Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
HTR1B 3351 METHYSERGIDE CHEMBL1065 antagonist, binder GuideToPharmacologyInteractions, DrugBank 1738111
HTR1B 3351 CLOZAPINE CHEMBL42 agonist, antagonist GuideToPharmacologyInteractions, DrugBank 17848919
HTR1B 3351 FROVATRIPTAN CHEMBL1279 agonist TdgClinicalTrial, GuideToPharmacologyInteractions, TEND
HTR1B 3351 CHEMBL266591 CHEMBL266591 agonist GuideToPharmacologyInteractions
HTR1B 3351 CHEMBL1332062 CHEMBL1332062 agonist GuideToPharmacologyInteractions
HTR1B 3351 L-694247 CHEMBL39317 agonist GuideToPharmacologyInteractions
HTR1B 3351 CHEMBL3186179 CHEMBL3186179 agonist GuideToPharmacologyInteractions
HTR1B 3351 LYSERGOL CHEMBL1909065 agonist GuideToPharmacologyInteractions
HTR1B 3351 PERGOLIDE CHEMBL531 agonist GuideToPharmacologyInteractions
HTR1B 3351 XANOMELINE CHEMBL21536 agonist GuideToPharmacologyInteractions
HTR1B 3351 ZIPRASIDONE CHEMBL708 agonist GuideToPharmacologyInteractions
HTR1B 3351 Capeserod CHEMBL2027925 agonist GuideToPharmacologyInteractions
HTR1B 3351 LIDOFLAZINE CHEMBL92870 agonist GuideToPharmacologyInteractions
HTR1B 3351 KETANSERIN CHEMBL51 antagonist GuideToPharmacologyInteractions
HTR1B 3351 METERGOLINE CHEMBL19215 antagonist GuideToPharmacologyInteractions
HTR1B 3351 OCAPERIDONE CHEMBL2104619 antagonist GuideToPharmacologyInteractions
HTR1B 3351 CHEMBL425190 CHEMBL425190 antagonist GuideToPharmacologyInteractions
HTR1B 3351 CHEMBL38288 CHEMBL38288 antagonist GuideToPharmacologyInteractions
HTR1B 3351 CABERGOLINE CHEMBL1201087 agonist GuideToPharmacologyInteractions, DrugBank 10641988, 18691132
HTR1B 3351 ZOLMITRIPTAN CHEMBL1185 agonist TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, TEND, DrugBank 10844127, 15096229, 11752352, 10463324, 20407761, 11594437, 11513839, 10563228, 9859690, 9399012
HTR1B 3351 LISURIDE CHEMBL157138 agonist GuideToPharmacologyInteractions, DrugBank 18691132
HTR1B 3351 RIZATRIPTAN CHEMBL905 agonist TdgClinicalTrial, GuideToPharmacologyInteractions, TEND, DrugBank 15056946, 11752352, 9650800, 11487512, 15821444, 12269863, 12093318
HTR1B 3351 ALMOTRIPTAN CHEMBL1505 TdgClinicalTrial, TEND
HTR1B 3351 ASENAPINE (CHEMBL3187365) CHEMBL3187365 agonist TdgClinicalTrial, GuideToPharmacologyInteractions
HTR1B 3351 SEROTONIN CHEMBL39 agonist GuideToPharmacologyInteractions
HTR1B 3351 5-METHOXYTRYPTAMINE CHEMBL8165 agonist GuideToPharmacologyInteractions
HTR1B 3351 CHEMBL97450 CHEMBL97450 agonist GuideToPharmacologyInteractions
HTR1B 3351 RU-24969 CHEMBL18785 agonist GuideToPharmacologyInteractions
HTR1B 3351 TRYPTAMINE CHEMBL6640 agonist GuideToPharmacologyInteractions
HTR1B 3351 BRL-15,572 CHEMBL534232 agonist GuideToPharmacologyInteractions
HTR1B 3351 BROMOCRIPTINE CHEMBL493 agonist GuideToPharmacologyInteractions
HTR1B 3351 CHEMBL20963 CHEMBL20963 agonist GuideToPharmacologyInteractions
HTR1B 3351 PALIPERIDONE CHEMBL1621 antagonist GuideToPharmacologyInteractions
HTR1B 3351 RISPERIDONE CHEMBL85 antagonist GuideToPharmacologyInteractions
HTR1B 3351 CHEMBL191971 CHEMBL191971 antagonist GuideToPharmacologyInteractions
HTR1B 3351 ZOTEPINE CHEMBL285802 antagonist GuideToPharmacologyInteractions
HTR1B 3351 SB-224289 CHEMBL281350 antagonist GuideToPharmacologyInteractions
HTR1B 3351 ERGOLOID MESYLATES CHEMBL2311030 agonist ChemblInteractions
HTR1B 3351 ELETRIPTAN HYDROBROMIDE CHEMBL1201003 agonist ChemblInteractions
HTR1B 3351 ROPINIROLE CHEMBL589 agonist DrugBank 18691132
