PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
EP300	36	SMAD3	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Qiu P (2006), Furumatsu T (2005), Itoh S (2000), Akiyoshi S (1999), Abecassis L (2004), Kaimori A (2010), Janknecht R (1998), Janknecht R (1998), Nishihara A (1999), Nishihara A (1999), Furumatsu T (2005), Ghosh AK (2004), Shen X (1998), Shen X (1998), Ghosh AK (2001), Postigo AA (2003), Postigo AA (2003), Yang WS (2005), Lim JY (2012), Lim JY (2012), Jinnin M (2007), Wang G (2005)	22
IRF3	4	IRF7	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Au WC (2001), Au WC (2001), Higgs R (2008), Higgs R (2008)	4
IRF7	2	IRF7	2	pull down, affinity chromatography technology	Au WC (2001), Kondo T (2012)	2
EP300	36	SMAD4	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology	Kim RH (2000), Luciakova K (2008), Janknecht R (1998), Chung CL (2011), Shen X (1998), Dornan D (2003), Yang Y (2015)	7
SMAD3	1	TANK	1	two hybrid	Wang J (2011)	1
PIAS4	5	SMAD3	1	affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down	Imoto S (2003), Long J (2003), Long J (2003), Long J (2003), Long J (2003), Long J (2003)	6
MYD88	1	IRAK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen BC (2002), Wesche H (1999), Li S (2002), Fitzgerald KA (2001), Fitzgerald KA (2001), Li S (2011), Neumann D (2007), Zhou J (2011), Burns K (2003), Mizobe T (2007), Loiarro M (2007), Choi KC (2006), Rao N (2005), Rao N (2005), Li CH (2006)	15
TRAF6	0	TP53	0	enzymatic study, affinity chromatography technology	Zhang X (2016), Zhang X (2016)	2
TRAF6	0	TBK1	1	affinity chromatography technology, affinity chromatography technology, pull down	Cai B (2017), Fang R (2017), Fang R (2017)	3
MAVS	1	RNF31	3	affinity chromatography technology	Khan M (2016)	1
SMAD4	9	SMAD2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Moren A (2003), Wotton D (1999), Mori N (2001), Wu JW (2002), Wu JW (2002), Nakao A (1997), Wicks SJ (2000), Wu JW (2001), Chen X (1997), Hanai J (1999), Lebrun JJ (1999), Poncelet AC (2001), Razani B (2001), Razani B (2001), Wang B (2008), Moren A (2005), Kurisaki K (2003), Prunier C (2003), Kato Y (2002), Xu J (2000), Wang L (2011), He W (2006), He W (2006), Dupont S (2009), Brown JD (1999), Pardali K (2000), Fu G (2011), Chen W (2007), Gao S (2009), Lin X (2003), Seo SR (2006), Brown KA (2008), Brown KA (2008), Halder SK (2005), Barrios-Rodiles M (2005), Barrios-Rodiles M (2005), Dai F (2007), Chacko BM (2004), Chacko BM (2004), Chacko BM (2004), Wu RY (1997), Wu RY (1997), Tomita M (2004), Colland F (2004), Tang Y (2003), Ding L (2009), Fattet L (2013), Wang J (2011), Ali A (2013), Yamakawa N (2002), Yamakawa N (2002), Li X (2015), Zhou F (2014), Yang Y (2015), Yan X (2016), Zhou F (2017)	56
IRF3	4	EP300	36	affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, pull down	Li S (2011), Weaver BK (1998), Suhara W (2002), Suhara W (2002), Suhara W (2002), Wathelet MG (1998), Lin R (2001), Takahasi K (2010), Takahasi K (2010), Yang H (2002)	10
TANK	1	TRAF6	0	affinity chromatography technology, affinity chromatography technology, pull down	Wang W (2015), Wang W (2015), Wang W (2015)	3
IRF7	2	ARAF	0	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
IRF7	2	DEAF1	12	affinity chromatography technology	Ordureau A (2013)	1
IRF7	2	LTN1	8	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
ARAF	0	TP53	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
SUMO2	0	PIAS4	5	pull down, two hybrid, two hybrid, pull down, pull down	Goehler H (2004), Goehler H (2004), Hecker CM (2006), Ullmann R (2012), Ouyang J (2009)	5
