PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HIST2H3C	0	CDCA8	0	pull down	Yamagishi Y (2010)	1
HIST1H3A	3	CDCA8	0	bioid	Lambert JP (2015)	1
HBP1	1	AURKB	2	affinity chromatography technology	Lampert F (2018)	1
8339	0	AURKB	2	bioid	Lambert JP (2015)	1
AURKB	2	INCENP	4	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Gassmann R (2004), Xu Z (2009), Xu Z (2009), Katayama H (2008), Kaitna S (2000), Maerki S (2009), Vader G (2006), Honda R (2003), Ban R (2011), Sun L (2008), Nozawa RS (2010), Jeyaprakash AA (2007), Klein UR (2006), Klein UR (2006), Fu J (2009), Fu J (2009), Li X (2004), Gomez V (2010)	18
EVI5	2	BIRC5	1	affinity chromatography technology, pull down	Faitar SL (2006), Faitar SL (2006)	2
EWSR1	2	INCENP	4	bioid	Elzi DJ (2014)	1
CDCA8	0	INCENP	4	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology	Gassmann R (2004), Gassmann R (2004), Xu Z (2009), Vader G (2006), Knauer SK (2006), Jeyaprakash AA (2007), Jeyaprakash AA (2007), Jeyaprakash AA (2007), Klein UR (2006), Klein UR (2006), Klein UR (2006), Klein UR (2006), Klein UR (2009)	13
HECW2	13	INCENP	4	affinity chromatography technology	Lu L (2013)	1
AURKA	1	BIRC5	1	affinity chromatography technology, enzymatic study	Fu J (2009), Fu J (2009)	2
8339	0	CDCA8	0	bioid	Lambert JP (2015)	1
8339	0	SGO1	2	bioid	Lambert JP (2015)	1
8339	0	BIRC5	1	bioid	Lambert JP (2015)	1
HIST2H3C	0	INCENP	4	pull down	Yamagishi Y (2010)	1
H2AFZ	1	INCENP	4	two hybrid, pull down	Rangasamy D (2003), Rangasamy D (2003)	2
IFI16	1	INCENP	4	affinity chromatography technology	Diner BA (2015)	1
HECW2	13	TRIM25	5	affinity chromatography technology	Lu L (2013)	1
SIRT7	1	INCENP	4	affinity chromatography technology	Tsai YC (2012)	1
SGO1	2	AURKB	2	affinity chromatography technology	Kawashima SA (2007)	1
EVI5	2	INCENP	4	affinity chromatography technology, pull down	Faitar SL (2006), Faitar SL (2006)	2
EGFR	5	HECW2	13	affinity chromatography technology	Yao Z (2017)	1
SGO1	2	CDCA8	0	two hybrid	Tsukahara T (2010)	1
HBP1	1	EWSR1	2	two hybrid	Lim J (2006)	1
TRIM25	5	INCENP	4	affinity chromatography technology	Choudhury NR (2017)	1
EWSR1	2	CDCA8	0	bioid	Elzi DJ (2014)	1
AURKB	2	AURKA	1	affinity chromatography technology	Fogeron ML (2013)	1
EGFR	5	EWSR1	2	affinity chromatography technology	Tong J (2014)	1
HIST1H3A	3	INCENP	4	bioid	Lambert JP (2015)	1
CBX5	3	CDCA8	0	affinity chromatography technology	Nozawa RS (2010)	1
HIST1H3A	3	H2AFZ	1	affinity chromatography technology	Tropberger P (2013)	1
AURKA	1	IFI16	1	pull down	Kamran M (2017)	1
SGO1	2	INCENP	4	affinity chromatography technology	Kawashima SA (2007)	1
CBX5	3	INCENP	4	affinity chromatography technology, two hybrid, affinity chromatography technology	Nozawa RS (2010), Nozawa RS (2010), Nozawa RS (2010)	3
HIST1H3A	3	PHF8	6	pull down, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, affinity chromatography technology, pull down, enzymatic study, pull down, affinity chromatography technology, enzymatic study	Feng W (2010), Feng W (2010), Kleine-Kohlbrecher D (2010), Kleine-Kohlbrecher D (2010), Qi HH (2010), Qiu J (2010), Qiu J (2010), Qiu J (2010), Zhu Z (2010), Fortschegger K (2010), Fortschegger K (2010), Fortschegger K (2010)	12
EVI5	2	AURKB	2	affinity chromatography technology, pull down	Faitar SL (2006), Faitar SL (2006)	2
AURKA	1	INCENP	4	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, enzymatic study	Katayama H (2008), Katayama H (2008), Katayama H (2008), Kaitna S (2000), Kaitna S (2000), Fu J (2009), Fu J (2009), Fu J (2009)	8
