PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
INPP5D	2	LYN	2	affinity chromatography technology, pull down	Baran CP (2003), Baran CP (2003)	2
KIT	4	PIK3R1	6	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, imaging technique	De Sepulveda P (1999), van Dijk TB (2000), Serve H (1994), Zhu MJ (2007), Zhu MJ (2007), Yokouchi M (1997), Chen TC (2014)	7
LYN	2	KIT	4	affinity chromatography technology, affinity chromatography technology, pull down	Liang X (2002), Linnekin D (1997), Linnekin D (1997)	3
CBL	7	PTPN11	20	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tanaka Y (2008), Tanaka Y (2008), Hoff H (2007), Chernock RD (2001), Chernock RD (2001)	5
SH3KBP1	1	INPPL1	6	affinity chromatography technology	Havrylov S (2009)	1
CD2AP	0	INPP5D	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bao M (2012), Bao M (2012), Bao M (2012)	3
GRB2	2	ARAP1	7	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Huttlin EL (2017)	2
GRB2	2	CD22	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Poe JC (2000), Poe JC (2000), Otipoby KL (2001)	3
BCR	3	GRB2	2	affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Million RP (2000), Million RP (2004), Million RP (2004), Puil L (1994), Puil L (1994), Ma G (1997), Maru Y (1995), Maru Y (1995), Gaston I (2004), Gaston I (2004), Brehme M (2009), Bisson N (2011), Huttlin EL (2017)	13
UBASH3B	4	ARAP1	7	affinity chromatography technology	Brehme M (2009)	1
SYK	3	INPP5D	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	de Castro RO (2012), de Castro RO (2012), de Castro RO (2012)	3
SHC1	0	EPOR	3	affinity chromatography technology	Damen JE (1993)	1
CBL	7	NCK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Erdreich-Epstein A (1999), Miyoshi-Akiyama T (2001), Izadi KD (1998), Izadi KD (1998), Wunderlich L (1999), Shishido T (2000), Okabe S (2006), Adler CE (2000), Adler CE (2000), Buvall L (2013), Buvall L (2013), Buvall L (2013), Buvall L (2013)	13
KRTAP10-9	1	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
INPP5D	2	CLYBL	0	affinity chromatography technology	Ruschmann J (2010)	1
DOK2	2	CRKL	1	two hybrid	Grossmann A (2015)	1
LRRK1	12	BCR	3	affinity chromatography technology	Titz B (2010)	1
SH3KBP1	1	INPP5D	2	affinity chromatography technology, two hybrid	Kowanetz K (2004), Conde C (2012)	2
INPPL1	6	PIK3R1	6	affinity chromatography technology	Brehme M (2009)	1
GRB2	2	PIK3R1	6	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Saleem A (1995), Saleem A (1995), Wang J (1995), Wang J (1995), Wang J (1995), Bandyopadhyay S (2010), Takahashi Y (1999), Gelkop S (2001), Jain SK (1997), Ren SY (2005), Brehme M (2009), Cerboni C (1998), Cerboni C (1998), Bisson N (2011), Bisson N (2011), Weinger JG (2008), Weinger JG (2008), Weinger JG (2008)	18
ZDHHC17	1	TRIP10	1	two hybrid, affinity chromatography technology	Butland SL (2014), Butland SL (2014)	2
SHC1	0	BCR	3	affinity chromatography technology	Brehme M (2009)	1
ARAP1	7	INPP5D	2	two hybrid	Yoon HY (2011)	1
GRB2	2	DAB2	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Bandyopadhyay S (2010), Tseng CP (1999), Mulkearns EE (2012)	3
PIK3R1	6	INPP5D	2	affinity chromatography technology	Zhang S (1999)	1