TNFAIP3	3	IRF7	2	affinity chromatography technology, affinity chromatography technology	Ning S (2010), Ning S (2010)	2
RNF31	3	SMAD3	1	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
IRAK1	1	IQSEC1	3	affinity chromatography technology	Li S (2011)	1
IRF7	2	TRIM28	1	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Liang Q (2011), Liang Q (2011), Liang Q (2011), Liang Q (2011)	4
TRAF6	0	IRAK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Wesche H (1999), Qian Y (2001), Cao Z (1996), Takatsuna H (2003), Li S (2002), Ling L (2000), Ling L (2000), Takaesu G (2001), Muzio M (1997), Chen F (2008), Li X (2001), Li X (2001), Xiong Y (2011), Xiong Y (2011), Tang H (2010), Muroi M (2011), Liu A (2012), Lee JY (2009), Lee JY (2009), Kollewe C (2004), Jiang Z (2002), Jensen LE (2001), Liu G (2007), Liu G (2007), Jiang Z (2003), Nguyen T (2009), Choi KC (2006), Rao N (2005), Rao N (2005), Lakshmanan U (2007), Lee HJ (2012), Lee HJ (2012), Zhang X (2013), Yao J (2007), Hu MM (2014), Jeon J (2014), Conze DB (2008), Tanishima M (2017)	38
TRIM28	1	CREBBP	29	affinity chromatography technology	Seki Y (2010)	1
MAFB	1	IRF7	2	affinity chromatography technology	Kim H (2010)	1
MYD88	1	TRAF6	0	genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fitzgerald KA (2001), Zhou J (2011), Zhou J (2011), Zhang X (2013), Zhang X (2013), Hirata Y (2006)	6
SMAD4	9	IRF3	4	affinity chromatography technology	Qing J (2004)	1
IRF3	4	TRIM21	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yang K (2009), Yang K (2009), Yang K (2009), Yang K (2009), Stacey KB (2012), Higgs R (2008), Higgs R (2008)	7
TP53	0	SMAD2	5	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Cordenonsi M (2003), Cordenonsi M (2003), Tateossian H (2009), Lu D (2013), Chen TC (2014)	5
SMAD3	1	IRF7	2	pull down, affinity chromatography technology, imaging technique	Qing J (2004), Qing J (2004), Qing J (2004)	3
IRF7	2	P4HA1	1	affinity chromatography technology	Li S (2011)	1
GCLM	1	IRF7	2	two hybrid	Wang J (2011)	1
IRF7	2	CCDC47	2	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
TP53	0	PIAS4	5	two hybrid	Goehler H (2004)	1
SMAD2	5	INSR	9	two hybrid, affinity chromatography technology, pull down	ONeill TJ (1997), ONeill TJ (1997), ONeill TJ (1997)	3
TP53	0	SMAD3	1	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Cordenonsi M (2003), Cordenonsi M (2003), Lu D (2013), Ali A (2013)	4
IRF7	2	TRMT2A	4	affinity chromatography technology	Li S (2011)	1
IRF7	2	TRIM21	0	affinity chromatography technology	Higgs R (2010)	1
SUMO2	0	TRIM28	1	pull down	Ouyang J (2009)	1
IRF7	2	TLK2	16	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
TBK1	1	MAVS	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Li S (2011), Xu LG (2005), Wang L (2012), Liu XY (2011), Liu S (2015), Fang R (2017), Zhang Q (2017)	7
FADD	1	TRIM21	0	affinity chromatography technology, affinity chromatography technology, pull down	Young JA (2011), Young JA (2011), Young JA (2011)	3
FADD	1	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology	Won M (2010), Saitoh Y (2016)	2
IRF7	2	HACE1	2	affinity chromatography technology	Li S (2011)	1
PIAS4	5	IRF3	4	affinity chromatography technology	Zhang J (2004)	1
INSR	9	IRF7	2	two hybrid	Wang J (2011)	1
TRAF6	0	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, two hybrid, enzymatic study, affinity chromatography technology, enzymatic study, two hybrid, two hybrid	Heyninck K (1999), Evans PC (2001), Lin SC (2008), Xiong Y (2011), Bremm A (2010), Kelly C (2012), Hayes SD (2012), Lin SC (2008), Garg AV (2013), Boone DL (2004), Schimmack G (2017), Schimmack G (2017)	12
