid, two hybrid	Fu L (2002), Fu L (2002), Fu L (2002), Fu L (2003), Fu L (2003)	5
CRYAA	0	HSPB2	1	two hybrid, affinity chromatography technology	Fu L (2003), Fu L (2003)	2
HSPB2	1	MCCC2	1	two hybrid	Grose JH (2015)	1
HSPB2	1	TRAF6	0	affinity chromatography technology, affinity chromatography technology	Wu Y (2009), Wu Y (2009)	2
AR	3	ACTB	8	two hybrid	Wolf SS (2007)	1
HSPB2	1	MYH6	12	two hybrid	Grose JH (2015)	1
HSPB2	1	MYOM2	8	two hybrid	Grose JH (2015)	1
FHL2	0	TRAF6	0	affinity chromatography technology, enzymatic study	Bai S (2008), Bai S (2008)	2
GAPDH	0	AR	3	two hybrid, pull down	Koshy B (1996), Koshy B (1996)	2
TRAF2	1	HSPB2	1	affinity chromatography technology	Wu Y (2009)	1
TTN	102	CRYAB	0	affinity chromatography technology	Bullard B (2004)	1
HSPB2	1	ASAH1	0	two hybrid	Grose JH (2015)	1
ALDOA	0	LGALS1	1	biochemical	Havugimana PC (2012)	1
COX1	0	COX2	0	affinity chromatography technology	Hornig-Do HT (2012)	1
CAPZA2	1	DCTN6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	3
AR	3	UBE2I	0	two hybrid, affinity chromatography technology, genetic interference, enzymatic study	Poukka H (1999), Poukka H (1999), Poukka H (1999), Ogawa H (2009)	4
EIF4A2	4	EIF4E	1	affinity chromatography technology	Ewing RM (2007)	1
ALDH2	2	RPL11	3	genetic interference	Srivas R (2016)	1
HSPB2	1	WDR1	3	two hybrid	Grose JH (2015)	1
MYOZ2	2	TCAP	0	affinity chromatography technology	Frey N (2002)	1
AR	3	FHL2	0	two hybrid, pull down, affinity chromatography technology	Mueller JM (2000), Mueller JM (2000), Mueller JM (2000)	3
HSPB2	1	MYOZ2	2	two hybrid	Grose JH (2015)	1
CFTR	5	MYH6	12	affinity chromatography technology	Pankow S (2015)	1
HSPB2	1	ENO1	3	two hybrid	Grose JH (2015)	1
567	0	CRYAB	0	pull down	Esposito G (2013)	1
HNRNPD	3	TNF	0	affinity chromatography technology	Xin H (2011)	1
HSPB2	1	TXNIP	2	two hybrid	Grose JH (2015)	1
HSPB2	1	DMPK	3	two hybrid, affinity chromatography technology, pull down, two hybrid	Suzuki A (1998), Suzuki A (1998), Suzuki A (1998), Sugiyama Y (2000)	4
ALDOA	0	ENO1	3	biochemical	Wan C (2015)	1
HSPB2	1	THEMIS2	0	two hybrid	Grose JH (2015)	1
TRAF6	0	SNCA	0	affinity chromatography technology	Zucchelli S (2010)	1
CAPZA2	1	ACTG1	5	affinity chromatography technology	Hein MY (2015)	1
CFTR	5	ATP5A1	0	affinity chromatography technology	Pankow S (2015)	1
A2M	8	ACTB	8	two hybrid	Soler-Lopez M (2011)	1
HSF1	1	DAXX	5	two hybrid, affinity chromatography technology, pull down	Boellmann F (2004), Boellmann F (2004), Zhang J (2010)	3
ACTG1	5	EEF1A1	0	biochemical	Wan C (2015)	1
SNU13	0	RPL11	3	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
HSPB2	1	DUSP1	1	two hybrid	Grose JH (2015)	1
HNRNPD	3	ETFA	0	affinity chromatography technology	Hein MY (2015)	1
HSPB2	1	C1QA	0	two hybrid	Grose JH (2015)	1
HNRNPD	3	ACTB	8	two hybrid	Lehner B (2004)	1
HSPB2	1	CYP1B1	1	two hybrid	Grose JH (2015)	1
EEF1A1	0	GAPDH	0	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
SNCA	0	EEF1A1	0	two hybrid	Vinayagam A (2011)	1
567	0	UBE2I	0	affinity chromatography technology	Huttlin EL (2017)	1
TRAF2	1	TRAF6	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Li S (2011), Davies CC (2005), Relaix F (1998), Rolland T (2014), Yu H (2011), Huttlin EL (2017)	7
HSPB2	1	FHL2	0	two hybrid	Grose JH (2015)	1
