PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
DNAJA1	2	RNF207	2	affinity chromatography technology	Roder K (2014)	1
DNAJA1	2	CANX	4	biochemical	Wan C (2015)	1
CDC73	1	HSPA8	4	affinity chromatography technology	Herr P (2015)	1
HSPA4	3	DNAJA1	2	biochemical	Wan C (2015)	1
NTRK1	1	CANX	4	affinity chromatography technology	Emdal KB (2015)	1
HSPA1A	0	HSPA8	4	biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012)	2
HSPA8	4	BAG2	0	two hybrid, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical	Takayama S (1999), Takayama S (1999), Takayama S (1999), Arndt V (2005), Arndt V (2005), Hegele A (2012), Hegele A (2012), Taipale M (2014), Taipale M (2014), Wan C (2015)	10
CDC73	1	YWHAE	0	affinity chromatography technology	Herr P (2015)	1
HSPA8	4	RNF207	2	affinity chromatography technology	Roder K (2014)	1
NTRK1	1	YWHAE	0	affinity chromatography technology	Emdal KB (2015)	1
KCNH2	5	NDUFS6	0	two hybrid	Stelzl U (2005)	1
CDC73	1	CUL1	7	affinity chromatography technology	Herr P (2015)	1
KCNH2	5	CDC73	1	two hybrid	Stelzl U (2005)	1
NTRK1	1	KCNH2	5	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	CDC73	1	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	CALR	1	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	HSPA1A	0	affinity chromatography technology	Emdal KB (2015)	1
KCNH2	5	STIP1	1	affinity chromatography technology	Walker VE (2007)	1
RAB11A	4	KCNH2	5	affinity chromatography technology, affinity chromatography technology	Lamothe S (2013), Lamothe S (2013)	2
CUL1	7	DNAJA1	2	affinity chromatography technology	Bennett EJ (2010)	1
CALR	1	KCNH2	5	affinity chromatography technology	Wang Y (2012)	1
HSP90AA1	7	KCNH2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ficker E (2003), Walker VE (2007), Iwai C (2013)	3
CDC73	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Mak AB (2010), Herr P (2015)	2
HSP90AA1	7	HSPA4	3	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	Kim TS (2006), Hidalgo-de-Quintana J (2008), Skarra DV (2011), Wan C (2015)	4
CDC73	1	CALR	1	affinity chromatography technology	Herr P (2015)	1
STIP1	1	BAG2	0	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
HSPA1A	0	BAG2	0	affinity chromatography technology	Schoenbuehler B (2016)	1
YWHAE	0	KCNH2	5	pull down, two hybrid, affinity chromatography technology	Kagan A (2002), Kagan A (2002), Kagan A (2002)	3
HSP90AA1	7	DNAJA1	2	affinity chromatography technology	Skarra DV (2011)	1
CANX	4	KCNH2	5	affinity chromatography technology, affinity chromatography technology	Wang Y (2012), Walker VE (2007)	2
KCNH2	5	BAG2	0	affinity chromatography technology	Walker VE (2007)	1
HSPA4	3	CDC73	1	two hybrid	Stelzl U (2005)	1
YWHAE	0	DNAJA1	2	affinity chromatography technology	Zuo S (2010)	1
CDC73	1	CANX	4	affinity chromatography technology	Herr P (2015)	1
DNAJA1	2	HSPA8	4	pull down, affinity chromatography technology, affinity chromatography technology, biochemical	Meacham GC (1999), Taipale M (2014), Taipale M (2014), Wan C (2015)	4
NEDD4L	3	NTRK1	1	enzymatic study	Persaud A (2009)	1
STUB1	4	HSP90AA1	7	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, enzymatic study, biochemical, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, pull down	Zhang L (2007), Zhang M (2005), Tateishi Y (2004), Tateishi Y (2004), Connell P (2001), Ko HS (2009), Kumar P (2007), Kumar P (2007), Wang L (2011), Stankiewicz M (2010), Graf C (2010), Kundrat L (2010), Kundrat L (2010), Kundrat L (2010), Kundrat L (2010), Morishima Y (2008), Zhou P (2003), Zhang M (2008), Grelle G (2006), Kim SA (2005), Arndt V (2005), Muller P (2012), Burch L (2004), Burch L (2004), Jang KW (2011), Schuelke JP (2010), Wang Q (2012), Shimamoto S (2013), Shimamoto S (2013), Shimamoto S (2013), Gano JJ (2010), Skarra DV (2011), Yang SW (2013), Grelle G (2006), Grelle G (2006), Narayan V (2015)	36
