PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CRK	0	KRT2	0	affinity chromatography technology	Brehme M (2009)	1
CUL3	17	CUL1	7	affinity chromatography technology, affinity chromatography technology, biochemical	Bennett EJ (2010), Bennett EJ (2010), Wan C (2015)	3
CBL	7	KRT2	0	affinity chromatography technology	Brehme M (2009)	1
RPS6KB2	3	KRT13	2	affinity chromatography technology	Roy R (2014)	1
MCM2	3	EWSR1	2	affinity chromatography technology	Drissi R (2015)	1
GRB2	2	AP2M1	5	affinity chromatography technology	Blagoev B (2003)	1
CUL1	7	KRT2	0	affinity chromatography technology	Bennett EJ (2010)	1
CUL2	3	KRT10	7	affinity chromatography technology	Bennett EJ (2010)	1
CBL	7	KRT1	3	affinity chromatography technology	Brehme M (2009)	1
ZNF598	6	KRT2	0	affinity chromatography technology	Garzia A (2017)	1
CUL4A	2	KRT10	7	affinity chromatography technology	Bennett EJ (2010)	1
CUL4B	8	KRT5	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL4A	2	EED	1	affinity chromatography technology	Higa LA (2006)	1
EIF4A3	1	KRT1	3	affinity chromatography technology	Singh G (2012)	1
SHC1	0	AP2M1	5	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Li J (2013)	2
CAND1	2	EWSR1	2	affinity chromatography technology	Bennett EJ (2010)	1
COPS6	0	NEDD8	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Sowa ME (2009), Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Birol M (2014)	5
SFN	1	KRT2	0	affinity chromatography technology	Wilker EW (2007)	1
EGFR	5	AP2M1	5	protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Deribe YL (2009), Foerster S (2013), Li J (2013), Tong J (2014), Li J (2013)	5
CUL4A	2	MDM2	2	affinity chromatography technology, affinity chromatography technology	Banks D (2006), Latini P (2011)	2
DCUN1D1	0	KRT1	3	affinity chromatography technology	Bennett EJ (2010)	1
MCM2	3	KRT2	0	affinity chromatography technology	Drissi R (2015)	1
AP2M1	5	KRT5	1	affinity chromatography technology	Brehme M (2009)	1
EPS15	1	GRB2	2	far western blotting, affinity chromatography technology, affinity chromatography technology, pull down	Schumacher C (1995), Parachoniak CA (2009), Parachoniak CA (2009), Parachoniak CA (2009)	4
COPS5	0	KRT13	2	affinity chromatography technology	Bennett EJ (2010)	1
CUL5	1	NEDD8	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2017), Zhu Z (2017)	3
CBL	7	PIK3R2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Lin H (2001), Hartley D (1995), Feshchenko EA (2004), Alcazar I (2009), Brehme M (2009), Brehme M (2009), Grossmann A (2015)	7
COPS5	0	EWSR1	2	affinity chromatography technology	Bennett EJ (2010)	1
CRY1	0	KRT2	0	affinity chromatography technology	Papp SJ (2015)	1
MAGOH	0	KRT10	7	affinity chromatography technology	Singh G (2012)	1
VCAM1	2	GRB2	2	affinity chromatography technology	Humphries JD (2009)	1
SFN	1	COPS6	0	affinity chromatography technology, affinity chromatography technology, biochemical	Choi HH (2011), Choi HH (2011), Choi HH (2011)	3
KRT2	0	PRSS1	0	biochemical	Wan C (2015)	1
VCAM1	2	INPPL1	6	affinity chromatography technology	Humphries JD (2009)	1
PIK3R2	3	KRT1	3	affinity chromatography technology	Brehme M (2009)	1
CUL5	1	COPS5	0	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010)	2
POU5F1	0	KRT1	3	affinity chromatography technology	Hawkins PG (2010)	1
CUL4B	8	KRT13	2	affinity chromatography technology	Bennett EJ (2010)	1
DCUN1D1	0	CAND1	2	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Kim AY (2008), Kim AY (2008), Kim AY (2008), Bennett EJ (2010), Bommelje CC (2013), Kim AY (2008), Huang G (2014), Huang G (2014), Keuss MJ (2016), Keuss MJ (2016), Keuss MJ (2016)	11
EWSR1	2	HDGF	0	bioid	Elzi DJ (2014)	1
SHC1	0	KRT77	3	affinity chromatography technology	Brehme M (2009)	1
SFN	1	MDM2	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Yang HY (2007), Yang HY (2007), Yang HY (2007), Wood NT (2009)	4
MTM1	0	CUL4A	2	biochemical	Wan C (2015)	1
COPS6	0	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Kristensen AR (2012), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	9
GRB2	2	KRT2	0	affinity chromatography technology	Brehme M (2009)	1
PIK3R2	3	SHC1	0	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009)	2
CUL3	17	PIK3R2	3	affinity chromatography technology	Bennett EJ (2010)	1
