PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CASP3	0	MDC1	8	enzymatic study	Solier S (2011)	1
USF2	3	BIRC5	1	affinity chromatography technology	Ewing RM (2007)	1
HIST2H3C	0	CDCA8	0	pull down	Yamagishi Y (2010)	1
KCNJ6	6	BIRC5	1	pull down	Dohi T (2004)	1
MED14	0	MED17	0	affinity chromatography technology, biochemical, biochemical	Ryu S (1999), Havugimana PC (2012), Wan C (2015)	3
CASP3	0	CASP7	1	enzymatic study	Walsh JG (2008)	1
BIRC5	1	MED4	2	affinity chromatography technology	Huttlin EL (2017)	1
HDAC6	0	USP9X	15	affinity chromatography technology	Joshi P (2013)	1
PPP1CC	2	HDAC6	0	biochemical, far western blotting, affinity chromatography technology, pull down	Brush MH (2004), Brush MH (2004), Brush MH (2004), Brush MH (2004)	4
BIRC5	1	CASP3	0	pull down, enzymatic study, pull down	Tamm I (1998), Shin S (2001), Shin S (2001)	3
BIRC5	1	MED14	0	affinity chromatography technology	Huttlin EL (2017)	1
ELAVL1	0	DIABLO	2	affinity chromatography technology	Abdelmohsen K (2009)	1
MED1	4	MED30	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang X (2005), Zhang X (2005), Ding N (2008), Malovannaya A (2010), Huttlin EL (2017)	5
DIABLO	2	BIRC5	1	affinity chromatography technology, pull down, affinity chromatography technology, pull down, fluorescent resonance energy transfe, pull down, affinity chromatography technology, pull down	Song Z (2003), Song Z (2003), McNeish IA (2005), Pavlyukov MS (2011), Pavlyukov MS (2011), Guvenc H (2013), Song Z (2004), Song Z (2004)	8
BIRC2	1	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Silke J (2005), Rajalingam K (2006), Rajalingam K (2006), Oberoi-Khanuja TK (2012), Huttlin EL (2017)	5
MED29	2	MED18	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Sato S (2004), Tomomori-Sato C (2004), Sato S (2003), Malovannaya A (2010), Wan C (2015), Huttlin EL (2017)	6
BIRC3	1	CASP7	1	pull down, affinity chromatography technology	Roy N (1997), Eckelman BP (2006)	2
8339	0	AURKB	2	bioid	Lambert JP (2015)	1
AURKB	2	INCENP	4	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Gassmann R (2004), Xu Z (2009), Xu Z (2009), Katayama H (2008), Kaitna S (2000), Maerki S (2009), Vader G (2006), Honda R (2003), Ban R (2011), Sun L (2008), Nozawa RS (2010), Jeyaprakash AA (2007), Klein UR (2006), Klein UR (2006), Fu J (2009), Fu J (2009), Li X (2004), Gomez V (2010)	18
H2AFX	1	HIST2H3C	0	affinity chromatography technology	Dittmann K (2011)	1
EVI5	2	BIRC5	1	affinity chromatography technology, pull down	Faitar SL (2006), Faitar SL (2006)	2
MED14	0	MED4	2	biochemical, biochemical, bioid, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Lambert JP (2015), Lambert JP (2015)	4
HSP90AA1	7	PRKDC	12	affinity chromatography technology	Falsone SF (2005)	1
CDCA8	0	XPO1	8	affinity chromatography technology	Knauer SK (2006)	1
MED6	0	MED8	0	biochemical	Wan C (2015)	1
CASP3	0	PRKDC	12	enzymatic study	Teraoka H (1996)	1
BIRC3	1	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rajalingam K (2006), Rajalingam K (2006), Yang W (2014), Yang W (2014)	4
PRKN	1	AURKB	2	affinity chromatography technology	Lee SB (2015)	1
HSP90AA1	7	CDK4	2	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tsutsumi S (2012), Wang H (2002), Taipale M (2012), Varjosalo M (2013), Huttlin EL (2015), Woodford MR (2016), Huttlin EL (2017)	7
MED6	0	MED14	0	biochemical, biochemical	Sun X (1998), Wan C (2015)	2
MED4	2	MED31	0	bioid, affinity chromatography technology	Lambert JP (2015), Lambert JP (2015)	2
MED10	0	MED1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference	Sato S (2004), Tomomori-Sato C (2004), Zhang X (2005), Zhang X (2005), Zhang X (2005), Zhang X (2005), Malik S (2000), Huttlin EL (2017), Horlbeck MA (2018)	9
MED18	0	MED31	0	affinity chromatography technology, affinity chromatography technology	Malovannaya A (2010), Huttlin EL (2017)	2
BIRC3	1	BIRC5	1	pull down	Dohi T (2004)	1
BIRC3	1	CASP9	6	pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, imaging technique	Deveraux QL (1998), Deveraux QL (1998), Eckelman BP (2006), Cheung HH (2006), Wang J (2011), McDonald ER (2004), Chen TC (2014)	7