TP53	0	EP300	36	pull down, genetic interference, pull down, enzymatic study, pull down, pull down, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, imaging technique, affinity chromatography technology, enzymatic study, affinity chromatography technology, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, unspecified method, affinity chromatography technology, enzymatic study, unspecified method, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, unspecified method	An W (2004), Pastorcic M (2000), Livengood JA (2002), Livengood JA (2002), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Tang Y (2008), Wang H (2008), Valbuena A (2008), Shi D (2009), Vega FM (2004), Finlan L (2004), Groenroos E (2004), Zhao Y (2006), Roe JS (2006), Pedeux R (2005), Sekaric P (2007), Pan X (2009), Tang Y (2006), Sen GS (2011), Li Y (2012), Li Y (2012), Gillotin S (2010), Grossman SR (2003), Issaeva N (2004), Kitagawa M (2008), Sabbatini P (2002), Burge S (2009), Zilfou JT (2001), Issaeva N (2004), Issaeva N (2004), Feng H (2009), Feng H (2009), Lill NL (1997), Dornan D (2004), Dornan D (2004), Di Agostino S (2006), Wells M (2008), Fath DM (2006), Kobet E (2000), Costanzo A (2002), Kumazawa T (2011), Borger DR (2006), Cui D (2013), Borger DR (2006), Lee SJ (2013), Tang HY (2006), Lin C (2011), Choi WI (2014), Ding G (2013), Kim MK (2013), Ali A (2013), Wu G (2014), Mizuguchi Y (2012), Sinha S (2012), Sinha S (2012), Her YR (2013), Her YR (2013), Wu SY (2009), Wu SY (2009), Liu L (1999), Sakaguchi K (1998), Harrod R (2003), Gu W (1997), Teufel DP (2007), Mantovani F (2007), Mantovani F (2007), Dornan D (2003), Dornan D (2003), Dornan D (2003), Dornan D (2003), Dornan D (2003), MacPartlin M (2005), Mujtaba S (2004), Wang YH (2003), Chen H (1999), Tang Z (2013), Graczyk A (2013), Graczyk A (2013), Chan HM (2001), Thomas MC (2005), Miller Jenkins LM (2015), Miller Jenkins LM (2015), Koh DI (2014), Koh DI (2014), Koh DI (2014), Li H (2015), Chen LF (2005), Shi D (2016), Wright DG (2016), Zhang X (2016), Procopio MG (2015), Tong Q (2015)	95
IRF3	4	MAVS	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Li S (2011), Wang Y (2012), Xu LG (2005), Liu S (2015), Liu S (2015), Zhou Z (2014)	6
IRF3	4	CREBBP	29	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Kim T (1999), Li S (2011), Weaver BK (1998), Lin R (1998), Bibeau-Poirier A (2006), Lin R (1999), Johnson J (2007), Marson A (2004), Aksoy E (2007), Devaraj SG (2007), Devaraj SG (2007), Melroe GT (2007), Melroe GT (2007), Suhara W (2002), Wathelet MG (1998), Qin BY (2005), Qin BY (2005), Lin R (2001), Lubyova B (2004), Jennings S (2005), Sarkar SN (2004), Kim H (2010), Yang H (2002), Xing J (2013), Chen Y (2015)	25
RNF31	3	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology	Tokunaga F (2012), Verhelst K (2012)	2
SUMO2	0	IRF7	2	imaging technique	Chang PC (2013)	1
PIAS4	5	IRF7	2	affinity chromatography technology	Zhang J (2004)	1
IRF7	2	TRMT61B	2	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
IRF7	2	AIP	1	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
TANK	1	IRF7	2	two hybrid, affinity chromatography technology	Gatot JS (2007), Gatot JS (2007)	2
NMI	3	TRIM21	0	affinity chromatography technology, affinity chromatography technology	Das A (2015), Das A (2015)	2
ALK	8	IRF7	2	affinity chromatography technology	Crockett DK (2004)	1