INPPL1	6	KRT2	0	affinity chromatography technology	Brehme M (2009)	1
FN1	17	LASP1	1	affinity chromatography technology	Humphries JD (2009)	1
CUL4A	2	DCUN1D1	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010), Monda JK (2013), Meyer-Schaller N (2009), Kim AY (2008), Kim AY (2008), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016)	9
HDGF	0	KRT2	0	affinity chromatography technology	Zhao J (2011)	1
FN1	17	KRT10	7	affinity chromatography technology	Humphries JD (2009)	1
CYLD	2	KRT10	7	affinity chromatography technology	Elliott PR (2016)	1
DCUN1D1	0	COPS6	0	affinity chromatography technology	Bennett EJ (2010)	1
EED	1	CUL1	7	affinity chromatography technology	Cao Q (2014)	1
CUL4A	2	CUL3	17	affinity chromatography technology	Bennett EJ (2010)	1
MCM2	3	CUL4B	8	affinity chromatography technology	Drissi R (2015)	1
POU5F1	0	KRT10	7	affinity chromatography technology	Hawkins PG (2010)	1
DCUN1D1	0	EWSR1	2	affinity chromatography technology	Bennett EJ (2010)	1
MAGOH	0	KRT2	0	affinity chromatography technology	Singh G (2012)	1
AP2M1	5	CRY1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
COPS5	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Min KW (2005), Min KW (2005), Chua YS (2011), Boh BK (2011), Emberley ED (2012), Emberley ED (2012), Choo YY (2011), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Enchev RI (2012), Birol M (2014), Pick E (2012), Sharon M (2009), Enchev RI (2012), Bornstein G (2015), Rockel B (2014), Schlierf A (2016), Reitsma JM (2017), Reitsma JM (2017)	23
CUL4A	2	CUL5	1	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010)	2
EGFR	5	PIK3R2	3	affinity chromatography technology, unspecified method, affinity chromatography technology, two hybrid, pull down, protein complementation assay	Tong J (2009), Jones RB (2006), Foerster S (2013), Kotlyar M (2015), Gout I (1992), Petschnigg J (2014)	6
COPS5	0	CAND1	2	biochemical, affinity chromatography technology	Bornstein G (2006), Bennett EJ (2010)	2
LGR4	3	KRT1	3	affinity chromatography technology	Carmon KS (2014)	1
VCAM1	2	EWSR1	2	affinity chromatography technology	Humphries JD (2009)	1
EGFR	5	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Ettenberg SA (1999), Tvorogov D (2002), Pennock S (2008), Umebayashi K (2008), Ng C (2008), Ng C (2008), Povlsen GK (2008), Khan EM (2008), Su X (2007), Shtiegman K (2007), Han W (2006), Visser GD (2005), Tsacoumangos A (2005), Prasad NK (2005), Gur G (2004), Kowanetz K (2004), Feshchenko EA (2004), Wu WJ (2003), Schmidt MH (2003), Bao J (2003), Rubin C (2003), Waterman H (1999), Bonaccorsi L (2007), Dey N (2011), Miraoui H (2010), Guo HB (2009), Tong J (2009), Tong J (2009), Sun Q (2010), Sanada F (2009), Rafiq K (2011), Ravid T (2004), Ravid T (2004), Duan L (2011), Duan L (2011), Haglund K (2005), Oksvold MP (2003), Oksvold MP (2003), Gui A (2012), Yang S (2006), de Melker AA (2004), Crovello CS (1998), Graus-Porta D (1997), Oksvold MP (2001), Raguz J (2007), de Melker AA (2004), Thien CB (2001), Kassenbrock CK (2004), Tarcic G (2009), Schroeder B (2012), Adachi S (2009), Shen F (2007), Mitsushima M (2006), Choi JH (2003), Burke P (2001), Tanaka S (1995), Meisner H (1995), Meisner H (1995), Kumar EA (2012), Tong J (2008), Dou H (2012), Levkowitz G (1999), Levkowitz G (1999), Bode AM (2009), Thomas C (2012), Meijer IM (2013), Chang CC (2012), Chang CC (2012), Smith CJ (2013), Gan Y (2010), Scott RP (2005), Fukazawa T (1996), Fukazawa T (1996), Fukazawa T (1996), Wang L (2013), Hong SY (2013), Sigismund S (2013), Sigismund S (2013), Sigismund S (2013), Meisner H (1997), Odintsova E (2013), Kondratov KA (2010), He Z (2014), Tong J (2014), Balaji K (2012), Kiuchi T (2014), Zhang B (2005), Waterman H (1999), Ha Thi HT (2015), Yao S (2015), Kortuem F (2015), Igloi Z (2015), Song F (2016), Song F (2016), Lin TY (2017), Conte A (2017)	96
CUL2	3	KRT1	3	affinity chromatography technology	Bennett EJ (2010)	1
TRAF6	0	KRT5	1	affinity chromatography technology	Yu J (2016)	1
DCUN1D1	0	CUL1	7	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Kim AY (2008), Kim AY (2008), Wu K (2011), Bennett EJ (2010), Huang G (2011), Monda JK (2013), Bommelje CC (2013), Meyer-Schaller N (2009), Kim AY (2008), Kim AY (2008), Huang G (2014), Huang G (2014), Huang G (2014), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016)	16
