PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TK1	0	CDKN1A	1	affinity chromatography technology, pull down	Huang DY (2001), Huang DY (2001)	2
SP110	3	NAP1L2	1	two hybrid	Ravasi T (2010)	1
CEBPA	0	SP110	3	affinity chromatography technology	Bararia D (2008)	1
ANXA7	0	SP110	3	two hybrid	Vinayagam A (2011)	1
TTR	0	SP110	3	two hybrid	Vinayagam A (2011)	1
SMN1	0	SP110	3	two hybrid	Vinayagam A (2011)	1
ZSCAN26	1	SP110	3	affinity chromatography technology	Hein MY (2015)	1
THOC1	1	SP110	3	affinity chromatography technology	Hein MY (2015)	1
SMN1	0	KPNB1	3	affinity chromatography technology, pull down	Narayanan U (2002), Narayanan U (2002)	2
FGFR1OP	0	SP110	3	affinity chromatography technology	Hein MY (2015)	1
TSC22D1	1	SP110	3	two hybrid	Vinayagam A (2011)	1
KIF22	1	SP110	3	affinity chromatography technology	Hein MY (2015)	1
NDUFV2	0	SP110	3	two hybrid	Stelzl U (2005)	1
OSGEP	1	SP110	3	two hybrid	Vinayagam A (2011)	1
TK1	0	SP110	3	two hybrid	Vinayagam A (2011)	1
KPNB1	3	SP110	3	affinity chromatography technology	Hein MY (2015)	1
CDKN1A	1	CEBPA	0	pull down, two hybrid	Timchenko NA (1997), Timchenko NA (1997)	2
SP110	3	ZSCAN9	0	two hybrid	Ravasi T (2010)	1
RUNX3	1	SP110	3	two hybrid	Ravasi T (2010)	1
USP7	14	SP110	3	affinity chromatography technology	Bhattacharya S (2015)	1
CDKN1A	1	SP110	3	two hybrid	Vinayagam A (2011)	1