PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HMGA1	0	IRF1	0	pull down	Yie J (1999)	1
NPM1	0	KEAP1	0	affinity chromatography technology	Chen R (2013)	1
EP300	36	YBX1	1	affinity chromatography technology	Sengupta S (2011)	1
MDM2	2	SET	8	pull down	Miyamoto-Sato E (2010)	1
MDM2	2	KAT2B	2	pull down, affinity chromatography technology, genetic interference, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study	Jin Y (2002), Jin Y (2002), Jin Y (2002), Jin Y (2004), Jin Y (2004), Jung CR (2010), Morgan JE (2017)	7
IRF8	4	IRF2	7	affinity chromatography technology	Sharf R (1995)	1
STAT1	1	IRF1	0	affinity chromatography technology, pull down, affinity chromatography technology	Chatterjee-Kishore M (2000), Chatterjee-Kishore M (2000), Remoli AL (2006)	3
IRF1	0	IRF2	7	pull down	Tooze RM (2006)	1
SET	8	HIST1H3A	3	pull down, unspecified method, affinity chromatography technology	Karetsou Z (2009), Schneider R (2004), Schneider R (2004)	3
SMARCA4	19	NPM1	0	affinity chromatography technology	Tando T (2010)	1
IRF1	0	YBX1	1	pull down, affinity chromatography technology	Narayan V (2011), Narayan V (2011)	2
IRF1	0	KEAP1	0	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
IRF1	0	TRIM28	1	pull down, affinity chromatography technology, pull down	Narayan V (2011), Narayan V (2011), Landre V (2013)	3
SET	8	TRIM28	1	affinity chromatography technology	Kalousi A (2015)	1
IRF1	0	HSP90AA1	7	affinity chromatography technology	Gao B (2013)	1
IRF2	7	HCFC1	4	affinity chromatography technology	Li S (2011)	1
KEAP1	0	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, two hybrid	Niture SK (2013), Prince TL (2015), Prince TL (2015)	3
PRDM1	5	IRF1	0	imaging technique	Barnes NA (2009)	1
PRDM1	5	IRF2	7	imaging technique, genetic interference	Barnes NA (2009), Ma Y (2017)	2
SMARCA4	19	STAT1	1	imaging technique, affinity chromatography technology, affinity chromatography technology	Ni Z (2005), Cheng MB (2010), Zhang Y (2010)	3
EP300	36	KAT2B	2	enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kiernan R (2003), Kim JH (2011), Lee M (2010), Santos-Rosa H (2003), Yang XJ (1996), Yang XJ (1996), Yang XJ (1996), Mizuguchi Y (2012)	8
MDM2	2	TRIM28	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang C (2005), Wang C (2005), Wang C (2005), Gilmore-Hebert M (2010), Okamoto K (2006), Okamoto K (2006), Okamoto K (2006)	7
CREBBP	29	MDM2	2	affinity chromatography technology, enzymatic study, affinity chromatography technology	Inoue Y (2011), Wang X (2004), Sanchez M (2012)	3
SMARCA4	19	HIST1H3A	3	pull down, pull down, pull down	Lavigne M (2009), Lavigne M (2009), Kouskouti A (2005)	3
TRIM28	1	CREBBP	29	affinity chromatography technology	Seki Y (2010)	1
CREBBP	29	HIST1H3A	3	enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Senyuk V (2005), Perissi V (1999), Pasheva E (2004), Shen WF (2001), Kouskouti A (2005), Kouskouti A (2005), Yasuda J (2004), Tropberger P (2013), Das C (2009)	9
IRF8	4	IRF1	0	two hybrid, affinity chromatography technology, pull down	Schaper F (1998), Sharf R (1995), Kautz B (2001)	3
CREBBP	29	HMGA1	0	two hybrid, enzymatic study	Nagpal S (1999), Munshi N (1998)	2
IRF8	4	CBL	7	affinity chromatography technology	Xiong H (2005)	1
IRF1	0	SP2	3	affinity chromatography technology, affinity chromatography technology	Letourneur M (2009), Letourneur M (2009)	2
SET	8	IRF1	0	pull down	Landre V (2013)	1
KAT2B	2	HIST1H3A	3	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, imaging technique, enzymatic study, enzymatic study	Brackertz M (2006), Seo SB (2002), Pasheva E (2004), Kouskouti A (2005), Kiernan RE (1999), Wong K (2005), Hoffmann A (2008), Shen M (2013), Yamaguchi Y (2004), Tropberger P (2013)	10
MDM2	2	SMARCA4	19	unspecified method	Nicholson J (2014)	1
MDM2	2	NPM1	0	affinity chromatography technology, pull down, unspecified method, affinity chromatography technology	Kurki S (2004), Kurki S (2004), Nicholson J (2012), Nicholson J (2012)	4