EPS15	1	KRT2	0	affinity chromatography technology	Brehme M (2009)	1
CBL	7	GRB2	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jain SK (1997), Liu SK (1998), Ettenberg SA (1999), Wong A (2002), Wong A (2002), Robertson H (1997), Donovan JA (1994), Park RK (1999), Erdreich-Epstein A (1999), Gesbert F (1998), Gesbert F (1998), Gesbert F (1998), Husson H (1997), Saci A (2002), Odai H (1997), Ng C (2008), Khan EM (2008), Bandyopadhyay S (2010), Jiang X (2003), Waterman H (2002), Miraoui H (2010), Ravid T (2004), Ingham RJ (1996), Erdreich-Epstein A (1997), Rellahan BL (2003), Izadi KD (1998), Wang Y (1999), Chu J (1998), Bonita DP (1997), Boussiotis VA (1997), Meisner H (1995), Meisner H (1995), Barber DL (1997), Shishido T (2000), Bartkiewicz M (1999), Buday L (1996), Tarcic G (2009), Belleudi F (2007), Brizzi MF (1996), Brenner B (2001), Donovan JA (1996), Donovan JA (1996), Donovan JA (1996), Gaston I (2004), Gaston I (2004), Tsygankov AY (1996), Tsygankov AY (1996), Hunter S (1997), Jain SK (1997), Levkowitz G (1996), Liu YC (1997), Odai H (1995), Odai H (1995), Meisner H (1995), Huang JY (2000), Panchamoorthy G (1996), Panchamoorthy G (1996), Yokouchi M (1997), Oda A (1996), Fukazawa T (1995), Fukazawa T (1995), Selbach M (2006), Brehme M (2009), Brehme M (2009), Fukazawa T (1995), Cerboni C (1998), Cerboni C (1998), Fixman ED (1997), Anderson SM (1997), Houtman JC (2006), Brizzi MF (1996), Scott RP (2005), Scott RP (2005), Bisson N (2011), Fukazawa T (1996), Fukazawa T (1996), Umehara H (2002), Taipale M (2014), Taipale M (2014), Grossmann A (2015), Grossmann A (2015), Igloi Z (2015), Huttlin EL (2017)	83
COPS6	0	KRT2	0	affinity chromatography technology	Bennett EJ (2010)	1
VCAM1	2	PIK3R2	3	affinity chromatography technology	Humphries JD (2009)	1
LASP1	1	KRT2	0	affinity chromatography technology	Duvall-Noelle N (2016)	1
MTM1	0	KRT2	0	affinity chromatography technology	St-Denis N (2016)	1
DCUN1D1	0	GRB2	2	affinity chromatography technology	Bennett EJ (2010)	1
RPS6KB2	3	KRT10	7	affinity chromatography technology	Roy R (2014)	1
MCM2	3	MAGOH	0	affinity chromatography technology	Drissi R (2015)	1
RPS6KB2	3	HNRNPA1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Roy R (2014), Roy R (2014), Roy R (2014), Roy R (2014)	4
CUL4A	2	CAND1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Min KW (2003), Angers S (2006), Hu J (2004), Chua YS (2011), Tron AE (2012), Zheng J (2002), He YJ (2006), He YJ (2006), McCall CM (2008), Bennett EJ (2010), Gastaldello S (2012), Liu J (2002), Liu J (2002), Olma MH (2009), Olma MH (2009), Yang Y (2016), Yang Y (2016)	18
EGFR	5	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Schulze WX (2006), Blagoev B (2003), Oneyama C (2002), Wong L (1999), Okutani T (1994), Okutani T (1994), Okutani T (1994), Tortora G (1997), Daly RJ (1996), Buday L (1994), Lowenstein EJ (1992), Lowenstein EJ (1992), Braverman LE (1999), Khan EM (2008), Bonaccorsi L (2007), Miraoui H (2010), Tong J (2009), Severe N (2011), Takahashi Y (1999), Tarcic G (2009), Thien CB (1997), Burke P (2001), Katayama H (1999), Meisner H (1995), Kurada BR (2009), Tong J (2008), Bisson N (2011), Fukazawa T (1996), Fukazawa T (1996), Jones RB (2006), Sigismund S (2013), Sigismund S (2013), Foerster S (2013), Bisson N (2011), Gotoh N (1994), Wu SL (2006), Wu SL (2006), Tong J (2014), Oksvold MP (2001), Kotlyar M (2015), Petschnigg J (2014), Li J (2013), Song F (2016), Song F (2016), Ueno H (1995), Ueno H (1995), Ueno H (1995), Prigent SA (1996), Kapoor GS (2010), Kapoor GS (2010), Okamura T (2009)	51
CYLD	2	KRT5	1	affinity chromatography technology	Elliott PR (2016)	1
UBASH3B	4	KRT2	0	affinity chromatography technology	Brehme M (2009)	1
CUL3	17	CUL5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010), Schenkova K (2012)	3
KAT2A	1	HDGF	0	affinity chromatography technology	Kim J (2010)	1
UBASH3B	4	KRT10	7	affinity chromatography technology	Brehme M (2009)	1
COPS6	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Olma MH (2009), Reitsma JM (2017)	7