TBK1	1	IRF3	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, pull down, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study	Friedman CS (2008), Li S (2011), Li S (2011), Cui J (2012), Piao W (2009), Nakhaei P (2012), Ikeda F (2007), Ikeda F (2007), Ng MH (2011), Wang L (2012), Yang K (2006), Yang K (2006), Liu XY (2010), Liu S (2015), Liu S (2015), Freischmidt A (2015), Zhang Q (2017), Zhang Q (2017)	18
CREBBP	29	TP53	0	enzymatic study, pull down, genetic interference, pull down, enzymatic study, fluorescent resonance energy transfe, enzymatic study, affinity chromatography technology, imaging technique, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, affinity chromatography technology, unspecified method, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, enzymatic study, enzymatic study, pull down, x-ray crystallography, x-ray crystallography, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Ito A (2002), Livengood JA (2002), Livengood JA (2002), Giebler HA (2000), Tang Y (2008), Jenkins LM (2009), Shi D (2009), Zhao Y (2006), Saifudeen Z (2005), Scolnick DM (1997), Scolnick DM (1997), Gu W (1997), Gu W (1997), Matsuda S (2004), Pasqualucci L (2011), Lee SK (1999), Dai C (2011), Lee CW (2010), Ferreon JC (2009), Ruas JL (2010), Ruas JL (2010), Huang WC (2007), Huang WC (2007), Mujtaba S (2004), Mujtaba S (2004), Mujtaba S (2004), Mujtaba S (2004), Col E (2002), Jansma AL (2014), Jansma AL (2014), Krois AS (2016), Hasegawa K (2008), Huang X (2013), Huang X (2013), Piskacek M (2016)	35
FADD	1	IRF7	2	affinity chromatography technology	Young JA (2011)	1
MYD88	1	IRF7	2	affinity chromatography technology, two hybrid, affinity chromatography technology, fluorescent resonance energy transfe	Zhao J (2006), Kawai T (2004), Kawai T (2004), Kawai T (2004)	4
RNF31	3	IRF7	2	affinity chromatography technology	Wang L (2017)	1
TBK1	1	IRF7	2	pull down	Ikeda F (2007)	1
TANK	1	IRF3	4	affinity chromatography technology	Gatot JS (2007)	1
SMAD2	5	IRF3	4	affinity chromatography technology	Qing J (2004)	1
SMAD2	5	CREBBP	29	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology	Xi Q (2008), Chan EC (2010), He W (2006), Chen W (2007), Colland F (2004), Cui Q (2005)	6
CREBBP	29	SMAD3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kang JS (2005), Alliston T (2005), Xi Q (2008), Cui Q (2005), Cui Q (2005), Chen W (2007), Nishihara A (1999), Tomita M (2004), Oussaief L (2009), Oussaief L (2009), Cui Q (2005)	11
EP300	36	SMAD2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Wotton D (1999), Pessah M (2001), Furumatsu T (2005), Wang J (2011), Suganuma T (2002)	5
IRF7	2	CREBBP	29	pull down	Yang H (2003)	1
ARAF	0	TRIM28	1	affinity chromatography technology	So J (2015)	1
TBK1	1	TANK	1	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Bouwmeester T (2004), Pomerantz JL (1999), Gatot JS (2007), Li S (2011), Li S (2011), Shen RR (2012), Ryzhakov G (2007), Wang J (2011), Seo S (2013), Saul VV (2014), Richter B (2016), Shostak K (2014)	12
SMAD3	1	SMAD2	5	affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Nakao A (1997), Lebrun JJ (1999), Dumont E (2003), Brown KA (2008), Brown KA (2008), Wu RY (1997), Wu RY (1997), Tang Y (2003), Tang Y (2003), Wang J (2011), Huttlin EL (2015), Huttlin EL (2017)	12
IRAK1	1	CCDC47	2	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
CREBBP	29	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Crusselle-Davis VJ (2007), Dohda T (2004), Dohda T (2004)	3
FADD	1	MYD88	1	two hybrid	Wang J (2011)	1
SMAD4	9	IRF7	2	pull down, affinity chromatography technology	Qing J (2004), Qing J (2004)	2
IRAK1	1	RNF31	3	affinity chromatography technology	Yang Y (2014)	1
IRF7	2	IQSEC1	3	affinity chromatography technology	Li S (2011)	1