HIST2H3C	0	BIRC5	1	pull down, pull down	Yamagishi Y (2010), Yamagishi Y (2010)	2
EGFR	5	INCENP	4	affinity chromatography technology	Yao Z (2017)	1
BIRC5	1	AURKB	2	two hybrid, pull down, genetic interference, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wheatley SP (2001), Chen J (2003), Chen J (2003), Wheatley SP (2001), Xu Z (2009), Maerki S (2009), Knauer SK (2006), Knauer SK (2006), Ban R (2011), Sun L (2008), Noton EA (2006), Noton EA (2006), Fu J (2009), Gomez V (2010)	14
HIST1H3A	3	FLOT1	0	bioid	Lambert JP (2015)	1
8339	0	INCENP	4	bioid	Lambert JP (2015)	1
AURKB	2	HIST2H3C	0	enzymatic study, pull down	Wang F (2011), Yamagishi Y (2010)	2
PHF8	6	INCENP	4	affinity chromatography technology	Hein MY (2015)	1
CDCA8	0	AURKB	2	affinity chromatography technology, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Sampath SC (2004), Gassmann R (2004), Gassmann R (2004), Xu Z (2009), Knauer SK (2006), Ban R (2011), Jeyaprakash AA (2007), Jelluma N (2008), Gomez V (2010), Gomez V (2010), Klein UR (2009)	11
SGO1	2	CBX5	3	imaging technique, affinity chromatography technology	Kiyomitsu T (2010), Nozawa RS (2010)	2
CDCA8	0	BIRC5	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, pull down, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sampath SC (2004), Gassmann R (2004), Gassmann R (2004), Knauer SK (2006), Knauer SK (2006), Knauer SK (2006), Jeyaprakash AA (2007), Jeyaprakash AA (2007), Jeyaprakash AA (2007), Klein UR (2006), Klein UR (2006), Noton EA (2006), Noton EA (2006), Jelluma N (2008), Gomez V (2010), Klein UR (2009), Huttlin EL (2015), Huttlin EL (2017)	18
AURKA	1	SIRT7	1	affinity chromatography technology	Hein MY (2015)	1
INCENP	4	AURKC	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li X (2004), Huttlin EL (2015), Huttlin EL (2017)	3
HBP1	1	INCENP	4	affinity chromatography technology	Lampert F (2018)	1
IFI16	1	CBX5	3	affinity chromatography technology	Diner BA (2015)	1
TRIM25	5	PHF8	6	affinity chromatography technology	Choudhury NR (2017)	1
CBX5	3	HIST1H3A	3	affinity chromatography technology, pull down, pull down, unspecified method, imaging technique, bioid, affinity chromatography technology	Terada Y (2006), Lavigne M (2009), Lavigne M (2009), Dawson MA (2009), Dawson MA (2009), Lambert JP (2015), Huttlin EL (2017)	7
SIRT7	1	EWSR1	2	affinity chromatography technology	Tsai YC (2012)	1
FLOT1	0	AURKB	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Gomez V (2010), Gomez V (2010), Gomez V (2010), Gomez V (2010)	4
AURKC	0	HIST1H3A	3	enzymatic study	Li X (2004)	1
SIRT7	1	HIST1H3A	3	pull down	Ford E (2006)	1
FLOT1	0	INCENP	4	affinity chromatography technology, pull down	Gomez V (2010), Gomez V (2010)	2
AURKB	2	AURKC	0	affinity chromatography technology, biochemical	Li X (2004), Li X (2004)	2
BIRC5	1	INCENP	4	pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology	Wheatley SP (2001), Wheatley SP (2001), Xu Z (2009), Vader G (2006), Knauer SK (2006), Knauer SK (2006), Jeyaprakash AA (2007), Klein UR (2006), Klein UR (2006), Klein UR (2006), Huttlin EL (2017)	11
AURKB	2	HIST1H3A	3	pull down, enzymatic study, enzymatic study, enzymatic study	Han A (2011), Han A (2011), Sun L (2008), Zeitlin SG (2001)	4
AURKC	0	BIRC5	1	two hybrid	Wang J (2011)	1
CBX5	3	AURKB	2	affinity chromatography technology, affinity chromatography technology	Kiyomitsu T (2010), Nozawa RS (2010)	2