MED8	0	MED17	0	biochemical	Wan C (2015)	1
F2RL1	1	BIRC5	1	affinity chromatography technology, affinity chromatography technology	Bae JS (2010), Bae JS (2010)	2
CDCA8	0	INCENP	4	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology	Gassmann R (2004), Gassmann R (2004), Xu Z (2009), Vader G (2006), Knauer SK (2006), Jeyaprakash AA (2007), Jeyaprakash AA (2007), Jeyaprakash AA (2007), Klein UR (2006), Klein UR (2006), Klein UR (2006), Klein UR (2006), Klein UR (2009)	13
PPP1CC	2	CDK2	0	affinity chromatography technology	Flores-Delgado G (2007)	1
BIRC5	1	CASP9	6	affinity chromatography technology, imaging technique	OConnor DS (2000), Chen TC (2014)	2
HDAC6	0	XPO1	8	affinity chromatography technology, affinity chromatography technology	Riolo MT (2012), Kirli K (2015)	2
BIRC5	1	USP9X	15	affinity chromatography technology	Vong QP (2005)	1
AURKA	1	BIRC5	1	affinity chromatography technology, enzymatic study	Fu J (2009), Fu J (2009)	2
XIAP	0	CASP7	1	pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, x-ray crystallography, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Riedl SJ (2001), Roy N (1997), Deveraux QL (1997), Deveraux QL (1997), Suzuki Y (2001), Bartke T (2004), Tenev T (2005), Paulsen M (2008), Huang Y (2001), Huang Y (2001), Chai J (2001), Chai J (2001), Huang Y (2003), Huang Y (2003), Sun M (2009), Takahashi R (1998), Lee JS (2012), Lin YF (2013), Lin YF (2013), Hou Y (2017)	20
RAN	1	XPO1	8	affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, biochemical	Tickenbrock L (2002), Fornerod M (1997), Plafker K (2000), Chase GP (2011), Lipowsky G (2000), Havugimana PC (2012), von Knethen A (2010), Wan C (2015)	8
MED30	0	MED17	0	affinity chromatography technology	Zhang X (2005)	1
H2AFX	1	HSP90AA1	7	affinity chromatography technology	Yang X (2010)	1
ELAVL1	0	MDC1	8	affinity chromatography technology	Abdelmohsen K (2009)	1
MED29	2	MED20	2	affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology	Sato S (2004), Sato S (2003), Zhang X (2005), Wan C (2015), Lambert JP (2015)	5
8339	0	CDCA8	0	bioid	Lambert JP (2015)	1
MED10	0	MED30	0	affinity chromatography technology, affinity chromatography technology	Sato S (2004), Zhang X (2005)	2
8339	0	BIRC5	1	bioid	Lambert JP (2015)	1
BIRC5	1	MED20	2	affinity chromatography technology	Huttlin EL (2017)	1
HSP90AA1	7	XPO1	8	affinity chromatography technology	Falsone SF (2005)	1
MDC1	8	PRKDC	12	pull down, affinity chromatography technology, imaging technique, affinity chromatography technology	Lou Z (2004), Lou Z (2004), Lou Z (2004), Lou Z (2004)	4
MED10	0	MED31	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sato S (2004), Sato S (2003), Zhang X (2005)	3
ELAVL1	0	PRKDC	12	affinity chromatography technology	Abdelmohsen K (2009)	1
CDK2	0	CASP3	0	affinity chromatography technology	Neganova I (2011)	1
PRKN	1	BECN1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Choubey V (2014), Lonskaya I (2014), Lonskaya I (2014), Lonskaya I (2014)	4
CDK2	0	XRCC6	3	enzymatic study, affinity chromatography technology	Diederichs S (2004), So J (2015)	2
HIST2H3C	0	INCENP	4	pull down	Yamagishi Y (2010)	1
XRCC6	3	HDAC6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Subramanian C (2011), Chaudhary N (2014), Chaudhary N (2014)	3
BIRC5	1	MED30	0	affinity chromatography technology	Huttlin EL (2017)	1
BIRC3	1	CASP3	0	pull down, affinity chromatography technology	Roy N (1997), Rajalingam K (2006)	2
CDK2	0	RAN	1	affinity chromatography technology	Neganova I (2011)	1
MED10	0	MED22	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Sato S (2004), Sato S (2003), Zhang X (2005), Wan C (2015)	4
MED30	0	MED20	2	affinity chromatography technology, bioid, affinity chromatography technology	Zhang X (2005), Lambert JP (2015), Lambert JP (2015)	3
PRKDC	12	XRCC6	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, enzymatic study, affinity chromatography technology	Shao RG (1999), Drouet J (2005), Gottlieb TM (1993), Shamanna RA (2011), Shamanna RA (2011), Havugimana PC (2012), Sartorius CA (2000), Sartorius CA (2000), Hein MY (2015)	9