IRF1	0	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Deng WG (2003), Deng WG (2003), Dornan D (2004), Gao B (2013), Burysek L (1999)	5
TRIM28	1	HCFC1	4	biochemical	Wan C (2015)	1
NPM1	0	HSP90AA1	7	affinity chromatography technology	Chen R (2013)	1
IRF1	0	HSPA1A	0	affinity chromatography technology	Gao B (2013)	1
NPM1	0	HIST1H3A	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Swaminathan V (2005), Haindl M (2008), Shuaib M (2010), Shuaib M (2010)	4
SMARCA4	19	IRF1	0	imaging technique	Ni Z (2005)	1
CREBBP	29	IRF1	0	pull down	Merika M (1998)	1
IRF1	0	TRMT2A	4	affinity chromatography technology	Li S (2011)	1
IRF9	0	STAT1	1	two hybrid, pull down	Horvath CM (1996), Horvath CM (1996)	2
CDKN1B	1	IRF1	0	two hybrid	Wang J (2011)	1
STUB1	4	HSP90AA1	7	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, enzymatic study, biochemical, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, pull down	Zhang L (2007), Zhang M (2005), Tateishi Y (2004), Tateishi Y (2004), Connell P (2001), Ko HS (2009), Kumar P (2007), Kumar P (2007), Wang L (2011), Stankiewicz M (2010), Graf C (2010), Kundrat L (2010), Kundrat L (2010), Kundrat L (2010), Kundrat L (2010), Morishima Y (2008), Zhou P (2003), Zhang M (2008), Grelle G (2006), Kim SA (2005), Arndt V (2005), Muller P (2012), Burch L (2004), Burch L (2004), Jang KW (2011), Schuelke JP (2010), Wang Q (2012), Shimamoto S (2013), Shimamoto S (2013), Shimamoto S (2013), Gano JJ (2010), Skarra DV (2011), Yang SW (2013), Grelle G (2006), Grelle G (2006), Narayan V (2015)	36
HSP90AA1	7	PRDM1	5	affinity chromatography technology	Taipale M (2012)	1
HSP90AA1	7	HMGA1	0	affinity chromatography technology	Taipale M (2012)	1
IRF2	7	EP300	36	affinity chromatography technology, enzymatic study, pull down	Masumi A (2001), Masumi A (2001), Masumi A (2001)	3
IRF1	0	CBL	7	affinity chromatography technology	Shen M (2011)	1
IRF2	7	MDM2	2	affinity chromatography technology, enzymatic study, unspecified method	Pettersson S (2009), Pettersson S (2009), Nicholson J (2014)	3
HSP90AA1	7	CDKN1B	1	genetic interference	Srivas R (2016)	1
NPM1	0	TRIM28	1	affinity chromatography technology, enzymatic study	Chen R (2013), Neo SH (2015)	2
IRF1	0	MDM2	2	affinity chromatography technology, pull down, enzymatic study, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology	Landre V (2013), Landre V (2013), Landre V (2013), Landre V (2013), Wevers BA (2014), Nicholson J (2014), Remoli AL (2016)	7
IRF1	0	HCFC1	4	affinity chromatography technology	Li S (2011)	1
EP300	36	HIST1H3A	3	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study	Liu B (2009), Brackertz M (2006), Faiola F (2005), Daujat S (2002), Kalkhoven E (2002), Seo SB (2002), Kim JH (2005), Bordoli L (2001), Kim MY (2001), Kutney SN (2004), Wang F (2010), Loven MA (2004), Kiernan RE (1999), Wong K (2005), Ogryzko VV (1996), Yamaguchi Y (2004), Furumatsu T (2005), An W (2002), Delvecchio M (2013), Delvecchio M (2013), Tropberger P (2013), Das C (2009), Shimura M (2011), Ji A (2003), Fu M (2005), Suganuma T (2002), Tang Z (2013), Kim JH (2006), Lopes da Rosa J (2013), Li X (2014), Wang YL (2008), Du C (2017), Yi P (2017), Wan W (2017)	34
HCFC1	4	HSP90AA1	7	affinity chromatography technology	Wysocka J (2003)	1
IRF1	0	KAT2A	1	pull down	Masumi A (1999)	1
NPM1	0	YBX1	1	affinity chromatography technology, affinity chromatography technology	Park G (2010), Chen R (2013)	2
IRF2	7	KAT2B	2	affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, pull down	Masumi A (2001), Masumi A (2001), Masumi A (2001), Masumi A (1999), Masumi A (1999)	5
HSP90AA1	7	IRF2	7	affinity chromatography technology	Taipale M (2012)	1
BIRC3	1	IRF1	0	enzymatic study, affinity chromatography technology	Harikumar KB (2014), Harikumar KB (2014)	2
IRF1	0	TRAF3	1	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
SMARCA4	19	CREBBP	29	genetic interference	DiRenzo J (2000)	1
CREBBP	29	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Crusselle-Davis VJ (2007), Dohda T (2004), Dohda T (2004)	3
