PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HTR6	3	COPG2	2	affinity chromatography technology	Meffre J (2012)	1
TTI1	3	SMG1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kaizuka T (2010), Izumi N (2010), Izumi N (2010), Izumi N (2010), Hurov KE (2010)	5
TNPO1	1	IPO8	9	biochemical	Wan C (2015)	1
HTR6	3	ATM	9	affinity chromatography technology	Meffre J (2012)	1
MTOR	14	RPTOR	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jacinto E (2004), Jacinto E (2004), Sarbassov DD (2004), Sarbassov DD (2004), Sarbassov DD (2004), Schalm SS (2003), Hara K (2002), Ha SH (2006), Wang L (2006), Frias MA (2006), Frias MA (2006), Buerger C (2006), Jacinto E (2006), McMahon LP (2005), Oshiro N (2004), Kawai S (2003), Choi KM (2003), Hara K (2002), Hara K (2002), Kim DH (2002), Kim DH (2002), Schieke SM (2006), Ha SH (2006), Wang L (2006), Frias MA (2006), Buerger C (2006), Sarbassov DD (2006), Tzatsos A (2006), Sarbassov DD (2005), Yang Q (2006), Kaizuka T (2010), Pearce LR (2007), Oh WJ (2010), Oh WJ (2010), Agrawal P (2012), Kwak D (2012), Wu D (2012), Wu D (2012), Wu D (2012), Wu D (2012), Gwinn DM (2010), Sancak Y (2007), Sancak Y (2007), Yang Q (2006), Carriere A (2011), Jacinto E (2006), Rosner M (2010), Kim DH (2003), Kim DH (2003), Carriere A (2008), Murata H (2011), Koike-Kumagai M (2009), Koike-Kumagai M (2009), Hussain S (2013), Hussain S (2013), Peterson TR (2009), Peterson TR (2009), Su WC (2009), Hernandez-Negrete I (2007), Yan X (2012), Ramirez-Rangel I (2011), Ramirez-Rangel I (2011), Martin J (2008), Martin J (2008), Linares JF (2013), Coffman K (2014), Oshiro N (2014), Thedieck K (2007), Thedieck K (2007), Thedieck K (2007), Dan HC (2008), Dan HC (2008), Dan HC (2008), Hong F (2008), Hong F (2008), Choo AY (2008), Toschi A (2009), Loewith R (2002), Xu Y (2013), Sancak Y (2010), Sancak Y (2010), Vander Haar E (2007), Vander Haar E (2007), Kaadige MR (2015), Misra UK (2014), Misra UK (2014), Thedieck K (2007), Thomas JD (2014), Park D (2014), Alayev A (2016), Alayev A (2016)	91
HTR6	3	EXOC2	5	affinity chromatography technology	Meffre J (2012)	1
TELO2	6	ATM	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Kaizuka T (2010), Takai H (2010), Takai H (2007), Takai H (2007)	4
HTR6	3	CAND2	7	affinity chromatography technology	Meffre J (2012)	1
TTI1	3	TELO2	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Kaizuka T (2010), Kaizuka T (2010), Takai H (2010), Takai H (2010), Izumi N (2010), Kristensen AR (2012), Hurov KE (2010)	7
HTR6	3	ATR	6	affinity chromatography technology	Meffre J (2012)	1
HTR6	3	NSF	3	affinity chromatography technology	Meffre J (2012)	1
HTR6	3	DNM2	2	affinity chromatography technology	Meffre J (2012)	1
HTR6	3	IPO8	9	affinity chromatography technology	Meffre J (2012)	1
TELO2	6	SMG1	7	affinity chromatography technology, affinity chromatography technology	Kaizuka T (2010), Takai H (2007)	2
TTI1	3	ATM	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kaizuka T (2010), Hurov KE (2010), Hurov KE (2010)	3
HTR6	3	MTOR	14	affinity chromatography technology, affinity chromatography technology	Meffre J (2012), Meffre J (2012)	2
HTR6	3	TTI1	3	affinity chromatography technology	Meffre J (2012)	1
HTR6	3	TNPO1	1	affinity chromatography technology	Meffre J (2012)	1
HTR6	3	COPS5	0	pull down, affinity chromatography technology, two hybrid, affinity chromatography technology	Yun HM (2010), Yun HM (2010), Yun HM (2010), Yun HM (2010)	4
MTOR	14	TTI1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kaizuka T (2010), Kaizuka T (2010), Agrawal P (2012), Hurov KE (2010)	4
RANBP6	5	CLTC	12	biochemical	Wan C (2015)	1
HTR6	3	CDK5	0	affinity chromatography technology	Meffre J (2012)	1
HTR6	3	XPOT	1	affinity chromatography technology	Meffre J (2012)	1
HTR6	3	TELO2	6	affinity chromatography technology	Meffre J (2012)	1
TNPO1	1	RANBP6	5	biochemical	Wan C (2015)	1
TTI1	3	ATR	6	affinity chromatography technology, affinity chromatography technology	Kaizuka T (2010), Hurov KE (2010)	2
COPS5	0	CLTC	12	affinity chromatography technology	Bennett EJ (2010)	1
HTR6	3	NCDN	4	affinity chromatography technology	Meffre J (2012)	1
HTR6	3	COG3	0	affinity chromatography technology	Meffre J (2012)	1
ATR	6	ATM	9	unspecified method, enzymatic study	Kim ST (1999), Stiff T (2006)	2
HTR6	3	NCAPG	3	affinity chromatography technology	Meffre J (2012)	1
TELO2	6	ATR	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kaizuka T (2010), Takai H (2010), Takai H (2010), Takai H (2007), Takai H (2007), Collis SJ (2007), Collis SJ (2007), Collis SJ (2007), Rendtlew Danielsen JM (2009), Rendtlew Danielsen JM (2009)	10
XPO4	4	MTOR	14	affinity chromatography technology	Boldt K (2016)	1
HTR6	3	XPO4	4	affinity chromatography technology	Meffre J (2012)	1
HTR6	3	RANBP6	5	affinity chromatography technology	Meffre J (2012)	1
HTR6	3	NF1	16	affinity chromatography technology, affinity chromatography technology	Meffre J (2012), Meffre J (2012)	2
ATR	6	CLTC	12	affinity chromatography technology	So J (2015)	1
HTR6	3	CLTC	12	affinity chromatography technology	Meffre J (2012)	1
HTR6	3	ATXN10	3	affinity chromatography technology	Meffre J (2012)	1
TELO2	6	MTOR	14	affinity chromatography technology, affinity chromatography technology, pull down	Takai H (2010), Takai H (2007), Takai H (2007)	3
ATM	9	COPS5	0	enzymatic study	Nagarajan A (2014)	1
HTR6	3	RPTOR	4	affinity chromatography technology, affinity chromatography technology	Meffre J (2012), Meffre J (2012)	2
HTR6	3	TBCD	4	affinity chromatography technology	Meffre J (2012)	1
HTR6	3	SMG1	7	affinity chromatography technology	Meffre J (2012)	1