PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
COMTD1	1	IFRD1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MYOD1	0	MEF2C	16	two hybrid, pull down	Black BL (1998), Micheli L (2005)	2
FOXL1	0	IFRD1	2	affinity chromatography technology	Li X (2015)	1
HNRNPL	3	IFRD1	2	affinity chromatography technology	Fei T (2017)	1
CD70	0	IFRD1	2	affinity chromatography technology	Huttlin EL (2017)	1
IFRD1	2	HDAC4	10	pull down	Micheli L (2005)	1
CTNNB1	30	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vietor I (2005), Billin AN (2000), Iguchi H (2007), Iioka H (2009)	4
IFRD1	2	HDAC1	4	affinity chromatography technology, affinity chromatography technology	Vietor I (2002), Vietor I (2002)	2
CSNK2A1	15	HDAC1	4	enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology	Pflum MK (2001), Cai R (2001), Sun JM (2007), Zhang M (2011), Joshi P (2013)	5
EIF2AK2	1	GTPBP4	2	affinity chromatography technology	Li S (2011)	1
EIF2AK2	1	IFRD1	2	affinity chromatography technology	Li S (2011)	1
CSNK2A1	15	IFRD1	2	enzymatic study	Ge H (1994)	1
IFRD1	2	IFRD1	2	pull down	Micheli L (2005)	1
MYOD1	0	IFRD1	2	affinity chromatography technology, pull down	Philipot O (2010), Micheli L (2005)	2
CSNK2A1	15	HNRNPL	3	enzymatic study	Zhang M (2011)	1
GTPBP4	2	IFRD1	2	affinity chromatography technology	Li S (2014)	1
IFRD1	2	MEF2C	16	pull down, pull down, affinity chromatography technology	Micheli L (2005), Micheli L (2005), Micheli L (2005)	3
HDAC4	10	MEF2C	16	affinity chromatography technology, pull down, pull down, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Wang AH (1999), Wang AH (1999), Wang AH (2001), Chan JK (2003), Wang AH (2005), Micheli L (2005), Backs J (2008), Dressel U (2001)	8
HDAC1	4	MYOD1	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology	Puri PL (2001), Puri PL (2001), Mal A (2001), Bruscoli S (2010)	4
HNRNPL	3	HDAC4	10	affinity chromatography technology	Fei T (2017)	1
CTNNB1	30	IFRD1	2	affinity chromatography technology	Vietor I (2005)	1
CTNNB1	30	HDAC4	10	affinity chromatography technology	Vietor I (2005)	1
TCEAL4	0	IFRD1	2	affinity chromatography technology	Hein MY (2015)	1