PRKN	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Imai Y (2003), Taipale M (2012), Zanon A (2013)	3
MED18	0	MED14	0	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Malovannaya A (2010), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	4
MED4	2	MED6	0	biochemical, biochemical, bioid, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Lambert JP (2015), Lambert JP (2015)	4
BIRC2	1	CASP3	0	pull down, pull down, enzymatic study, enzymatic study, affinity chromatography technology	Roy N (1997), Choi YE (2009), Choi YE (2009), Clem RJ (2001), Rajalingam K (2006)	5
MED29	2	MED6	0	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical	Sato S (2004), Sato S (2003), Havugimana PC (2012), Wan C (2015)	4
BIRC5	1	CDK2	0	affinity chromatography technology	OConnor DS (2000)	1
MED30	0	MED21	1	pull down, affinity chromatography technology, affinity chromatography technology	Sato S (2003), Zhang X (2005), Huttlin EL (2017)	3
MED18	0	MED22	1	affinity chromatography technology, affinity chromatography technology	Malovannaya A (2010), Huttlin EL (2017)	2
BIRC5	1	MED31	0	affinity chromatography technology	Huttlin EL (2017)	1
MED29	2	MED30	0	affinity chromatography technology	Sato S (2004)	1
BIRC5	1	MED18	0	affinity chromatography technology	Huttlin EL (2017)	1
MED10	0	MED6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical	Sato S (2004), Sato S (2003), Sato S (2003), Zhang X (2005), Zhang X (2005), Havugimana PC (2012), Akoulitchev S (2000), Wan C (2015)	8
ELAVL1	0	MED1	4	affinity chromatography technology	Abdelmohsen K (2009)	1
EVI5	2	INCENP	4	affinity chromatography technology, pull down	Faitar SL (2006), Faitar SL (2006)	2
ELAVL1	0	XPO1	8	affinity chromatography technology	Abdelmohsen K (2009)	1
BIRC5	1	LAMTOR4	0	affinity chromatography technology	Huttlin EL (2017)	1
BIRC5	1	MED21	1	affinity chromatography technology	Huttlin EL (2017)	1
MED1	4	MED14	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, genetic interference	Zhang X (2005), Malovannaya A (2010), Donner AJ (2010), Ryu S (1999), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017), Horlbeck MA (2018)	8
BIRC5	1	XPO1	8	pull down, affinity chromatography technology	Knauer SK (2006), Knauer SK (2006)	2
BIRC5	1	UFD1	1	affinity chromatography technology, affinity chromatography technology	Vong QP (2005), Vong QP (2005)	2
ELAVL1	0	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method	Abdelmohsen K (2009), Durie D (2011), Durie D (2011), Durie D (2011)	4
MED1	4	MED6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Zhang X (2005), Zhang X (2005), Malovannaya A (2010), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	6
XIAP	0	BIRC5	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Arora V (2007), Dohi T (2004), Dohi T (2004), Pavlyukov MS (2011)	4
BIRC2	1	CASP9	6	pull down, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, unspecified method, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Deveraux QL (1998), Deveraux QL (1998), Eckelman BP (2006), Cheung HH (2006), Kulathila R (2009), Kulathila R (2009), Vucic D (2000), Rolland T (2014), McDonald ER (2004), Chen TC (2014), Vu NT (2016), Vu NT (2016)	12
AURKB	2	AURKA	1	affinity chromatography technology	Fogeron ML (2013)	1
MED10	0	MED21	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sato S (2004), Malik S (2000), Huttlin EL (2017)	3
MED20	2	MED8	0	biochemical, bioid, affinity chromatography technology	Wan C (2015), Lambert JP (2015), Lambert JP (2015)	3
MED21	1	MED6	0	biochemical, biochemical, biochemical, affinity chromatography technology	Sun X (1998), Sun X (1998), Havugimana PC (2012), Huttlin EL (2017)	4
BIRC2	1	USP9X	15	affinity chromatography technology	Goncharov T (2013)	1
