PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ERBIN	5	ATP2B4	5	unspecified method	Boisguerin P (2004)	1
KCNA5	2	VANGL2	2	affinity chromatography technology	Huttlin EL (2017)	1
SRC	2	FYN	1	unspecified method, affinity chromatography technology, affinity chromatography technology	Pirozzi G (1997), Chen Y (2009), Huttlin EL (2017)	3
KCNA5	2	FHL1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Poparic I (2011), Yang Z (2008), Yang Z (2008)	3
KCNA5	2	KCNA2	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Albarwani S (2003), Nitabach MN (2001), Nitabach MN (2001)	3
SRC	2	RACK1	2	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chang BY (1998), Chang BY (1998), Chang BY (1998), Chang BY (1998), Chen S (2008)	5
KCNA5	2	FYN	1	affinity chromatography technology	Nitabach MN (2001)	1
KCNA5	2	GOLM1	1	affinity chromatography technology	Huttlin EL (2017)	1
RACK1	2	FYN	1	affinity chromatography technology, pull down, affinity chromatography technology	Yaka R (2003), Yaka R (2002), Yaka R (2002)	3
KCNA5	2	SLC30A6	1	affinity chromatography technology	Huttlin EL (2017)	1
KCNA5	2	CYB5R1	0	affinity chromatography technology	Huttlin EL (2017)	1
KCNA5	2	TMEM223	0	affinity chromatography technology	Huttlin EL (2017)	1
KCNA2	6	KCNAB1	0	affinity chromatography technology	Nakahira K (1996)	1
KCNA3	3	DLG4	11	affinity chromatography technology, affinity chromatography technology	Marks DR (2007), Doczi MA (2011)	2
HSP90AA1	7	KCNA5	2	affinity chromatography technology	Taipale M (2012)	1
DCTN2	0	KCNA5	2	affinity chromatography technology	Choi WS (2005)	1
STUB1	4	SRC	2	pull down, affinity chromatography technology, imaging technique, enzymatic study	Yang M (2011), Yang M (2011), Yang M (2011), Yang M (2011)	4
KCNAB2	3	KCNA4	5	affinity chromatography technology, affinity chromatography technology	Kim SJ (2013), Kim SJ (2013)	2
DLG4	11	ACTN2	2	pull down	Eldstrom J (2002)	1
KCNAB2	3	KCNA5	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim SJ (2013), Kim SJ (2013), Huttlin EL (2017)	3
CAV1	0	KCNA5	2	affinity chromatography technology, affinity chromatography technology	Vicente R (2008), Perez-Verdaguer M (2016)	2
SRC	2	KCNA5	2	affinity chromatography technology, affinity chromatography technology	Holmes TC (1996), Nitabach MN (2001)	2
FYN	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Loewenberg M (2006), Taipale M (2012), Taipale M (2012), Huttlin EL (2017)	4
SIRT1	3	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Lin Z (2012), Hein MY (2015)	2
GOLM1	1	DCTN2	0	two hybrid	Stelzl U (2005)	1
KCNA5	2	DOLK	1	affinity chromatography technology	Huttlin EL (2017)	1
KCNA4	5	SIRT1	3	affinity chromatography technology, affinity chromatography technology	Kim SJ (2013), Kim SJ (2013)	2
ACTN2	2	DLG1	2	affinity chromatography technology, affinity chromatography technology	Eldstrom J (2003), Eldstrom J (2003)	2
KCNA5	2	TFRC	1	biochemical	Vicente R (2008)	1
KCNA5	2	ADCY3	5	affinity chromatography technology	Huttlin EL (2017)	1
ATP2B4	5	DLG1	2	pull down	Schuh K (2003)	1
KCNA2	6	KCNAB2	3	affinity chromatography technology, affinity chromatography technology	Coleman SK (1999), Nakahira K (1996)	2
KCNA3	3	KCNA4	5	affinity chromatography technology	Coleman SK (1999)	1
ERBIN	5	ACTN2	2	unspecified method	Boisguerin P (2004)	1
KCNA5	2	LEMD2	3	affinity chromatography technology	Huttlin EL (2017)	1
KCNA3	3	KCNA5	2	fluorescent resonance energy transfe, biochemical, affinity chromatography technology	Vicente R (2008), Vicente R (2008), Huttlin EL (2017)	3
KCNA5	2	TMX2	0	affinity chromatography technology	Huttlin EL (2017)	1
KCNAB2	3	SIRT1	3	affinity chromatography technology, affinity chromatography technology	Kim SJ (2013), Kim SJ (2013)	2
KCNA5	2	SLC27A6	2	affinity chromatography technology	Huttlin EL (2017)	1
ERBIN	5	KCNA5	2	unspecified method	Boisguerin P (2004)	1
HSP90AA1	7	PRKCQ	3	affinity chromatography technology	Taipale M (2012)	1
KCNA3	3	KCNA2	6	affinity chromatography technology	Coleman SK (1999)	1
KCNA5	2	ATP2A3	5	affinity chromatography technology	Huttlin EL (2017)	1
