PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
APOA1	0	SERTAD3	2	affinity chromatography technology	Zhou M (2004)	1
DDX31	1	TTR	0	affinity chromatography technology	Huttlin EL (2017)	1
DDX31	1	CLU	1	affinity chromatography technology	Huttlin EL (2017)	1
APOA1	0	NLRP1	5	affinity chromatography technology	Zhou M (2004)	1
ALB	1	SETX	7	affinity chromatography technology	Zhou M (2004)	1
ALB	1	APP	1	pull down	Olah J (2011)	1
MAPK6	1	UCHL5	1	affinity chromatography technology	Rodriguez J (2016)	1
GDPD1	0	APOA1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
APOA1	0	ZNRD1	0	two hybrid	Wang J (2011)	1
ALDH2	2	FGA	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
APOL1	0	APOA1	0	biochemical	Duchateau PN (1997)	1
APOA1	0	APOA1	0	x-ray crystallography, affinity chromatography technology, pull down, pull down	Borhani DW (1997), Zhou M (2004), Reschly EJ (2002), Pyle LE (1996)	4
APOA1	0	C1QA	0	affinity chromatography technology	Zhou M (2004)	1
APOA1	0	3514	0	affinity chromatography technology	Zhou M (2004)	1
MAPK6	1	ALB	1	affinity chromatography technology	Huttlin EL (2017)	1
APP	1	SNX27	5	pull down	Ghai R (2013)	1
PLTP	3	APOA2	1	pull down, biochemical	Pussinen PJ (1998), Pussinen PJ (1998)	2
CLU	1	SETX	7	affinity chromatography technology	Hein MY (2015)	1
ALDH2	2	APOA1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ALB	1	APOC1	1	affinity chromatography technology	Zhou M (2004)	1
MAPK6	1	3240	0	affinity chromatography technology	Huttlin EL (2017)	1
PLTP	3	APOA1	0	pull down, biochemical	Pussinen PJ (1998), Pussinen PJ (1998)	2
SCARB1	2	APOA1	0	pull down	Pilon A (2000)	1
ALB	1	3514	0	affinity chromatography technology	Zhou M (2004)	1
ALB	1	KRT1	3	affinity chromatography technology	Zhou M (2004)	1
APOA1	0	FN1	17	affinity chromatography technology	Zhou M (2004)	1
APOA1	0	MOCOS	5	affinity chromatography technology	Zhou M (2004)	1
BRAP	0	APOA1	0	two hybrid	Fatima S (2015)	1
DDX19B	2	3514	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
APOA1	0	28916	0	affinity chromatography technology	Zhou M (2004)	1
APOA1	0	SAA2	1	two hybrid	Ritter M (2002)	1
ABCA13	23	APOA1	0	pull down	Remaley AT (2001)	1
UCHL5	1	APOA1	0	affinity chromatography technology	Fang Y (2011)	1
APOD	0	APOA2	1	biochemical, biochemical	Yang CY (1994), Cheung MC (1986)	2
CD40LG	0	APOA1	0	affinity chromatography technology	Raper J (1999)	1
FN1	17	KRT16	2	affinity chromatography technology	Humphries JD (2009)	1
MIS12	0	3240	0	affinity chromatography technology	Hutchins JR (2010)	1
ALDH2	2	APP	1	pull down	Olah J (2011)	1
APOA1	0	APOA2	1	pull down, pull down, biochemical	Clay MA (2000), Clay MA (2000), Cheung MC (1986)	3
FN1	17	FBLN1	1	pull down, two hybrid	Balbona K (1992), Wang J (2011)	2
ALB	1	TTR	0	affinity chromatography technology	Zhou M (2004)	1
VKORC1	1	APOC3	1	two hybrid	Schaafhausen A (2011)	1
PDE1A	1	APP	1	pull down	Olah J (2011)	1
ALB	1	FN1	17	affinity chromatography technology	Zhou M (2004)	1
SNX27	5	TTR	0	affinity chromatography technology	Huttlin EL (2017)	1
AKT2	1	SNX27	5	two hybrid	Wang J (2011)	1
APOA1	0	PDE4B	3	affinity chromatography technology	Zhou M (2004)	1
