PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TK1	0	CDKN1A	1	affinity chromatography technology, pull down	Huang DY (2001), Huang DY (2001)	2
SMN1	0	LRIF1	3	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
CDKN1A	1	SETDB1	3	two hybrid	Vinayagam A (2011)	1
PCDHA4	1	GDF9	2	two hybrid	Stelzl U (2005)	1
ANXA7	0	EEF1A1	0	two hybrid	Vinayagam A (2011)	1
TK1	0	LRIF1	3	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
SMN1	0	SETDB1	3	two hybrid	Vinayagam A (2011)	1
CDKN1A	1	EEF1A1	0	two hybrid	Vinayagam A (2011)	1
STX5	0	HAP1	1	two hybrid	Stelzl U (2005)	1
TSC22D1	1	SETDB1	3	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
CDK4	2	SETDB1	3	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
STX5	0	LRIF1	3	two hybrid	Stelzl U (2005)	1
TCF21	0	APLP1	1	two hybrid	Stelzl U (2005)	1
APLP1	1	DAB1	1	two hybrid, pull down, affinity chromatography technology	Homayouni R (1999), Homayouni R (1999), Homayouni R (1999)	3
HSPE1	0	APLP1	1	two hybrid	Stelzl U (2005)	1
CDKN1A	1	ING5	3	two hybrid	Vinayagam A (2011)	1
LRIF1	3	HAP1	1	two hybrid, two hybrid	Goehler H (2004), Goehler H (2004)	2
PHF10	3	UTP14A	0	two hybrid	Stelzl U (2005)	1
TK1	0	SETDB1	3	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
VIM	0	SETDB1	3	two hybrid	Goehler H (2004)	1
ZNF24	1	RBM48	1	two hybrid	Stelzl U (2005)	1
CDKN1A	1	CDK4	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Selma Dagtas A (2010), Guidoboni M (2005), Santiago FS (2007), Santiago FS (2007), Hsu SP (2008), Kehn K (2004), Kokontis JM (1998), Orend G (1998), Zheleva DI (2002), Mandal M (1998), Chen J (1996), Chen J (1996), Ramachandran N (2004), Gorospe M (1996), Fogeron ML (2013), Hukkelhoven E (2012), Hukkelhoven E (2012), Hukkelhoven E (2012), Huttlin EL (2017), Roessig L (2001)	20
SNCA	0	CDK4	2	two hybrid	Vinayagam A (2011)	1
VIM	0	UTP14A	0	two hybrid	Goehler H (2004)	1
CDKN1A	1	RBM48	1	two hybrid	Vinayagam A (2011)	1
KAT5	1	APLP1	1	two hybrid	Li Q (2004)	1
CDKN1A	1	GDF9	2	two hybrid	Vinayagam A (2011)	1
RCC1	2	LRIF1	3	two hybrid	Vinayagam A (2011)	1
SAT1	0	RBM48	1	two hybrid	Stelzl U (2005)	1
SMN1	0	EEF1A1	0	two hybrid	Vinayagam A (2011)	1
APLP1	1	RBM48	1	two hybrid	Goehler H (2004)	1
HSPE1	0	EEF1A1	0	two hybrid	Stelzl U (2005)	1
ANXA7	0	LRIF1	3	two hybrid	Vinayagam A (2011)	1
STX5	0	APLP1	1	two hybrid	Stelzl U (2005)	1
ANXA7	0	APLP1	1	two hybrid	Vinayagam A (2011)	1
SNCA	0	APLP1	1	two hybrid	Vinayagam A (2011)	1
TK1	0	APLP1	1	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
GSTM4	0	LRIF1	3	two hybrid	Stelzl U (2005)	1
RCC1	2	APLP1	1	two hybrid	Vinayagam A (2011)	1
CDKN1A	1	LRIF1	3	two hybrid	Vinayagam A (2011)	1
PNP	1	RBM48	1	two hybrid	Stelzl U (2005)	1
ZNF24	1	UTP14A	0	two hybrid	Stelzl U (2005)	1
SNCA	0	EEF1A1	0	two hybrid	Vinayagam A (2011)	1
CRCT1	1	VIM	0	two hybrid	Stelzl U (2005)	1