EPOR	3	GRB2	2	pull down, pull down, affinity chromatography technology	Tauchi T (1995), Feng GS (1996), Barber DL (1997)	3
NCK1	0	INPP5D	2	affinity chromatography technology, affinity chromatography technology	de Castro RO (2012), de Castro RO (2012)	2
INPP5D	2	KRTAP10-7	0	two hybrid	Rolland T (2014)	1
INPP5D	2	KRTAP10-9	1	two hybrid	Rolland T (2014)	1
INPP5D	2	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
EPOR	3	SYK	3	affinity chromatography technology	Duprez V (1998)	1
CBL	7	GRB2	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jain SK (1997), Liu SK (1998), Ettenberg SA (1999), Wong A (2002), Wong A (2002), Robertson H (1997), Donovan JA (1994), Park RK (1999), Erdreich-Epstein A (1999), Gesbert F (1998), Gesbert F (1998), Gesbert F (1998), Husson H (1997), Saci A (2002), Odai H (1997), Ng C (2008), Khan EM (2008), Bandyopadhyay S (2010), Jiang X (2003), Waterman H (2002), Miraoui H (2010), Ravid T (2004), Ingham RJ (1996), Erdreich-Epstein A (1997), Rellahan BL (2003), Izadi KD (1998), Wang Y (1999), Chu J (1998), Bonita DP (1997), Boussiotis VA (1997), Meisner H (1995), Meisner H (1995), Barber DL (1997), Shishido T (2000), Bartkiewicz M (1999), Buday L (1996), Tarcic G (2009), Belleudi F (2007), Brizzi MF (1996), Brenner B (2001), Donovan JA (1996), Donovan JA (1996), Donovan JA (1996), Gaston I (2004), Gaston I (2004), Tsygankov AY (1996), Tsygankov AY (1996), Hunter S (1997), Jain SK (1997), Levkowitz G (1996), Liu YC (1997), Odai H (1995), Odai H (1995), Meisner H (1995), Huang JY (2000), Panchamoorthy G (1996), Panchamoorthy G (1996), Yokouchi M (1997), Oda A (1996), Fukazawa T (1995), Fukazawa T (1995), Selbach M (2006), Brehme M (2009), Brehme M (2009), Fukazawa T (1995), Cerboni C (1998), Cerboni C (1998), Fixman ED (1997), Anderson SM (1997), Houtman JC (2006), Brizzi MF (1996), Scott RP (2005), Scott RP (2005), Bisson N (2011), Fukazawa T (1996), Fukazawa T (1996), Umehara H (2002), Taipale M (2014), Taipale M (2014), Grossmann A (2015), Grossmann A (2015), Igloi Z (2015), Huttlin EL (2017)	83
SHC1	0	DOK1	2	affinity chromatography technology, affinity chromatography technology, unspecified method	Dunant NM (2000), Dunant NM (2000), Liu BA (2012)	3
SHC1	0	DOK2	2	affinity chromatography technology	Dunant NM (2000)	1
5175	0	INPP5D	2	pull down, far western blotting	Pumphrey NJ (1999), Pumphrey NJ (1999)	2
DOK1	2	CRKL	1	pull down, affinity chromatography technology, affinity chromatography technology, far western blotting, pull down, affinity chromatography technology, two hybrid	van Dijk TB (2000), Bhat A (1998), Bhat A (1998), Bhat A (1998), Bhat A (1998), Martelli MP (2001), Grossmann A (2015)	7
SLAMF1	2	PTPN11	20	affinity chromatography technology, affinity chromatography technology	Howie D (2002), Morra M (2001)	2
CD22	3	SYK	3	affinity chromatography technology	Law CL (1996)	1
LYN	2	5175	0	affinity chromatography technology	Cicmil M (2000)	1
INPPL1	6	INPP5D	2	affinity chromatography technology	Brehme M (2009)	1
INPP5D	2	DAB1	1	two hybrid	Conde C (2012)	1
GRB2	2	SH3KBP1	1	pull down, pull down	Gout I (2000), Borinstein SC (2000)	2
