PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
LAT	0	ITK	7	affinity chromatography technology, enzymatic study	Shan X (1999), Perez-Villar JJ (2002)	2
ERBB2	6	ITK	7	unspecified method	Jones RB (2006)	1
DOK1	2	SRC	2	pull down, unspecified method	van Dijk TB (2000), Liu BA (2012)	2
SRC	2	FYN	1	unspecified method, affinity chromatography technology, affinity chromatography technology	Pirozzi G (1997), Chen Y (2009), Huttlin EL (2017)	3
GRB2	2	HSP90AA1	7	affinity chromatography technology	Brehme M (2009)	1
HSP90AA1	7	IKBKG	0	affinity chromatography technology, affinity chromatography technology	Gano JJ (2010), Hein MY (2015)	2
ERBB3	3	CDC37	0	affinity chromatography technology	Li J (2013)	1
730211	0	HSP90AA1	7	biochemical	Havugimana PC (2012)	1
HSP90AB1	2	SRC	2	affinity chromatography technology	Karras GI (2017)	1
SRC	2	HNRNPK	4	enzymatic study	Messias AC (2006)	1
SRC	2	WAS	0	affinity chromatography technology, pull down, pull down	Banin S (1996), Banin S (1996), Finan PM (1996)	3
GRB2	2	KHDRBS1	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, unspecified method, affinity chromatography technology, two hybrid	Liu SK (1998), Oneyama C (2002), Shen Z (1999), Shen Z (1999), Bandyopadhyay S (2010), Asbach B (2012), Bisson N (2011), Wang J (2011)	8
ERBB2	6	DOK1	2	unspecified method	Jones RB (2006)	1
FYN	1	3327	0	affinity chromatography technology	Huttlin EL (2017)	1
730211	0	HSP90AB1	2	biochemical	Havugimana PC (2012)	1
PLCG1	6	WAS	0	pull down, pull down	Banin S (1996), Finan PM (1996)	2
ERBB2	6	ERBB3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Scaltriti M (2009), Graus-Porta D (1997), Le XF (2005), Chen TC (2014), Ritch PS (2005)	5
HSP90AA1	7	ERBB2	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Xu W (2001), Jeong JH (2008), Mollapour M (2010), Citri A (2002), Jung Y (2007), Suzuki T (2011), Tsutsumi S (2012), Taipale M (2012), Bali P (2005), Woodford MR (2016), Yan YY (2011), Yan YY (2011)	12
ERBB3	3	ITK	7	unspecified method	Jones RB (2006)	1
SMURF1	4	HNRNPK	4	affinity chromatography technology	Xie Y (2013)	1
SMURF1	4	ITK	7	enzymatic study	Andrews PS (2010)	1
FYN	1	KHDRBS1	1	pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, enzymatic study	Oneyama C (2002), Fusaki N (1997), Loewenberg M (2006), Asbach B (2012), Asbach B (2012), Kaabeche K (2004)	6
SRC	2	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, two hybrid	Olayioye MA (1999), Keely SJ (2000), Sato K (2000), Lee CW (2007), Jaganathan S (2011), Jaganathan S (2011), Lee IT (2010), Hitosugi T (2007), Chang CC (2012), Chang CC (2012), Tung WH (2011), Kotlyar M (2015), Petschnigg J (2014), Li J (2013), Yao Z (2017)	15
IKBKG	0	ITK	7	pull down	Fenner BJ (2010)	1
DOK1	2	PLCG1	6	pull down	van Dijk TB (2000)	1
FASLG	0	ITK	7	unspecified method, affinity chromatography technology	Voss M (2009), Voss M (2009)	2
EGFR	5	IKBKG	0	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
ITK	7	NSUN6	2	biochemical	Wan C (2015)	1
ITK	7	GAPDHS	1	affinity chromatography technology	Huttlin EL (2017)	1
FASLG	0	FYN	1	pull down, pull down, pull down, unspecified method, imaging technique	Wenzel J (2001), Hane M (1995), Zuccato E (2007), Voss M (2009), Chen TC (2014)	5
HSP90AA1	7	ITK	7	affinity chromatography technology	Taipale M (2012)	1
EGFR	5	HNRNPK	4	affinity chromatography technology	Yao Z (2017)	1
FUS	0	HSP90AB1	2	affinity chromatography technology	Wang T (2014)	1
