PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ANGPT2	4	ITGB1	4	pull down, affinity chromatography technology, affinity chromatography technology	Lee HS (2014), Hu B (2006), Hu B (2006)	3
ADAM32	3	ITGA5	7	affinity chromatography technology	Huttlin EL (2017)	1
ITGA5	7	CD9	1	affinity chromatography technology	Hirano T (1999)	1
ITGA5	7	SEL1L	2	affinity chromatography technology	Diaferia GR (2013)	1
EWSR1	2	ITGA5	7	biochemical	Havugimana PC (2012)	1
CTDSPL	1	ITGA5	7	bioid	St-Denis N (2016)	1
ITGA5	7	CIB1	2	affinity chromatography technology, affinity chromatography technology	Yamodo IH (2012), Yamodo IH (2012)	2
ATP1B3	0	ATP1A1	9	biochemical	Wan C (2015)	1
ITGB3	6	CIB1	2	affinity chromatography technology, affinity chromatography technology	Yamodo IH (2012), Yamodo IH (2012)	2
FBXO6	0	ITGA5	7	affinity chromatography technology	Liu B (2012)	1
UBC	7	UBAP1	2	pull down, pull down, pull down, pull down	Fenner BJ (2009), Stefani F (2011), Kharitidi D (2015), Zhang X (2017)	4
LGALS3BP	5	CD9	1	affinity chromatography technology	Lee JH (2010)	1
FGFR2	6	CBL	7	affinity chromatography technology	Kaabeche K (2004)	1
AUP1	0	SEL1L	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Klemm EJ (2011), Klemm EJ (2011), Mueller B (2008), Christianson JC (2012), Christianson JC (2012)	5
FBXO6	0	ILK	0	affinity chromatography technology	Liu B (2012)	1
HNRNPU	12	ITGA5	7	biochemical	Havugimana PC (2012)	1
ITGB1	4	ILK	0	affinity chromatography technology, two hybrid	Hannigan GE (1996), McDonald PC (2008)	2
ITGB1	4	ITGA5	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, pull down	Lobert VH (2010), Lobert VH (2010), Zhang H (2003), Rantala JK (2011), Havugimana PC (2012), Wan C (2015), Lee HS (2014)	7
FBXO6	0	ATP1A1	9	affinity chromatography technology	Liu B (2012)	1
LGALS3BP	5	HNRNPU	12	affinity chromatography technology	Fogeron ML (2013)	1
ITGB1	4	LGALS3BP	5	pull down	Stampolidis P (2015)	1
FN1	17	ILK	0	affinity chromatography technology	Humphries JD (2009)	1
FBXO6	0	AUP1	0	affinity chromatography technology	Liu B (2012)	1
GRK6	3	ITGA5	7	two hybrid	Wang J (2011)	1
FBXO6	0	ITGB1	4	affinity chromatography technology	Liu B (2012)	1
ITGA5	7	ILK	0	affinity chromatography technology	Hannigan GE (1996)	1
CD9	1	ITGB1	4	affinity chromatography technology, affinity chromatography technology	Radford KJ (1996), Mazzocca A (2002)	2
CBL	7	ITGA5	7	affinity chromatography technology	Kaabeche K (2005)	1
LGALS3BP	5	FN1	17	affinity chromatography technology	Huttlin EL (2017)	1
ITGA5	7	RABIF	0	two hybrid	Wixler V (1999)	1
FN1	17	HNRNPU	12	affinity chromatography technology	Humphries JD (2009)	1
TIMP2	1	ITGA5	7	pull down, affinity chromatography technology	Seo DW (2003), Seo DW (2003)	2
LGALS8	4	ITGA5	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBC	7	HNRNPU	12	affinity chromatography technology	Matsumoto M (2005)	1
ILK	0	EWSR1	2	affinity chromatography technology	Ewing RM (2007)	1
TIMP2	1	ITGB1	4	pull down	Seo DW (2003)	1
TLN1	5	ITGB3	6	pull down, pull down, pull down, pull down, pull down	Patil S (1999), Calderwood DA (2002), Calderwood DA (2002), Anthis NJ (2009), Ulmer TS (2001)	5
ATP1B3	0	ITGB5	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ITGB1	4	TLN1	5	unspecified method, biochemical, pull down, pull down	Martel V (2001), Havugimana PC (2012), Anthis NJ (2009), Anthis NJ (2009)	4
FN1	17	TLN1	5	affinity chromatography technology, affinity chromatography technology	Humphries JD (2009), Humphries JD (2009)	2
STAMBP	2	UBC	7	enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, pull down, enzymatic study, enzymatic study	Bremm A (2010), Komander D (2009), McCullough J (2006), Nakasone MA (2013), Davies CW (2013), Trang VH (2014), Wauer T (2015), Michel MA (2015), Bueno AN (2015), Baiady N (2016), Baiady N (2016), Castaneda CA (2016), Kliza K (2017)	13