MDC1	8	H2AFX	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, unspecified method, imaging technique	Stewart GS (2003), Stewart GS (2003), Xu X (2003), Lukas C (2004), Strauss C (2011), Strauss C (2011), Stewart GS (2003), Stewart GS (2003), Stewart GS (2003), Pan MR (2011), Pei H (2011), Campbell SJ (2010), Rassoolzadeh H (2015)	13
MED14	0	MED8	0	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
HIST3H3	0	HSP90AA1	7	biochemical, affinity chromatography technology	Campos EI (2010), Campos EI (2010)	2
BIRC5	1	MED1	4	affinity chromatography technology	Huttlin EL (2017)	1
MED29	2	MED1	4	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Sato S (2004), Tomomori-Sato C (2004), Zhang X (2005), Malovannaya A (2010), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	7
MED1	4	MED4	2	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, bioid, affinity chromatography technology, affinity chromatography technology	Zhang X (2005), Malovannaya A (2010), Havugimana PC (2012), Wan C (2015), Lambert JP (2015), Lambert JP (2015), Huttlin EL (2017)	7
MED10	0	MED20	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Sato S (2004), Sato S (2003), Zhang X (2005), Zhang X (2005), Malik S (2000), Wan C (2015), Lambert JP (2015)	7
MED20	2	MED4	2	biochemical, bioid, bioid, affinity chromatography technology, affinity chromatography technology	Wan C (2015), Lambert JP (2015), Lambert JP (2015), Lambert JP (2015), Lambert JP (2015)	5
MED21	1	SSC5D	7	two hybrid	Rolland T (2014)	1
MED1	4	MED21	1	affinity chromatography technology, biochemical, affinity chromatography technology	Zhang X (2005), Havugimana PC (2012), Huttlin EL (2017)	3
ELAVL1	0	MED4	2	affinity chromatography technology	Abdelmohsen K (2009)	1
PPP1CC	2	BIRC5	1	affinity chromatography technology	Flores-Delgado G (2007)	1
ELAVL1	0	CDCA8	0	affinity chromatography technology	Abdelmohsen K (2009)	1
BIRC5	1	PYCARD	1	affinity chromatography technology	Huttlin EL (2017)	1
CDK4	2	PRKDC	12	genetic interference	Shen JP (2017)	1
MED20	2	MED17	0	biochemical, bioid, affinity chromatography technology	Wan C (2015), Lambert JP (2015), Lambert JP (2015)	3
DIABLO	2	BIRC3	1	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Verhagen AM (2000), Yang QH (2004), Hu S (2003), Burke SP (2010), Budhidarmo R (2014), Hu S (2003), Wo L (2016)	7
MED29	2	MED17	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical	Sato S (2004), Tomomori-Sato C (2004), Sato S (2003), Zhang X (2005), Wan C (2015)	5
BECN1	2	BIRC5	1	affinity chromatography technology	Hagenbuchner J (2015)	1
HDAC6	0	BIRC5	1	affinity chromatography technology	Riolo MT (2012)	1
MED30	0	MED4	2	pull down, bioid, affinity chromatography technology	Sato S (2003), Lambert JP (2015), Lambert JP (2015)	3
MED22	1	MED4	2	biochemical, biochemical, bioid, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Lambert JP (2015), Lambert JP (2015)	4
HSP90AA1	7	AURKC	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2012), Huttlin EL (2015), Huttlin EL (2017)	3
MED20	2	MED21	1	affinity chromatography technology, affinity chromatography technology	Lambert JP (2015), Huttlin EL (2017)	2
RAN	1	BIRC5	1	pull down, imaging technique, affinity chromatography technology	Guvenc H (2013), Guvenc H (2013), Guvenc H (2013)	3
ELAVL1	0	HDAC6	0	affinity chromatography technology, affinity chromatography technology	Scott GK (2008), Scott GK (2008)	2
CASP7	1	CASP9	6	enzymatic study	Walsh JG (2008)	1
PRKN	1	AURKA	1	affinity chromatography technology	Lee SB (2015)	1
BIRC2	1	CASP7	1	pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Roy N (1997), Choi YE (2009), Choi YE (2009), Tenev T (2005), Eckelman BP (2006), Vucic D (2000)	6
MED1	4	MED8	0	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Zhang X (2005), Malovannaya A (2010), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	5
MED10	0	MED18	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sato S (2004), Tomomori-Sato C (2004), Sato S (2003), Sato S (2003), Zhang X (2005), Malovannaya A (2010), Huttlin EL (2017)	7
AURKB	2	HIST3H3	0	enzymatic study, enzymatic study, enzymatic study	Fernandez-Miranda G (2010), Ban R (2011), Sun L (2010)	3
