PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ITPR1	25	TRPC3	0	affinity chromatography technology	Yuan JP (2003)	1
SYNPO	5	ITPR3	9	affinity chromatography technology	Hein MY (2015)	1
ITPR1	25	CA8	0	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Hirota J (2003), Hirota J (2003), Hirota J (2003), Huttlin EL (2015), Huttlin EL (2017)	5
RAB29	0	ITPR1	25	affinity chromatography technology	Huttlin EL (2017)	1
SYNPO	5	CAPZA2	1	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
FAM19A4	0	ITPR1	25	affinity chromatography technology	Huttlin EL (2017)	1
CALM1	0	AKT1	1	pull down, affinity chromatography technology	Shen X (2005), Shen X (2005)	2
ITPR1	25	TRPC4	3	affinity chromatography technology, two hybrid	Yuan JP (2003), Mery L (2001)	2
TRPC3	0	TRPC6	3	affinity chromatography technology, fluorescent resonance energy transfe	Hofmann T (2002), Hofmann T (2002)	2
VCP	6	UFD1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Wang Q (2008), Ballar P (2007), Alexandru G (2008), Zhong X (2006), Fernandez-Saiz V (2010), Nagahama M (2009), Noguchi M (2005), Bruderer RM (2004), Bruderer RM (2004), Bruderer RM (2004), Erzurumlu Y (2013), Li JM (2013), Fogeron ML (2013), Haenzelmann P (2016), Haenzelmann P (2016), Haenzelmann P (2016), Raman M (2015), Raman M (2015), Mountassif D (2015), Wang T (2016), Guo X (2017)	21
AMFR	2	ERLIN2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jo Y (2011), Jo Y (2011), Jo Y (2011), Pearce MM (2007), Huber MD (2013), Christianson JC (2012)	6
TRIM25	5	ITPR1	25	affinity chromatography technology	Choudhury NR (2017)	1
ITPR1	25	BRCA1	7	pull down, affinity chromatography technology, biochemical, fluorescent resonance energy transfe	Hedgepeth SC (2015), Hedgepeth SC (2015), Hedgepeth SC (2015), Hedgepeth SC (2015)	4
SYNPO	5	ITPR1	25	affinity chromatography technology	Hein MY (2015)	1
TRPC1	0	TRPC3	0	affinity chromatography technology, affinity chromatography technology	Struebing C (2003), Xu XZ (1997)	2
BCL2	0	ITPR1	25	affinity chromatography technology, affinity chromatography technology, pull down	Oakes SA (2005), Rong YP (2009), Rong YP (2009)	3
FBXL14	2	ITPR1	25	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	ITPR3	9	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	CTDNEP1	1	affinity chromatography technology	Choudhury NR (2017)	1
ITPR3	9	VCP	6	affinity chromatography technology	Kuchay S (2017)	1
TRPC4	3	TRPC1	0	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Struebing C (2003), Hofmann T (2002), Hofmann T (2002)	3
UFD1	1	PSMD2	2	affinity chromatography technology	Chen M (2011)	1
AMFR	2	VCP	6	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, two hybrid, pull down, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhong X (2004), Zhong X (2004), Lee JN (2008), Cao J (2007), Ballar P (2007), Ballar P (2007), Ye Y (2005), Ye Y (2005), Zhong X (2004), Yang H (2010), Yang H (2010), Ballar P (2010), Jo Y (2011), St-Pierre P (2012), Grelle G (2006), Scheich C (2007), Ballar P (2006), Haenzelmann P (2011), Haenzelmann P (2011), Haenzelmann P (2011), Wang Q (2011), Yu CC (2013), Erzurumlu Y (2013), Liu S (2013), Wang Q (2011), Grelle G (2006), Grelle G (2006), Grelle G (2006), Grelle G (2006), Christianson JC (2012), Zhang T (2015), Khodayari N (2017)	32
RHOA	0	ITPR1	25	affinity chromatography technology, pull down	Mehta D (2003), Mehta D (2003)	2