APOA1	0	APOC1	1	two hybrid, affinity chromatography technology	Ritter M (2002), Zhou M (2004)	2
APOA1	0	APOC3	1	affinity chromatography technology	Zhou M (2004)	1
SNX27	5	APOA1	0	affinity chromatography technology	Huttlin EL (2017)	1
APOA1	0	FAM83C	4	affinity chromatography technology	Zhou M (2004)	1
APOA1	0	SMPDL3A	2	affinity chromatography technology	Zhou M (2004)	1
UCHL5	1	KRT1	3	affinity chromatography technology	Fang Y (2011)	1
U2AF2	7	VCP	6	affinity chromatography technology	Whisenant TC (2015)	1
UPF3A	2	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
FN1	17	KRT9	1	affinity chromatography technology	Humphries JD (2009)	1
CLU	1	HBA1	0	affinity chromatography technology	Antonelou MH (2011)	1
APOA1	0	DNTT	1	affinity chromatography technology	Zhou M (2004)	1
APOA1	0	KRT9	1	affinity chromatography technology	Zhou M (2004)	1
APOA1	0	PTPN5	0	affinity chromatography technology	Zhou M (2004)	1
DDX31	1	APOA1	0	affinity chromatography technology	Huttlin EL (2017)	1
SNX27	5	FGA	5	affinity chromatography technology	Huttlin EL (2017)	1
ALB	1	APOA1	0	affinity chromatography technology	Zhou M (2004)	1
DDX31	1	3240	0	affinity chromatography technology	Huttlin EL (2017)	1
APOA1	0	DGAT1	5	biochemical	Cheung MC (1986)	1
UCHL5	1	APP	1	pull down	Olah J (2011)	1
APOA2	1	LCAT	2	biochemical	Cheung MC (1986)	1
SCARB1	2	APOA2	1	pull down	Pilon A (2000)	1
MAPK6	1	KRT16	2	affinity chromatography technology	Rodriguez J (2016)	1
APOA1	0	QDPR	0	affinity chromatography technology	Zhou M (2004)	1
VCAM1	2	VCP	6	affinity chromatography technology, affinity chromatography technology	Humphries JD (2009), Braunstein I (2015)	2
UCHL5	1	KRT9	1	affinity chromatography technology	Fang Y (2011)	1
VCP	6	APP	1	affinity chromatography technology	Jang JK (2017)	1
APOA1	0	FBLN1	1	two hybrid	Wang J (2011)	1
ZNF558	0	APOA1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ALB	1	PDE4B	3	affinity chromatography technology	Zhou M (2004)	1
AKT2	1	APP	1	pull down	Olah J (2011)	1
APOA1	0	ROBO3	8	affinity chromatography technology	Zhou M (2004)	1
SNX27	5	CP	4	affinity chromatography technology	Huttlin EL (2017)	1
APOA1	0	PDE1A	1	two hybrid	Ritter M (2002)	1
TOMM20	0	APOA1	0	two hybrid	Stelzl U (2005)	1
APOA1	0	SPP1	0	two hybrid	Wang J (2011)	1
MAPK6	1	TOMM20	0	affinity chromatography technology	Rodriguez J (2016)	1
TTR	0	VCP	6	affinity chromatography technology	Kadowaki H (2015)	1
APOA1	0	JAK3	3	two hybrid	Wang J (2011)	1
VCAM1	2	APOA1	0	affinity chromatography technology	Huttlin EL (2017)	1
UCHL5	1	APOB	8	affinity chromatography technology	Fang Y (2011)	1
APOF	0	APOA1	0	biochemical	Koren E (1982)	1
3240	0	APOA1	0	unspecified method	Spagnuolo MS (2005)	1
DDX31	1	CP	4	affinity chromatography technology	Huttlin EL (2017)	1
APP	1	FBLN1	1	two hybrid, pull down, affinity chromatography technology	Ohsawa I (2001), Ohsawa I (2001), Ohsawa I (2001)	3
APOA1	0	KRT16	2	affinity chromatography technology	Zhou M (2004)	1
ALB	1	3240	0	affinity chromatography technology	Zhou M (2004)	1
MAP7D1	2	APOA1	0	two hybrid	Stelzl U (2005)	1
FN1	17	VCP	6	affinity chromatography technology	Humphries JD (2009)	1
