PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SUV39H1	0	KDM1A	2	two hybrid	Weimann M (2013)	1
ZNF829	0	CRYBG1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
STAT3	0	KDM1A	2	affinity chromatography technology, enzymatic study	Yang J (2010), Yang J (2010)	2
TRIM28	1	STAT3	0	affinity chromatography technology, pull down, affinity chromatography technology	Tsuruma R (2008), Tsuruma R (2008), Tsuruma R (2008)	3
CBX5	3	TRIM28	1	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nielsen AL (2002), Cammas F (2002), Cammas F (2002), Nielsen AL (2001), Lechner MS (2000), Lechner MS (2005), Lechner MS (2005), Lechner MS (2005), Lechner MS (2005), Ryan RF (1999), Rosnoblet C (2011), Hu C (2012), Hu C (2012), White D (2012), Nozawa RS (2010), Kubota S (2013), Kubota S (2013), Kubota S (2013), Garvin AJ (2013), Huttlin EL (2017), Hauri S (2016)	21
ZNF829	0	SUV39H1	0	two hybrid	Weimann M (2013)	1
CBX5	3	ZNF829	0	affinity chromatography technology	Nozawa RS (2010)	1
SMARCAD1	1	ZNF829	0	affinity chromatography technology	Rowbotham SP (2011)	1
TRIM28	1	SMARCAD1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Seki Y (2010), Rowbotham SP (2011), Rowbotham SP (2011), Rowbotham SP (2011), Rowbotham SP (2011)	5
ZNF829	0	KDM1A	2	two hybrid	Weimann M (2013)	1
ZNF829	0	TRIM28	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
STAT3	0	ZNF829	0	two hybrid	Grossmann A (2015)	1
KDM1A	2	TRIM28	1	affinity chromatography technology	Cui S (2011)	1
SMARCAD1	1	KDM1A	2	affinity chromatography technology	Rowbotham SP (2011)	1
CBX5	3	SUV39H1	0	two hybrid, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Fujita N (2003), Rual JF (2005), Nozawa RS (2010), Rolland T (2014), Huttlin EL (2017), Hauri S (2016)	6
APPL1	1	ZNF829	0	two hybrid	Grossmann A (2015)	1