LRRK1	12	INPP5D	2	affinity chromatography technology	Titz B (2010)	1
LRRK1	12	SHC1	0	affinity chromatography technology	Titz B (2010)	1
IL4R	1	SHC1	0	affinity chromatography technology, pull down	Ikizawa K (2000), Kashiwada M (2001)	2
LYN	2	DOK1	2	enzymatic study, pull down, enzymatic study	van Dijk TB (2000), van Dijk TB (2000), Liang X (2002)	3
INPP5D	2	DOK2	2	affinity chromatography technology, affinity chromatography technology	Dunant NM (2000), Dunant NM (2000)	2
SYK	3	PIK3R1	6	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Moon KD (2005), Moon KD (2005), Moon KD (2005), Moon KD (2005), Huang ZY (2006)	5
LYN	2	SH3KBP1	1	affinity chromatography technology	Narita T (2005)	1
5175	0	PTPN11	20	affinity chromatography technology, pull down, far western blotting, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Ilan N (2000), Pumphrey NJ (1999), Pumphrey NJ (1999), Hua CT (1998), Hua CT (1998), Jackson DE (1997), Jackson DE (1997)	7
UBASH3B	4	INPPL1	6	affinity chromatography technology	Brehme M (2009)	1
INPP5D	2	KRT31	0	two hybrid	Rolland T (2014)	1
IL4R	1	PTPN11	20	pull down	Kashiwada M (2001)	1
PIK3R1	6	PTPN11	20	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang S (1999), Takahashi Y (1999), Craddock BL (1997), Wu CJ (2000), Wu CJ (2001), Yu WM (2006)	6
CRKL	1	PTPN11	20	affinity chromatography technology	Chin H (1997)	1
CRKL	1	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, pull down	Gesbert F (1998), Gelkop S (2001), Ren SY (2005)	3
ARAP1	7	SH3KBP1	1	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Yoon HY (2011), Yoon HY (2011), Yoon HY (2011), Yoon HY (2011), Havrylov S (2009), Huttlin EL (2017)	6
SHC1	0	CD22	3	affinity chromatography technology, affinity chromatography technology	Poe JC (2000), Poe JC (2000)	2
GRB2	2	PTPN11	20	affinity chromatography technology, affinity chromatography technology, far western blotting, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ganju RK (2000), Bennett AM (1994), Ward AC (1998), Yin T (1997), Tang J (1997), Tang H (1999), Hadari YR (1998), Zhang S (1999), Wong L (1996), Brehme M (2009), Craddock BL (1997), Bisson N (2011), Blagoev B (2003), Bisson N (2011), Tauchi T (1995), Huttlin EL (2017), Kapoor GS (2010), Kapoor GS (2010), Vogel W (1996), Vogel W (1996), Yu WM (2006)	21
INPP5D	2	UBASH3B	4	affinity chromatography technology, affinity chromatography technology	de Castro RO (2012), de Castro RO (2012)	2
NCK1	0	PIK3R1	6	affinity chromatography technology	Gelkop S (2001)	1
INPP5D	2	KHDRBS3	0	two hybrid	Rolland T (2014)	1
KIT	4	GRB2	2	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down	De Sepulveda P (1999), Thoemmes K (1999), Feng GS (1996), Sun J (2007), Zhu MJ (2007), Wollberg P (2003), Brizzi MF (1996)	7
INPP5D	2	KRTAP10-3	1	two hybrid	Rolland T (2014)	1
NCK1	0	GRB2	2	affinity chromatography technology, affinity chromatography technology	de Castro RO (2012), de Castro RO (2012)	2
DAB1	1	SH3KBP1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sato Y (2007), Sato Y (2007), Bior BK (2013)	3
SYK	3	UBASH3B	4	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	de Castro RO (2012), de Castro RO (2012), Thomas DH (2010), Thomas DH (2010), Thomas DH (2010)	5