PLCG1	6	LAT	0	biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, fluorescent resonance energy transfe	Zhang W (1998), Paz PE (2001), Paz PE (2001), Zhang W (1998), Jiang Y (2007), Braiman A (2006), Braiman A (2006), Matalon O (2016), Matalon O (2016)	9
CD2	2	FYN	1	pull down	Lin H (1998)	1
EGFR	5	DOK1	2	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
EGFR	5	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Ettenberg SA (1999), Tvorogov D (2002), Pennock S (2008), Umebayashi K (2008), Ng C (2008), Ng C (2008), Povlsen GK (2008), Khan EM (2008), Su X (2007), Shtiegman K (2007), Han W (2006), Visser GD (2005), Tsacoumangos A (2005), Prasad NK (2005), Gur G (2004), Kowanetz K (2004), Feshchenko EA (2004), Wu WJ (2003), Schmidt MH (2003), Bao J (2003), Rubin C (2003), Waterman H (1999), Bonaccorsi L (2007), Dey N (2011), Miraoui H (2010), Guo HB (2009), Tong J (2009), Tong J (2009), Sun Q (2010), Sanada F (2009), Rafiq K (2011), Ravid T (2004), Ravid T (2004), Duan L (2011), Duan L (2011), Haglund K (2005), Oksvold MP (2003), Oksvold MP (2003), Gui A (2012), Yang S (2006), de Melker AA (2004), Crovello CS (1998), Graus-Porta D (1997), Oksvold MP (2001), Raguz J (2007), de Melker AA (2004), Thien CB (2001), Kassenbrock CK (2004), Tarcic G (2009), Schroeder B (2012), Adachi S (2009), Shen F (2007), Mitsushima M (2006), Choi JH (2003), Burke P (2001), Tanaka S (1995), Meisner H (1995), Meisner H (1995), Kumar EA (2012), Tong J (2008), Dou H (2012), Levkowitz G (1999), Levkowitz G (1999), Bode AM (2009), Thomas C (2012), Meijer IM (2013), Chang CC (2012), Chang CC (2012), Smith CJ (2013), Gan Y (2010), Scott RP (2005), Fukazawa T (1996), Fukazawa T (1996), Fukazawa T (1996), Wang L (2013), Hong SY (2013), Sigismund S (2013), Sigismund S (2013), Sigismund S (2013), Meisner H (1997), Odintsova E (2013), Kondratov KA (2010), He Z (2014), Tong J (2014), Balaji K (2012), Kiuchi T (2014), Zhang B (2005), Waterman H (1999), Ha Thi HT (2015), Yao S (2015), Kortuem F (2015), Igloi Z (2015), Song F (2016), Song F (2016), Lin TY (2017), Conte A (2017)	96
CBL	7	GRB2	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jain SK (1997), Liu SK (1998), Ettenberg SA (1999), Wong A (2002), Wong A (2002), Robertson H (1997), Donovan JA (1994), Park RK (1999), Erdreich-Epstein A (1999), Gesbert F (1998), Gesbert F (1998), Gesbert F (1998), Husson H (1997), Saci A (2002), Odai H (1997), Ng C (2008), Khan EM (2008), Bandyopadhyay S (2010), Jiang X (2003), Waterman H (2002), Miraoui H (2010), Ravid T (2004), Ingham RJ (1996), Erdreich-Epstein A (1997), Rellahan BL (2003), Izadi KD (1998), Wang Y (1999), Chu J (1998), Bonita DP (1997), Boussiotis VA (1997), Meisner H (1995), Meisner H (1995), Barber DL (1997), Shishido T (2000), Bartkiewicz M (1999), Buday L (1996), Tarcic G (2009), Belleudi F (2007), Brizzi MF (1996), Brenner B (2001), Donovan JA (1996), Donovan JA (1996), Donovan JA (1996), Gaston I (2004), Gaston I (2004), Tsygankov AY (1996), Tsygankov AY (1996), Hunter S (1997), Jain SK (1997), Levkowitz G (1996), Liu YC (1997), Odai H (1995), Odai H (1995), Meisner H (1995), Huang JY (2000), Panchamoorthy G (1996), Panchamoorthy G (1996), Yokouchi M (1997), Oda A (1996), Fukazawa T (1995), Fukazawa T (1995), Selbach M (2006), Brehme M (2009), Brehme M (2009), Fukazawa T (1995), Cerboni C (1998), Cerboni C (1998), Fixman ED (1997), Anderson SM (1997), Houtman JC (2006), Brizzi MF (1996), Scott RP (2005), Scott RP (2005), Bisson N (2011), Fukazawa T (1996), Fukazawa T (1996), Umehara H (2002), Taipale M (2014), Taipale M (2014), Grossmann A (2015), Grossmann A (2015), Igloi Z (2015), Huttlin EL (2017)	83