EWSR1	2	ITGB5	3	two hybrid	Wang J (2011)	1
FGFR2	6	CTDSPL	1	two hybrid	Yao Z (2017)	1
CLK1	1	ITGA5	7	enzymatic study	Lipp JJ (2015)	1
ITGB5	3	ITGA5	7	affinity chromatography technology	Wang L (2012)	1
L1CAM	3	ITGA5	7	pull down	Silletti S (2000)	1
FN1	17	ITGB1	4	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Humphries JD (2009), Humphries JD (2009), Kharitidi D (2015), Lee HS (2014)	4
FN1	17	FUBP1	1	affinity chromatography technology	Humphries JD (2009)	1
ITGA5	7	UBC	7	affinity chromatography technology	Kaabeche K (2005)	1
ITGB3	6	ITGB1	4	imaging technique	Moon HE (2015)	1
FN1	17	UBC	7	affinity chromatography technology	Humphries JD (2009)	1
BTNL3	0	ITGA5	7	affinity chromatography technology	Huttlin EL (2017)	1
ILK	0	ATP1A1	9	affinity chromatography technology	So J (2015)	1
FAM19A4	0	ITGA5	7	affinity chromatography technology	Huttlin EL (2017)	1
FN1	17	ITGA5	7	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Busk M (1992), Lobert VH (2010), Humphries JD (2009), Humphries JD (2009), Kharitidi D (2015), Lee HS (2014)	6
LGALS8	4	ITGB1	4	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Hadari YR (2000), Hadari YR (2000), Huttlin EL (2015), Huttlin EL (2017)	4
EWSR1	2	ATP1B3	0	bioid	Elzi DJ (2014)	1
ATP1A1	9	ITGA5	7	biochemical	Wan C (2015)	1
UBC	7	ATP1A1	9	affinity chromatography technology	Bish RA (2007)	1
ATP1B3	0	ITGA5	7	biochemical	Wan C (2015)	1
UBAP1	2	ITGA5	7	pull down	Kharitidi D (2015)	1
FBXO6	0	SEL1L	2	affinity chromatography technology	Liu B (2012)	1
CBL	7	UBC	7	x-ray crystallography, pull down, affinity chromatography technology, pull down, enzymatic study, pull down, enzymatic study, x-ray crystallography, pull down, pull down, enzymatic study	Peschard P (2007), Peschard P (2007), Davies GC (2004), Davies GC (2004), Kassenbrock CK (2004), Zhou ZR (2008), Kim M (2004), Dou H (2013), Liu N (2015), Buetow L (2016), Kliza K (2017)	11
ITGB3	6	FN1	17	pull down	Kauf AC (2001)	1
FUBP1	1	ITGA5	7	biochemical	Havugimana PC (2012)	1
EWSR1	2	GIPC1	1	affinity chromatography technology	Elzi DJ (2014)	1
FBXO6	0	L1CAM	3	affinity chromatography technology	Liu B (2012)	1
ILK	0	ITGB3	6	affinity chromatography technology	Yamaji S (2002)	1
FN1	17	EWSR1	2	affinity chromatography technology	Humphries JD (2009)	1
ITGA5	7	GIPC1	1	two hybrid, pull down	Tani TT (2001), Tani TT (2001)	2
ITGA5	7	LGALS3BP	5	pull down	Stampolidis P (2015)	1
FBXO6	0	LGALS3BP	5	affinity chromatography technology	Liu B (2012)	1
ITGB3	6	ITGA5	7	affinity chromatography technology, biochemical, pull down	Wang L (2012), Wan C (2015), Vallar L (1999)	3
ANGPT2	4	ITGA5	7	pull down, affinity chromatography technology	Lee HS (2014), Hu B (2006)	2
ITGA5	7	FGFR2	6	affinity chromatography technology, affinity chromatography technology	Kaabeche K (2005), Kaabeche K (2005)	2
AUP1	0	ITGA5	7	two hybrid	Kato A (2002)	1
ITGB1	4	SEL1L	2	affinity chromatography technology	Diaferia GR (2013)	1
LGALS8	4	FN1	17	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ILK	0	AUP1	0	affinity chromatography technology	Ewing RM (2007)	1
UBC	7	SHARPIN	1	pull down	Zhang X (2017)	1
FAM19A4	0	FN1	17	affinity chromatography technology	Huttlin EL (2017)	1
FAM19A4	0	ITGB1	4	affinity chromatography technology	Huttlin EL (2017)	1
TLN1	5	ITGA5	7	imaging technique	Lilja J (2017)	1
ITGA5	7	STAMBP	2	two hybrid	Wang J (2011)	1
AUP1	0	UBC	7	affinity chromatography technology, affinity chromatography technology	Klemm EJ (2011), Klemm EJ (2011)	2
ITGA5	7	SHARPIN	1	affinity chromatography technology, fluorescent resonance energy transfe	Rantala JK (2011), De Franceschi N (2015)	2