PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TRAF6	0	IRAK2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Wesche H (1999), Muzio M (1997), Keating SE (2007), Li S (2011), Li S (2011), Wang J (2011), Wang H (2015), Huttlin EL (2017)	8
TOLLIP	3	TRAF6	0	affinity chromatography technology	Lee JY (2009)	1
MYD88	1	IRAK4	0	affinity chromatography technology, protein complementation assay, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Li S (2002), Ulrichts P (2008), Ulrichts P (2008), Zhou J (2011), Zhou J (2011), Burns K (2003), Burns K (2003), Strelow A (2003), Loiarro M (2007), Jeon J (2014), Rolland T (2014)	11
MYD88	1	IRAK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen BC (2002), Wesche H (1999), Li S (2002), Fitzgerald KA (2001), Fitzgerald KA (2001), Li S (2011), Neumann D (2007), Zhou J (2011), Burns K (2003), Mizobe T (2007), Loiarro M (2007), Choi KC (2006), Rao N (2005), Rao N (2005), Li CH (2006)	15
IL1R1	0	TNFRSF10B	1	affinity chromatography technology	Huttlin EL (2017)	1
PELI1	1	MYD88	1	affinity chromatography technology	Choi KC (2006)	1
IL1R1	0	HERPUD1	2	affinity chromatography technology	McLaughlin M (2010)	1
IL1R1	0	TUBB8	2	affinity chromatography technology	Huttlin EL (2017)	1
IL1R1	0	IL1RN	2	x-ray crystallography	Schreuder H (1997)	1
TOM1	3	TOLLIP	3	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, x-ray crystallography, pull down	Yamakami M (2003), Yamakami M (2003), Yamakami M (2003), Katoh Y (2006), Katoh Y (2004), Rolland T (2014), Katoh Y (2004), Xiao S (2015), Xiao S (2015)	9
IRAK2	3	PELI1	1	affinity chromatography technology	Butler MP (2007)	1
MYD88	1	IRAK2	3	affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology	Wesche H (1999), Fitzgerald KA (2001), Muzio M (1997), Zhou J (2011)	4
IL1R1	0	SIGIRR	3	affinity chromatography technology	Wald D (2003)	1
TRAF6	0	IRAK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Wesche H (1999), Qian Y (2001), Cao Z (1996), Takatsuna H (2003), Li S (2002), Ling L (2000), Ling L (2000), Takaesu G (2001), Muzio M (1997), Chen F (2008), Li X (2001), Li X (2001), Xiong Y (2011), Xiong Y (2011), Tang H (2010), Muroi M (2011), Liu A (2012), Lee JY (2009), Lee JY (2009), Kollewe C (2004), Jiang Z (2002), Jensen LE (2001), Liu G (2007), Liu G (2007), Jiang Z (2003), Nguyen T (2009), Choi KC (2006), Rao N (2005), Rao N (2005), Lakshmanan U (2007), Lee HJ (2012), Lee HJ (2012), Zhang X (2013), Yao J (2007), Hu MM (2014), Jeon J (2014), Conze DB (2008), Tanishima M (2017)	38
IRAK4	0	PELI1	1	affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology	Butler MP (2007), Ordureau A (2008), Smith H (2009), Smith H (2011), Jiang Z (2003), Choi KC (2006)	6
MYD88	1	TRAF6	0	genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fitzgerald KA (2001), Zhou J (2011), Zhou J (2011), Zhang X (2013), Zhang X (2013), Hirata Y (2006)	6
TRAF6	0	TICAM2	0	pull down, pull down, affinity chromatography technology, pull down	Bin LH (2003), Bin LH (2003), Verstak B (2014), Verstak B (2014)	4
IL1RAP	3	MYD88	1	genetic interference	Fitzgerald KA (2001)	1
IL1R1	0	MYD88	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Burns K (2000), Muzio M (1997), Jiang Z (2003), Chen R (2012), Burns K (1998), Jeon J (2014)	6
IL1R1	0	MFAP3	2	affinity chromatography technology	Huttlin EL (2017)	1