CFTR	5	ENO1	3	affinity chromatography technology	Pankow S (2015)	1
HSPB2	1	GAPDH	0	two hybrid	Grose JH (2015)	1
TXNIP	2	DDIT4	0	pull down, affinity chromatography technology, imaging technique	Jin HO (2011), Jin HO (2011), Jin HO (2011)	3
CFTR	5	HSPB2	1	affinity chromatography technology	Ahner A (2013)	1
HSPB2	1	CAPZA2	1	two hybrid	Grose JH (2015)	1
SNCA	0	ACTB	8	affinity chromatography technology, affinity chromatography technology	Jeannotte AM (2008), Jeannotte AM (2008)	2
HSPB2	1	ALDOA	0	two hybrid	Grose JH (2015)	1
HSPB2	1	PGM1	2	two hybrid	Grose JH (2015)	1
HSPB2	1	SDHA	2	two hybrid	Grose JH (2015)	1
UBL5	0	HSPB2	1	two hybrid	Kantham L (2003)	1
CFTR	5	DCTN1	6	affinity chromatography technology	Pankow S (2015)	1
CRYAB	0	CRYGC	0	two hybrid, two hybrid, affinity chromatography technology, two hybrid, two hybrid	Fu L (2002), Fu L (2002), Fu L (2002), Fu L (2003), Fu L (2003)	5
HSPB2	1	HSPB3	1	affinity chromatography technology	Sugiyama Y (2000)	1
SNCA	0	CRYAB	0	pull down, x-ray crystallography, pull down, biochemical, pull down	Rekas A (2004), Rekas A (2004), Bruinsma IB (2011), Waudby CA (2010), Waudby CA (2010)	5
HSPB2	1	HSPB2	1	two hybrid, affinity chromatography technology, two hybrid	Sugiyama Y (2000), Sugiyama Y (2000), Grose JH (2015)	3
DAXX	5	HSPB2	1	affinity chromatography technology	Charette SJ (2000)	1
MDH1	0	PGM1	2	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
AR	3	HSPB2	1	affinity chromatography technology, affinity chromatography technology	Zoubeidi A (2007), Zoubeidi A (2007)	2
ENO1	3	ENO3	4	biochemical, affinity chromatography technology	Havugimana PC (2012), Huttlin EL (2017)	2
CFTR	5	CAPZA2	1	affinity chromatography technology	Pankow S (2015)	1
MAPKAPK5	0	HSPB2	1	enzymatic study	New L (1998)	1
DUSP1	1	NDUFA13	2	affinity chromatography technology	Li X (2016)	1
ALDH2	2	PGM1	2	biochemical	Wan C (2015)	1
HSPB2	1	NARS	3	two hybrid	Grose JH (2015)	1
CAPZA2	1	DCTN1	6	affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Gupta GD (2015), Hein MY (2015), Huttlin EL (2017)	4
ACTG1	5	ACTA1	1	biochemical	Kristensen AR (2012)	1
CTSD	0	ETFA	0	biochemical	Wan C (2015)	1
SNCA	0	COX1	0	unspecified method	Woods WS (2007)	1
TNF	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Micheau O (2003), Kuai J (2004), Kuai J (2004), Haas TL (2009), Ea CK (2006), Fritsch J (2014), Yamaguchi N (2015)	7
SNCA	0	HSPB8	0	pull down	Bruinsma IB (2011)	1
HSPB2	1	COX1	0	two hybrid	Grose JH (2015)	1
CFTR	5	A2M	8	affinity chromatography technology, affinity chromatography technology	Wang X (2006), Pankow S (2015)	2
567	0	A2M	8	pull down	Gouin-Charnet A (2000)	1
MYOZ2	2	FLNC	8	affinity chromatography technology	Frey N (2002)	1
HSPB2	1	PKP2	4	two hybrid	Grose JH (2015)	1
HSPB2	1	NDUFA6	0	two hybrid	Grose JH (2015)	1
HSPB2	1	COX3	0	two hybrid	Grose JH (2015)	1
HNRNPD	3	CTSB	5	two hybrid	Lehner B (2004)	1
HSPB2	1	PPM1K	0	two hybrid	Grose JH (2015)	1
HSPB2	1	SDF2	0	two hybrid	Grose JH (2015)	1
HSPB2	1	UBE2I	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brunet Simioni M (2009), Ahner A (2013), Ahner A (2013)	3
HSPB2	1	ACAA2	2	two hybrid	Grose JH (2015)	1
CFTR	5	RYR2	26	affinity chromatography technology	Wang X (2006)	1
