PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
GPS1	1	COPS2	5	affinity chromatography technology, affinity chromatography technology, pull down, far western blotting, two hybrid, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Stotland A (2012), Huang X (2005), Sharon M (2009), Kapelari B (2000), Tsuge T (2001), Havugimana PC (2012), Kristensen AR (2012), Lingaraju GM (2014), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	11
TRIM21	0	USP4	3	two hybrid, enzymatic study, enzymatic study, two hybrid	Di Donato F (2001), Wada K (2006), Wada K (2006), Hayes SD (2012)	4
IRF8	4	IRF2	7	affinity chromatography technology	Sharf R (1995)	1
IRF1	0	IRF2	7	pull down	Tooze RM (2006)	1
TRAF6	0	IRF8	4	affinity chromatography technology	Zhao J (2006)	1
PDGFRB	8	ETV6	1	affinity chromatography technology	Huang W (2012)	1
COPS6	0	NFKB1	2	affinity chromatography technology	Bennett EJ (2010)	1
COPS6	0	CDK4	2	affinity chromatography technology	Bennett EJ (2010)	1
COPS2	5	COPS4	0	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Huang X (2005), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	8
COPS6	0	COPS4	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, pull down, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sharon M (2009), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Kotiguda GG (2012), Kotiguda GG (2012), Kotiguda GG (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	14
COPS5	0	GPS1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Sowa ME (2009), Stotland A (2012), Bennett EJ (2010), Oh W (2006), Chun Y (2013), Chun Y (2013), Chun Y (2013), Lingaraju GM (2014), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	11
PDGFRB	8	IRF8	4	affinity chromatography technology	Huang W (2012)	1
NFKB1	2	RELA	1	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, imaging technique, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Palvimo JJ (1996), Dhar SK (2006), Williams SA (2006), Williams SA (2006), Hassa PO (2005), Hassa PO (2005), Sasaki CY (2005), Jeon YJ (2010), Urban MB (1991), Beauchef G (2012), Ryo A (2003), Burstein E (2005), Beinke S (2002), Sharif-Askari E (2010), Mifflin RC (2002), Nie M (2003), Nehra R (2010), Wang J (2011), Mellits KH (1993), Gallois C (1998), Milanovic M (2013), Milanovic M (2013), Kwon JH (2003), Cimen I (2011), Saha RN (2007), Wi SM (2014), Wi SM (2014), Hochrainer K (2012), Longoni N (2013), Li X (2015)	31
IRF8	4	CDK4	2	affinity chromatography technology	Li S (2011)	1
GPS1	1	RELA	1	affinity chromatography technology	Schweitzer K (2015)	1
IRF8	4	IRF1	0	two hybrid, affinity chromatography technology, pull down	Schaper F (1998), Sharf R (1995), Kautz B (2001)	3
RELA	1	IRF8	4	pull down	Drew PD (1995)	1
IRF8	4	CBL	7	affinity chromatography technology	Xiong H (2005)	1
NFKB1	2	IRF2	7	pull down	Drew PD (1995)	1
COPS5	0	COPS4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Fang L (2008), Bennett EJ (2010), Oh W (2006), Olma MH (2009), Olma MH (2009), Kotiguda GG (2012), Kristensen AR (2012), Huttlin EL (2015), Bhansali M (2014), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	13
RELA	1	CDK4	2	affinity chromatography technology	Veena MS (2014)	1
IRF8	4	GPS1	1	affinity chromatography technology	Li S (2011)	1
TRAF6	0	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sanz L (2000), Sanz L (2000), Nakamura K (2010), Kim JY (2009), Seibenhener ML (2004), Feng Y (2005), Martin P (2006), Martin P (2006), Geetha T (2012), Geetha T (2012), Linares JF (2013), Linares JF (2011), Linares JF (2015), Schimmack G (2017), Tsai WT (2016)	15
COPS5	0	COPS2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Fang L (2008), Huang X (2005), Bennett EJ (2010), Kapelari B (2000), Oh W (2006), Olma MH (2009), Havugimana PC (2012), Christmann M (2013), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Scherer PC (2016), Huttlin EL (2017), Boldt K (2016)	15
ZBTB17	2	IRF8	4	two hybrid	Alter-Koltunoff M (2003)	1
IRF8	4	COPS5	0	affinity chromatography technology	Li S (2011)	1
IRF8	4	USP4	3	affinity chromatography technology, affinity chromatography technology	Lin R (2017), Lin R (2017)	2
IRF1	0	CBL	7	affinity chromatography technology	Shen M (2011)	1
IRF8	4	ETV6	1	affinity chromatography technology	Kong HJ (2007)	1
COPS5	0	TOP1	1	affinity chromatography technology	Bennett EJ (2010)	1
IRF8	4	COPS6	0	affinity chromatography technology	Li S (2011)	1
RELA	1	IRF2	7	pull down	Drew PD (1995)	1
IRF8	4	COPS4	0	affinity chromatography technology	Li S (2011)	1
SQSTM1	0	IRF8	4	affinity chromatography technology, affinity chromatography technology	Kim JY (2009), Kim JY (2009)	2
TRAF6	0	USP4	3	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology	Xiao N (2011), Xiao N (2011), Xiao N (2011), Xiao N (2011), Zhou F (2012), Zhou F (2012)	6
IRF8	4	TRIM21	0	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Kong HJ (2007), Kong HJ (2007), Kong HJ (2007), Kong HJ (2007)	4
COPS6	0	GPS1	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Stotland A (2012), Sharon M (2009), Bennett EJ (2010), Lingaraju GM (2014), Huttlin EL (2015), Huttlin EL (2017)	7
COPS5	0	COPS6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, pull down, x-ray crystallography, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Fang L (2008), Sharon M (2009), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Choi HH (2011), Kristensen AR (2012), Birol M (2014), Birol M (2014), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	18
IRF8	4	COPS2	5	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Cohen H (2000), Cohen H (2000), Cohen H (2000), Li S (2011)	4
IRF8	4	MID1	1	affinity chromatography technology	Li S (2011)	1
SPI1	1	IRF8	4	pull down, pull down	Eklund EA (1998), Kautz B (2001)	2
GPS1	1	COPS4	0	affinity chromatography technology, two hybrid, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical	Stotland A (2012), Tsuge T (2001), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Lingaraju GM (2014), Wan C (2015)	7
NFKB1	2	IRF8	4	pull down	Drew PD (1995)	1
SPI1	1	IRF1	0	pull down, pull down	Eklund EA (1998), Kautz B (2001)	2
COPS5	0	NFKB1	2	affinity chromatography technology, two hybrid	Bennett EJ (2010), Wang J (2011)	2
COPS6	0	COPS2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huang X (2005), Bennett EJ (2010), Kapelari B (2000), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	11
COPS5	0	CDK4	2	affinity chromatography technology	Bennett EJ (2010)	1
CBL	7	TRIM21	0	affinity chromatography technology	Brehme M (2009)	1
SQSTM1	0	TRIM21	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology	Kim JY (2009), Kim JY (2009), Kimura T (2015), Milan E (2015), Pan JA (2016), Pan JA (2016)	6
IRF8	4	IRF8	4	affinity chromatography technology	Kong HJ (2007)	1
IRF6	2	IRF8	4	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Li S (2011), Li S (2011), Li S (2011), Li S (2011)	4
CDK4	2	TOP1	1	genetic interference	Shen JP (2017)	1
TOP1	1	IRF8	4	unspecified method	Trzcinska AM (2002)	1