KIT	4	INPP5D	2	pull down	van Dijk TB (2000)	1
SH3KBP1	1	DAB2	1	affinity chromatography technology, two hybrid, affinity chromatography technology	Havrylov S (2009), Kowanetz K (2003), Kowanetz K (2003)	3
GRB2	2	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Blagoev B (2003), Skolnik EY (1993), Skolnik EY (1993), Puil L (1994), Satoh T (1996), Fixman ED (1996), Fixman ED (1996), Fixman ED (1996), Ishihara H (1997), Fournier E (1999), Ravichandran KS (1994), Lamprecht R (2002), Park RK (1999), Sakaguchi K (2001), Park RK (1999), Park RK (1999), Hallak H (2001), Yokote K (1994), Saci A (2002), Zhang S (1999), Lazar DF (1994), VanderKuur J (1995), Kanai M (1997), Spivak-Kroizman T (1994), Giordano V (1997), Drobot L (2005), Erdreich-Epstein A (1997), Takahashi Y (1999), Barber DL (1997), Ahn SC (2003), Odai H (1995), Panchamoorthy G (1996), Panchamoorthy G (1996), Brehme M (2009), Brehme M (2009), Brehme M (2009), Cerboni C (1998), Zhang L (1999), Brizzi MF (1996), Brizzi MF (1996), Liu BA (2012), Bisson N (2011), Fukazawa T (1996), Bisson N (2011), Umehara H (2002), Oksvold MP (2001), Oksvold MP (2001), Li J (2013), Li J (2013), Ueno H (1995), Prigent SA (1996), Wills MK (2014), Rausch O (1997), Ho JM (2002), Ho JM (2002), Yu WM (2006), Klint P (1995)	57
PIK3R1	6	SH3KBP1	1	pull down, affinity chromatography technology, affinity chromatography technology, two hybrid	Gout I (2000), Tossidou I (2010), Borthwick EB (2004), Borthwick EB (2004)	4
SHC1	0	PRKCD	2	affinity chromatography technology, pull down, affinity chromatography technology	Leitges M (2002), Leitges M (2002), Brehme M (2009)	3
KRTAP10-7	0	KRTAP10-9	1	two hybrid	Rolland T (2014)	1
DOK1	2	BCR	3	affinity chromatography technology, affinity chromatography technology, pull down	Bhat A (1998), Bhat A (1998), Bhat A (1998)	3
INPP5D	2	CD22	3	affinity chromatography technology, affinity chromatography technology	Poe JC (2000), Poe JC (2000)	2
CRKL	1	SYK	3	affinity chromatography technology, pull down	Oda A (2001), Oda A (2001)	2
CBL	7	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Park RK (1999), Gesbert F (1998), Erdreich-Epstein A (1997), Wang Y (1999), Brehme M (2009), Brehme M (2009), Cerboni C (1998), Brizzi MF (1996), Fukazawa T (1996)	9
CRKL	1	SHC1	0	affinity chromatography technology	Chin H (1997)	1
LRRK1	12	PTPN11	20	affinity chromatography technology	Titz B (2010)	1
PRKCD	2	DAB2	1	enzymatic study	Tseng CP (1999)	1
DOK1	2	NCK1	0	unspecified method, affinity chromatography technology	Liu BA (2012), Wick MJ (2001)	2
CBL	7	SYK	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Lupher ML (1998), Lupher ML (1998), Bertagnolo V (2001), Melander F (2003), Macglashan D (2004), Rao N (2001), Rao N (2001), Yankee TM (1999), Saci A (2000), Moon KD (2005), Lottin-Divoux S (2006), Grossmann AH (2004), Ota S (2000), Ota S (2000), Panchamoorthy G (1996), Marcilla A (1995), Justa-Schuch D (2016)	17
LRRK1	12	GRB2	2	affinity chromatography technology, affinity chromatography technology	Titz B (2010), Brehme M (2009)	2
