PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
KCTD17	0	KCTD5	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
KCND2	2	KCTD17	0	affinity chromatography technology	Huttlin EL (2017)	1
KCND2	2	BAG1	1	affinity chromatography technology	Huttlin EL (2017)	1
DPP10	1	KCND2	2	affinity chromatography technology, pull down	Jerng HH (2004), Jerng HH (2004)	2
KCND2	2	STUB1	4	affinity chromatography technology	Huttlin EL (2017)	1
BAG3	4	STUB1	4	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kristensen AR (2012), Taipale M (2014), Taipale M (2014), Hein MY (2015)	4
KCND2	2	FLNC	8	two hybrid, pull down	Petrecca K (2000), Petrecca K (2000)	2
KCTD17	0	KCTD2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
KCND2	2	KCNIP1	0	two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Scannevin RH (2004), Scannevin RH (2004), An WF (2000), An WF (2000), Lin YL (2004), Lin YL (2004)	6
KCND2	2	KCNIP2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, biochemical, biochemical	Foeger NC (2010), Baehring R (2001), Dementieva IS (2009), Levy DI (2010), An WF (2000), Lin YL (2004), Kim LA (2004), Kim LA (2004), Kim LA (2004)	9
DLG4	11	KCND2	2	two hybrid	Eldstrom J (2002)	1
FLNA	10	KCND2	2	affinity chromatography technology	Levy DI (2010)	1
HSPA8	4	BAG3	4	two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Takayama S (1999), Takayama S (1999), Takayama S (1999), Gentilella A (2011), Hishiya A (2011), Chen Y (2013), Chen Y (2013), Taipale M (2014), Taipale M (2014), Rolland T (2014), Hein MY (2015)	11
KCNIP1	0	KCNIP2	0	pull down, affinity chromatography technology, affinity chromatography technology	Lin YL (2004), Huttlin EL (2015), Huttlin EL (2017)	3
STUB1	4	HSPA8	4	pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study, x-ray crystallography, pull down, pull down, pull down, pull down, affinity chromatography technology, enzymatic study, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, unspecified method, affinity chromatography technology, x-ray crystallography, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, enzymatic study	Ballinger CA (1999), Ballinger CA (1999), Ballinger CA (1999), Tateishi Y (2004), Tateishi Y (2004), Jiang J (2001), Wang L (2011), Wang L (2011), Wang L (2011), Stankiewicz M (2010), Yang M (2011), Yang M (2011), Urushitani M (2004), Grelle G (2006), Kim SA (2005), Arndt V (2005), Alberti S (2004), Meacham GC (2001), Smith MC (2013), Smith MC (2013), Matsumura Y (2013), Spooner RA (2008), Taipale M (2014), Taipale M (2014), Heimdal K (2014), Grelle G (2006), Grelle G (2006), Kamynina E (2007), Zhang H (2015), Zhang H (2015), Zhang H (2015), Li P (2015), Guo Y (2016), Zhang H (2017), Pakdaman Y (2017)	35
KCND2	2	GNB4	2	affinity chromatography technology	Huttlin EL (2017)	1
KCND2	2	BAG3	4	affinity chromatography technology	Huttlin EL (2017)	1
KCND2	2	HSPA8	4	affinity chromatography technology	Huttlin EL (2017)	1
KCND2	2	KCTD5	0	affinity chromatography technology	Huttlin EL (2017)	1
KCND2	2	KCNE4	1	pull down, affinity chromatography technology	Levy DI (2010), Levy DI (2010)	2
KCND2	2	KCNIP3	1	imaging technique, affinity chromatography technology, affinity chromatography technology	Kunjilwar K (2013), Kunjilwar K (2013), Kunjilwar K (2013)	3
KCND2	2	DPP6	4	pull down, affinity chromatography technology	Jerng HH (2004), Kunjilwar K (2013)	2
FLNA	10	KCNE4	1	affinity chromatography technology, two hybrid	Levy DI (2010), Levy DI (2010)	2
KCNE4	1	KCNIP2	0	affinity chromatography technology, affinity chromatography technology	Levy DI (2010), Levy DI (2010)	2
BAG1	1	BAG3	4	biochemical	Havugimana PC (2012)	1
KCND2	2	NCS1	2	affinity chromatography technology	Nakamura TY (2001)	1
BAG1	1	STUB1	4	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Demand J (2001), Tateishi Y (2004), Tsukahara F (2010), Arndt V (2005), Taipale M (2014), Taipale M (2014), Narayan V (2015)	7
KCND2	2	KCTD2	0	affinity chromatography technology	Huttlin EL (2017)	1
BAG3	4	DPP10	1	affinity chromatography technology	Chen Y (2013)	1
BAG1	1	HSPA8	4	two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, unspecified method, x-ray crystallography, pull down, two hybrid, pull down, affinity chromatography technology	Takayama S (1997), Takayama S (1999), Takayama S (1999), Takayama S (1997), Takayama S (1997), Elliott E (2007), Alberti S (2002), Tsukahara F (2010), Brive L (2001), Lueders J (2000), Townsend PA (2003), Townsend PA (2003), Townsend PA (2004), Sharp A (2009), Sharp A (2009), Sondermann H (2001), Gebauer M (1998), Rolland T (2014), Mock JY (2015), Karras GI (2017)	20