PPP1CC	2	AURKA	1	pull down, affinity chromatography technology, pull down, enzymatic study, enzymatic study	Katayama H (2001), Katayama H (2001), Katayama H (2001), Katayama H (2001), Katayama H (2001)	5
MED30	0	MED8	0	pull down	Sato S (2003)	1
EVI5	2	AURKB	2	affinity chromatography technology, pull down	Faitar SL (2006), Faitar SL (2006)	2
MED6	0	MED17	0	biochemical	Wan C (2015)	1
AIP	1	HSP90AA1	7	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Li J (2011), Schuelke JP (2010), Taipale M (2014), Taipale M (2014), Kazlauskas A (2000)	5
MED18	0	MED6	0	affinity chromatography technology, biochemical, affinity chromatography technology	Malovannaya A (2010), Wan C (2015), Huttlin EL (2017)	3
BIRC5	1	MED10	0	affinity chromatography technology	Huttlin EL (2017)	1
MED4	2	MED17	0	biochemical, bioid, affinity chromatography technology	Wan C (2015), Lambert JP (2015), Lambert JP (2015)	3
H2AFX	1	ELAVL1	0	affinity chromatography technology	Yang X (2010)	1
AURKA	1	INCENP	4	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, enzymatic study	Katayama H (2008), Katayama H (2008), Katayama H (2008), Kaitna S (2000), Kaitna S (2000), Fu J (2009), Fu J (2009), Fu J (2009)	8
MED29	2	MED21	1	affinity chromatography technology, pull down, biochemical, affinity chromatography technology	Sato S (2004), Zhang X (2005), Havugimana PC (2012), Huttlin EL (2017)	4
MED1	4	MED31	0	affinity chromatography technology, affinity chromatography technology	Zhang X (2005), Huttlin EL (2017)	2
HSP90AA1	7	BECN1	2	affinity chromatography technology	Xu C (2011)	1
FBXL7	0	BIRC5	1	enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Liu Y (2015), Liu Y (2015), Liu Y (2015), Kamran M (2017), Kamran M (2017), Kamran M (2017)	6
BIRC5	1	MDC1	8	affinity chromatography technology, affinity chromatography technology	Capalbo G (2010), Capalbo G (2010)	2
MED1	4	MED17	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Zhang X (2005), Zhang X (2005), Liu X (2008), Malovannaya A (2010), Donner AJ (2010), Wan C (2015), Huttlin EL (2017)	7
PRKN	1	XRCC6	3	affinity chromatography technology	Zanon A (2013)	1
MED21	1	MED31	0	affinity chromatography technology	Huttlin EL (2017)	1
MED4	2	MED18	0	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, bioid, affinity chromatography technology, affinity chromatography technology	Young ET (2008), Malovannaya A (2010), Havugimana PC (2012), Wan C (2015), Lambert JP (2015), Lambert JP (2015), Huttlin EL (2017)	7
XPO1	8	AURKA	1	affinity chromatography technology	Kirli K (2015)	1
BIRC5	1	CASP7	1	pull down, enzymatic study, pull down	Tamm I (1998), Shin S (2001), Shin S (2001)	3
BIRC5	1	HBZ	0	affinity chromatography technology	Huttlin EL (2017)	1
ELAVL1	0	EVI5	2	affinity chromatography technology	Abdelmohsen K (2009)	1
HIST2H3C	0	BIRC5	1	pull down, pull down	Yamagishi Y (2010), Yamagishi Y (2010)	2
ELAVL1	0	MED20	2	affinity chromatography technology	Abdelmohsen K (2009)	1
BIRC5	1	AURKB	2	two hybrid, pull down, genetic interference, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wheatley SP (2001), Chen J (2003), Chen J (2003), Wheatley SP (2001), Xu Z (2009), Maerki S (2009), Knauer SK (2006), Knauer SK (2006), Ban R (2011), Sun L (2008), Noton EA (2006), Noton EA (2006), Fu J (2009), Gomez V (2010)	14
MED10	0	MED4	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, bioid, affinity chromatography technology	Sato S (2004), Tomomori-Sato C (2004), Zhang X (2005), Havugimana PC (2012), Wan C (2015), Lambert JP (2015), Lambert JP (2015)	7
BIRC5	1	MED22	1	affinity chromatography technology	Huttlin EL (2017)	1
BIRC5	1	MED6	0	affinity chromatography technology	Huttlin EL (2017)	1
XIAP	0	CASP9	6	two hybrid, far western blotting, pull down, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, unspecified method, x-ray crystallography, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique	Rual JF (2005), Davoodi J (2004), Deveraux QL (1998), Deveraux QL (1998), Richter BW (2001), Morizane Y (2005), Fu J (2003), Fu J (2003), Hao Y (2004), Varfolomeev E (2007), Vucic D (2002), Qiu XB (2005), Srinivasula SM (2001), Cheung HH (2006), Kulathila R (2009), Shiozaki EN (2003), Davoodi J (2007), Checinska A (2007), Huang Y (2003), Sun M (2009), Martin SA (2005), Lee JS (2012), Rolland T (2014), McDonald ER (2004), Chen TC (2014)	25