CAPZA2	1	WDR1	3	affinity chromatography technology	Hein MY (2015)	1
HSPB2	1	EEF1A1	0	two hybrid	Grose JH (2015)	1
HSPB2	1	ALDH2	2	two hybrid	Grose JH (2015)	1
HSPB2	1	TNF	0	affinity chromatography technology	Knapinska AM (2011)	1
GARS	1	NARS	3	biochemical	Havugimana PC (2012)	1
CFTR	5	CTSD	0	affinity chromatography technology	Pankow S (2015)	1
TCAP	0	TTN	102	two hybrid, enzymatic study, biochemical, two hybrid, pull down, two hybrid, enzymatic study	Gregorio CC (1998), Mayans O (1998), Zou P (2003), Zou P (2003), Mues A (1998), Mues A (1998), Lange S (2005)	7
TXNIP	2	SLC2A1	5	affinity chromatography technology	Wu N (2013)	1
HSPB2	1	NT5DC2	3	two hybrid	Grose JH (2015)	1
HSPB2	1	CKM	0	two hybrid	Grose JH (2015)	1
HSPB2	1	ZNF335	3	two hybrid	Grose JH (2015)	1
HSPB2	1	HSF1	1	affinity chromatography technology, affinity chromatography technology	Brunet Simioni M (2009), Brunet Simioni M (2009)	2
CAPZA2	1	FHL2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HSPB2	1	MLF2	1	two hybrid	Grose JH (2015)	1
HSPB2	1	RPL36AL	0	two hybrid	Grose JH (2015)	1
HSPB2	1	567	0	two hybrid	Grose JH (2015)	1
TRAF6	0	EEF1A1	0	affinity chromatography technology	Yu J (2016)	1
HSPB2	1	DCTN6	0	two hybrid	Grose JH (2015)	1
DAXX	5	AR	3	two hybrid, pull down, affinity chromatography technology, pull down	Lin DY (2004), Lin DY (2004), Lin DY (2004), Sun S (2016)	4
EEF1A1	0	ENO3	4	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
HSPB2	1	PARVA	0	two hybrid	Grose JH (2015)	1
HSPB2	1	DDIT4	0	two hybrid	Grose JH (2015)	1
CFTR	5	567	0	affinity chromatography technology	Pankow S (2015)	1
ACAA2	2	ENO1	3	biochemical	Wan C (2015)	1
SNCA	0	GAPDH	0	two hybrid, pull down	Vinayagam A (2011), Tsuchiya K (2005)	2
HNRNPD	3	SDF2	0	two hybrid	Lehner B (2004)	1
HSPB8	0	HSPB2	1	two hybrid, affinity chromatography technology, two hybrid	Sun X (2004), Sun X (2004), Benndorf R (2001)	3
EEF1A1	0	RPL11	3	biochemical	Havugimana PC (2012)	1
HSPB2	1	BEX4	0	two hybrid	Grose JH (2015)	1
FHL2	0	CKM	0	pull down	Lange S (2002)	1
AR	3	TGFB1I1	2	two hybrid, affinity chromatography technology, pull down, two hybrid, unspecified method	Wang X (2002), Wang X (2002), Wang X (2002), He B (2002), He B (2002)	5
HSPB2	1	HADHB	4	two hybrid	Grose JH (2015)	1
HSPB2	1	RYR2	26	two hybrid	Grose JH (2015)	1
HSPB2	1	MDH1	0	two hybrid	Grose JH (2015)	1
EEF1A1	0	SNU13	0	biochemical	Wan C (2015)	1
HSPB2	1	TATDN1	1	two hybrid	Grose JH (2015)	1
HSPB2	1	THUMPD2	0	two hybrid	Grose JH (2015)	1
SNU13	0	RPS11	0	biochemical	Havugimana PC (2012)	1
UBE2I	0	CFTR	5	enzymatic study, enzymatic study	Ahner A (2013), Gong X (2016)	2
TRAF2	1	ACTG1	5	imaging technique	Chen TC (2014)	1
HSPB2	1	CTSB	5	two hybrid	Grose JH (2015)	1
ATP6V1E1	0	ALDOA	0	two hybrid	Lu M (2001)	1
HSPB2	1	CMYA5	10	two hybrid	Grose JH (2015)	1
HSPB2	1	EIF4A2	4	two hybrid	Grose JH (2015)	1
PGM1	2	ENO1	3	biochemical	Wan C (2015)	1
EEF1A1	0	RPS11	0	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
HSPB2	1	FLNC	8	two hybrid	Grose JH (2015)	1
RPL11	3	RPS11	0	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
HNRNPD	3	HSPB2	1	biochemical, affinity chromatography technology, fluorescent resonance energy transfe	Knapinska AM (2011), Knapinska AM (2011), Knapinska AM (2011)	3
HSPB2	1	ACTG1	5	two hybrid	Grose JH (2015)	1
