Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications
IFNGR1	3459	INTERFERON GAMA-1B	CHEMBL1201564	agonist, binder	TdgClinicalTrial, ChemblInteractions, TEND, DrugBank, TTD	17618444, 11752352, 17251453
IFNGR1	3459	INDOLE-3-CARBINOL	CHEMBL155625		NCI	14988219
IFNGR1	3459	SALMETEROL	CHEMBL1263	agonist	GuideToPharmacologyInteractions

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
IFNGR1	rs2234711	AG	Tumor necrosis factor alpha	efficacy	yes	When comparing responders vs. non-responders. However, no significant association was seen when comparing the GG vs AA genotype, or the AG+GG vs AA genotype. Additionally, no association was seen for any genotype when considering responders vs. non- and partial-responders. Please note that alleles have been complemented to the plus chromosomal strand.	Genotype AG is associated with decreased response to Tumor necrosis factor alpha (TNF-alpha) inhibitors in people with Colitis, Ulcerative as compared to genotype AA.	28139755	1448604165
IFNGR1	rs2234711	AG	Tumor necrosis factor alpha	efficacy	yes	When comparing responders vs. non-responders. However, no significant association was seen when comparing the GG vs AA genotype, or the AG+GG vs AA genotype. Additionally, no association was seen for any genotype when considering responders vs. non- and partial-responders. Please note that alleles have been complemented to the plus chromosomal strand.	Genotype AG is associated with decreased response to Tumor necrosis factor alpha (TNF-alpha) inhibitors in people with Inflammatory Bowel Diseases as compared to genotype AA.	28139755	1448604213