BIRC2	1	BIRC3	1	affinity chromatography technology, affinity chromatography technology	Rajalingam K (2006), Rajalingam K (2006)	2
8339	0	INCENP	4	bioid	Lambert JP (2015)	1
MED18	0	MED8	0	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Malovannaya A (2010), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	4
MED29	2	MED8	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical	Sato S (2004), Tomomori-Sato C (2004), Sato S (2003), Havugimana PC (2012), Wan C (2015)	5
XPO1	8	AURKB	2	affinity chromatography technology	Kirli K (2015)	1
AURKA	1	USP9X	15	affinity chromatography technology	Fogeron ML (2013)	1
MED18	0	MED21	1	pull down, affinity chromatography technology, biochemical, affinity chromatography technology	Zhang X (2005), Malovannaya A (2010), Havugimana PC (2012), Huttlin EL (2017)	4
AURKA	1	HIST3H3	0	enzymatic study, enzymatic study, enzymatic study	Ban R (2011), Molli PR (2010), Fu J (2009)	3
MED1	4	MED18	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Zhang X (2005), Zhang X (2005), Malovannaya A (2010), Malovannaya A (2010), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	7
PRKN	1	BIRC5	1	affinity chromatography technology	Hagenbuchner J (2015)	1
MED30	0	MED6	0	pull down, affinity chromatography technology, affinity chromatography technology	Sato S (2003), Zhang X (2005), Ding N (2008)	3
AURKB	2	HIST2H3C	0	enzymatic study, pull down	Wang F (2011), Yamagishi Y (2010)	2
MED30	0	MED22	1	pull down, pull down, affinity chromatography technology	Sato S (2003), Sato S (2003), Sato S (2003)	3
BIRC5	1	PRKDC	12	affinity chromatography technology, affinity chromatography technology	Capalbo G (2010), Capalbo G (2010)	2
H2AFX	1	XRCC6	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology	Mischo HE (2005), Mischo HE (2005), Heo K (2008), Heo K (2008), Heo K (2008), Lee HS (2010), Kobayashi J (2012), Huttlin EL (2017)	8
ELAVL1	0	CASP3	0	affinity chromatography technology	Abdelmohsen K (2009)	1
HIST3H3	0	BIRC5	1	unspecified method	Li X (2012)	1
MED21	1	MED14	0	biochemical, biochemical, affinity chromatography technology	Sun X (1998), Havugimana PC (2012), Huttlin EL (2017)	3
PYCARD	1	BECN1	2	affinity chromatography technology	Shi CS (2012)	1
MED10	0	MED8	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Sato S (2004), Sato S (2004), Tomomori-Sato C (2004), Sato S (2003), Sato S (2003), Zhang X (2005), Brower CS (2002), Wan C (2015)	8
CDCA8	0	AURKB	2	affinity chromatography technology, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Sampath SC (2004), Gassmann R (2004), Gassmann R (2004), Xu Z (2009), Knauer SK (2006), Ban R (2011), Jeyaprakash AA (2007), Jelluma N (2008), Gomez V (2010), Gomez V (2010), Klein UR (2009)	11
ELAVL1	0	RAN	1	affinity chromatography technology	Abdelmohsen K (2009)	1
MED21	1	MED8	0	biochemical, affinity chromatography technology	Havugimana PC (2012), Huttlin EL (2017)	2
MED18	0	MED17	0	pull down, affinity chromatography technology, biochemical, affinity chromatography technology	Zhang X (2005), Malovannaya A (2010), Wan C (2015), Huttlin EL (2017)	4
MED10	0	MED29	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Sato S (2004), Sato S (2004), Tomomori-Sato C (2004), Sato S (2003), Wan C (2015)	5
PRKDC	12	H2AFX	1	enzymatic study, enzymatic study, affinity chromatography technology, pull down, enzymatic study, enzymatic study	Park EJ (2003), Mischo HE (2005), Heo K (2008), Heo K (2008), Li A (2010), Kim K (2012)	6
BIRC2	1	BIRC5	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Dohi T (2004), Samuel T (2005), Samuel T (2005), Jung SA (2015), Jung SA (2015), Jung SA (2015)	6
MED4	2	MED8	0	biochemical, biochemical, bioid, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Lambert JP (2015), Lambert JP (2015)	4
