Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
IMPDH2 3615 CHEMBL451855 CHEMBL451855 DrugBank 17139284, 17016423
IMPDH2 3615 CHEMBL1207374 CHEMBL1207374 DrugBank 17139284, 17016423, 10592235
IMPDH2 3615 MYCOPHENOLATE MOFETIL HYDROCHLORIDE CHEMBL1200955 inhibitor ChemblInteractions
IMPDH2 3615 RIBAVIRIN CHEMBL1643 inhibitor GuideToPharmacologyInteractions, DrugBank 17139284, 17016423
IMPDH2 3615 CHEMBL1161866 CHEMBL1161866 DrugBank 17496727
IMPDH2 3615 MYCOPHENOLIC ACID CHEMBL866 inhibitor PharmGKB, TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, TEND, DrugBank, TTD 15614187, 16629948, 11752352, 15621150, 17496727, 10592235, 16647299
IMPDH2 3615 MYCOPHENOLATE MOFETIL CHEMBL1456 inhibitor PharmGKB, TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, TEND, DrugBank, TTD 11752352, 15621150, 17463174
IMPDH2 3615 THIOGUANINE CHEMBL727 inhibitor GuideToPharmacologyInteractions, ChemblInteractions

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
IMPDH2 rs470119 T fluorouracil efficacy no Allele T is not associated with response to fluorouracil in people with Colonic Neoplasms as compared to allele C. 20665215 827813437
IMPDH2 rs11706052 G mycophenolic acid efficacy not stated Lymphocytes from subjects carrying the G allele had a reduced antiproliferative effect of mycophenolic acid treatment compared to cells from AA individuals. Allele G is associated with decreased response to mycophenolic acid as compared to genotype AA. 19770842 769171119
IMPDH2 rs11706052 AA mercaptopurine dosage no Genotype AA is not associated with dose of mercaptopurine or methotrexate in children with Precursor Cell Lymphoblastic Leukemia-Lymphoma as compared to genotypes AG + GG. 29683944 1449311080