Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
APOC3 345 RITONAVIR CHEMBL163 PharmGKB

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
APOC3 rs2854116 CC + CT fenofibrate efficacy no No significant difference in the change in plasma triglyceride (TG) or high-density lipoprotein (HDL) levels between genotypes was seen, after three weeks of treatment with fenofibrate. Please note alleles have been complemented to the plus chromosomal strand. Genotypes CC + CT are not associated with response to fenofibrate in people with Hypertriglyceridemia as compared to genotype TT. 19057464 982038082
APOC3 rs4520 CT + TT fenofibrate efficacy no No significant difference in the change in plasma triglyceride (TG) or high-density lipoprotein (HDL) levels between genotypes was seen, after three weeks of treatment with fenofibrate. Genotypes CT + TT are not associated with response to fenofibrate in people with Hypertriglyceridemia as compared to genotype CC. 19057464 982038089
APOC3 rs2542052 AA + AC fenofibrate efficacy no No significant difference in the change in plasma triglyceride (TG) or high-density lipoprotein (HDL) levels between genotypes was seen, after three weeks of treatment with fenofibrate. Genotypes AA + AC are not associated with response to fenofibrate in people with Hypertriglyceridemia as compared to genotype CC. 19057464 982038068
APOC3 rs2542051 AC + CC fenofibrate efficacy no No significant difference in the change in plasma triglyceride (TG) or high-density lipoprotein (HDL) levels between genotypes was seen, after three weeks of treatment with fenofibrate. Genotypes AC + CC are not associated with response to fenofibrate in people with Hypertriglyceridemia as compared to genotype AA. 19057464 982038060
APOC3 rs2854117 CT + TT fenofibrate efficacy no No significant difference in the change in plasma triglyceride (TG) or high-density lipoprotein (HDL) levels between genotypes was seen, after three weeks of treatment with fenofibrate. Please note alleles have been complemented to the plus chromosomal strand. Genotypes CT + TT are not associated with response to fenofibrate in people with Hypertriglyceridemia as compared to genotype CC. 19057464 982038075
APOC3 rs5128 CC + CG fenofibrate efficacy no No significant difference in the change in plasma triglyceride (TG) or high-density lipoprotein (HDL) levels between genotypes was seen, after three weeks of treatment with fenofibrate. Genotypes CC + CG are not associated with response to fenofibrate in people with Hypertriglyceridemia as compared to genotype GG. 19057464 982038097