KRT5	1	KRT10	7	biochemical	Wan C (2015)	1
MCM5	1	KRT19	0	affinity chromatography technology	Drissi R (2015)	1
AP2M1	5	KRT1	3	affinity chromatography technology	Brehme M (2009)	1
CUL1	7	KRT13	2	affinity chromatography technology	Bennett EJ (2010)	1
KRT5	1	KRT40	0	two hybrid	Rolland T (2014)	1
COPS5	0	CUL4A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Angers S (2006), He YJ (2006), McCall CM (2008), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Olma MH (2009), Olma MH (2009), Rao F (2014), Pick E (2012), Groisman R (2003), Groisman R (2003), Huttlin EL (2015), Cavadini S (2016), Scherer PC (2016), Scherer PC (2016), Huttlin EL (2017)	19
GRB2	2	KRT5	1	affinity chromatography technology	Brehme M (2009)	1
COPS5	0	MDM2	2	affinity chromatography technology, pull down	Zhang XC (2008), Zhang XC (2008)	2
LGR4	3	KRT77	3	affinity chromatography technology	Carmon KS (2014)	1
KAT2A	1	KRT2	0	affinity chromatography technology	Kim J (2010)	1
MDM2	2	CUL4B	8	affinity chromatography technology	Latini P (2011)	1
CYLD	2	KRT1	3	affinity chromatography technology	Elliott PR (2016)	1
FN1	17	KRT5	1	affinity chromatography technology	Humphries JD (2009)	1
CYLD	2	TRAF6	0	enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology	Kovalenko A (2003), Bremm A (2010), Wu J (2015), Wu J (2015)	4
CUL5	1	EWSR1	2	affinity chromatography technology	Bennett EJ (2010)	1
RC3H1	6	KRT5	1	affinity chromatography technology	Murakawa Y (2015)	1
CUL5	1	KRT13	2	affinity chromatography technology	Bennett EJ (2010)	1
EGFR	5	HDGF	0	affinity chromatography technology	Yao Z (2017)	1
CYLD	2	KRT77	3	affinity chromatography technology	Elliott PR (2016)	1
MCM2	3	SFN	1	affinity chromatography technology	Drissi R (2015)	1
KRT2	0	KRT19	0	two hybrid	Rolland T (2014)	1
DCUN1D1	0	KRT77	3	affinity chromatography technology	Bennett EJ (2010)	1
GRB2	2	KRT1	3	affinity chromatography technology	Brehme M (2009)	1
MCM5	1	KRT2	0	affinity chromatography technology	Drissi R (2015)	1
KRT10	7	KRT2	0	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
VCAM1	2	EIF4A3	1	affinity chromatography technology	Humphries JD (2009)	1
CBL	7	KRT5	1	affinity chromatography technology	Brehme M (2009)	1
EPS15	1	AP2M1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009), Li J (2013), Huttlin EL (2015), Huttlin EL (2017)	5
CRK	0	SFN	1	affinity chromatography technology	Brehme M (2009)	1
CUL3	17	HNRNPA1	1	affinity chromatography technology	Bennett EJ (2010)	1
NEDD8	0	KRT13	2	affinity chromatography technology	Bennett EJ (2010)	1
EIF4A3	1	KRT5	1	affinity chromatography technology	Singh G (2012)	1
UBASH3B	4	INPPL1	6	affinity chromatography technology	Brehme M (2009)	1
KRT2	0	KRT13	2	two hybrid	Rolland T (2014)	1
KRT2	0	KRT38	4	two hybrid	Rolland T (2014)	1
CUL5	1	HNRNPA1	1	affinity chromatography technology	Bennett EJ (2010)	1
EIF4A3	1	KRT19	0	affinity chromatography technology	Singh G (2012)	1
COPS6	0	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Huttlin EL (2015), Huttlin EL (2017)	6
COPS5	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Huttlin EL (2017)	8
CRK	0	INPPL1	6	affinity chromatography technology	Brehme M (2009)	1
CUL3	17	CUL2	3	biochemical	Wan C (2015)	1
DCUN1D1	0	KRT5	1	affinity chromatography technology	Bennett EJ (2010)	1
EPS15	1	CRK	0	far western blotting, pull down, affinity chromatography technology, affinity chromatography technology	Schumacher C (1995), Schumacher C (1995), Brehme M (2009), Brehme M (2009)	4
CAND1	2	KRT1	3	affinity chromatography technology	Bennett EJ (2010)	1
EED	1	HNRNPA1	1	affinity chromatography technology	Cao Q (2014)	1
UBASH3B	4	EWSR1	2	affinity chromatography technology	Li J (2013)	1
CUL4A	2	EWSR1	2	affinity chromatography technology	Bennett EJ (2010)	1
GRB2	2	FN1	17	two hybrid, affinity chromatography technology	Wang J (2008), Humphries JD (2009)	2
EGFR	5	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Schulze WX (2006), Sakaguchi K (1998), Tong J (2009), Crovello CS (1998), Graus-Porta D (1997), Oksvold MP (2001), Burke P (2001), Katayama H (1999), Tong J (2008), Zhang L (1999), Levkowitz G (1999), Fukazawa T (1996), Jones RB (2006), Sigismund S (2013), Foerster S (2013), Gotoh N (1994), Tong J (2014), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014), Li J (2013), Li J (2013), Prigent SA (1996), Prigent SA (1996), Grosse R (2000), Yao Z (2017), Wills MK (2014), Wills MK (2014), Kapoor GS (2010)	29