KCNA5	2	NPHP1	2	affinity chromatography technology	Huttlin EL (2017)	1
KCNA3	3	TFRC	1	biochemical	Vicente R (2008)	1
KCNA5	2	HSPA8	4	affinity chromatography technology	Li P (2015)	1
KCNA5	2	KCNA5	2	biochemical	Vicente R (2008)	1
STUB1	4	HSP90AA1	7	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, enzymatic study, biochemical, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, pull down	Zhang L (2007), Zhang M (2005), Tateishi Y (2004), Tateishi Y (2004), Connell P (2001), Ko HS (2009), Kumar P (2007), Kumar P (2007), Wang L (2011), Stankiewicz M (2010), Graf C (2010), Kundrat L (2010), Kundrat L (2010), Kundrat L (2010), Kundrat L (2010), Morishima Y (2008), Zhou P (2003), Zhang M (2008), Grelle G (2006), Kim SA (2005), Arndt V (2005), Muller P (2012), Burch L (2004), Burch L (2004), Jang KW (2011), Schuelke JP (2010), Wang Q (2012), Shimamoto S (2013), Shimamoto S (2013), Shimamoto S (2013), Gano JJ (2010), Skarra DV (2011), Yang SW (2013), Grelle G (2006), Grelle G (2006), Narayan V (2015)	36
KCNA5	2	PRKCB	4	affinity chromatography technology	David M (2012)	1
KCNA5	2	DLG1	2	affinity chromatography technology, affinity chromatography technology	Godreau D (2003), Mathur R (2006)	2
FYN	1	CAV1	0	biochemical	Mastick CC (1997)	1
KCNA5	2	C1orf43	0	affinity chromatography technology	Huttlin EL (2017)	1
KCNA5	2	RACK1	2	affinity chromatography technology, affinity chromatography technology	David M (2012), David M (2012)	2
TNK2	7	KCNA5	2	pull down, enzymatic study	Yokoyama N (2003), Yokoyama N (2003)	2
KCNA5	2	DLG4	11	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Eldstrom J (2003), Eldstrom J (2002), Eldstrom J (2002), Eldstrom J (2002), Mathur R (2006)	5
NPHP1	2	TNK2	7	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Eley L (2008), Eley L (2008), Eley L (2008), Eley L (2008), Chan W (2011)	5
STUB1	4	HSPA8	4	pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study, x-ray crystallography, pull down, pull down, pull down, pull down, affinity chromatography technology, enzymatic study, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, unspecified method, affinity chromatography technology, x-ray crystallography, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, enzymatic study	Ballinger CA (1999), Ballinger CA (1999), Ballinger CA (1999), Tateishi Y (2004), Tateishi Y (2004), Jiang J (2001), Wang L (2011), Wang L (2011), Wang L (2011), Stankiewicz M (2010), Yang M (2011), Yang M (2011), Urushitani M (2004), Grelle G (2006), Kim SA (2005), Arndt V (2005), Alberti S (2004), Meacham GC (2001), Smith MC (2013), Smith MC (2013), Matsumura Y (2013), Spooner RA (2008), Taipale M (2014), Taipale M (2014), Heimdal K (2014), Grelle G (2006), Grelle G (2006), Kamynina E (2007), Zhang H (2015), Zhang H (2015), Zhang H (2015), Li P (2015), Guo Y (2016), Zhang H (2017), Pakdaman Y (2017)	35
VANGL2	2	HSPA8	4	affinity chromatography technology	Huttlin EL (2017)	1
PRKCB	4	RACK1	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Ron D (1999), Ron D (1999), Chen S (2008), Sato T (2014), Sato T (2014), Sato T (2014)	6
KCNA5	2	KCNAB1	0	affinity chromatography technology	David M (2012)	1
KCNA5	2	ABCD4	2	affinity chromatography technology	Huttlin EL (2017)	1
KCNA5	2	ACTN2	2	two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down	Eldstrom J (2003), Maruoka ND (2000), Maruoka ND (2000), Maruoka ND (2000), Maruoka ND (2000), Cukovic D (2001), Cukovic D (2001)	7
KCNA4	5	DLG1	2	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Eldstrom J (2003), Inanobe A (2002), Kim E (1996), Kim E (1995)	4
RACK1	2	KCNAB1	0	affinity chromatography technology	David M (2012)	1
FYN	1	KCNA2	6	affinity chromatography technology	Nitabach MN (2001)	1
SNTA1	1	KCNA4	5	unspecified method	Boisguerin P (2004)	1
KCNA2	6	KCNA4	5	affinity chromatography technology, affinity chromatography technology	Coleman SK (1999), Coleman SK (1999)	2
FYN	1	TNK2	7	affinity chromatography technology, pull down	Linseman DA (2001), Linseman DA (2001)	2