TRPC5	5	TRPC4	3	affinity chromatography technology, fluorescent resonance energy transfe	Hofmann T (2002), Hofmann T (2002)	2
TRIM25	5	CAPZA2	1	affinity chromatography technology	Choudhury NR (2017)	1
ITPR3	9	TRPC3	0	pull down	Tang J (2001)	1
ERLIN2	2	PSMD2	2	affinity chromatography technology	Pearce MM (2007)	1
TRIM25	5	AMFR	2	enzymatic study, pull down	Wang Y (2014), Wang Y (2014)	2
7221	0	TRPC6	3	affinity chromatography technology, affinity chromatography technology	Chu X (2004), Chu X (2004)	2
FAM19A4	0	ITPR3	9	affinity chromatography technology	Huttlin EL (2017)	1
ERLIN1	3	ERLIN2	2	affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pearce MM (2009), Pearce MM (2009), Pearce MM (2009), Havugimana PC (2012), Wang G (2012), Huber MD (2013), Huber MD (2013), Jo Y (2011), Christianson JC (2012)	9
BRCA1	7	VCP	6	affinity chromatography technology, pull down, affinity chromatography technology	Zhang H (2000), Zhang H (2000), Ertych N (2016)	3
TRPC4	3	TRPC3	0	affinity chromatography technology	Struebing C (2003)	1
CTDNEP1	1	ITPR3	9	bioid	St-Denis N (2016)	1
ITPR1	25	EPB41L1	4	two hybrid, affinity chromatography technology, affinity chromatography technology	Maximov A (2003), Maximov A (2003), Maximov A (2003)	3
ITPR1	25	UFD1	1	affinity chromatography technology	Pearce MM (2007)	1
ITPR3	9	TRPC6	3	pull down	Tang J (2001)	1
TESPA1	2	ITPR3	9	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ITPR1	25	MRVI1	2	affinity chromatography technology, affinity chromatography technology	Schlossmann J (2000), Schlossmann J (2000)	2
PRKCD	2	ITPR1	25	pull down	Rex EB (2010)	1
VCP	6	TRIM25	5	affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Choudhury NR (2017)	2
SDC2	0	EPB41L1	4	affinity chromatography technology	Maximov A (2003)	1
TRPC1	0	ITPR3	9	affinity chromatography technology, pull down, affinity chromatography technology	Singh BB (2000), Tang J (2001), Sundivakkam PC (2009)	3
ITPR1	25	ITPR3	9	biochemical	Joseph SK (1995)	1
RAB29	0	ITPR3	9	affinity chromatography technology	Huttlin EL (2017)	1
CAPZA2	1	ITPR3	9	affinity chromatography technology	Hein MY (2015)	1
ITPR1	25	7221	0	affinity chromatography technology	Yuan JP (2003)	1
ITPR1	25	ERLIN1	3	affinity chromatography technology	Pearce MM (2009)	1
RHOA	0	TRPC1	0	affinity chromatography technology, pull down	Mehta D (2003), Mehta D (2003)	2
ITPR1	25	AMFR	2	affinity chromatography technology	Pearce MM (2007)	1
ITPR3	9	TRPC5	5	pull down	Tang J (2001)	1
ITPR3	9	TRPC4	3	pull down, two hybrid	Tang J (2001), Mery L (2001)	2
PRKCD	2	VCP	6	pull down	Rex EB (2010)	1
TRPC1	0	TRPC6	3	affinity chromatography technology	Struebing C (2003)	1
ITPR1	25	TRPC1	0	affinity chromatography technology	Yuan JP (2003)	1
TRPC5	5	TRPC3	0	affinity chromatography technology	Struebing C (2003)	1
ERLIN2	2	RNF170	1	affinity chromatography technology, affinity chromatography technology	Wright FA (2015), Huttlin EL (2017)	2
SDC2	0	ITPR1	25	affinity chromatography technology	Maximov A (2003)	1
AMFR	2	UFD1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Cao J (2007), Cao J (2007), Cao J (2007), Cao J (2007)	4
ITPR1	25	AHCYL1	2	pull down, affinity chromatography technology	Ando H (2003), Ando H (2003)	2
TRIM25	5	ERLIN1	3	affinity chromatography technology	Choudhury NR (2017)	1
BRCA1	7	TRIM25	5	affinity chromatography technology	Ertych N (2016)	1