NEDD8	0	HNRNPA1	1	affinity chromatography technology	Bennett EJ (2010)	1
FN1	17	EIF4A3	1	affinity chromatography technology	Humphries JD (2009)	1
EGFR	5	EWSR1	2	affinity chromatography technology	Tong J (2014)	1
CUL4B	8	KRT10	7	affinity chromatography technology	Bennett EJ (2010)	1
HNRNPA1	1	EIF4A3	1	affinity chromatography technology	Roy R (2014)	1
IQCB1	3	KRT10	7	affinity chromatography technology	Sang L (2011)	1
CUL4B	8	CUL5	1	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010)	2
EGFR	5	KRT5	1	affinity chromatography technology	Yao Z (2017)	1
DCUN1D1	0	KRT2	0	affinity chromatography technology	Bennett EJ (2010)	1
TRAF6	0	CUL5	1	affinity chromatography technology, pull down, affinity chromatography technology	Zhu Z (2016), Zhu Z (2016), Zhu Z (2017)	3
CUL3	17	KRT31	0	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	AP2M1	5	affinity chromatography technology	Bennett EJ (2010)	1
HNRNPA1	1	EWSR1	2	affinity chromatography technology, affinity chromatography technology	Close P (2012), Roy R (2014)	2
KRT10	7	KRT77	3	biochemical	Wan C (2015)	1
TRAF6	0	KRT2	0	affinity chromatography technology	Yu J (2016)	1
MDM2	2	EED	1	affinity chromatography technology	Wienken M (2016)	1
YEATS4	0	KRT2	0	affinity chromatography technology	Hein MY (2015)	1
FN1	17	KRT2	0	affinity chromatography technology	Humphries JD (2009)	1
EGFR	5	UBASH3B	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kowanetz K (2004), Raguz J (2007), Raguz J (2007), Tong J (2008), Foerster S (2013), Li J (2013), Tong J (2014), Li J (2013)	8
CUL2	3	CUL4B	8	affinity chromatography technology	Bennett EJ (2010)	1
PIK3R2	3	KRT2	0	affinity chromatography technology	Brehme M (2009)	1
INPPL1	6	KRT1	3	affinity chromatography technology	Brehme M (2009)	1
CUL3	17	KRT2	0	affinity chromatography technology	Bennett EJ (2010)	1
EGFR	5	INPPL1	6	affinity chromatography technology, affinity chromatography technology	Pesesse X (2001), Sanada F (2009)	2
GRB2	2	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Blagoev B (2003), Skolnik EY (1993), Skolnik EY (1993), Puil L (1994), Satoh T (1996), Fixman ED (1996), Fixman ED (1996), Fixman ED (1996), Ishihara H (1997), Fournier E (1999), Ravichandran KS (1994), Lamprecht R (2002), Park RK (1999), Sakaguchi K (2001), Park RK (1999), Park RK (1999), Hallak H (2001), Yokote K (1994), Saci A (2002), Zhang S (1999), Lazar DF (1994), VanderKuur J (1995), Kanai M (1997), Spivak-Kroizman T (1994), Giordano V (1997), Drobot L (2005), Erdreich-Epstein A (1997), Takahashi Y (1999), Barber DL (1997), Ahn SC (2003), Odai H (1995), Panchamoorthy G (1996), Panchamoorthy G (1996), Brehme M (2009), Brehme M (2009), Brehme M (2009), Cerboni C (1998), Zhang L (1999), Brizzi MF (1996), Brizzi MF (1996), Liu BA (2012), Bisson N (2011), Fukazawa T (1996), Bisson N (2011), Umehara H (2002), Oksvold MP (2001), Oksvold MP (2001), Li J (2013), Li J (2013), Ueno H (1995), Prigent SA (1996), Wills MK (2014), Rausch O (1997), Ho JM (2002), Ho JM (2002), Yu WM (2006), Klint P (1995)	57
ADRB2	0	KRT2	0	affinity chromatography technology	Roy SJ (2013)	1
CUL1	7	MDM2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Inuzuka H (2010), Inuzuka H (2010), He Y (2014)	3
UBASH3B	4	CRK	0	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009)	2
ADRB2	0	KRT10	7	affinity chromatography technology	Roy SJ (2013)	1
CUL5	1	CUL1	7	affinity chromatography technology	Bennett EJ (2010)	1
MCM2	3	HNRNPA1	1	affinity chromatography technology	Drissi R (2015)	1
KRT2	0	KRT77	3	biochemical	Wan C (2015)	1
FN1	17	MCM2	3	affinity chromatography technology	Humphries JD (2009)	1
KRT31	0	KRT77	3	two hybrid	Rolland T (2014)	1
SHC1	0	KRT1	3	affinity chromatography technology	Brehme M (2009)	1
DCUN1D1	0	KRT10	7	affinity chromatography technology	Bennett EJ (2010)	1
COPS5	0	HNRNPA1	1	affinity chromatography technology	Bennett EJ (2010)	1
COPS5	0	KRT1	3	affinity chromatography technology	Bennett EJ (2010)	1
AP2M1	5	CRK	0	affinity chromatography technology	Brehme M (2009)	1
