PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
FBXL5	3	FAM96B	0	affinity chromatography technology, affinity chromatography technology	Tan MK (2013), Huttlin EL (2017)	2
UBA2	0	PSMA3	1	biochemical	Wan C (2015)	1
FBXL5	3	IREB2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Vashisht AA (2009), Vashisht AA (2009), Salahudeen AA (2009), Salahudeen AA (2009), Moroishi T (2014)	5
KRAS	1	IREB2	3	genetic interference	Luo J (2009)	1
ELAVL2	4	IREB2	3	affinity chromatography technology	Huttlin EL (2017)	1
FBXL5	3	CIAO1	3	affinity chromatography technology	Huttlin EL (2017)	1
CAMKMT	1	IREB2	3	affinity chromatography technology	Huttlin EL (2015)	1
VHL	0	APP	1	pull down	Olah J (2011)	1
RBCK1	0	IREB2	3	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, two hybrid	Yamanaka K (2003), Yamanaka K (2003), Zumbrennen KB (2008), Zumbrennen KB (2008), Yamanaka K (2003)	5
FAM96A	0	IREB2	3	affinity chromatography technology, affinity chromatography technology	Stehling O (2013), Stehling O (2013)	2
CBS	0	IREB2	3	biochemical	Kristensen AR (2012)	1
IREB2	3	SF1	9	biochemical	Wan C (2015)	1
RBCK1	0	APP	1	pull down	Olah J (2011)	1
ENSA	0	IREB2	3	affinity chromatography technology	Huttlin EL (2017)	1
SLC9A3R1	2	IREB2	3	biochemical	Wan C (2015)	1
TNPO1	1	IREB2	3	biochemical	Kristensen AR (2012)	1
IREB2	3	UBA2	0	biochemical	Kristensen AR (2012)	1
PSMA3	1	IREB2	3	affinity chromatography technology	Fedorova OA (2011)	1
VHL	0	IREB2	3	affinity chromatography technology	Wang J (2005)	1
PSMA3	1	SF1	9	two hybrid	Rolland T (2014)	1
IREB2	3	APP	1	pull down	Olah J (2011)	1
KRAS	1	PSMA3	1	two hybrid	Rolland T (2014)	1
CIAO1	3	IREB2	3	affinity chromatography technology, affinity chromatography technology	Stehling O (2013), Stehling O (2013)	2
INSL3	1	IREB2	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FAM96B	0	IREB2	3	affinity chromatography technology	Stehling O (2013)	1
KRAS	1	APP	1	pull down	Olah J (2011)	1
TERT	7	IREB2	3	two hybrid	Wang W (2013)	1
ALDH3B1	0	IREB2	3	affinity chromatography technology	Huttlin EL (2017)	1
CBS	0	UBA2	0	biochemical	Kristensen AR (2012)	1
CIAO1	3	FAM96A	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, biochemical	Rual JF (2005), Stehling O (2013), Stehling O (2013), Stehling O (2013), Stehling O (2013), Rolland T (2014), Wan C (2015)	7
CIAO1	3	SF1	9	affinity chromatography technology, two hybrid	Stehling O (2013), Rolland T (2014)	2
CIAO1	3	APP	1	pull down	Olah J (2011)	1
ARL15	0	IREB2	3	affinity chromatography technology	Huttlin EL (2017)	1
IREB2	3	USP53	1	two hybrid	Wang J (2011)	1
YBX1	1	IREB2	3	pull down, affinity chromatography technology	Ashizuka M (2002), Ashizuka M (2002)	2
CCNL2	2	IREB2	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CAMKMT	1	APP	1	pull down	Olah J (2011)	1
CIAO1	3	FAM96B	0	two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, biochemical, two hybrid	Rual JF (2005), Havugimana PC (2012), Stehling O (2013), Stehling O (2013), Stehling O (2013), Stehling O (2013), Rolland T (2014), Gari K (2012), Wan C (2015), Yu H (2011)	10