PLK2	0	ITPR1	25	affinity chromatography technology	Hein MY (2015)	1
TRPC4	3	TRPC6	3	affinity chromatography technology	Struebing C (2003)	1
CALM1	0	ITPR1	25	affinity chromatography technology	Jang DJ (2007)	1
ITPR1	25	FKBP1A	0	affinity chromatography technology, two hybrid	MacMillan D (2005), Cameron AM (1997)	2
ERLIN2	2	UFD1	1	affinity chromatography technology	Pearce MM (2007)	1
ITPR1	25	RNF170	1	affinity chromatography technology	Wright FA (2015)	1
STARD13	4	EPB41L1	4	two hybrid	Nagaraja GM (2004)	1
GTF2H5	0	ITPR1	25	affinity chromatography technology	Hein MY (2015)	1
TRPC5	5	TRPC1	0	affinity chromatography technology, fluorescent resonance energy transfe	Struebing C (2003), Hofmann T (2002)	2
RNF170	1	ERLIN1	3	affinity chromatography technology	Huttlin EL (2017)	1
ITPR1	25	ERLIN2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pearce MM (2009), Pearce MM (2007), Wright FA (2015)	3
ITPR1	25	CABP1	0	affinity chromatography technology, pull down, biochemical, pull down	Kasri NN (2004), Kasri NN (2004), Yang J (2002), Yang J (2002)	4
AKT1	1	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Vandermoere F (2006), Vandermoere F (2006), Vandermoere F (2006), Klein JB (2005), Klein JB (2005), Klein JB (2005), Yu CC (2013), Yu CC (2013)	8
CALM1	0	PSMD2	2	pull down	Shen X (2005)	1
TESPA1	2	ITPR1	25	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AKT1	1	ITPR3	9	enzymatic study	Szado T (2008)	1
TRIM25	5	SYNPO	5	affinity chromatography technology	Choudhury NR (2017)	1
PRKG1	3	ITPR1	25	enzymatic study, affinity chromatography technology, affinity chromatography technology	Schlossmann J (2000), Schlossmann J (2000), Schlossmann J (2000)	3
ITPR1	25	PSMD2	2	affinity chromatography technology	Pearce MM (2007)	1
ITPR3	9	7221	0	pull down	Tang J (2001)	1
STARD13	4	ITPR1	25	two hybrid	Nagaraja GM (2004)	1
BANK1	6	ITPR1	25	affinity chromatography technology	Yokoyama K (2002)	1
ITPR1	25	TRPC6	3	affinity chromatography technology	Yuan JP (2003)	1
PRKG1	3	MRVI1	2	two hybrid, enzymatic study, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Schlossmann J (2000), Schlossmann J (2000), Schlossmann J (2000), Schlossmann J (2000), Ammendola A (2001), Ammendola A (2001)	6
TRIM25	5	PSMD2	2	affinity chromatography technology	Choudhury NR (2017)	1
ERLIN1	3	AMFR	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jo Y (2011), Jo Y (2011), Christianson JC (2012)	3
BRCA1	7	PSMD2	2	affinity chromatography technology	Ertych N (2016)	1
TRPC5	5	TRPC6	3	affinity chromatography technology	Struebing C (2003)	1
ITPR1	25	VCP	6	affinity chromatography technology	Pearce MM (2009)	1
BCL2	0	BRCA1	7	fluorescent resonance energy transfe, affinity chromatography technology	Laulier C (2011), Laulier C (2011)	2
ITPR1	25	TRPC5	5	affinity chromatography technology	Yuan JP (2003)	1
BRCA1	7	AKT1	1	pull down, affinity chromatography technology, pull down, enzymatic study, pull down	Altiok S (1999), Xiang T (2008), Xiang T (2008), Xiang T (2008), Xiang T (2011)	5
CTDNEP1	1	ITPR1	25	bioid	St-Denis N (2016)	1
CAPZA2	1	ITPR1	25	affinity chromatography technology	Hein MY (2015)	1
ITPR1	25	AKT1	1	affinity chromatography technology, affinity chromatography technology, protein complementation assay, enzymatic study	Szado T (2008), Szado T (2008), Szado T (2008), Szado T (2008)	4