ITK	7	CBL	7	pull down	Bunnell SC (1996)	1
SRC	2	KHDRBS1	1	two hybrid, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, fluorescent resonance energy transfe, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study	Stelzl U (2005), Oneyama C (2002), Koch CA (1992), Shen Z (1999), Shen Z (1999), Finan PM (1996), Asbach B (2012), Asbach B (2012), Asbach B (2012), Kaabeche K (2004), Pincheira R (2008), Wong G (1992), Williger BT (1997), Wong BR (1999)	14
CBL	7	PLCG1	6	far western blotting, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, imaging technique	Tvorogov D (2002), Tvorogov D (2002), Tvorogov D (2002), Graham LJ (1998), Singh AJ (2007), Rellahan BL (2003), Rellahan BL (2003), Okabe S (2006), Choi JH (2003), Choi JH (2003), Braiman A (2006), Braiman A (2006), Braiman A (2006), Chen TC (2014)	14
EGFR	5	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Schulze WX (2006), Blagoev B (2003), Oneyama C (2002), Wong L (1999), Okutani T (1994), Okutani T (1994), Okutani T (1994), Tortora G (1997), Daly RJ (1996), Buday L (1994), Lowenstein EJ (1992), Lowenstein EJ (1992), Braverman LE (1999), Khan EM (2008), Bonaccorsi L (2007), Miraoui H (2010), Tong J (2009), Severe N (2011), Takahashi Y (1999), Tarcic G (2009), Thien CB (1997), Burke P (2001), Katayama H (1999), Meisner H (1995), Kurada BR (2009), Tong J (2008), Bisson N (2011), Fukazawa T (1996), Fukazawa T (1996), Jones RB (2006), Sigismund S (2013), Sigismund S (2013), Foerster S (2013), Bisson N (2011), Gotoh N (1994), Wu SL (2006), Wu SL (2006), Tong J (2014), Oksvold MP (2001), Kotlyar M (2015), Petschnigg J (2014), Li J (2013), Song F (2016), Song F (2016), Ueno H (1995), Ueno H (1995), Ueno H (1995), Prigent SA (1996), Kapoor GS (2010), Kapoor GS (2010), Okamura T (2009)	51
FUS	0	HNRNPK	4	affinity chromatography technology	Wang T (2014)	1
FASLG	0	GRB2	2	affinity chromatography technology, pull down, pull down	Ghadimi MP (2002), Ghadimi MP (2002), Wenzel J (2001)	3
FGFR1	2	SRC	2	affinity chromatography technology, affinity chromatography technology	Dudka AA (2010), Vecchione A (2007)	2
PLCG1	6	ERBB2	6	affinity chromatography technology, biochemical, unspecified method	Peles E (1991), Arteaga CL (1991), Jones RB (2006)	3
KHDRBS1	1	HNRNPK	4	two hybrid, pull down, affinity chromatography technology, pull down, genetic interference, genetic interference, two hybrid, two hybrid, two hybrid	Yang JP (2002), Yang JP (2002), Yang JP (2002), Yang JP (2002), Yang JP (2002), Yang JP (2002), Hegele A (2012), Hegele A (2012), Wang J (2011)	9
DOK1	2	ITK	7	unspecified method	Liu BA (2012)	1
LAT	0	GRB2	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down	Paz PE (2001), Zhang W (1998), Perez-Villar JJ (2002), Motto DG (1994), Houtman JC (2006)	5
FYN	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Loewenberg M (2006), Taipale M (2012), Taipale M (2012), Huttlin EL (2017)	4
FUS	0	HSP90AA1	7	affinity chromatography technology	Wang T (2014)	1
EGFR	5	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay	Citri A (2002), Yang S (2006), Shimamura T (2005), Lavictoire SJ (2003), Lavictoire SJ (2003), Foerster S (2013), Kotlyar M (2015), Petschnigg J (2014)	8