NTRK1	1	HSPA8	4	affinity chromatography technology	Emdal KB (2015)	1
CUL1	7	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Taipale M (2012)	2
STUB1	4	HSPA4	3	pull down, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down, pull down, enzymatic study, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ballinger CA (1999), Ballinger CA (1999), Ballinger CA (1999), Dai Q (2005), Tateishi Y (2004), Tateishi Y (2004), Ko HS (2009), Qian SB (2009), Kumar P (2007), Kumar P (2007), Wang L (2011), Wang L (2011), Wang L (2011), Graf C (2010), Kundrat L (2010), Matsumoto K (2011), Kundrat L (2010), Kundrat L (2010), Morishima Y (2008), Luo W (2010), Soss SE (2011), Zhou P (2003), Kalia LV (2011), Gao Y (2010), Gao Y (2010), Grelle G (2006), Rao SN (2010), Tetzlaff JE (2008), Kim SA (2005), Dai Q (2003), Zhang X (2011), Zhang X (2011), Muller P (2012), Jang KW (2011), Schuelke JP (2010), Jinwal UK (2012), Shimamoto S (2013), Shimamoto S (2013), Shimamoto S (2013), Mao RF (2013), Lee JS (2013), Lee JS (2013)	42
CUL1	7	YWHAE	0	affinity chromatography technology	Bennett EJ (2010)	1
CUL1	7	HSPA4	3	affinity chromatography technology, affinity chromatography technology	Oshikawa K (2003), Bennett EJ (2010)	2
NTRK1	1	CUL1	7	affinity chromatography technology	Emdal KB (2015)	1
YWHAE	0	CALR	1	biochemical	Wan C (2015)	1
YWHAE	0	HSPA8	4	affinity chromatography technology	Gloeckner CJ (2007)	1
CAV3	0	NEDD4L	3	affinity chromatography technology, affinity chromatography technology	Guo J (2012), Guo J (2012)	2
STUB1	4	HSPA8	4	pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study, x-ray crystallography, pull down, pull down, pull down, pull down, affinity chromatography technology, enzymatic study, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, unspecified method, affinity chromatography technology, x-ray crystallography, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, enzymatic study	Ballinger CA (1999), Ballinger CA (1999), Ballinger CA (1999), Tateishi Y (2004), Tateishi Y (2004), Jiang J (2001), Wang L (2011), Wang L (2011), Wang L (2011), Stankiewicz M (2010), Yang M (2011), Yang M (2011), Urushitani M (2004), Grelle G (2006), Kim SA (2005), Arndt V (2005), Alberti S (2004), Meacham GC (2001), Smith MC (2013), Smith MC (2013), Matsumura Y (2013), Spooner RA (2008), Taipale M (2014), Taipale M (2014), Heimdal K (2014), Grelle G (2006), Grelle G (2006), Kamynina E (2007), Zhang H (2015), Zhang H (2015), Zhang H (2015), Li P (2015), Guo Y (2016), Zhang H (2017), Pakdaman Y (2017)	35
KCNH2	5	RNF139	4	affinity chromatography technology	Hantouche C (2017)	1
FKBP8	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Edlich F (2007), Edlich F (2007), Okamoto T (2006), Okamoto T (2006), Okamoto T (2006), Skarra DV (2011)	6
HSPA4	3	HSPA8	4	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical	Hidalgo-de-Quintana J (2008), Havugimana PC (2012), Taipale M (2014), Taipale M (2014), Wan C (2015)	5
KCNH2	5	HSPA1A	0	affinity chromatography technology	Hantouche C (2017)	1
KCNH2	5	NEDD4L	3	affinity chromatography technology, affinity chromatography technology	Guo J (2012), Wang T (2014)	2
HSPA4	3	KCNH2	5	affinity chromatography technology	Ficker E (2003)	1
KCNH2	5	DNAJA1	2	affinity chromatography technology	Walker VE (2007)	1