HTR1B 3351 OLANZAPINE CHEMBL715 agonist, antagonist TdgClinicalTrial, GuideToPharmacologyInteractions, DrugBank 17848919
HTR1B 3351 LOXAPINE CHEMBL831 binder DrugBank
HTR1B 3351 ERGOTAMINE CHEMBL442 agonist TdgClinicalTrial, TEND, DrugBank 15224175, 11015308, 10188968, 10455274
HTR1B 3351 PINDOLOL CHEMBL500 DrugBank 2512511, 10727715, 2664084, 7944828, 3141589
HTR1B 3351 DAPOXETINE CHEMBL2110900 DrugBank
HTR1B 3351 LITHIUM CHEMBL2146126 PharmGKB
HTR1B 3351 NARATRIPTAN CHEMBL1278 agonist TdgClinicalTrial, GuideToPharmacologyInteractions, TEND
HTR1B 3351 CLOMIPRAMINE CHEMBL415 PharmGKB
HTR1B 3351 PAROXETINE CHEMBL490 PharmGKB
HTR1B 3351 DIHYDROERGOTAMINE CHEMBL1732 agonist TdgClinicalTrial, GuideToPharmacologyInteractions
HTR1B 3351 ELZASONAN HYDROCHLORIDE CHEMBL2106698 antagonist ChemblInteractions
HTR1B 3351 GSK163090 CHEMBL1631540 antagonist ChemblInteractions
HTR1B 3351 VENLAFAXINE CHEMBL637 PharmGKB
HTR1B 3351 CHEMBL159332 CHEMBL159332 agonist GuideToPharmacologyInteractions
HTR1B 3351 CHEMBL313714 CHEMBL313714 agonist GuideToPharmacologyInteractions
HTR1B 3351 OXYMETAZOLINE CHEMBL762 agonist GuideToPharmacologyInteractions
HTR1B 3351 CHEMBL1741437 CHEMBL1741437 agonist GuideToPharmacologyInteractions
HTR1B 3351 GR-127935 CHEMBL15928 agonist, antagonist GuideToPharmacologyInteractions
HTR1B 3351 TERGURIDE CHEMBL73151 agonist GuideToPharmacologyInteractions
HTR1B 3351 AMINOLEVULINIC ACID CHEMBL601 allosteric modulator GuideToPharmacologyInteractions
HTR1B 3351 GR-55562 CHEMBL119264 antagonist GuideToPharmacologyInteractions
HTR1B 3351 RITANSERIN CHEMBL267777 antagonist GuideToPharmacologyInteractions
HTR1B 3351 Trelanserin CHEMBL3183740 antagonist TdgClinicalTrial, ChemblInteractions
HTR1B 3351 ELETRIPTAN CHEMBL1510 agonist GuideToPharmacologyInteractions, TEND, DrugBank 11069595, 11752352, 11513839, 12384251, 11050304, 10193663
HTR1B 3351 PROPRANOLOL CHEMBL27 DrugBank 7881730, 9760032
HTR1B 3351 APOMORPHINE CHEMBL53 agonist DrugBank 18691132
HTR1B 3351 ARIPIPRAZOLE CHEMBL1112 agonist, antagonist GuideToPharmacologyInteractions, DrugBank 17848919
HTR1B 3351 YOHIMBINE CHEMBL15245 antagonist GuideToPharmacologyInteractions, DrugBank 6136920, 10611634
HTR1B 3351 BOPINDOLOL CHEMBL357995 DrugBank 2512511, 10727715, 2664084, 7944828, 3141589
HTR1B 3351 VORTIOXETINE CHEMBL2104993 partial agonist, agonist TdgClinicalTrial, GuideToPharmacologyInteractions, DrugBank 21486038
HTR1B 3351 FROVATRIPTAN SUCCINATE CHEMBL1200371 agonist ChemblInteractions
HTR1B 3351 ALMOTRIPTAN MALATE CHEMBL1200521 agonist ChemblInteractions
HTR1B 3351 NARATRIPTAN HYDROCHLORIDE CHEMBL1200601 agonist ChemblInteractions
HTR1B 3351 SUMATRIPTAN SUCCINATE CHEMBL1201150 agonist ChemblInteractions
HTR1B 3351 SUMATRIPTAN CHEMBL128 agonist TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, TEND
HTR1B 3351 DONITRIPTAN CHEMBL1742428 agonist GuideToPharmacologyInteractions, ChemblInteractions
HTR1B 3351 RIZATRIPTAN BENZOATE CHEMBL1201032 agonist ChemblInteractions
HTR1B 3351 CHEMBL277120 CHEMBL277120 agonist GuideToPharmacologyInteractions
HTR1B 3351 8-OH-DPAT CHEMBL56 agonist GuideToPharmacologyInteractions
HTR1B 3351 ALNIDITAN CHEMBL88240 agonist GuideToPharmacologyInteractions
HTR1B 3351 CHEMBL1570196 CHEMBL1570196 agonist GuideToPharmacologyInteractions
HTR1B 3351 CHEMBL292779 CHEMBL292779 agonist GuideToPharmacologyInteractions
HTR1B 3351 ROXINDOLE CHEMBL431367 agonist GuideToPharmacologyInteractions