GRB2	2	SOCS1	1	pull down	De Sepulveda P (1999)	1
ITK	7	SOCS1	1	pull down	De Sepulveda P (1999)	1
GRB2	2	FUS	0	affinity chromatography technology	Brehme M (2009)	1
CDC37	0	SRC	2	pull down	Rao J (2001)	1
IKBKG	0	HSP90AB1	2	affinity chromatography technology	Hein MY (2015)	1
ITK	7	730211	0	affinity chromatography technology	Huttlin EL (2017)	1
FASLG	0	SRC	2	unspecified method	Voss M (2009)	1
GRB2	2	KPNA2	0	two hybrid	Wang J (2011)	1
GRB2	2	WAS	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Banin S (1996), She HY (1997), She HY (1997), She HY (1997)	4
FGFR1	2	ERBB3	3	unspecified method	Jones RB (2006)	1
ITK	7	WAS	0	pull down, pull down	Cory GO (1996), Bunnell SC (1996)	2
IKBKG	0	CDC37	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Chen G (2002), Taipale M (2014), Taipale M (2014), Liu D (2014), Hein MY (2015), Hein MY (2015), Li J (2013)	8
SOCS1	1	ERBB2	6	unspecified method	Jones RB (2006)	1
ITK	7	KPNA2	0	affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, enzymatic study	Perez-Villar JJ (2001), Perez-Villar JJ (2001), Perez-Villar JJ (2001), Perez-Villar JJ (2001), Perez-Villar JJ (2001)	5
FYN	1	HSP90AB1	2	affinity chromatography technology	Huttlin EL (2017)	1
EGFR	5	FUS	0	affinity chromatography technology	Liccardi G (2014)	1
LAT	0	CBL	7	affinity chromatography technology	Jiang Y (2007)	1
KPNA2	0	HSP90AB1	2	biochemical	Kristensen AR (2012)	1
PLCG1	6	IBTK	3	affinity chromatography technology	Spatuzza C (2008)	1
ITK	7	PLCG1	6	pull down, affinity chromatography technology, enzymatic study	Perez-Villar JJ (1999), Perez-Villar JJ (1999), Hao S (2002)	3
SRC	2	SPRR2A	2	pull down, affinity chromatography technology	Demetris AJ (2008), Demetris AJ (2008)	2
ERBB2	6	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Scaltriti M (2009), Shtiegman K (2007), Haslekas C (2005), Riedemann J (2007), Burke P (2001), Meijer IM (2011), Chen TC (2014), Li J (2013), Li J (2013), Caiazza F (2010), Caiazza F (2010), Sharif A (2009)	12
SRC	2	ERBB2	6	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference	Ren Z (2002), Li X (2007), Liang K (2010), Liang K (2010), Shen JP (2017)	5
CBL	7	SRC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kassenbrock CK (2002), Rafiq K (2011), Rellahan BL (2003), Vantler M (2006), Shishido T (2000), Shishido T (2000), Song JJ (2010), Sanjay A (2006), Sanjay A (2006), Tanaka S (1995), Tanaka S (1995), Tanaka S (1995), Szymkiewicz I (2004), Hashimoto S (2006)	14
FUS	0	PPIA	0	affinity chromatography technology	Wang T (2014)	1
ITK	7	HNRNPK	4	pull down	Bunnell SC (1996)	1
ITK	7	ITK	7	enzymatic study	Hao S (2002)	1
ITK	7	SRC	2	pull down	Bunnell SC (2000)	1
CBL	7	ERBB2	6	pull down, affinity chromatography technology	Zhou P (2003), Bisaro B (2016)	2
ITK	7	IBTK	3	affinity chromatography technology	Spatuzza C (2008)	1
ERBB2	6	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method	Schulze WX (2006), Bourguignon LY (2001), Olayioye MA (1998), Li X (2007), Li X (2007), Crovello CS (1998), Jones RB (2006)	7
FYN	1	CBL	7	affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid	Taher TE (2002), Deckert M (1998), Deckert M (1998), Deckert M (1998), Ghosh AK (2004), Rellahan BL (2003), Boussiotis VA (1997), Andoniou CE (2000), Shishido T (2000), Okabe S (2006), Kaabeche K (2004), Tsygankov AY (1996), Tsygankov AY (1996), Tsygankov AY (1996), Tsygankov AY (1996), Tsygankov AY (1996), Tanaka S (1995), Reedquist KA (1996), Grossmann AH (2004), Panchamoorthy G (1996), Fukazawa T (1995), Fukazawa T (1995), Fukazawa T (1995), Nishio H (2002), Anderson SM (1997), Fukazawa T (1996), Grossmann A (2015)	27