MED20	2	MED6	0	biochemical, affinity chromatography technology	Wan C (2015), Lambert JP (2015)	2
MED21	1	MED22	1	biochemical, affinity chromatography technology	Havugimana PC (2012), Huttlin EL (2017)	2
CDCA8	0	BIRC5	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, pull down, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sampath SC (2004), Gassmann R (2004), Gassmann R (2004), Knauer SK (2006), Knauer SK (2006), Knauer SK (2006), Jeyaprakash AA (2007), Jeyaprakash AA (2007), Jeyaprakash AA (2007), Klein UR (2006), Klein UR (2006), Noton EA (2006), Noton EA (2006), Jelluma N (2008), Gomez V (2010), Klein UR (2009), Huttlin EL (2015), Huttlin EL (2017)	18
INCENP	4	AURKC	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li X (2004), Huttlin EL (2015), Huttlin EL (2017)	3
MED29	2	MED31	0	affinity chromatography technology, affinity chromatography technology	Sato S (2004), Sato S (2003)	2
MED18	0	MED20	2	pull down, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, biochemical, bioid, affinity chromatography technology, affinity chromatography technology	Sato S (2003), Sato S (2003), Zhang X (2005), Malovannaya A (2010), Rolland T (2014), Wan C (2015), Lambert JP (2015), Lambert JP (2015), Huttlin EL (2017)	9
MED21	1	MED4	2	biochemical, bioid, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Lambert JP (2015), Lambert JP (2015), Huttlin EL (2017)	4
BECN1	2	CDK4	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
BIRC5	1	AIP	1	affinity chromatography technology	Vargiolu M (2009)	1
XIAP	0	DIABLO	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, pull down, x-ray crystallography, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down	Hunter AM (2003), Davoodi J (2004), Song Z (2003), Verhagen AM (2000), Verhagen AM (2000), Verhagen AM (2000), Verhagen AM (2000), Verhagen AM (2002), Samuel T (2006), McNeish IA (2005), Yoon K (2004), Fu J (2003), Fu J (2003), Fu J (2003), Fu J (2003), Hu S (2003), Hao Y (2004), Sekine K (2005), Csomos RA (2009), Bartke T (2004), Burke SP (2010), Burke SP (2010), Vucic D (2002), Qiu XB (2005), Qiu XB (2005), Scott FL (2005), Srinivasula SM (2001), Martins LM (2002), Kulathila R (2009), Huang Y (2001), Chai J (2001), Liu Z (2001), Liu Z (2001), Gao Z (2007), Davoodi J (2007), Hegde R (2002), Krieg A (2009), Huang Y (2003), Huang Y (2003), Arnt CR (2002), Damgaard RB (2013), Lee S (2014), Hao Y (2004), Hao Y (2004), Masoumi KC (2012), Guvenc H (2013), Buetow L (2015), Wo L (2016), Huttlin EL (2017), Wu G (2001), Wu G (2001), Hou Y (2017)	52
HSP90AA1	7	BIRC5	1	affinity chromatography technology	Plescia J (2005)	1
BIRC5	1	BIRC5	1	x-ray crystallography, x-ray crystallography, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology	Verdecia MA (2000), Chantalat L (2000), Shin S (2001), Knauer SK (2006), Klein UR (2006), Noton EA (2006), Noton EA (2006), Pavlyukov MS (2011), Guvenc H (2013), Song Z (2004), Song Z (2004)	11
BIRC5	1	XRCC6	3	affinity chromatography technology	Capalbo G (2010)	1
AURKA	1	HDAC6	0	enzymatic study, pull down	Pugacheva EN (2007), Pugacheva EN (2007)	2
MED20	2	MED14	0	biochemical, affinity chromatography technology	Wan C (2015), Lambert JP (2015)	2
XPO1	8	USP9X	15	affinity chromatography technology	Kirli K (2015)	1
XIAP	0	CASP3	0	affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down	Suzuki Y (2001), Suzuki Y (2001), Silke J (2002), Riedl SJ (2001), Riedl SJ (2001), Roy N (1997), Deveraux QL (1997), Deveraux QL (1997), Suzuki Y (2001), Bartke T (2004), Nakhaei P (2012), Qiu XB (2005), Nomura T (2003), Paulsen M (2008), Scott FL (2005), Mufti AR (2006), Rajalingam K (2006), Dudich E (2006), Chai J (2001), Checinska A (2007), Sun M (2009), Takahashi R (1998), Conde C (2012), Walsh JG (2008), Lee JS (2012), Lin YF (2013), Huttlin EL (2015), Chen TC (2014), Huttlin EL (2017), Hou Y (2017)	30
MED10	0	MED14	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Sato S (2004), Zhang X (2005), Malik S (2000), Wan C (2015)	4
