PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
KCNC2	1	KCNC1	3	affinity chromatography technology	Devaux J (2003)	1
KCNC4	1	KCNC1	3	affinity chromatography technology	Huttlin EL (2017)	1
CAMK2A	6	DLG1	2	affinity chromatography technology, enzymatic study	Gardoni F (2003), Gardoni F (2003)	2
ANK3	16	KCNC1	3	affinity chromatography technology	Devaux J (2003)	1
KCNC1	3	CAMK2A	6	affinity chromatography technology	El-Haou S (2009)	1
KCNC1	3	DLG1	2	affinity chromatography technology	El-Haou S (2009)	1
KCNC1	3	KCNG3	2	two hybrid	Ottschytsch N (2002)	1
KCNC1	3	KCNH1	11	two hybrid	Ottschytsch N (2002)	1
KCNC1	3	KCNV2	1	two hybrid	Ottschytsch N (2002)	1