PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MAD1L1	2	FAM131C	0	two hybrid	Rual JF (2005)	1
EWSR1	2	FAM131C	0	two hybrid	Rual JF (2005)	1
GRN	2	FAM131C	0	two hybrid	Rual JF (2005)	1
HPCAL4	0	FAM131C	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
APP	1	MYC	2	pull down	Virok DP (2011)	1
LMO3	0	FAM131C	0	two hybrid	Rolland T (2014)	1
NDN	0	FAM131C	0	two hybrid	Corominas R (2014)	1
MYC	2	FAM131C	0	genetic interference	Toyoshima M (2012)	1
SFI1	3	FAM131C	0	two hybrid	Rolland T (2014)	1
VSNL1	0	FAM131C	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
MYC	2	DNAJA3	2	affinity chromatography technology	Koch HB (2007)	1
FAM131C	0	APP	1	pull down	Olah J (2011)	1
DNAJA3	2	FAM131C	0	two hybrid	Rual JF (2005)	1