MAFB	1	IRF3	4	affinity chromatography technology, affinity chromatography technology	Kim H (2010), Kim H (2010)	2
TNFAIP3	3	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang M (2013), Wang M (2013), Liu J (2013), Liu J (2013)	4
IRF7	2	NMI	3	affinity chromatography technology, affinity chromatography technology	Wang J (2013), Wang J (2013)	2
SMAD4	9	CREBBP	29	affinity chromatography technology	Yang Y (2015)	1
IRF7	2	MAVS	1	affinity chromatography technology	Xu LG (2005)	1
TRIM28	1	TP53	0	enzymatic study, affinity chromatography technology, affinity chromatography technology	Doyle JM (2010), Gilmore-Hebert M (2010), Okamoto K (2006)	3
PIAS4	5	SMAD2	5	affinity chromatography technology, two hybrid, affinity chromatography technology	Imoto S (2003), Long J (2003), Long J (2003)	3
TRAF6	0	IRF7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kawai T (2004), Young JA (2011), Hu Y (2011), Ning S (2008), Ning S (2008), Naiki Y (2015), Naiki Y (2015)	7
ACADS	0	IRF7	2	two hybrid	Wang J (2011)	1
SMAD3	1	SMAD4	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology	Seoane J (2004), Moren A (2003), Wu JW (2002), Nakao A (1997), Hanai J (1999), Lebrun JJ (1999), Poncelet AC (2001), Jablonska E (2010), Prunier C (2003), Kato Y (2002), Kaimori A (2010), Tang LY (2011), Tang LY (2011), Dupont S (2009), Dupont S (2009), Pardali K (2000), Kardassis D (2000), Xu L (2003), Fu G (2011), Chen W (2007), Kang JM (2012), Gao S (2009), Li H (2009), Li H (2009), Brown KA (2008), Brown KA (2008), Halder SK (2005), Barrios-Rodiles M (2005), Dai F (2007), Dai F (2007), Chacko BM (2004), Chacko BM (2004), Chacko BM (2004), Stroschein SL (1999), Stroschein SL (1999), Stroschein SL (1999), Wu RY (1997), Wu RY (1997), Wu RY (1997), Wu RY (1997), Tomita M (2004), Colland F (2004), Colland F (2004), Tang Y (2003), Ding L (2009), Fattet L (2013), Wang J (2011), Xue J (2014), Ali A (2013), Gao S (2009), Yamakawa N (2002), Yamakawa N (2002), Wang G (2005), Li X (2015), Zhou F (2014), Yang Y (2015), Yan X (2016), Yan X (2016), Wu Y (2017), Wu Y (2017)	60
IRAK1	1	TNFAIP3	3	affinity chromatography technology	Xiong Y (2011)	1
MAVS	1	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li S (2011), Wang Y (2012), Xu LG (2005), Wang P (2013), Wang P (2013), Shi Z (2015), Shi Z (2015), Minassian A (2015), Khan M (2016), Fang R (2017), Fang R (2017)	11
SMAD2	5	IRF7	2	pull down, affinity chromatography technology	Qing J (2004), Qing J (2004)	2
MAVS	1	FADD	1	affinity chromatography technology	Kawai T (2005)	1
MYD88	1	SMAD3	1	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
IRF7	2	IRAK1	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, enzymatic study	Li S (2011), Li S (2011), Uematsu S (2005), Uematsu S (2005), Uematsu S (2005), Uematsu S (2005)	6
IRF7	2	EP300	36	pull down	Yang H (2003)	1
IRF3	4	DEAF1	12	affinity chromatography technology	Ordureau A (2013)	1
IRF7	2	PALD1	2	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
IRF3	4	TRAF6	0	affinity chromatography technology	Liu S (2015)	1
TP53	0	IRF7	2	two hybrid	Chen J (2008)	1
SUMO3	0	IRF7	2	imaging technique	Chang PC (2013)	1
PIAS4	5	SMAD4	9	affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Imoto S (2003), Long J (2003), Long J (2003), Long J (2003), Lee PS (2003)	5
SUMO2	0	TANK	1	affinity chromatography technology	Renner F (2011)	1
RNF31	3	TRAF6	0	enzymatic study	Kliza K (2017)	1
TNFAIP3	3	TBK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Gao L (2011), Saitoh T (2005)	3
EP300	36	SUMO2	0	pull down, enzymatic study	Ullmann R (2012), Ullmann R (2012)	2