ALB	1	CTSL	3	affinity chromatography technology	Zhou M (2004)	1
APOB	8	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fisher EA (2008), Rutledge AC (2009), Zhang J (2017)	3
APOA1	0	SAFB2	3	affinity chromatography technology	Zhou M (2004)	1
APP	1	MAP7D1	2	affinity chromatography technology	Huttlin EL (2017)	1
TNFRSF10C	0	APOA1	0	two hybrid	Stelzl U (2005)	1
AKT2	1	APOA1	0	two hybrid	Wang J (2011)	1
APOA2	1	DGAT1	5	biochemical	Cheung MC (1986)	1
SNX27	5	ALB	1	affinity chromatography technology	Huttlin EL (2017)	1
APOA1	0	TMEM43	1	affinity chromatography technology	Huttlin EL (2017)	1
APOA1	0	TXNDC2	1	affinity chromatography technology	Zhou M (2004)	1
MAPK6	1	APOA1	0	two hybrid, affinity chromatography technology	Vinayagam A (2011), Huttlin EL (2017)	2
APOA1	0	643314	0	affinity chromatography technology	Zhou M (2004)	1
APP	1	ROBO3	8	pull down	Virok DP (2011)	1
APOA1	0	TNS3	6	affinity chromatography technology	Zhou M (2004)	1
APOA1	0	SPEF2	3	affinity chromatography technology	Zhou M (2004)	1
APOA1	0	ABCA1	5	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Fitzgerald ML (2002), Fitzgerald ML (2002), Zhang M (2016), Zhang M (2016)	4
UPF3A	2	APOA1	0	affinity chromatography technology	Huttlin EL (2017)	1
ATP4A	6	APOA1	0	affinity chromatography technology	Lapierre LA (2007)	1
C1QA	0	FN1	17	pull down	Bing DH (1982)	1
UCHL5	1	HBA1	0	pull down	Fang Y (2011)	1
GPLD1	5	APOA1	0	affinity chromatography technology, pull down	Deeg MA (2001), Deeg MA (2001)	2
APOA1	0	APOD	0	biochemical	Cheung MC (1986)	1
GDPD1	0	APOA2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
APOA1	0	100616101	0	affinity chromatography technology	Zhou M (2004)	1
APOA1	0	CP	4	affinity chromatography technology	Zhou M (2004)	1
RRP1B	6	28916	0	affinity chromatography technology	Crawford NP (2009)	1
MAPK6	1	NAXE	2	two hybrid	Vinayagam A (2011)	1
ALB	1	KRT16	2	affinity chromatography technology	Zhou M (2004)	1
VKORC1	1	APOC1	1	two hybrid	Schaafhausen A (2011)	1
DDX19B	2	FGA	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AKT2	1	APOB	8	two hybrid	Wang J (2011)	1
APOA1	0	CMTM5	0	two hybrid	Rolland T (2014)	1
APOA1	0	VCP	6	affinity chromatography technology	Rutledge AC (2009)	1
VCAM1	2	HBA1	0	affinity chromatography technology	Humphries JD (2009)	1
APOA1	0	CLU	1	affinity chromatography technology	Zhou M (2004)	1
CLEC4G	0	APOA1	0	two hybrid	Wang J (2008)	1
DDX19B	2	APOA1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
KRT9	1	KRT1	3	biochemical	Havugimana PC (2012)	1
DDX19B	2	APP	1	pull down	Olah J (2011)	1
NAXE	2	APOA1	0	affinity chromatography technology	Ritter M (2002)	1
APOA1	0	HBA1	0	affinity chromatography technology	Zhou M (2004)	1
VCAM1	2	KRT1	3	affinity chromatography technology	Humphries JD (2009)	1
DDX31	1	PLTP	3	affinity chromatography technology	Huttlin EL (2017)	1
ALB	1	APOA2	1	affinity chromatography technology	Zhou M (2004)	1
APOA1	0	CTSL	3	affinity chromatography technology	Zhou M (2004)	1
GDPD1	0	3240	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAPK6	1	FGA	5	affinity chromatography technology	Huttlin EL (2017)	1
VKORC1	1	3240	0	two hybrid	Schaafhausen A (2011)	1