CD2	2	ITK	7	affinity chromatography technology	Lin H (1998)	1
ITK	7	KHDRBS1	1	enzymatic study, pull down, pull down, unspecified method	Hao S (2002), Andreotti AH (1997), Bunnell SC (1996), Asbach B (2012)	4
EGFR	5	PLCG1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tvorogov D (2002), Bedrin MS (1997), Crovello CS (1998), Choi JH (2003), Jones RB (2006), Tong J (2014), Egan JE (2002), Wu D (2009), Wu D (2009)	9
ITK	7	CDC37	0	affinity chromatography technology	Huttlin EL (2017)	1
WAS	0	LCP2	0	affinity chromatography technology	Krause M (2000)	1
ITK	7	HSP90AB1	2	affinity chromatography technology	Huttlin EL (2017)	1
PLCG1	6	KHDRBS1	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Oneyama C (2002), Jabado N (1998), Shen Z (1999), Shen Z (1999), Jabado N (1997), Jabado N (1997)	6
FGFR1	2	PLCG1	6	two hybrid, imaging technique, two hybrid, pull down, enzymatic study, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology	Xu H (1998), Chen TC (2014), Hu Y (2004), Shi E (1993), Shi E (1993), Bae JH (2009), Bae JH (2009), Bae JH (2009), Browaeys-Poly E (2010), Browaeys-Poly E (2010), Vecchione A (2007)	11
GRB2	2	HNRNPK	4	two hybrid, affinity chromatography technology, two hybrid, two hybrid	Bandyopadhyay S (2010), Brehme M (2009), Wang J (2011), Rolland T (2014)	4
GRB2	2	LCP2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, unspecified method, affinity chromatography technology, two hybrid	Lewitzky M (2001), Robinson A (1996), Erdreich-Epstein A (1999), Hendricks-Taylor LR (1997), Asada H (1999), Bandyopadhyay S (2010), Chu J (1998), Berry DM (2002), Brehme M (2009), Rolland T (2014)	10
3327	0	HSP90AA1	7	biochemical	Havugimana PC (2012)	1
ERBB3	3	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Schulze WX (2006), Crovello CS (1998), Li J (2013)	3
ITK	7	FYN	1	pull down, pull down	Bunnell SC (2000), Bunnell SC (1996)	2
ERBB3	3	HSP90AB1	2	affinity chromatography technology	Li J (2013)	1
PLCG1	6	SRC	2	affinity chromatography technology	Dhar A (1994)	1
SRC	2	ERBB3	3	unspecified method	Jones RB (2006)	1
SRC	2	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Funakoshi-Tago M (2005), Funakoshi-Tago M (2005), Lee SH (2012)	3
LCP2	0	ITK	7	affinity chromatography technology, pull down, enzymatic study	Shim EK (2004), Bunnell SC (2000), Kim KS (2002)	3
WAS	0	EGFR	5	affinity chromatography technology, affinity chromatography technology	She HY (1997), She HY (1997)	2
SRC	2	GRB2	2	affinity chromatography technology, affinity chromatography technology	Wan KF (2003), Saci A (2002)	2
ITK	7	DYNC1I2	0	affinity chromatography technology	Huttlin EL (2017)	1
HSP90AA1	7	FGFR1	2	affinity chromatography technology, affinity chromatography technology	Taipale M (2012), Vecchione A (2007)	2
EGFR	5	LAT	0	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
FYN	1	LAT	0	enzymatic study	Jiang Y (2007)	1
HSP90AB1	2	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Cheng MB (2010), Gano JJ (2010), Skarra DV (2011), Kristensen AR (2012), Taipale M (2014), Taipale M (2014), Wan C (2015), Hein MY (2015)	8
LCP2	0	PLCG1	6	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Yablonski D (2001), Yablonski D (2001), Braiman A (2006), Braiman A (2006), Braiman A (2006)	5