TNFRSF10B	1	MFAP3	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TOLLIP	3	IRAK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Burns K (2000), Brissoni B (2006), Li S (2011), Lee JY (2009), Yagasaki Y (2004), Neumann D (2007), Ohnuma K (2005), Ohnuma K (2005), Jensen LE (2001), Rao N (2005), Lee HJ (2012), Lei L (2016)	12
IL1R1	0	ICK	1	affinity chromatography technology	Huttlin EL (2017)	1
IL1R1	0	PIK3R1	6	affinity chromatography technology, affinity chromatography technology	Reddy SA (1997), Reddy SA (1997)	2
IRAK1	1	IRAK2	3	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, fluorescent resonance energy transfe	Li S (2011), Li S (2011), Ross K (2002), Ross K (2002)	4
IL1R1	0	ATP2A3	5	affinity chromatography technology	Huttlin EL (2017)	1
IL1R1	0	IRAK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jiang Z (2003), Jiang Z (2002), Jiang Z (2002), Chen R (2012), Cao Z (1996), Cao Z (1996), Rao N (2005), Jeon J (2014)	8
IL1R1	0	IRAK4	0	affinity chromatography technology	Jiang Z (2003)	1
IL1RAP	3	MARCH8	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Chen R (2012), Chen R (2012), Chen R (2012)	3
IL1B	0	IL1R1	0	pull down	Symons JA (1995)	1
IL1R1	0	TOLLIP	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Burns K (2000), Brissoni B (2006), Brissoni B (2006)	3
IL1RAP	3	TOLLIP	3	two hybrid, affinity chromatography technology	Burns K (2000), Burns K (2000)	2
SIGIRR	3	IRAK1	1	affinity chromatography technology	Wald D (2003)	1
IRAK2	3	IL1R1	0	affinity chromatography technology	Muzio M (1997)	1
TOLLIP	3	HERPUD1	2	two hybrid	Bandyopadhyay S (2010)	1
TRAF6	0	IRAK4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li S (2002), Li S (2002), Zhang X (2013)	3
IRAK4	0	IRAK2	3	affinity chromatography technology	Li S (2011)	1
TOLLIP	3	IRAK2	3	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
IL1RAP	3	IRAK1	1	affinity chromatography technology, affinity chromatography technology	Huang J (1997), Jeon J (2014)	2
IRAK4	0	IRAK1	1	affinity chromatography technology, enzymatic study, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Li S (2002), Li S (2002), Ulrichts P (2008), Li S (2011), Neumann D (2007), Burns K (2003), Liu G (2007), Strelow A (2003), Nguyen T (2009), Choi KC (2006), Rao N (2005), Rao N (2005), Jeon J (2014)	13
PELI1	1	IL1R1	0	affinity chromatography technology	Jiang Z (2003)	1
IL1R1	0	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jiang Z (2003), Jiang Z (2002), Jiang Z (2003), Rafferty BJ (2010)	4
IL1R1	0	TICAM2	0	affinity chromatography technology	Bin LH (2003)	1
IL1R1	0	IL1RAP	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huang J (1997), Huang J (1997), Jeon J (2014)	3
IL1R1	0	MARCH8	0	affinity chromatography technology	Chen R (2012)	1
TRAF6	0	SIGIRR	3	affinity chromatography technology, affinity chromatography technology	Wald D (2003), Wald D (2003)	2
IL1R1	0	TOM1	3	affinity chromatography technology	Brissoni B (2006)	1
PELI1	1	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jiang Z (2003), Jiang Z (2003), Choi KC (2006), Jensen LE (2003)	4
IL1R1	0	BMPR1A	5	affinity chromatography technology	Huttlin EL (2017)	1
IL1RAP	3	TICAM2	0	affinity chromatography technology	Bin LH (2003)	1
PELI1	1	IRAK1	1	affinity chromatography technology, enzymatic study, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Butler MP (2007), Ordureau A (2008), Lin CC (2008), Smith H (2009), Smith H (2011), Jiang Z (2003), Choi KC (2006), Choi KC (2006), Butler MP (2005), Schauvliege R (2006), Murphy M (2015)	11