Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications
KCNJ6	3763	METHADONE	CHEMBL651		PharmGKB
KCNJ6	3763	FLUPIRTINE	CHEMBL255044		TdgClinicalTrial
KCNJ6	3763	SCH-23390	CHEMBL62	gating inhibitor	GuideToPharmacologyInteractions
KCNJ6	3763	HALOTHANE	CHEMBL931	inhibitor	DrugBank	15175324, 16243998

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
KCNJ6	rs6517442	C	remifentanil	efficacy	no	Please note that alleles have been complemented to the positive strand.	Allele C is not associated with response to remifentanil in infants with Pain as compared to allele T.	27027462	1450373806
KCNJ6	rs2835859	TT	fentanyl	"dosage","efficacy"	yes	A formula was developed to predict individual opioid use during the first 24-h post-operative period for patients who underwent craniofacial surgery. The post-operative period R squared values were higher when genotype information was included. In the first group fentanyl was administered by IV, on demand, with a bolus dose of 20 micrograms and a 10 minute lockout period 24-h post-op.	Genotype TT is associated with increased dose of fentanyl in people with Pain, Postoperative as compared to genotypes CC + CT.	25615449	1444694050
KCNJ6	rs2070995	TT	methadone		yes	[stat_test: t test]	Genotype TT is associated with increased dose of methadone in people with Substance-Related Disorders as compared to genotypes CC + CT.	20220551	769173176
KCNJ6	rs6517442	TT	morphine	efficacy	yes	Infants with the TT genotype took longer to achieve a pain-free ALPS-Neo score than infants with the CC or CT genotypes. Please note that alleles have been complemented to the positive strand.	Genotype TT is associated with decreased response to morphine or remifentanil in infants with Pain as compared to genotypes CC + CT.	27027462	1450373783
KCNJ6	rs6517442	CC	morphine	efficacy	yes	Infants with the CC genotype were quicker to achieve a pain-free ALPS-Neo score than infants with the CT or TT genotypes. Please note that alleles have been complemented to the positive strand.	Genotype CC is associated with increased response to morphine in infants with Pain as compared to genotypes CT + TT.	27027462	1450373797
KCNJ6	rs2070995	TT	opioids		no	A tendency was found, not a significant association.Tilidine or tramadol:n=81;morphine:n=74;fentanyl:n=55;buprenorphine:n=41;oxycodone:n=38;hydromorphone:n=14;dihydrocodeine:n=2;levomethadone or piritramide:n=2 (patients could receive more than 1 drug). Doses of the different drugs were converted to oral morphine equivalents for comparison.	Genotype TT is associated with increased dose of opioids in people with Pain as compared to genotypes CC + CT.	20220551	769173180