PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NHLRC1	3	DVL2	5	two hybrid, affinity chromatography technology, enzymatic study, imaging technique	Sharma J (2012), Sharma J (2012), Sharma J (2012), Sharma J (2012)	4
HSP90AA1	7	UBE2N	1	pull down	Zhang M (2005)	1
STUB1	4	UBE2E1	1	pull down, pull down	Soss SE (2011), Parsons JL (2009)	2
NHLRC1	3	UBE2E1	1	pull down	Gentry MS (2005)	1
HSP90AA1	7	HSPA4	3	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	Kim TS (2006), Hidalgo-de-Quintana J (2008), Skarra DV (2011), Wan C (2015)	4
NHLRC1	3	UBE2D3	1	pull down, pull down	Sharma J (2012), Gentry MS (2005)	2
NHLRC1	3	NNAT	0	two hybrid, affinity chromatography technology	Sharma J (2011), Sharma J (2011)	2
UBE2N	1	STUB1	4	pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, pull down	Zhang M (2005), Graf C (2010), Soss SE (2011), Huen MS (2008), Lim GG (2013), Taipale M (2014), Taipale M (2014), Zhu X (2014), Zhang M (2005), Zhang M (2005), Kim HT (2007), Blessing NA (2017)	12
STUB1	4	HSP90AA1	7	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, enzymatic study, biochemical, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, pull down	Zhang L (2007), Zhang M (2005), Tateishi Y (2004), Tateishi Y (2004), Connell P (2001), Ko HS (2009), Kumar P (2007), Kumar P (2007), Wang L (2011), Stankiewicz M (2010), Graf C (2010), Kundrat L (2010), Kundrat L (2010), Kundrat L (2010), Kundrat L (2010), Morishima Y (2008), Zhou P (2003), Zhang M (2008), Grelle G (2006), Kim SA (2005), Arndt V (2005), Muller P (2012), Burch L (2004), Burch L (2004), Jang KW (2011), Schuelke JP (2010), Wang Q (2012), Shimamoto S (2013), Shimamoto S (2013), Shimamoto S (2013), Gano JJ (2010), Skarra DV (2011), Yang SW (2013), Grelle G (2006), Grelle G (2006), Narayan V (2015)	36
STUB1	4	HSPA4	3	pull down, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down, pull down, enzymatic study, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ballinger CA (1999), Ballinger CA (1999), Ballinger CA (1999), Dai Q (2005), Tateishi Y (2004), Tateishi Y (2004), Ko HS (2009), Qian SB (2009), Kumar P (2007), Kumar P (2007), Wang L (2011), Wang L (2011), Wang L (2011), Graf C (2010), Kundrat L (2010), Matsumoto K (2011), Kundrat L (2010), Kundrat L (2010), Morishima Y (2008), Luo W (2010), Soss SE (2011), Zhou P (2003), Kalia LV (2011), Gao Y (2010), Gao Y (2010), Grelle G (2006), Rao SN (2010), Tetzlaff JE (2008), Kim SA (2005), Dai Q (2003), Zhang X (2011), Zhang X (2011), Muller P (2012), Jang KW (2011), Schuelke JP (2010), Jinwal UK (2012), Shimamoto S (2013), Shimamoto S (2013), Shimamoto S (2013), Mao RF (2013), Lee JS (2013), Lee JS (2013)	42
PPP1R3C	3	GYS1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017), Yadav L (2017)	3
NHLRC1	3	UBE2H	3	pull down	Gentry MS (2005)	1
NHLRC1	3	UBE2D1	0	pull down	Gentry MS (2005)	1
STUB1	4	UBE2D3	1	pull down, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Murata S (2001), Soss SE (2011), Page RC (2012), Parsons JL (2009), Stankiewicz M (2010), Gao XC (2011), Kundrat L (2010), Kundrat L (2010), Tsukahara F (2010), Todi SV (2010), Smith MC (2013), Ronnebaum SM (2013), Seki T (2013), Heimdal K (2014), Todi SV (2009), Yuan L (2015), Kim JH (2017), Blessing NA (2017), Pakdaman Y (2017)	19
EPM2A	1	NHLRC1	3	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology	Lohi H (2005), Lohi H (2005), Lohi H (2005), Gentry MS (2005), Gentry MS (2005), Gentry MS (2005), Gentry MS (2005), Gentry MS (2005), Solaz-Fuster MC (2008), Dubey D (2008), Dubey D (2008), Couarch P (2011), Zeng L (2012), Sanchez-Martin P (2013), Sanchez-Martin P (2013), Zeng L (2012), Mittal S (2015), Mittal S (2015), Sanchez-Martin P (2015)	19
STUB1	4	NHLRC1	3	affinity chromatography technology, affinity chromatography technology	Rao SN (2010), Sengupta S (2011)	2
NHLRC1	3	HSPA4	3	affinity chromatography technology	Rao SN (2010)	1
NHLRC1	3	PRDM8	3	affinity chromatography technology, affinity chromatography technology	Turnbull J (2012), Turnbull J (2012)	2
NHLRC1	3	NHLRC1	3	two hybrid, affinity chromatography technology	Mittal S (2015), Mittal S (2015)	2
UBE2N	1	EPM2A	1	affinity chromatography technology, affinity chromatography technology	Sanchez-Martin P (2015), Sanchez-Martin P (2015)	2
STUB1	4	UBE2D1	0	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Xu Z (2008), Xia T (2007), Jiang J (2001), Graf C (2010), Soss SE (2011), Pabarcus MK (2009), Wang Y (2011), Summers DW (2009), Clapp KM (2010), Wang L (2011), Ren HY (2011), Urushitani M (2004), Plechanovova A (2012), Al-Ramahi I (2006), Germano S (2006), Alberti S (2004), Peng HM (2004), Qian SB (2009), Yang M (2011), Lee H (2006), Windheim M (2008), Tsukahara F (2010), Zhou P (2003), Chymkowitch P (2011), Shimamoto S (2013), Spooner RA (2008), Zhang M (2005), Uchiki T (2009), Wang Y (2011), Wang Y (2015), Narayan V (2015), Clapp KM (2012), Kim HT (2007), McClurg UL (2016), Blessing NA (2017), Landre V (2017), Kopp Y (2017)	37
NHLRC1	3	PPP1R3C	3	enzymatic study, two hybrid	Worby CA (2008), Solaz-Fuster MC (2008)	2
PPP1R3C	3	EPM2A	1	affinity chromatography technology, two hybrid	Worby CA (2008), Viana R (2015)	2
STUB1	4	EPM2A	1	affinity chromatography technology	Sengupta S (2011)	1
NHLRC1	3	AGL	4	affinity chromatography technology	Cheng A (2007)	1
GYS1	1	NHLRC1	3	affinity chromatography technology, pull down	Lohi H (2005), Zeng L (2012)	2
HSP90AA1	7	NHLRC1	3	affinity chromatography technology	Taipale M (2012)	1
UBE2N	1	NHLRC1	3	affinity chromatography technology	Sanchez-Martin P (2015)	1