Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
KLRC1 rs7301582 CC adalimumab efficacy yes Response measured 12 weeks after initiation of therapy. Genotype CC is associated with decreased response to adalimumab, certolizumab pegol, etanercept, glucocorticoids, infliximab or methotrexate in people with Arthritis, Rheumatoid as compared to genotypes CT + TT. 26453102 1448266567
KLRC1 rs2734414 TT adalimumab efficacy no Response measured 12 weeks after initiation of therapy. Genotype TT is not associated with response to adalimumab, certolizumab pegol, etanercept, glucocorticoids, infliximab or methotrexate in people with Arthritis, Rheumatoid as compared to genotypes AA + AT. 26453102 1448266578
KLRC1 rs2734440 TT adalimumab efficacy no Response measured 12 weeks after initiation of therapy. Genotype TT is not associated with response to adalimumab, certolizumab pegol, etanercept, glucocorticoids, infliximab or methotrexate in people with Arthritis, Rheumatoid as compared to genotypes CC + CT. 26453102 1448266589