LGR4	3	PRSS1	0	affinity chromatography technology	Carmon KS (2014)	1
MAGOH	0	KRT1	3	affinity chromatography technology	Singh G (2012)	1
CUL5	1	KRT5	1	affinity chromatography technology	Bennett EJ (2010)	1
EPS15	1	KRT1	3	affinity chromatography technology	Brehme M (2009)	1
MDM2	2	KRT2	0	affinity chromatography technology	Jacob AG (2014)	1
CUL1	7	KRT1	3	affinity chromatography technology	Bennett EJ (2010)	1
COPS6	0	EWSR1	2	affinity chromatography technology	Bennett EJ (2010)	1
CRK	0	GRB2	2	pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Riordan SM (2000), Matsuda M (1996), Okada S (1996), Okada S (1996), Garcia-Guzman M (2000), Brehme M (2009)	6
CUL5	1	KRT1	3	affinity chromatography technology	Bennett EJ (2010)	1
MCM5	1	HNRNPA1	1	affinity chromatography technology	Drissi R (2015)	1
KRT2	0	KRT1	3	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
EGFR	5	FN1	17	protein complementation assay	Deribe YL (2009)	1
CUL5	1	KRT10	7	affinity chromatography technology	Bennett EJ (2010)	1
CUL4B	8	DCUN1D1	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010), Monda JK (2013), Meyer-Schaller N (2009), Kim AY (2008), Kim AY (2008), Monda JK (2013), Keuss MJ (2016)	8
PIK3R2	3	KRT38	4	two hybrid	Rolland T (2014)	1
NEDD8	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012)	4
EPS15	1	KRT10	7	affinity chromatography technology	Brehme M (2009)	1
KRT2	0	KRT5	1	biochemical	Wan C (2015)	1
PIK3R2	3	KRT5	1	affinity chromatography technology	Brehme M (2009)	1
VCAM1	2	MCM2	3	affinity chromatography technology	Humphries JD (2009)	1
CAND1	2	CUL5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chua YS (2011), Chua YS (2011), Tron AE (2012), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Liu J (2002), Huttlin EL (2017)	8
RPS6KB2	3	KRT5	1	affinity chromatography technology	Roy R (2014)	1
HNRNPA1	1	KRT2	0	affinity chromatography technology	Roy R (2014)	1
VCAM1	2	EPS15	1	affinity chromatography technology	Humphries JD (2009)	1
CRY1	0	KRT10	7	affinity chromatography technology	Papp SJ (2015)	1
CUL4B	8	CAND1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Min KW (2003), Min KW (2003), Bennett EJ (2010), Bennett EJ (2010), Hein MY (2015)	6
SHC1	0	KRT2	0	affinity chromatography technology	Brehme M (2009)	1
CBL	7	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Park RK (1999), Gesbert F (1998), Erdreich-Epstein A (1997), Wang Y (1999), Brehme M (2009), Brehme M (2009), Cerboni C (1998), Brizzi MF (1996), Fukazawa T (1996)	9
NEDD8	0	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010)	3
FN1	17	KRT31	0	affinity chromatography technology	Humphries JD (2009)	1
CUL2	3	HNRNPA1	1	affinity chromatography technology	Bennett EJ (2010)	1
ADRB2	0	KRT1	3	affinity chromatography technology	Roy SJ (2013)	1
SHC1	0	KRT10	7	affinity chromatography technology	Brehme M (2009)	1
EGFR	5	CUL4B	8	affinity chromatography technology	Tong J (2014)	1
CAND1	2	KRT13	2	affinity chromatography technology	Bennett EJ (2010)	1
SHC1	0	KRT5	1	affinity chromatography technology	Brehme M (2009)	1
COPS5	0	KRT10	7	affinity chromatography technology	Bennett EJ (2010)	1
CRY1	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Busino L (2007), Papp SJ (2015), Huttlin EL (2017)	3
ZNF598	6	CAND1	2	affinity chromatography technology	Garzia A (2017)	1
PAN2	3	HNRNPA1	1	affinity chromatography technology	Bett JS (2013)	1
DCUN1D1	0	CUL5	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Kim AY (2008), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Monda JK (2013), Meyer-Schaller N (2009), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016)	9
DCUN1D1	0	COPS5	0	affinity chromatography technology	Bennett EJ (2010)	1
CYLD	2	KRT13	2	affinity chromatography technology	Elliott PR (2016)	1
EGFR	5	CRK	0	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, two hybrid, protein complementation assay, affinity chromatography technology	Schulze WX (2006), Hashimoto Y (1998), Hashimoto Y (1998), Katayama H (1999), Ota S (1998), Jones RB (2006), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	9
CUL4B	8	HNRNPA1	1	affinity chromatography technology	Bennett EJ (2010)	1
HNRNPA1	1	KRT5	1	affinity chromatography technology	Roy R (2014)	1
INPPL1	6	KRT5	1	affinity chromatography technology	Brehme M (2009)	1