DCTN1	6	FLNC	8	biochemical	Havugimana PC (2012)	1
HSPB2	1	GARS	1	two hybrid	Grose JH (2015)	1
UBE2I	0	DAXX	5	two hybrid, enzymatic study, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, two hybrid	Ryu SW (2000), Knipscheer P (2008), Hsieh YL (2013), Hsieh YL (2013), Hsieh YL (2013), Chang CC (2011), Lin DY (2006), Lin DY (2006)	8
CFTR	5	SDHA	2	affinity chromatography technology	Pankow S (2015)	1
HSPB2	1	RPS11	0	two hybrid	Grose JH (2015)	1
TNF	0	BGN	0	pull down	Tufvesson E (2002)	1
ETFA	0	ATP5A1	0	biochemical, affinity chromatography technology	Wan C (2015), Floyd BJ (2016)	2
HSPB2	1	BGN	0	two hybrid	Grose JH (2015)	1
WDR1	3	ENO1	3	biochemical	Wan C (2015)	1
HSPB2	1	RPL11	3	two hybrid	Grose JH (2015)	1
HSPB8	0	HSPB3	1	two hybrid	Fontaine JM (2005)	1
CRYAB	0	HSPB2	1	two hybrid, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down, two hybrid	Sugiyama Y (2000), Sugiyama Y (2000), Fu L (2003), Fu L (2003), Delbecq SP (2012), Aquilina JA (2013), Grose JH (2015)	7
CRYAA	0	CRYAB	0	two hybrid, two hybrid, affinity chromatography technology, fluorescent resonance energy transfe, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, fluorescent resonance energy transfe, pull down, pull down, fluorescent resonance energy transfe, pull down, two hybrid, pull down, pull down, pull down, fluorescent resonance energy transfe	Fu L (2002), Fu L (2002), Fu L (2002), Sreelakshmi Y (2005), Fu L (2003), Fu L (2003), Fu L (2003), Fu L (2003), Rao G (2008), Biswas A (2007), Wu M (2012), Wu M (2012), Fujii N (2008), Fujii N (2008), Sreelakshmi Y (2006), Delbecq SP (2012), Rolland T (2014), Validandi V (2011), Ramkumar S (2015), Tiwary E (2015), Tiwary E (2015)	21
ACTB	8	ACTG1	5	two hybrid, two hybrid, two hybrid	Rual JF (2005), Rolland T (2014), Yu H (2011)	3
HSPB2	1	RPL36A	0	two hybrid	Grose JH (2015)	1
CAPZA2	1	ACTA1	1	affinity chromatography technology	Hein MY (2015)	1
HSPB2	1	SLC2A1	5	two hybrid	Grose JH (2015)	1
HSPB2	1	ABCD4	2	two hybrid	Grose JH (2015)	1
SNCA	0	HSPB2	1	pull down	Bruinsma IB (2011)	1
HSPB2	1	ACTB	8	two hybrid	Grose JH (2015)	1
HSPB2	1	119385	0	two hybrid	Grose JH (2015)	1
HSPB2	1	TCAP	0	two hybrid	Grose JH (2015)	1
UBE2I	0	HSF1	1	enzymatic study	Mohideen F (2009)	1
HSPB2	1	ETFA	0	two hybrid	Grose JH (2015)	1
SDHA	2	MDH1	0	biochemical	Havugimana PC (2012)	1
HSPB2	1	TTN	102	two hybrid	Grose JH (2015)	1
EEF1A1	0	FHL2	0	affinity chromatography technology	Huttlin EL (2017)	1
HSPB2	1	ATP5A1	0	two hybrid	Grose JH (2015)	1
TTN	102	MYBPC3	2	far western blotting	Freiburg A (1996)	1
ALDOA	0	ACAA2	2	biochemical	Wan C (2015)	1
HSPB2	1	MYBPC3	2	two hybrid	Grose JH (2015)	1
HSPB2	1	COX2	0	two hybrid	Grose JH (2015)	1
HSPB2	1	LGALS1	1	two hybrid	Grose JH (2015)	1
FHL2	0	TTN	102	two hybrid, pull down	Lange S (2002), Lange S (2002)	2
CFTR	5	GARS	1	affinity chromatography technology	Pankow S (2015)	1
ENO1	3	GAPDH	0	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
HSPB2	1	ATP6V1E1	0	two hybrid	Grose JH (2015)	1
CRYGC	0	HSPB2	1	two hybrid	Fu L (2003)	1
GAPDH	0	ACTC1	5	two hybrid	Vinayagam A (2011)	1
ENO1	3	HNRNPD	3	affinity chromatography technology	Castello A (2012)	1
ACTB	8	EEF1A1	0	biochemical	Wan C (2015)	1
GAPDH	0	ENO3	4	biochemical	Wan C (2015)	1