PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
AKT1	1	APOH	0	two hybrid	Wang J (2008)	1
TP53	0	FLNA	10	affinity chromatography technology	Horikawa I (2014)	1
APOH	0	FLNA	10	affinity chromatography technology	Huttlin EL (2017)	1
GRB2	2	RBBP6	7	two hybrid, affinity chromatography technology	Bandyopadhyay S (2010), Bisson N (2011)	2
GEM	1	CLEC4G	0	two hybrid	Wang J (2008)	1
TP53	0	ANXA2	0	pull down	Lu H (1997)	1
GRB2	2	FLNA	10	affinity chromatography technology	Bisson N (2011)	1
ANXA2	0	APOH	0	pull down	Ma K (2000)	1
GEM	1	APOH	0	two hybrid	Wang J (2008)	1
RBBP6	7	APOH	0	two hybrid	Wang J (2008)	1
CDC42	3	APOH	0	two hybrid	Wang J (2008)	1
ATP4A	6	APOH	0	affinity chromatography technology	Lapierre LA (2007)	1
CDC42	3	TP53	0	two hybrid	Stelzl U (2005)	1
GRB2	2	APOH	0	two hybrid	Wang J (2008)	1
FLNA	10	ANXA2	0	affinity chromatography technology	Hein MY (2015)	1
APOH	0	LRP8	4	affinity chromatography technology	Lutters BC (2003)	1
CLEC4G	0	APOH	0	two hybrid	Wang J (2008)	1
TP53	0	APOH	0	two hybrid	Wang J (2008)	1
RBBP6	7	TP53	0	affinity chromatography technology, pull down	Simons A (1997), Simons A (1997)	2
GRB2	2	CDC42	3	two hybrid	Vinayagam A (2011)	1
ATP4A	6	ANXA2	0	affinity chromatography technology	Lapierre LA (2007)	1
APOH	0	LRP2	13	pull down	Moestrup SK (1998)	1
TP53	0	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
GRB2	2	ANXA2	0	affinity chromatography technology, affinity chromatography technology	Buday L (1994), Brehme M (2009)	2