EPS15	1	KRT38	4	affinity chromatography technology	Brehme M (2009)	1
HNRNPA1	1	KRT1	3	affinity chromatography technology	Roy R (2014)	1
CUL1	7	KRT10	7	affinity chromatography technology	Bennett EJ (2010)	1
COPS6	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Huttlin EL (2017)	6
CAND1	2	KRT2	0	affinity chromatography technology	Bennett EJ (2010)	1
DCUN1D1	0	CUL2	3	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim AY (2008), Kim AY (2008), Bennett EJ (2010), Monda JK (2013), Heir P (2013), Bommelje CC (2013), Meyer-Schaller N (2009), Kim AY (2008), Kim AY (2008), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016), Chen K (2016)	13
HDGF	0	KRT10	7	affinity chromatography technology	Zhao J (2011)	1
NEDD8	0	KRT10	7	affinity chromatography technology	Bennett EJ (2010)	1
CUL2	3	KAT2A	1	pull down, affinity chromatography technology	Mao X (2009), Mao X (2009)	2
HDGF	0	KRT1	3	affinity chromatography technology	Zhao J (2011)	1
KRT1	3	KRT77	3	biochemical	Wan C (2015)	1
CUL4B	8	EWSR1	2	affinity chromatography technology	Bennett EJ (2010)	1
VCAM1	2	AP2M1	5	affinity chromatography technology	Humphries JD (2009)	1
POU5F1	0	KRT19	0	affinity chromatography technology	Hawkins PG (2010)	1
CRK	0	KRT1	3	affinity chromatography technology	Brehme M (2009)	1
CUL4B	8	KRT2	0	affinity chromatography technology	Bennett EJ (2010)	1
RPS6KB2	3	KRT1	3	affinity chromatography technology	Roy R (2014)	1
ADRB2	0	CUL2	3	affinity chromatography technology	Xie L (2009)	1
CUL3	17	KRT1	3	affinity chromatography technology	Bennett EJ (2010)	1
PAN2	3	KRT19	0	affinity chromatography technology	Bett JS (2013)	1
CYLD	2	KRT2	0	affinity chromatography technology	Elliott PR (2016)	1
UBASH3B	4	CBL	7	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kowanetz K (2004), Kowanetz K (2004), Raguz J (2007), Hoeller D (2006), Peruzzi G (2007), Brehme M (2009)	6
CRK	0	LASP1	1	two hybrid	Grossmann A (2015)	1
DCUN1D1	0	CUL3	17	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Kim AY (2008), Kim AY (2008), Bennett EJ (2010), Bennett EJ (2010), Monda JK (2013), Bommelje CC (2013), Meyer-Schaller N (2009), Meyer-Schaller N (2009), Kim AY (2008), Kim AY (2008), Huang G (2014), Huang G (2014), Monda JK (2013), Wan C (2015), Keuss MJ (2016), Keuss MJ (2016), Keuss MJ (2016), Keuss MJ (2016), Huttlin EL (2017)	19
CRK	0	KRT77	3	affinity chromatography technology	Brehme M (2009)	1
CYLD	2	MCM5	1	affinity chromatography technology	Elliott PR (2016)	1
VCAM1	2	MCM5	1	affinity chromatography technology	Humphries JD (2009)	1
AP2M1	5	KRT10	7	affinity chromatography technology	Brehme M (2009)	1
TRAF6	0	KRT1	3	affinity chromatography technology	Yu J (2016)	1
POU5F1	0	KRT2	0	affinity chromatography technology	Hawkins PG (2010)	1
CUL3	17	KRT10	7	affinity chromatography technology	Bennett EJ (2010)	1
AP2M1	5	KRT2	0	affinity chromatography technology	Brehme M (2009)	1
CAND1	2	KRT5	1	affinity chromatography technology	Bennett EJ (2010)	1
PIK3R2	3	KRT10	7	affinity chromatography technology	Brehme M (2009)	1
EPS15	1	KRT5	1	affinity chromatography technology	Brehme M (2009)	1
CUL1	7	KRT5	1	affinity chromatography technology	Bennett EJ (2010)	1
EWSR1	2	KRT2	0	affinity chromatography technology	Elzi DJ (2014)	1
CUL2	3	KRT5	1	affinity chromatography technology	Bennett EJ (2010)	1
AP2M1	5	KRT77	3	affinity chromatography technology	Brehme M (2009)	1
COPS6	0	KRT5	1	affinity chromatography technology	Bennett EJ (2010)	1
DCUN1D1	0	NEDD8	0	affinity chromatography technology	Bennett EJ (2010)	1
CBL	7	INPPL1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vandenbroere I (2003), Prasad NK (2005), De Schutter J (2009), De Schutter J (2009), Brehme M (2009)	5
CUL3	17	CUL4B	8	affinity chromatography technology	Bennett EJ (2010)	1
KRT2	0	KRT40	0	two hybrid	Rolland T (2014)	1
KRT10	7	KRT1	3	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
EED	1	EIF4A3	1	affinity chromatography technology	Cao Q (2014)	1
COPS6	0	CUL4A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Angers S (2006), He YJ (2006), McCall CM (2008), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Olma MH (2009), Olma MH (2009), Huttlin EL (2015), Huttlin EL (2017)	12