PIK3R1	6	EPOR	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, protein complementation assay, affinity chromatography technology	Shigematsu H (1997), Shigematsu H (1997), Damen JE (1995), Damen JE (1995), Montoye T (2005), Bulut GB (2013)	6
SHC1	0	PIK3R1	6	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Harrison-Findik D (1995), Ren SY (2005), Ren SY (2005), Brehme M (2009), Cerboni C (1998), Lee DY (2010)	6
SH3KBP1	1	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Watanabe S (2000), Watanabe S (2000), Petrelli A (2002), Soubeyran P (2002), Soubeyran P (2002), Szymkiewicz I (2002), Borinstein SC (2000), Schmidt MH (2006), Schmidt MH (2004), Schmidt MH (2004), Verdier F (2002), Verdier F (2002), Feshchenko EA (2004), Chandra V (2010), Niiro H (2012), Feng L (2011), Havrylov S (2009), Zhang J (2009), Zhang J (2009), Ababou A (2009), Le Bras S (2007), Jozic D (2005), Kowanetz K (2004), Kowanetz K (2003), Kowanetz K (2003), Tibaldi EV (2003), Tibaldi EV (2003), Take H (2000), Take H (2000), Schroeder B (2012), Schroeder B (2012), Peruzzi G (2007), Selbach M (2006), Sato S (2013), Taipale M (2014), Taipale M (2014), Diesenberg K (2015), Petrelli A (2002), Huttlin EL (2017)	39
SHC1	0	ARAP1	7	affinity chromatography technology	Brehme M (2009)	1
UBASH3B	4	CBL	7	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kowanetz K (2004), Kowanetz K (2004), Raguz J (2007), Hoeller D (2006), Peruzzi G (2007), Brehme M (2009)	6
SYK	3	NCK1	0	affinity chromatography technology, affinity chromatography technology	de Castro RO (2012), de Castro RO (2012)	2
LYN	2	CBL	7	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Taher TE (2002), Dombrosky-Ferlan PM (1997), Kaabeche K (2004), Wu J (2008), Tanaka S (1995), Marcilla A (1995)	6
CBL	7	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid	Gesbert F (1998), Gesbert F (1998), Zhang S (1999), Dufour C (2008), Feshchenko EA (2004), Kassenbrock CK (2002), Fang D (2001), Valiya Veettil M (2011), Miao H (2002), Miao H (2002), Ueno H (1998), Gelkop S (2001), Wang Y (1999), Saci A (2000), Matsuo T (1996), Matsuo T (1996), Jackson JG (2000), Meisner H (1995), Saci A (1999), Saci A (1999), Beckwith M (1996), Beckwith M (1996), Song JJ (2010), Hartley D (1996), Finkelstein LD (2000), Ren SY (2005), Hunter S (1997), Hunter S (1997), Jain SK (1997), Jain SK (1997), Swaminathan G (2007), van Leeuwen JE (1999), Ren SY (2005), Ren SY (2005), Alcazar I (2009), Liu YC (1997), Matsuo T (1996), Matsuo T (1996), Lottin-Divoux S (2006), Kitanaka A (1996), Liu YC (1997), Grossmann AH (2004), Panchamoorthy G (1996), Panchamoorthy G (1996), Chernock RD (2001), Chernock RD (2001), Fukazawa T (1995), Fukazawa T (1995), Brehme M (2009), Hakak Y (2000), Hakak Y (2000), Fukazawa T (1995), Liu Y (1999), Cerboni C (1998), Cerboni C (1998), Momose H (2003), Fukazawa T (1996), Fukazawa T (1996), Bulut GB (2013), Bulut GB (2013), Grossmann A (2015)	61
INPP5D	2	BCR	3	affinity chromatography technology	Ruschmann J (2010)	1
DAB2	1	INPP5D	2	pull down	Morris SM (2001)	1
GRB2	2	INPP5D	2	unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kavanaugh WM (1996), Kavanaugh WM (1996), de Castro RO (2012), Ho JM (2002)	4
KRTAP10-9	1	KRTAP10-3	1	two hybrid	Rolland T (2014)	1