CDKN2C	0	CDK4	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Ewing RM (2007), Ewing RM (2007), Guan KL (1994), Guan KL (1994), Guan KL (1994), Li J (2002), Wang J (2011), Varjosalo M (2013), Varjosalo M (2013), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017), Ivanov AA (2017)	13
KAT5	1	APBB1	3	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology	Kim SY (2007), Sumioka A (2005), Sumioka A (2005), von Rotz RC (2004), Cao X (2004), Li Q (2004), Matz A (2014)	7
HAP1	1	ING5	3	two hybrid	Goehler H (2004)	1
PCDHA4	1	SETDB1	3	two hybrid	Stelzl U (2005)	1
CRCT1	1	LRIF1	3	two hybrid	Stelzl U (2005)	1
TK1	0	RBM48	1	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
CRCT1	1	EEF1A1	0	two hybrid	Stelzl U (2005)	1
ZNF24	1	EEF1A1	0	two hybrid	Stelzl U (2005)	1
TSC22D1	1	LRIF1	3	two hybrid	Vinayagam A (2011)	1
ZNF24	1	HAP1	1	two hybrid	Stelzl U (2005)	1
VIM	0	RBM48	1	two hybrid	Goehler H (2004)	1
MPHOSPH6	1	LRIF1	3	two hybrid	Stelzl U (2005)	1
DAB2	1	APLP1	1	pull down	Morris SM (2001)	1
CDKN2C	0	GDF9	2	two hybrid	Stelzl U (2005)	1
ZNF24	1	APLP1	1	two hybrid, affinity chromatography technology	Stelzl U (2005), Stelzl U (2005)	2
APLP1	1	HAP1	1	two hybrid	Goehler H (2004)	1
MPHOSPH6	1	RBM48	1	two hybrid	Stelzl U (2005)	1
CRCT1	1	APLP1	1	two hybrid	Stelzl U (2005)	1
GSTM4	0	APLP1	1	two hybrid	Stelzl U (2005)	1
PCDHA4	1	APLP1	1	two hybrid	Stelzl U (2005)	1
CSNK2B	5	UTP14A	0	two hybrid	Vinayagam A (2011)	1
DAB1	1	PIN1	0	two hybrid	Rolland T (2014)	1
ANXA7	0	GDF9	2	two hybrid	Vinayagam A (2011)	1
PCDHA4	1	RBM48	1	two hybrid	Stelzl U (2005)	1
PCDHA4	1	LRIF1	3	two hybrid	Stelzl U (2005)	1
CDKN2C	0	APLP1	1	two hybrid	Stelzl U (2005)	1
PNP	1	LRIF1	3	two hybrid	Stelzl U (2005)	1
PIN1	0	LRIF1	3	two hybrid	Vinayagam A (2011)	1
SAT1	0	HSPE1	0	two hybrid	Stelzl U (2005)	1
VIM	0	APLP1	1	two hybrid	Vinayagam A (2011)	1
ANXA7	0	SETDB1	3	two hybrid	Vinayagam A (2011)	1
APLP1	1	EEF1A1	0	two hybrid	Goehler H (2004)	1
EIF2S2	0	CSNK2B	5	pull down, far western blotting, far western blotting, affinity chromatography technology, enzymatic study	Llorens F (2003), Llorens F (2003), Llorens F (2003), Llorens F (2003), Llorens F (2003)	5
PHF10	3	SETDB1	3	two hybrid	Stelzl U (2005)	1
GLP1R	4	APLP1	1	protein complementation assay, affinity chromatography technology	Huang X (2013), Huang X (2013)	2
ZNF24	1	KAT5	1	two hybrid	Stelzl U (2005)	1
RAP1B	0	LRIF1	3	two hybrid	Vinayagam A (2011)	1
EIF2S2	0	APLP1	1	two hybrid	Stelzl U (2005)	1
HAP1	1	KAT5	1	pull down, two hybrid	Goehler H (2004), Goehler H (2004)	2
ZNF24	1	SETDB1	3	two hybrid	Stelzl U (2005)	1
PIN1	0	SNCA	0	imaging technique, affinity chromatography technology, affinity chromatography technology	Ryo A (2006), Ryo A (2006), Ryo A (2006)	3
APBB3	2	APLP1	1	pull down, affinity chromatography technology	Tanahashi H (1999), Huttlin EL (2017)	2
