PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
IRF4	1	ETV7	2	two hybrid	Ravasi T (2010)	1
MYD88	1	IRAK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen BC (2002), Wesche H (1999), Li S (2002), Fitzgerald KA (2001), Fitzgerald KA (2001), Li S (2011), Neumann D (2007), Zhou J (2011), Burns K (2003), Mizobe T (2007), Loiarro M (2007), Choi KC (2006), Rao N (2005), Rao N (2005), Li CH (2006)	15
IRF4	1	ELP1	5	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
IRF4	1	PRRC2B	9	affinity chromatography technology	Li S (2011)	1
TRAF2	1	USP4	3	affinity chromatography technology, enzymatic study	Xiao N (2011), Xiao N (2011)	2
TOP1	1	IRF4	1	unspecified method	Trzcinska AM (2002)	1
SPI1	1	BCL6	6	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Wei F (2009), Wei F (2009), Wei F (2009), Wei F (2009)	4
IRF4	1	TLK2	16	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
TRAF6	0	IRAK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Wesche H (1999), Qian Y (2001), Cao Z (1996), Takatsuna H (2003), Li S (2002), Ling L (2000), Ling L (2000), Takaesu G (2001), Muzio M (1997), Chen F (2008), Li X (2001), Li X (2001), Xiong Y (2011), Xiong Y (2011), Tang H (2010), Muroi M (2011), Liu A (2012), Lee JY (2009), Lee JY (2009), Kollewe C (2004), Jiang Z (2002), Jensen LE (2001), Liu G (2007), Liu G (2007), Jiang Z (2003), Nguyen T (2009), Choi KC (2006), Rao N (2005), Rao N (2005), Lakshmanan U (2007), Lee HJ (2012), Lee HJ (2012), Zhang X (2013), Yao J (2007), Hu MM (2014), Jeon J (2014), Conze DB (2008), Tanishima M (2017)	38
MYD88	1	TRAF6	0	genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fitzgerald KA (2001), Zhou J (2011), Zhou J (2011), Zhang X (2013), Zhang X (2013), Hirata Y (2006)	6
IRF4	1	MYD88	1	affinity chromatography technology, imaging technique	Watanabe T (2014), Watanabe T (2014)	2
USP4	3	IRF4	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Guo Z (2017), Guo Z (2017), Guo Z (2017)	3
IRF4	1	NFATC2	1	affinity chromatography technology, affinity chromatography technology	Rengarajan J (2002), Rengarajan J (2002)	2
IRF4	1	TRAF2	1	two hybrid	Rual JF (2005)	1
TRAF2	1	TRAF6	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Li S (2011), Davies CC (2005), Relaix F (1998), Rolland T (2014), Yu H (2011), Huttlin EL (2017)	7
IRF4	1	VPS35	2	affinity chromatography technology	Li S (2011)	1
IRAK1	1	YTHDC2	11	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
IRF4	1	PEG10	2	affinity chromatography technology	Li S (2011)	1
IRF4	1	BATF	0	two hybrid	Ravasi T (2010)	1
IRF4	1	YTHDC2	11	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
IRF4	1	CARM1	0	affinity chromatography technology	Li S (2011)	1
NFATC2	1	TLK2	16	affinity chromatography technology	Gabriel CH (2016)	1
RIPK2	0	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	McCarthy JV (1998), LeBlanc PM (2008), Marinis JM (2011)	3
RIPK2	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology	Thome M (1998), Li S (2011)	2
IRF4	1	IRAK1	1	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
TRAF6	0	USP4	3	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology	Xiao N (2011), Xiao N (2011), Xiao N (2011), Xiao N (2011), Zhou F (2012), Zhou F (2012)	6
IRF4	1	STAT6	1	pull down, affinity chromatography technology, pull down	Gupta S (1999), Gupta S (1999), Gupta S (2001)	3
IRF4	1	HOXB13	1	two hybrid	Ravasi T (2010)	1
IRF4	1	PROX1	0	two hybrid	Ravasi T (2010)	1
IRF4	1	BCL6	6	affinity chromatography technology, pull down, affinity chromatography technology, pull down	Gupta S (1999), Gupta S (1999), Gupta S (1999), Gupta S (2001)	4
FKBP4	0	IRF4	1	affinity chromatography technology	Mamane Y (2000)	1
IRF4	1	RIPK2	0	affinity chromatography technology, imaging technique, affinity chromatography technology	Watanabe T (2014), Watanabe T (2014), Watanabe T (2014)	3
IRF4	1	TRAF6	0	affinity chromatography technology, imaging technique	Watanabe T (2014), Watanabe T (2014)	2
3227	0	IRF4	1	two hybrid	Ravasi T (2010)	1
IRF4	1	SPI1	1	pull down, x-ray crystallography	Brass AL (1999), Escalante CR (2002)	2