IRF1	0	IRF9	0	two hybrid, two hybrid	Ravasi T (2010), Childs KS (2003)	2
EP300	36	STAT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Paulson M (1999), Hiroi M (2003), Ray S (2002), Strassheim D (2009), Liu X (2008), Ghosh AK (2001), Yang WS (2005), Zhang Y (2015), Kotla S (2015), Kotla S (2015)	10
MDM2	2	HSP90AA1	7	affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, biochemical, unspecified method, affinity chromatography technology	Lu TL (2010), Burch L (2004), Burch L (2004), Burch L (2004), Burch L (2004), Burch LR (2004), Okoro DR (2013)	7
SPI1	1	IRF8	4	pull down, pull down	Eklund EA (1998), Kautz B (2001)	2
TRAF3	1	BIRC3	1	affinity chromatography technology, enzymatic study, affinity chromatography technology	Mao AP (2010), de Jong SJ (2013), Goncharov T (2013)	3
IRF1	0	QARS	1	two hybrid	Wang J (2011)	1
HSPA1A	0	HMGA1	0	far western blotting	Sgarra R (2008)	1
IRF1	0	STUB1	4	pull down, affinity chromatography technology, pull down, enzymatic study, enzymatic study, pull down, affinity chromatography technology, enzymatic study, enzymatic study	Narayan V (2011), Narayan V (2011), Narayan V (2011), Narayan V (2011), Landre V (2013), Landre V (2013), Gao B (2013), Narayan V (2015), Landre V (2017)	9
IRF1	0	KAT2B	2	pull down, pull down, affinity chromatography technology	Masumi A (1999), Masumi A (1999), Gao B (2013)	3
STUB1	4	HSPA1A	0	pull down, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ballinger CA (1999), Ballinger CA (1999), Imai Y (2002), Havugimana PC (2012), Jinwal UK (2012), Yang SW (2013), Choi JR (2016), Schoenbuehler B (2016)	8
CREBBP	29	STAT1	1	pull down, genetic interference, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology	Zhang JJ (1996), Zhang JJ (1996), Horvai AE (1997), Horvai AE (1997), Ma Z (2005), Vaelineva T (2005), Strassheim D (2009), Kraemer OH (2006), Kraemer OH (2006), Jansma AL (2014), Chen Y (2015)	11
IRF1	0	NPM1	0	affinity chromatography technology, pull down	Narayan V (2011), Narayan V (2011)	2
KAT2B	2	HMGA1	0	enzymatic study	Munshi N (1998)	1
CREBBP	29	KAT2B	2	pull down, biochemical, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Tini M (2002), Cho H (1998), Cho H (1998), Cho H (1998), Korzus E (1998), Korzus E (1998), Korzus E (1998), Yang XJ (1996), Yang XJ (1996), Yang XJ (1996)	10
HSP90AA1	7	HSPA1A	0	pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Kanelakis KC (2002), Gano JJ (2010), Falsone SF (2005), Brychzy A (2003), Scholz GM (2001), Scholz GM (2001)	6
CREBBP	29	IRF9	0	affinity chromatography technology	Tang X (2007)	1
IRF1	0	SEC63	3	affinity chromatography technology	Li S (2011)	1
SPI1	1	IRF1	0	pull down, pull down	Eklund EA (1998), Kautz B (2001)	2
TRIM28	1	STAT1	1	affinity chromatography technology, affinity chromatography technology	Kamitani S (2008), Tsuruma R (2008)	2
KAT2B	2	CDKN1B	1	pull down, affinity chromatography technology, pull down, enzymatic study	Perez-Luna M (2012), Perez-Luna M (2012), Perez-Luna M (2012), Perez-Luna M (2012)	4
EP300	36	NPM1	0	enzymatic study	Swaminathan V (2005)	1
HMGA1	0	NPM1	0	far western blotting, far western blotting	Sgarra R (2006), Sgarra R (2008)	2
IRF2	7	KAT2A	1	pull down	Masumi A (1999)	1
KAT2A	1	HIST1H3A	3	enzymatic study, enzymatic study, enzymatic study, enzymatic study	Faiola F (2005), Yamaguchi Y (2004), Guelman S (2009), Wang YL (2008)	4
IRF1	0	HIST1H3A	3	affinity chromatography technology	Shen M (2011)	1
HSPA1A	0	YBX1	1	biochemical	Havugimana PC (2012)	1
EP300	36	MDM2	2	pull down, affinity chromatography technology, biochemical, pull down, pull down, enzymatic study, affinity chromatography technology, biochemical, enzymatic study	Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Matt T (2004), Wang X (2004), Gillotin S (2010), Kobet E (2000), Nihira NT (2017)	9
TRIM28	1	HIST1H3A	3	imaging technique	Li X (2010)	1
TRIM28	1	SMARCA4	19	affinity chromatography technology	Seki Y (2010)	1