CASP3	0	CASP9	6	enzymatic study, enzymatic study, enzymatic study, enzymatic study, imaging technique	Qiu XB (2005), Denault JB (2007), Srinivasula SM (2001), Walsh JG (2008), Chen TC (2014)	5
BIRC5	1	MED17	0	affinity chromatography technology	Huttlin EL (2017)	1
BIRC2	1	DIABLO	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, unspecified method, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hegde R (2003), Verhagen AM (2000), Samuel T (2006), Samuel T (2006), Yang QH (2004), Hu S (2003), Hu S (2003), Csomos RA (2009), Burke SP (2010), Kulathila R (2009), Kulathila R (2009), Arnt CR (2002), Budhidarmo R (2014), Lee S (2014), Wo L (2016), Huttlin EL (2017)	16
ELAVL1	0	BIRC5	1	affinity chromatography technology	Abdelmohsen K (2009)	1
MED1	4	MED20	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Zhang X (2005), Zhang X (2005), Malovannaya A (2010), Wan C (2015), Lambert JP (2015), Huttlin EL (2017)	6
MED29	2	MED4	2	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Sato S (2004), Tomomori-Sato C (2004), Havugimana PC (2012), Wan C (2015), Lambert JP (2015)	5
HSP90AA1	7	AURKB	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2012), Taipale M (2012), Fogeron ML (2013), Huttlin EL (2015), Huttlin EL (2017)	5
BECN1	2	PRKDC	12	affinity chromatography technology	Behrends C (2010)	1
AURKA	1	HSP90AA1	7	affinity chromatography technology	Fogeron ML (2013)	1
CDK2	0	PRKDC	12	affinity chromatography technology	Neganova I (2011)	1
MED20	2	MED22	1	biochemical, affinity chromatography technology	Wan C (2015), Lambert JP (2015)	2
MED17	0	MED22	1	biochemical	Wan C (2015)	1
BIRC5	1	MED8	0	affinity chromatography technology	Huttlin EL (2017)	1
MED29	2	MED14	0	affinity chromatography technology, biochemical, biochemical	Sato S (2004), Havugimana PC (2012), Wan C (2015)	3
CDCA8	0	MED14	0	genetic interference	Horlbeck MA (2018)	1
MED18	0	MED30	0	affinity chromatography technology, affinity chromatography technology	Malovannaya A (2010), Huttlin EL (2017)	2
BIRC5	1	SSC5D	7	affinity chromatography technology	Huttlin EL (2017)	1
ELAVL1	0	MED21	1	affinity chromatography technology	Abdelmohsen K (2009)	1
BIRC5	1	H2AFX	1	affinity chromatography technology	Capalbo G (2010)	1
MED1	4	MED22	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang X (2005), Malovannaya A (2010), Donner AJ (2010), Huttlin EL (2017)	4
BIRC5	1	CDK4	2	affinity chromatography technology	Suzuki A (2000)	1
MED10	0	MED17	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Sato S (2004), Tomomori-Sato C (2004), Sato S (2003), Sato S (2003), Zhang X (2005), Zhang X (2005), Malik S (2000), Brower CS (2002), Wan C (2015)	9
CDK2	0	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Neganova I (2011), Varjosalo M (2013)	2
AURKB	2	AURKC	0	affinity chromatography technology, biochemical	Li X (2004), Li X (2004)	2
BIRC5	1	INCENP	4	pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology	Wheatley SP (2001), Wheatley SP (2001), Xu Z (2009), Vader G (2006), Knauer SK (2006), Knauer SK (2006), Jeyaprakash AA (2007), Klein UR (2006), Klein UR (2006), Klein UR (2006), Huttlin EL (2017)	11
HDAC6	0	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Kekatpure VD (2009), Rao R (2008), Bali P (2005), Kovacs JJ (2005), New M (2013), Rao R (2012), Kovacs JJ (2005)	7
ELAVL1	0	PPP1CC	2	affinity chromatography technology	Abdelmohsen K (2009)	1
AURKC	0	BIRC5	1	two hybrid	Wang J (2011)	1
BIRC5	1	MED29	2	affinity chromatography technology	Huttlin EL (2017)	1
XPO1	8	BECN1	2	affinity chromatography technology	Kirli K (2015)	1
BIRC5	1	CCDC102A	3	affinity chromatography technology	Huttlin EL (2017)	1
MED29	2	MED22	1	affinity chromatography technology	Sato S (2004)	1
CASP3	0	BECN1	2	enzymatic study	Luo S (2010)	1
MED17	0	MED21	1	biochemical, affinity chromatography technology	Havugimana PC (2012), Huttlin EL (2017)	2
PRKN	1	ELAVL1	0	affinity chromatography technology	Zanon A (2013)	1
BIRC3	1	USP9X	15	affinity chromatography technology	Goncharov T (2013)	1