APLP1	1	UTP14A	0	two hybrid, two hybrid	Stelzl U (2005), Goehler H (2004)	2
SAT1	0	GDF9	2	two hybrid	Stelzl U (2005)	1
SMN1	0	GDF9	2	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
VIM	0	ING5	3	two hybrid	Goehler H (2004)	1
TK1	0	EEF1A1	0	two hybrid	Vinayagam A (2011)	1
TSC22D1	1	VIM	0	two hybrid	Vinayagam A (2011)	1
TK1	0	GDF9	2	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
APLP1	1	ING5	3	two hybrid	Goehler H (2004)	1
SNCA	0	ARRB1	2	affinity chromatography technology	Kim KS (2010)	1
HLA-DQA1	1	APLP1	1	two hybrid	Stelzl U (2005)	1
CDKN1A	1	APLP1	1	two hybrid	Vinayagam A (2011)	1
SMN1	0	RBM48	1	two hybrid	Vinayagam A (2011)	1
ANXA7	0	VIM	0	two hybrid	Vinayagam A (2011)	1
HSPE1	0	LRIF1	3	two hybrid	Stelzl U (2005)	1
APLP1	1	SETDB1	3	two hybrid	Goehler H (2004)	1
APLP1	1	LRIF1	3	two hybrid	Goehler H (2004)	1
ZNF24	1	LRIF1	3	two hybrid	Stelzl U (2005)	1
SETDB1	3	LRIF1	3	two hybrid	Goehler H (2004)	1
TSC22D1	1	APLP1	1	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
RAP1B	0	APLP1	1	two hybrid	Vinayagam A (2011)	1
CDKN2C	0	LRIF1	3	two hybrid	Stelzl U (2005)	1
PIN1	0	APLP1	1	two hybrid	Vinayagam A (2011)	1
SAT1	0	KAT5	1	two hybrid	Stelzl U (2005)	1
APBB1	3	APLP1	1	pull down, affinity chromatography technology	Tanahashi H (1999), Huttlin EL (2017)	2
MPHOSPH6	1	GDF9	2	two hybrid	Stelzl U (2005)	1
PIN1	0	DAB2	1	affinity chromatography technology, pull down	He J (2003), He J (2003)	2
PHF10	3	APLP1	1	two hybrid	Stelzl U (2005)	1
ARRB1	2	VIM	0	affinity chromatography technology	Xiao K (2007)	1
SAT1	0	SETDB1	3	two hybrid	Stelzl U (2005)	1
SMN1	0	APLP1	1	two hybrid	Vinayagam A (2011)	1
VIM	0	HAP1	1	two hybrid	Goehler H (2004)	1
APBB2	2	APLP1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TK1	0	CDK4	2	two hybrid	Vinayagam A (2011)	1
ANXA7	0	CDK4	2	two hybrid	Vinayagam A (2011)	1
TOE1	1	APLP1	1	two hybrid	Stelzl U (2005)	1
PNP	1	APLP1	1	two hybrid	Stelzl U (2005)	1
SAT1	0	LRIF1	3	two hybrid	Stelzl U (2005)	1
SAT1	0	APLP1	1	two hybrid	Stelzl U (2005)	1
CDKN1A	1	VIM	0	two hybrid	Vinayagam A (2011)	1
NACA	1	APLP1	1	two hybrid	Stelzl U (2005)	1
HSPE1	0	PIN1	0	biochemical	Wan C (2015)	1
CSNK2B	5	APLP1	1	two hybrid	Vinayagam A (2011)	1
KAT5	1	LRIF1	3	two hybrid	Goehler H (2004)	1
VIM	0	LRIF1	3	two hybrid	Stelzl U (2005)	1
HLA-DQA1	1	LRIF1	3	two hybrid	Stelzl U (2005)	1
ARRB1	2	APLP1	1	affinity chromatography technology	Xiao K (2007)	1
PCDHA4	1	EEF1A1	0	two hybrid	Stelzl U (2005)	1
NACA	1	LRIF1	3	two hybrid	Stelzl U (2005)	1
CSNK2B	5	CDKN1A	1	pull down	Goetz C (2000)	1
APLP1	1	GDF9	2	two hybrid	Goehler H (2004)	1
APBB2	2	APBB1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDK4	2	APLP1	1	two hybrid	Vinayagam A (2011)	1
SAT1	0	UTP14A	0	two hybrid	Stelzl U (2005)	1
CDKN2C	0	RBM48	1	two hybrid	Stelzl U (2005)	1
ANXA7	0	RBM48	1	two hybrid	Vinayagam A (2011)	1
MPHOSPH6	1	APLP1	1	two hybrid	Stelzl U (2005)	1