CBL	7	INPPL1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vandenbroere I (2003), Prasad NK (2005), De Schutter J (2009), De Schutter J (2009), Brehme M (2009)	5
ZDHHC17	1	INPP5D	2	two hybrid	Butland SL (2014)	1
GRB2	2	CD2AP	0	affinity chromatography technology, affinity chromatography technology, two hybrid	Brehme M (2009), Bisson N (2011), Wang J (2011)	3
EPOR	3	CBL	7	affinity chromatography technology	Wakioka T (1999)	1
KIT	4	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zeng S (2005), Brizzi MF (1996), Dong Y (2015)	3
BCR	3	KIT	4	affinity chromatography technology, affinity chromatography technology, imaging technique	Hallek M (1996), Hallek M (1996), Chen TC (2014)	3
INPP5D	2	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dunant NM (2000), Dunant NM (2000), Wisniewski D (1999), Leitges M (2002), Damen JE (1996), Damen JE (1996), March ME (2000), Hunter MG (2004), Ho JM (2002)	9
SHC1	0	INPPL1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wisniewski D (1999), Wisniewski D (1999), Pesesse X (2001), Habib T (1998), Brehme M (2009), Brehme M (2009)	6
DOK1	2	PIK3R1	6	pull down, unspecified method	van Dijk TB (2000), Liu BA (2012)	2
INPP5D	2	KRT40	0	two hybrid	Rolland T (2014)	1
KRTAP10-3	1	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
BCR	3	CRKL	1	affinity chromatography technology, two hybrid, two hybrid, far western blotting, affinity chromatography technology	Heaney C (1997), Heaney C (1997), Kolibaba KS (1999), Kolibaba KS (1999), Million RP (2004)	5
LYN	2	EPOR	3	pull down, affinity chromatography technology, affinity chromatography technology	Chin H (1998), Chin H (1998), Chin H (1998)	3
CBL	7	BCR	3	pull down, pull down, affinity chromatography technology, enzymatic study	Gaston I (2004), Panchamoorthy G (1996), Brehme M (2009), Tsukahara F (2010)	4
LYN	2	CD22	3	enzymatic study, affinity chromatography technology	Poe JC (2000), Greer SF (1999)	2
CRKL	1	INPP5D	2	pull down, affinity chromatography technology	Arai A (2001), Arai A (2001)	2
SH3KBP1	1	CD2AP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tossidou I (2010), Gaidos G (2007), Huttlin EL (2017)	3
SYK	3	LYN	2	affinity chromatography technology, pull down	Sidorenko SP (1995), Sidorenko SP (1995)	2
KRTAP10-7	0	KRTAP10-3	1	two hybrid	Rolland T (2014)	1
MME	3	LYN	2	affinity chromatography technology	Ganju RK (1996)	1
LRRK1	12	INPPL1	6	affinity chromatography technology	Titz B (2010)	1
GRB2	2	SYK	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ganju RK (2000), Saci A (2002), de Castro RO (2012), de Castro RO (2012)	4
SH3KBP1	1	KIT	4	affinity chromatography technology	Szymkiewicz I (2002)	1
XIAP	0	INPP5D	2	affinity chromatography technology, two hybrid	Conde C (2012), Conde C (2012)	2
DOK1	2	DOK2	2	affinity chromatography technology	Dunant NM (2000)	1
EPOR	3	INPP5D	2	protein complementation assay	Montoye T (2005)	1
GRB2	2	DOK1	2	affinity chromatography technology	Kepley CL (2004)	1
UBASH3B	4	BCR	3	affinity chromatography technology	Brehme M (2009)	1
EPOR	3	PTPN11	20	affinity chromatography technology, pull down	Tauchi T (1996), Tauchi T (1995)	2