CAV1	0	SRC	2	pull down	Li S (1996)	1
KCNA4	5	SRC	2	affinity chromatography technology	Nitabach MN (2001)	1
DLG1	2	KCNA3	3	affinity chromatography technology	Hanada T (1997)	1
FYN	1	KCNA4	5	affinity chromatography technology	Nitabach MN (2001)	1
RAB4A	0	KCNA5	2	imaging technique	Zadeh AD (2008)	1
KCNA5	2	SARAF	0	affinity chromatography technology	Huttlin EL (2017)	1
HSPA8	4	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down	Polanowska-Grabowska R (1997), Giommarelli C (2010), Gano JJ (2010), Skarra DV (2011), Wan C (2015), Sun L (2012)	6
TNK2	7	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mahajan NP (2005), Mahajan NP (2005), Taipale M (2012), Gao B (2013), Mahendrarajah N (2017), Mahendrarajah N (2017), Mahendrarajah N (2017)	7
KCNA5	2	ATP2B4	5	affinity chromatography technology	Huttlin EL (2017)	1
SRC	2	TNK2	7	pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down	Chan W (2009), Modzelewska K (2006), Chan W (2011), Chan W (2011), Chan W (2011), Yokoyama N (2003)	6
KCNA5	2	GHDC	0	affinity chromatography technology	Huttlin EL (2017)	1
KCNA5	2	RHBDD3	1	affinity chromatography technology	Huttlin EL (2017)	1
KCNA5	2	SIRT1	3	affinity chromatography technology, affinity chromatography technology	Kim SJ (2013), Kim SJ (2013)	2
RAB5A	0	KCNA5	2	imaging technique	Zadeh AD (2008)	1
RAB4A	0	RAB5A	0	biochemical	Vitale G (1998)	1
HSP90AA1	7	PRKCB	4	affinity chromatography technology	Taipale M (2012)	1
GOLM1	1	RACK1	2	two hybrid	Stelzl U (2005)	1
KCNA5	2	ADCK2	0	affinity chromatography technology	Huttlin EL (2017)	1
KCNA5	2	STUB1	4	affinity chromatography technology, affinity chromatography technology	Li P (2015), Li P (2015)	2
HSP90AA1	7	SRC	2	affinity chromatography technology, affinity chromatography technology	Hutchison KA (1992), Tsutsumi S (2012)	2
DLG4	11	KCNA2	6	two hybrid, pull down	Eldstrom J (2002), Eldstrom J (2002)	2
CAV1	0	TFRC	1	affinity chromatography technology	Hinrichs JW (2004)	1
KCNA4	5	DLG4	11	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, far western blotting, pull down, pull down, imaging technique, pull down, two hybrid, pull down	Inanobe A (2002), Niethammer M (1998), Kim E (1996), Kim E (1996), Eldstrom J (2002), Eldstrom J (2002), Eldstrom J (2002), Niethammer M (1996), Piserchio A (2002), Imamura F (2002), Imamura F (2002), Imamura F (2002), Kim E (1995), Kim E (1995)	14
DCTN2	0	DYNC1I1	1	affinity chromatography technology	Splinter D (2012)	1
KCNA5	2	ANKLE2	5	affinity chromatography technology	Huttlin EL (2017)	1
HSP90AA1	7	CAV1	0	affinity chromatography technology	Ji Y (2007)	1
SLC27A6	2	RACK1	2	two hybrid	Stelzl U (2005)	1
SNTA1	1	KCNA5	2	unspecified method	Boisguerin P (2004)	1
FYN	1	DLG4	11	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tezuka T (1999), Hou XY (2002), Hou XY (2002)	3
KCNAB2	3	KCNAB1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
KCNA5	2	YIPF4	1	affinity chromatography technology	Huttlin EL (2017)	1
KCNA5	2	ABCB10	0	affinity chromatography technology	Huttlin EL (2017)	1
KCNA3	3	CAV1	0	biochemical, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Vicente R (2008), Vicente R (2008), Perez-Verdaguer M (2016), Perez-Verdaguer M (2016)	4
DYNC1I1	1	KCNA5	2	affinity chromatography technology	Choi WS (2005)	1
ERBIN	5	KCNA4	5	pull down, unspecified method	Jaulin-Bastard F (2001), Boisguerin P (2004)	2
PRKCQ	3	FYN	1	pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid	Ron D (1999), Ron D (1999), Ron D (1999), Ron D (1999), Ron D (1999), Ron D (1999), Ron D (1999)	7
KCNA5	2	PRKCQ	3	affinity chromatography technology	David M (2012)	1
KCNA5	2	NT5C3A	2	affinity chromatography technology	Huttlin EL (2017)	1
KCNA5	2	DNAJC18	1	affinity chromatography technology	Huttlin EL (2017)	1
SIRT1	3	UBE2I	0	enzymatic study	Hsieh YL (2013)	1
C17orf80	1	KCNA5	2	affinity chromatography technology	Huttlin EL (2017)	1
KCNA5	2	KCNA4	5	affinity chromatography technology	Nitabach MN (2001)	1
UBE2I	0	KCNA5	2	pull down, enzymatic study	Benson MD (2007), Benson MD (2007)	2