PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
IL2RG	0	CAPNS1	0	two hybrid	Noguchi M (1997)	1
IL2RG	0	STK4	1	two hybrid	Wang J (2011)	1
IL2RG	0	GRB10	4	affinity chromatography technology	Warren KJ (2016)	1
GRB10	4	JAK2	1	affinity chromatography technology	Moutoussamy S (1998)	1
JAK3	3	IL2RG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Miyazaki T (1994), Russell SM (1994), Warren KJ (2016)	3
IL2RG	0	CD320	1	affinity chromatography technology	Huttlin EL (2017)	1
NEDD4L	3	NDFIP2	2	enzymatic study, affinity chromatography technology, affinity chromatography technology, far western blotting	Persaud A (2009), Konstas AA (2002), Konstas AA (2002), Konstas AA (2002)	4
NEDD4L	3	GRB10	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Velez P (2016), Velez P (2016), Warren KJ (2016)	3
IL2RG	0	KRTAP10-3	1	two hybrid	Rolland T (2014)	1
SHB	4	JAK3	3	pull down	Lindholm CK (2002)	1
IL2RG	0	FLVCR1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ERRFI1	1	IL2RG	0	two hybrid	Ying H (2010)	1
IL4R	1	GRB10	4	affinity chromatography technology	Warren KJ (2016)	1
IL2RG	0	PTPRD	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
IL4R	1	JAK1	6	pull down, affinity chromatography technology, affinity chromatography technology	Usacheva A (2002), Seki Y (2002), Huttlin EL (2017)	3
IL4R	1	SHC1	0	affinity chromatography technology, pull down	Ikizawa K (2000), Kashiwada M (2001)	2
IL4R	1	JAK2	1	affinity chromatography technology	Murata T (1996)	1
IL2RG	0	JAK2	1	affinity chromatography technology	Tanaka N (1994)	1
IL4R	1	JAK3	3	affinity chromatography technology	Doucet C (2002)	1
IL2RG	0	IL4R	1	affinity chromatography technology	Seki Y (2002)	1
IL2RG	0	IL21	2	affinity chromatography technology	Asao H (2001)	1
IL2RG	0	IL2	0	affinity chromatography technology	Asao H (2001)	1
GRB10	4	NEDD4	2	affinity chromatography technology	Murdaca J (2004)	1
SHC1	0	JAK2	1	pull down, pull down	VanderKuur J (1995), Giordano V (1997)	2
SHB	4	JAK1	6	pull down	Lindholm CK (2002)	1
SHB	4	IL2RG	0	pull down	Lindholm CK (2002)	1
SHC1	0	IL2RG	0	affinity chromatography technology	Ravichandran KS (1996)	1
NEDD4	2	STK4	1	pull down	Persaud A (2009)	1
IL2RG	0	JAK1	6	affinity chromatography technology	Tanaka N (1994)	1
IL4R	1	NEDD4L	3	affinity chromatography technology	Warren KJ (2016)	1
IL2RG	0	NDFIP2	2	affinity chromatography technology	Huttlin EL (2015)	1
JAK3	3	JAK1	6	affinity chromatography technology	Doucet C (2002)	1
IL2RG	0	REEP6	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
JAK3	3	JAK2	1	affinity chromatography technology	Doucet C (2002)	1
NEDD4	2	IL2RG	0	affinity chromatography technology	Malarde V (2009)	1
KRTAP10-3	1	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
IL2RG	0	IL13RA1	0	affinity chromatography technology	Doucet C (2002)	1
IL2RG	0	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
ERRFI1	1	NEDD4	2	affinity chromatography technology, pull down, enzymatic study	Sun M (2016), Sun M (2016), Sun M (2016)	3
NDFIP2	2	NEDD4	2	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology	Cristillo AD (2003), Cristillo AD (2003), Shearwin-Whyatt LM (2004), Woelk T (2006), Ohzono C (2010), Persaud A (2009), Persaud A (2009), Konstas AA (2002)	8
ERRFI1	1	SHC1	0	affinity chromatography technology, affinity chromatography technology	Li J (2013), Li J (2013)	2
IL2RG	0	NEDD4L	3	affinity chromatography technology	Warren KJ (2016)	1