HSPA8	4	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down	Polanowska-Grabowska R (1997), Giommarelli C (2010), Gano JJ (2010), Skarra DV (2011), Wan C (2015), Sun L (2012)	6
NTRK1	1	STIP1	1	affinity chromatography technology	Emdal KB (2015)	1
STUB1	4	BAG2	0	pull down, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dai Q (2005), Dai Q (2005), Arndt V (2005), Arndt V (2005), Arndt V (2005), Taipale M (2014), Taipale M (2014), Taipale M (2014), Taipale M (2014)	9
NTRK1	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rao R (2010), Taipale M (2012), Emdal KB (2015)	3
CUL1	7	HSPA1A	0	affinity chromatography technology	Bennett EJ (2010)	1
CDC73	1	DNAJA1	2	affinity chromatography technology	Herr P (2015)	1
HSPA1A	0	STIP1	1	biochemical, affinity chromatography technology	Wan C (2015), Scholz GM (2001)	2
CALR	1	CANX	4	affinity chromatography technology	Oliver JD (1999)	1
HSP90AA1	7	CANX	4	biochemical	Wan C (2015)	1
HSPA1A	0	RNF207	2	affinity chromatography technology	Roder K (2014)	1
STUB1	4	HSPA1A	0	pull down, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ballinger CA (1999), Ballinger CA (1999), Imai Y (2002), Havugimana PC (2012), Jinwal UK (2012), Yang SW (2013), Choi JR (2016), Schoenbuehler B (2016)	8
KCNH2	5	STUB1	4	affinity chromatography technology, affinity chromatography technology	Iwai C (2013), Hantouche C (2017)	2
KCNH2	5	HSPA8	4	affinity chromatography technology, affinity chromatography technology	Walker VE (2007), Hantouche C (2017)	2
ALG10B	0	KCNH2	5	affinity chromatography technology	Kupershmidt S (2003)	1
HSP90AA1	7	HSPA1A	0	pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Kanelakis KC (2002), Gano JJ (2010), Falsone SF (2005), Brychzy A (2003), Scholz GM (2001), Scholz GM (2001)	6
STIP1	1	HSP90AA1	7	pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Scheufler C (2000), Johnson BD (1998), Mollapour M (2010), Li J (2011), Kundrat L (2010), Tsutsumi S (2012), Sarkar S (2012), Gano JJ (2010), Skarra DV (2011), Horibe T (2011), Brinker A (2002), Taipale M (2014), Taipale M (2014), Mollapour M (2014), Graumann K (2000), Hein MY (2015), Chadli A (2010), Chadli A (2008), Woodford MR (2016), Scholz GM (2001), Sun L (2012), Woodford MR (2016), Huttlin EL (2017)	23
HSPA1A	0	DNAJA1	2	affinity chromatography technology	Hageman J (2011)	1
NTRK1	1	RAB11A	4	affinity chromatography technology	Emdal KB (2015)	1
KCNH2	5	CAV3	0	affinity chromatography technology, affinity chromatography technology	Guo J (2012), Guo J (2012)	2
STIP1	1	HSPA4	3	affinity chromatography technology, pull down, pull down, pull down, biochemical	Johnson BD (1998), Horibe T (2011), Brinker A (2002), Graumann K (2000), Wan C (2015)	5
HSPA8	4	STIP1	1	biochemical, far western blotting, pull down, pull down, pull down, biochemical	Havugimana PC (2012), Gebauer M (1998), Gebauer M (1998), Liu FH (1999), Tsukahara F (2000), Wan C (2015)	6
KCNE1	0	KCNH2	5	affinity chromatography technology	McDonald TV (1997)	1
HSP90AA1	7	BAG2	0	affinity chromatography technology	Gano JJ (2010)	1
RNF207	2	KCNH2	5	affinity chromatography technology	Roder K (2014)	1
CUL1	7	KCNH2	5	affinity chromatography technology	Bennett EJ (2010)	1
YWHAE	0	HSPA1A	0	affinity chromatography technology	Gloeckner CJ (2007)	1
BAG2	0	HSPA4	3	pull down	Dai Q (2005)	1
NTRK1	1	DNAJA1	2	affinity chromatography technology	Emdal KB (2015)	1
CUL1	7	HSPA8	4	affinity chromatography technology	Bennett EJ (2010)	1
KCNH2	5	FKBP8	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Walker VE (2007), Walker VE (2007), Walker VE (2007)	3
NTRK1	1	HSPA4	3	affinity chromatography technology, affinity chromatography technology	Rao R (2010), Emdal KB (2015)	2