Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
IL2 3558 DIDEMNIN B CHEMBL2304286 NCI 3258949
IL2 3558 TARGININE CHEMBL256147 NCI 8475085
IL2 3558 ACETAMINOPHEN CHEMBL112 NCI 11053919
IL2 3558 CHEMBL106187 CHEMBL106187 DrugBank 17139284, 17016423, 10592235
IL2 3558 GIRENTUXIMAB CHEMBL1743027 DrugBank
IL2 3558 CEFEPIME CHEMBL186 NCI 8106902
IL2 3558 CYCLOSPORINE CHEMBL160 NCI 12135706, 7529939
IL2 3558 HALOFUGINONE CHEMBL1197091 NCI 15177499
IL2 3558 ITRACONAZOLE CHEMBL22587 NCI 1330944
IL2 3558 TYLOSIN CHEMBL42743 NCI 1513198
IL2 3558 QUININE CHEMBL170 NCI 2846451, 3497888
IL2 3558 ROXITHROMYCIN CHEMBL1214185 NCI 1513198
IL2 3558 CHEMBL429852 CHEMBL429852 DrugBank 17139284, 17016423, 10592235
IL2 3558 PERFOSFAMIDE CHEMBL61511 NCI 3497116
IL2 3558 GONADOTROPIN, CHORIONIC CHEMBL1201509 NCI 9334854
IL2 3558 INTERFERON BETA-1B CHEMBL1201563 NCI 9628465
IL2 3558 PRAVASTATIN CHEMBL1144 NCI 16051523
IL2 3558 TROPISETRON CHEMBL56564 NCI 11053919
IL2 3558 APREMILAST CHEMBL514800 DrugBank
IL2 3558 PRASTERONE CHEMBL90593 NCI 16091484
IL2 3558 GLYBURIDE CHEMBL472 NCI 10466081
IL2 3558 PEFLOXACIN CHEMBL267648 NCI 9869897
IL2 3558 PYRIMETHAMINE CHEMBL36 NCI 3497888
IL2 3558 CALCITRIOL CHEMBL846 NCI 3492067
IL2 3558 DIETHYLSTILBESTROL DIPHOSPHATE CHEMBL1200598 NCI 8083332
IL2 3558 GARLIC CHEMBL2108463 NCI 10737264
IL2 3558 GENTAMICIN CHEMBL3039597 NCI 1598936
IL2 3558 METHOTREXATE CHEMBL34259 NCI 9669212
IL2 3558 PENTAMIDINE ISETHIONATE CHEMBL935 NCI 8564607
IL2 3558 PROCHLORPERAZINE CHEMBL728 NCI 8564607
IL2 3558 BECLOMETHASONE CHEMBL1586 NCI 8071057
IL2 3558 EDARAVONE CHEMBL290916 NCI 1698527
IL2 3558 TICARCILLIN CHEMBL1449 NCI 1598936
IL2 3558 AZIRIDINE CHEMBL540990 NCI 17197726
IL2 3558 BROMOCRIPTINE CHEMBL493 NCI 8191163
IL2 3558 CLOZAPINE CHEMBL42 NCI 15053234
IL2 3558 IMIPENEM CHEMBL148 NCI 7796708
IL2 3558 AMIKACIN SULFATE CHEMBL1164318 NCI 1598936
IL2 3558 MIDOSTAURIN CHEMBL608533 NCI 15914319
IL2 3558 METOCLOPRAMIDE CHEMBL86 NCI 8191163
IL2 3558 OFLOXACIN CHEMBL4 NCI 2115511
IL2 3558 TRICHOSTATIN CHEMBL99 NCI 8682722

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
IL2 rs6822844 G adalimumab efficacy no Allele G is not associated with response to adalimumab, etanercept, infliximab or Tumor necrosis factor alpha (TNF-alpha) inhibitors in people with Arthritis, Rheumatoid as compared to allele T. 23007924 981417569
IL2 rs6822844 GG rituximab efficacy yes The GG genotype frequency was increased in responders as compared to non-responders. This was significant in multivariate logistic regression analysis after adjusting for gender, age, corticosteroids, DMARDs and other therapies. SNP is described as being in the IL2-IL21 gene region. Genotype GG is associated with increased response to rituximab in people with Lupus Erythematosus, Systemic as compared to genotype GT. 23645042 1184166980
IL2 rs6822844 GG rituximab efficacy yes The GG genotype frequency was increased in responders as compared to non-responders. For a list of the various systemic autoimmune diseases included, please refer to the paper directly. This analysis was run including patients with systemic lupus erythematosus (n = 144; significant result) and without including them (n = 60; non-significant result). SNP is described as being in the IL2-IL21 gene region. Genotype GG is associated with increased response to rituximab in people with Autoimmune Diseases as compared to genotype GT. 23645042 1184166985