PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PLAUR	0	ITGAM	5	pull down	Simon DI (2000)	1
ITGAM	5	ICAM1	6	pull down	Santoso S (2002)	1
PRTN3	2	ITGAM	5	affinity chromatography technology	David A (2003)	1
ITGAM	5	BCAP31	0	affinity chromatography technology, affinity chromatography technology, pull down, biochemical	Zen K (2004), Zen K (2004), Zen K (2004), Zen K (2004)	4
ITGAM	5	IRAK1	1	affinity chromatography technology	Shi C (2001)	1
IRAK1	1	LMNA	2	affinity chromatography technology	So J (2015)	1
LMNA	2	ITGAM	5	two hybrid	Dittmer TA (2014)	1
ITGAM	5	SHARPIN	1	unspecified method	Pouwels J (2013)	1
ITGAM	5	JAM3	0	pull down	Santoso S (2002)	1
AUP1	0	ITGAM	5	two hybrid	Kato A (2002)	1
RAD21	3	ITGAM	5	affinity chromatography technology	Panigrahi AK (2011)	1