Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
IL1A 3552 AMG-108 CHEMBL2109458 TdgClinicalTrial
IL1A 3552 RILONACEPT CHEMBL1201830 binder TdgClinicalTrial, TEND, DrugBank 23319019, 23553601
IL1A 3552 MITOMYCIN CHEMBL105 NCI 8195120
IL1A 3552 RA-18C3 CHEMBL2109653 inhibitor ChemblInteractions
IL1A 3552 HYDROXYCHLOROQUINE CHEMBL1535 NCI 8336306

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
IL1A rs11677416 C olanzapine "dosage","efficacy" yes Adjacent SNPs also showed evidence for association. Associated allele is reported as the minor allele being associated with greater response. dbSNP shows C to be the minor allele in all populations reported upon. GWAS p = 6.6 x 10 (-7) for 492K SNPs, so Bonferroni-corrected p is 0.32 . Allele C is associated with increased response to olanzapine in people with Schizophrenia as compared to allele T. 21107309 981502120