Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
HTR4 3360 VELUSETRAG CHEMBL2087337 agonist ChemblInteractions, DrugBank
HTR4 3360 METOCLOPRAMIDE HYDROCHLORIDE HYDRATE CHEMBL1200940 agonist ChemblInteractions
HTR4 3360 NARONAPRIDE CHEMBL2103858 agonist ChemblInteractions
HTR4 3360 PIBOSEROD CHEMBL356359 DrugBank 16495076, 15902472
HTR4 3360 ACETAMINOPHEN CHEMBL112 NCI 8699917
HTR4 3360 ZOLMITRIPTAN CHEMBL1185 TEND
HTR4 3360 CISAPRIDE CHEMBL1729 agonist NCI, TEND, DrugBank, TTD 11218067, 11752352, 10328995, 10556228, 10027842, 11034583, 12519861, 1555639, 7557734, 7952869, 8321323
HTR4 3360 TEGASEROD CHEMBL76370 partial agonist, agonist, antagonist DrugBank, TTD 11876686, 11752352, 12150698, 15466450, 15645012, 11207504
HTR4 3360 CISAPRIDE MONOHYDRATE CHEMBL1200788 agonist ChemblInteractions
HTR4 3360 PRUCALOPRIDE CHEMBL117287 agonist ChemblInteractions, DrugBank 11438309
HTR4 3360 FLUPHENAZINE DECANOATE CHEMBL1200854 antagonist TTD
HTR4 3360 Revexepride CHEMBL3545035 agonist ChemblInteractions
HTR4 3360 PUMOSETRAG CHEMBL1643880 agonist TTD
HTR4 3360 RENZAPRIDE CHEMBL159825 agonist DrugBank, TTD 1364818
HTR4 3360 Capeserod CHEMBL2027925 partial agonist ChemblInteractions
HTR4 3360 TEGASEROD MALEATE CHEMBL1516474 partial agonist ChemblInteractions
HTR4 3360 TROPISETRON CHEMBL56564 NCI 9826103
HTR4 3360 FLUOXETINE CHEMBL41 NCI 9228186
HTR4 3360 CINITAPRIDE CHEMBL2104523 agonist DrugBank 9562338, 9211565

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
HTR4 rs1971431 C opioids dosage no Variant had no significant association with opioid dose in either the development sample or the validation sample. Please note that alleles have been complemented to the positive strand. Allele C is not associated with dose of opioids in people with Pain as compared to allele T. 21398039 1449714552
HTR4 rs2068190 A opioids dosage no Variant had no significant association with opioid dose in either the development sample or the validation sample. Please note that alleles have been complemented to the positive strand. Allele A is not associated with dose of opioids in people with Pain as compared to allele G. 21398039 1449714566
HTR4 rs1862342 T opioids dosage no Variant had no significant association with opioid dose in either the development sample or the validation sample. Please note that alleles have been complemented to the positive strand. Allele T is not associated with dose of opioids in people with Pain as compared to allele C. 21398039 1449714573
HTR4 rs4264931 A opioids dosage no Variant had no significant association with opioid dose in either the development sample or the validation sample. Allele A is not associated with dose of opioids in people with Pain as compared to allele G. 21398039 1449714559