HTR1B 3351 GAMMA-AMINOBUTYRIC ACID CHEMBL96 agonist GuideToPharmacologyInteractions
HTR1B 3351 CHEMBL418834 CHEMBL418834 antagonist GuideToPharmacologyInteractions
HTR1B 3351 CHEMBL326418 CHEMBL326418 antagonist GuideToPharmacologyInteractions
HTR1B 3351 PIPAMPERONE CHEMBL440294 antagonist GuideToPharmacologyInteractions
HTR1B 3351 RAUWOLSCINE CHEMBL10347 antagonist GuideToPharmacologyInteractions
HTR1B 3351 CHEMBL65280 CHEMBL65280 antagonist GuideToPharmacologyInteractions
HTR1B 3351 CHEMBL183460 CHEMBL183460 antagonist GuideToPharmacologyInteractions
HTR1B 3351 SERTINDOLE CHEMBL12713 antagonist GuideToPharmacologyInteractions
HTR1B 3351 METITEPINE CHEMBL93240 antagonist GuideToPharmacologyInteractions
HTR1B 3351 CHEMBL1628625 CHEMBL1628625 antagonist GuideToPharmacologyInteractions
HTR1B 3351 PENBUTOLOL CHEMBL1290 antagonist DrugBank 8098761
HTR1B 3351 AMOXAPINE CHEMBL1113 antagonist DrugBank 1666997

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
HTR1B rs130058 AA + TT fluoxetine efficacy yes Please note the association was only significant using the GAF/CGAS scale as outcome measure. Effect of HTR1B rs130058 on clinical improvement was measured by differences in scores obtained in GAF/CGAS, CDI, OCI-CV, SCARED, CGI-S, and CGI-I scales after fluoxetine treatment. For the other scales the results were not significantly different between the genotypes. Genotypes AA + TT are associated with increased response to fluoxetine in children with Mental Disorders as compared to genotype AT. 27660918 1448265419
HTR1B rs9361233 CC + TT fluoxetine efficacy yes Genotypes CC + TT is associated with increased response to fluoxetine in children with Depressive Disorder, Major as compared to genotype CT. 28025020 1448602188
HTR1B rs9361235 CC + TT fluoxetine efficacy yes Genotypes CC + TT is associated with increased response to fluoxetine in children with Depressive Disorder, Major as compared to genotype CT. 28025020 1448602202
HTR1B rs6296 C methylphenidate efficacy no Allele C is not associated with response to methylphenidate in people with Attention Deficit Disorder with Hyperactivity as compared to allele G. 23131881 981478739
HTR1B rs11568817 C methylphenidate efficacy no Allele C is not associated with response to methylphenidate in people with Attention Deficit Disorder with Hyperactivity as compared to allele A. 23131881 981478735
HTR1B rs13212041 TT methylphenidate efficacy no Genotype TT is not associated with response to methylphenidate in people with Attention Deficit Disorder with Hyperactivity as compared to genotypes CC + CT. 23131881 981478794
HTR1B rs6296 C venlafaxine efficacy no Response assessed as remission, defined as MADRS score =<10 at the end of treatment. Allele C is not associated with response to venlafaxine in people with Depressive Disorder, Major as compared to allele G. 28068779 1448601840
HTR1B rs130058 A venlafaxine efficacy no Response assessed as remission, defined as MADRS score =<10 at the end of treatment. Allele A is not associated with response to venlafaxine in people with Depressive Disorder, Major as compared to allele T. 28068779 1448601834
HTR1B rs11568817 C venlafaxine efficacy no Response assessed as remission, defined as MADRS score =<10 at the end of treatment. Allele C is not associated with response to venlafaxine in people with Depressive Disorder, Major as compared to allele A. 28068779 1448601828