PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RB1	2	INS	0	biochemical	Radulescu RT (1995)	1
CRYAB	0	INS	0	unspecified method	Ghosh JG (2007)	1
MAPK6	1	INS	0	two hybrid	Vinayagam A (2011)	1
HSPB1	2	INS	0	pull down	Rogalla T (1999)	1
CRYAB	0	HSPB1	2	biochemical, pull down, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Kato K (1992), Kato K (1992), Fu L (2002), Fu L (2002), Fu L (2003), Fu L (2003), MacIntyre DA (2008), Zhang H (2010), Delbecq SP (2012), Aquilina JA (2013), DeGrado-Warren J (2008), Huttlin EL (2015), Huttlin EL (2017)	13
NOV	0	INS	0	pull down	Burren CP (1999)	1
INS	0	RGS20	2	two hybrid	Rolland T (2014)	1
INS	0	APP	1	pull down	Olah J (2011)	1
IGFBP7	1	INS	0	pull down	Yamanaka Y (1997)	1
PTEN	24	INS	0	enzymatic study	Leslie NR (2001)	1
MAPK6	1	HSPB1	2	affinity chromatography technology	Rodriguez J (2016)	1
INS	0	TCF4	26	two hybrid	Rolland T (2014)	1
KMT2A	58	INS	0	enzymatic study	Jeong W (2004)	1
TXNDC17	0	INS	0	enzymatic study	Jeong W (2004)	1
CRYAB	0	APP	1	pull down, pull down, unspecified method, x-ray crystallography, pull down	Raman B (2005), Narayanan S (2006), Shammas SL (2011), Mainz A (2015), Narayan P (2012)	5