UPF3A	2	ALB	1	affinity chromatography technology	Huttlin EL (2017)	1
APOF	0	APOA2	1	biochemical	Koren E (1982)	1
APOA1	0	SETX	7	affinity chromatography technology	Zhou M (2004)	1
APOA1	0	RRP1B	6	affinity chromatography technology	Zhou M (2004)	1
APOA1	0	ABCA6	3	affinity chromatography technology	Zhou M (2004)	1
DDX19B	2	3240	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
APOA1	0	FAM169A	4	affinity chromatography technology	Zhou M (2004)	1
APOA1	0	FGA	5	affinity chromatography technology, imaging technique	Zhou M (2004), Chen TC (2014)	2
ABCA13	23	APOA2	1	pull down	Remaley AT (2001)	1
VCAM1	2	KRT9	1	affinity chromatography technology	Humphries JD (2009)	1
ALB	1	FGA	5	affinity chromatography technology	Zhou M (2004)	1
VKORC1	1	APOA1	0	two hybrid	Schaafhausen A (2011)	1
APP	1	CLU	1	pull down, pull down, fluorescent resonance energy transfe, affinity chromatography technology	Hammad SM (1997), Ghiso J (1993), Chen P (2013), Chen P (2013)	4
MIS12	0	APOA1	0	affinity chromatography technology	Hutchins JR (2010)	1
MIS12	0	FGA	5	affinity chromatography technology	Hutchins JR (2010)	1
LBP	2	APOA1	0	affinity chromatography technology	Park CT (1996)	1
TTR	0	CLU	1	pull down	Lee KW (2009)	1
U2AF2	7	APOA1	0	affinity chromatography technology	Whisenant TC (2015)	1
APOA1	0	LCAT	2	pull down, pull down, biochemical, enzymatic study, pull down, enzymatic study, pull down	Minnich A (1992), Furukawa Y (1992), Cheung MC (1986), Fielding CJ (1972), Collet X (1999), Zhao Y (2005), Sparks DL (1999)	7
APOA1	0	TTR	0	affinity chromatography technology	Zhou M (2004)	1
APOA1	0	APP	1	pull down	Olah J (2011)	1
ALB	1	KRT9	1	affinity chromatography technology	Zhou M (2004)	1
GDPD1	0	CP	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GOT1L1	1	APOA1	0	affinity chromatography technology	Huttlin EL (2017)	1
DDX31	1	3514	0	affinity chromatography technology	Huttlin EL (2017)	1
ALB	1	28916	0	affinity chromatography technology	Zhou M (2004)	1
RRP1B	6	3514	0	affinity chromatography technology	Crawford NP (2009)	1
ZNF558	0	ALB	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DDX31	1	ALB	1	affinity chromatography technology	Huttlin EL (2017)	1
FN1	17	KRT1	3	affinity chromatography technology	Humphries JD (2009)	1
ALB	1	APOC3	1	affinity chromatography technology	Zhou M (2004)	1
FN1	17	HBA1	0	affinity chromatography technology	Humphries JD (2009)	1
GDPD1	0	ALB	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
VKORC1	1	APOA2	1	two hybrid	Schaafhausen A (2011)	1
APOA1	0	C1QC	1	affinity chromatography technology	Zhou M (2004)	1
APOA1	0	APOB	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rutledge AC (2009), Rutledge AC (2009), Zhang J (2017), Zhang J (2017)	4
SNX27	5	3240	0	affinity chromatography technology	Huttlin EL (2017)	1
FN1	17	FGA	5	affinity chromatography technology	Moussavi-Harami SF (2013)	1
APOA1	0	KRT1	3	affinity chromatography technology	Zhou M (2004)	1
APOA1	0	CNMD	2	affinity chromatography technology	Zhou M (2004)	1
ALDH2	2	3514	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FN1	17	C1QC	1	affinity chromatography technology	Moussavi-Harami SF (2013)	1