HSP90AA1	7	ERBB3	3	affinity chromatography technology, affinity chromatography technology	Taipale M (2012), Li J (2013)	2
FUS	0	ITK	7	affinity chromatography technology	Wang T (2014)	1
HSP90AB1	2	CDC37	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Erazo T (2013), Erazo T (2013), Taipale M (2014), Taipale M (2014), Taipale M (2014), Taipale M (2014), Hein MY (2015), Li J (2013), Karras GI (2017), Synoradzki K (2015)	10
GRB2	2	HSP90AB1	2	affinity chromatography technology	Brehme M (2009)	1
EGFR	5	LCP2	0	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
EGFR	5	ITK	7	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
HSP90AA1	7	SRC	2	affinity chromatography technology, affinity chromatography technology	Hutchison KA (1992), Tsutsumi S (2012)	2
FGFR1	2	ITK	7	unspecified method	Liu BA (2012)	1
FYN	1	CDC37	0	affinity chromatography technology	Huttlin EL (2017)	1
EGFR	5	HSP90AB1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Lavictoire SJ (2003), Lavictoire SJ (2003), Foerster S (2013), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	6
FYN	1	SOCS1	1	pull down	De Sepulveda P (1999)	1
PLCG1	6	ERBB3	3	unspecified method	Jones RB (2006)	1
PLCG1	6	GRB2	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Pei Z (1997), Pei Z (1997), Nel AE (1995), Scholler JK (2000), Choi JH (2005), Choi JH (2005)	6
GRB2	2	DOK1	2	affinity chromatography technology	Kepley CL (2004)	1
CDC37	0	ERBB2	6	affinity chromatography technology	Li J (2013)	1
EGFR	5	CDC37	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lavictoire SJ (2003), Foerster S (2013), Li J (2013), Li J (2013)	4
ITK	7	PPIA	0	x-ray crystallography, enzymatic study, affinity chromatography technology	Brazin KN (2002), Brazin KN (2002), Brazin KN (2002)	3
FGFR1	2	CDC37	0	affinity chromatography technology, affinity chromatography technology	Vecchione A (2007), Vecchione A (2007)	2
HNRNPK	4	PLCG1	6	affinity chromatography technology	Huttlin EL (2017)	1
FYN	1	IKBKG	0	affinity chromatography technology	Lee SH (2012)	1
HSP90AA1	7	CDC37	0	x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Roe SM (2004), Silverstein AM (1998), Mollapour M (2010), Basso AD (2002), Tsutsumi S (2012), De Nardo D (2005), Sarkar S (2012), Gano JJ (2010), Taipale M (2012), Skarra DV (2011), Zhang H (2004), Taipale M (2014), Taipale M (2014), Mollapour M (2014), Hein MY (2015), Hein MY (2015), Li J (2013), Woodford MR (2016), Shao J (2003), Scholz GM (2001), Sun L (2012), Sun L (2012), Woodford MR (2016), Synoradzki K (2015)	24
FUS	0	KPNA2	0	affinity chromatography technology	Wang T (2014)	1
CBL	7	LCP2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Park RK (1999), Erdreich-Epstein A (1999), Chu J (1998), Shen M (2009)	4
ITK	7	GRB2	2	pull down, pull down	Bunnell SC (2000), Andreotti AH (1997)	2
WAS	0	CBL	7	affinity chromatography technology	Watanabe Y (2013)	1
ITK	7	3327	0	affinity chromatography technology	Huttlin EL (2017)	1
ITK	7	SPRR2A	2	pull down	Demetris AJ (2008)	1
LAT	0	LCP2	0	affinity chromatography technology	Xie JJ (2013)	1
EGFR	5	SOCS1	1	affinity chromatography technology	Xia L (2002)	1
EGFR	5	ERBB3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marques MM (1999), Li J (2013), Li J (2013), Sharif A (2009)	4
FYN	1	WAS	0	affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, enzymatic study	Banin S (1996), Banin S (1996), Banin S (1996), Banin S (1999), Rivero-Lezcano OM (1995), Suetsugu S (2002)	6