Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
IL11 3589 AZACITIDINE CHEMBL1489 NCI 12543079
IL11 3589 DOXORUBICIN CHEMBL53463 NCI 9363868
IL11 3589 ALENDRONIC ACID CHEMBL870 NCI 12522661
IL11 3589 ETIDRONIC ACID CHEMBL871 NCI 12522661
IL11 3589 FLUOROURACIL CHEMBL185 NCI 1832057, 7691257

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
IL11 rs1126757 CT + TT escitalopram efficacy yes Carriers of the T allele responded significantly better to escitalopram treatment, as compared to CC homozygotes. Response was defined as a percentage Montgomery-Asberg Depression Rating Scale (MADRS) change of greater than 50% between baseline and 12 weeks. Please note alleles have been complemented to the plus chromosomal strand. Genotypes CT + TT is associated with increased response to escitalopram in people with Depression as compared to genotype CC. 23142150 1184510180