PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SUV39H1	0	KDM1A	2	two hybrid	Weimann M (2013)	1
HSPA8	4	PPP1R12B	2	affinity chromatography technology	Polanowska-Grabowska R (1997)	1
IL16	2	HSPA8	4	pull down, affinity chromatography technology	Zhang Y (2008), Zhang Y (2008)	2
KDM1A	2	HDAC3	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cui S (2011), Bantscheff M (2011), Joshi P (2013), Joshi P (2013)	4
TFIP11	5	IL16	2	two hybrid	Yu H (2011)	1
IL16	2	EFEMP2	0	two hybrid	Rual JF (2005)	1
CSNK2A1	15	IL16	2	enzymatic study	Wilson KC (2002)	1
IL16	2	DMRTB1	1	two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009)	2
SSSCA1	0	TRIP6	2	biochemical	Havugimana PC (2012)	1
IL16	2	PPP1R12B	2	two hybrid, affinity chromatography technology, pull down	Bannert N (2003), Bannert N (2003), Bannert N (2003)	3
CDK1	0	IL16	2	enzymatic study	Wilson KC (2002)	1
HDAC3	5	HSPA8	4	pull down	Guenther MG (2002)	1
IL16	2	HDAC3	5	pull down, affinity chromatography technology	Zhang Y (2008), Zhang Y (2008)	2
IL16	2	SUV39H1	0	two hybrid	Weimann M (2013)	1
IL16	2	RNF169	1	affinity chromatography technology	Huttlin EL (2017)	1
CD4	1	HSPA8	4	affinity chromatography technology	Bernhard OK (2004)	1
ZNF148	4	HDAC3	5	affinity chromatography technology, affinity chromatography technology, imaging technique	Feng Y (2009), Feng Y (2009), Feng Y (2009)	3
IL16	2	PPP1R12C	1	two hybrid, affinity chromatography technology	Bannert N (2003), Bannert N (2003)	2
IL16	2	IL16	2	pull down	Cruikshank WW (1994)	1
CSNK2A1	15	KDM1A	2	affinity chromatography technology	Peng B (2015)	1
CSNK2A1	15	HDAC3	5	enzymatic study, affinity chromatography technology	Zhang X (2005), Rajendran P (2011)	2
EWSR1	2	DMRTB1	1	two hybrid	Rual JF (2005)	1
IL16	2	CAMK1	4	affinity chromatography technology	Huttlin EL (2017)	1
CSNK2A1	15	CDK1	0	enzymatic study	Russo GL (1992)	1
PPP1R12A	6	PPP1R12B	2	affinity chromatography technology, bioid	Yadav L (2017), Yadav L (2017)	2
IL16	2	PPP1R12A	6	two hybrid, affinity chromatography technology	Bannert N (2003), Bannert N (2003)	2
IL16	2	KDM1A	2	two hybrid	Weimann M (2013)	1
IL16	2	USHBP1	1	two hybrid	Rual JF (2005)	1
IL16	2	ZNF148	4	affinity chromatography technology	Huttlin EL (2017)	1
NPB	0	IL16	2	affinity chromatography technology	Huttlin EL (2017)	1
KDM1A	2	PPP1R12A	6	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Cho HS (2011), Cho HS (2011), Cho HS (2011), Cho HS (2011)	4
CD4	1	IL16	2	pull down	Cruikshank WW (1994)	1
IL16	2	GABPB1	0	two hybrid	Venkatesan K (2009)	1
LNX2	2	IL16	2	two hybrid	Yu H (2011)	1
EWSR1	2	IL16	2	bioid	Elzi DJ (2014)	1
PPP1R12A	6	PPP1R12C	1	affinity chromatography technology, bioid	Yadav L (2017), Yadav L (2017)	2
IL16	2	SSSCA1	0	two hybrid	Rual JF (2005)	1
IL16	2	NRBP2	2	affinity chromatography technology	Huttlin EL (2017)	1
EWSR1	2	HDAC3	5	two hybrid	Ravasi T (2010)	1
IL16	2	TRIP6	2	two hybrid	Yu H (2011)	1
FBXL13	1	IL16	2	affinity chromatography technology	Fung E (2018)	1
SUV39H1	0	HDAC3	5	affinity chromatography technology, pull down	Vaute O (2002), Vaute O (2002)	2