INPP5D	2	PRKCD	2	affinity chromatography technology	Leitges M (2002)	1
SHC1	0	UBASH3B	4	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Li J (2013)	2
INPP5D	2	CBL	7	affinity chromatography technology	Bao M (2012)	1
IL4R	1	INPP5D	2	pull down	Kashiwada M (2001)	1
INPP5D	2	PTPN11	20	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu L (1997), Chernock RD (2001), Chernock RD (2001)	3
ZDHHC17	1	PIK3R1	6	two hybrid, affinity chromatography technology	Butland SL (2014), Butland SL (2014)	2
MME	3	INPP5D	2	affinity chromatography technology	DallEra MA (2007)	1
CBL	7	CRKL	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid	Alsayed Y (2000), Alsayed Y (2000), Kyono WT (1998), Lin H (2001), Park RK (1998), Taher TE (2002), Sattler M (1997), Erdreich-Epstein A (1999), Erdreich-Epstein A (1999), Sattler M (1997), Sattler M (1997), Gesbert F (1998), Chin H (1997), Feshchenko EA (2004), Izadi KD (1998), de Jong R (1995), de Jong R (1995), Boussiotis VA (1997), Boussiotis VA (1997), Barber DL (1997), Uemura N (1999), Okabe S (2006), Alsayed Y (2000), Alsayed Y (2000), Brenner B (2001), van Leeuwen JE (1999), Ribon V (1996), Bhat A (1997), Bhat A (1997), Huang JY (2000), Chernock RD (2001), Chernock RD (2001), Grossmann AH (2004), Sakamoto H (2004), Nishihara T (2003), Peterson ME (2008), Fukazawa T (1996), Martelli MP (2001), Joshi S (2014), Grossmann A (2015)	40
CRKL	1	EPOR	3	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Chin H (1997), Arai A (2001), Arai A (2001), Barber DL (1997)	4
SLAMF1	2	INPP5D	2	affinity chromatography technology	Mikhalap SV (1999)	1
5175	0	PIK3R1	6	affinity chromatography technology	Pellegatta F (1998)	1
TRIP10	1	INPP5D	2	affinity chromatography technology	Linkermann A (2009)	1
KRTAP10-7	0	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
INPP5D	2	DOK1	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Dunant NM (2000), Dunant NM (2000), van Dijk TB (2000), Kepley CL (2004)	4
INPPL1	6	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009), Brehme M (2009), Bisson N (2011)	4
BCR	3	PIK3R1	6	far western blotting	Weinger JG (2008)	1
LYN	2	SHC1	0	affinity chromatography technology	Ptasznik A (1995)	1
DOK2	2	NCK1	0	affinity chromatography technology	Master Z (2001)	1
NCK1	0	UBASH3B	4	affinity chromatography technology, affinity chromatography technology	de Castro RO (2012), de Castro RO (2012)	2
DOK1	2	KIT	4	affinity chromatography technology, pull down	Liang X (2002), Liang X (2002)	2
UBASH3B	4	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	de Castro RO (2012), Li J (2013), Li J (2013)	3
GRB2	2	CRKL	1	affinity chromatography technology	Park RK (1999)	1
CD2AP	0	CBL	7	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Haglund K (2004), Haglund K (2004), Kirsch KH (2001), Kirsch KH (2001), Cormont M (2003), Lynch DK (2003), Tibaldi EV (2003), Bao M (2012), Yao B (2007), Selbach M (2006), Taipale M (2014), Taipale M (2014), Igloi Z (2015)	13
KIT	4	CRKL	1	pull down, affinity chromatography technology	van Dijk TB (2000), Sattler M (1997)	2
PTPN11	20	KIT	4	pull down, affinity chromatography technology, unspecified method	Tauchi T (1994), Kozlowski M (1998), Wollberg P (2003)	3