COPS6	0	CUL5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009)	5
CAND1	2	HNRNPA1	1	affinity chromatography technology	Bennett EJ (2010)	1
POU5F1	0	YEATS4	0	affinity chromatography technology	Oliviero G (2015)	1
CUL3	17	GRB2	2	affinity chromatography technology	Bennett EJ (2010)	1
NEDD8	0	KRT2	0	affinity chromatography technology	Bennett EJ (2010)	1
CAND1	2	EIF4A3	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL2	3	CAND1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Min KW (2003), Menon S (2008), Mao X (2011), Chua YS (2011), Chua YS (2011), Tron AE (2012)	7
CUL1	7	HNRNPA1	1	affinity chromatography technology	Bennett EJ (2010)	1
FN1	17	MCM5	1	affinity chromatography technology	Humphries JD (2009)	1
SHC1	0	INPPL1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wisniewski D (1999), Wisniewski D (1999), Pesesse X (2001), Habib T (1998), Brehme M (2009), Brehme M (2009)	6
CRK	0	KRT5	1	affinity chromatography technology	Brehme M (2009)	1
COPS5	0	KRT2	0	affinity chromatography technology	Bennett EJ (2010)	1
MAGOH	0	KRT19	0	affinity chromatography technology	Singh G (2012)	1
CUL5	1	KRT2	0	affinity chromatography technology	Bennett EJ (2010)	1
CYLD	2	HNRNPA1	1	affinity chromatography technology	Elliott PR (2016)	1
SHC1	0	CRK	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009), Ota S (1998), Larsson H (1999)	4
CUL1	7	EWSR1	2	affinity chromatography technology	Bennett EJ (2010)	1
MDM2	2	ADRB2	0	enzymatic study	Shenoy SK (2001)	1
COPS5	0	COPS6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, pull down, x-ray crystallography, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Fang L (2008), Sharon M (2009), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Choi HH (2011), Kristensen AR (2012), Birol M (2014), Birol M (2014), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	18
CUL4B	8	KRT1	3	affinity chromatography technology	Bennett EJ (2010)	1
VCAM1	2	HNRNPA1	1	affinity chromatography technology	Humphries JD (2009)	1
LGR4	3	KRT2	0	affinity chromatography technology	Carmon KS (2014)	1
CRK	0	KRT19	0	affinity chromatography technology	Brehme M (2009)	1
CUL4A	2	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Guerrero-Santoro J (2008), Angers S (2006), Bennett EJ (2010), Bennett EJ (2010), Sertic S (2013)	5
VCAM1	2	KRT1	3	affinity chromatography technology	Humphries JD (2009)	1
IQCB1	3	KRT1	3	affinity chromatography technology	Sang L (2011)	1
CUL4A	2	KRT2	0	affinity chromatography technology	Bennett EJ (2010)	1
UBASH3B	4	CUL3	17	pull down	Krupina K (2016)	1
CUL2	3	EWSR1	2	affinity chromatography technology	Bennett EJ (2010)	1
YEATS4	0	KRT5	1	affinity chromatography technology	Hein MY (2015)	1
CUL4A	2	KRT1	3	affinity chromatography technology	Bennett EJ (2010)	1
FN1	17	HNRNPA1	1	affinity chromatography technology	Humphries JD (2009)	1
EIF4A3	1	KRT2	0	affinity chromatography technology	Singh G (2012)	1
VCAM1	2	KRT19	0	affinity chromatography technology	Humphries JD (2009)	1
CUL5	1	KRT77	3	affinity chromatography technology	Bennett EJ (2010)	1
EGFR	5	SFN	1	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Wu SL (2006), Wu SL (2006), Kotlyar M (2015), Petschnigg J (2014), Li J (2013)	5
MTM1	0	KRT5	1	affinity chromatography technology	St-Denis N (2016)	1
CRK	0	KRT10	7	affinity chromatography technology	Brehme M (2009)	1
IQCB1	3	KRT5	1	affinity chromatography technology	Sang L (2011)	1
KAT2A	1	CUL4A	2	affinity chromatography technology	Li Y (2011)	1
LGR4	3	KRT5	1	affinity chromatography technology	Carmon KS (2014)	1
EED	1	KRT2	0	affinity chromatography technology	Cao Q (2014)	1
GRB2	2	CYLD	2	affinity chromatography technology	Huttlin EL (2017)	1
CUL4A	2	CUL1	7	biochemical	He YJ (2006)	1
UBASH3B	4	KRT1	3	affinity chromatography technology	Brehme M (2009)	1
EIF4A3	1	KRT10	7	affinity chromatography technology	Singh G (2012)	1
IQCB1	3	KRT2	0	affinity chromatography technology	Sang L (2011)	1
COPS6	0	KRT10	7	affinity chromatography technology	Bennett EJ (2010)	1
PAN2	3	KRT1	3	affinity chromatography technology	Bett JS (2013)	1
COPS6	0	KRT1	3	affinity chromatography technology	Bennett EJ (2010)	1
FN1	17	EWSR1	2	affinity chromatography technology	Humphries JD (2009)	1
MCM2	3	CUL4A	2	affinity chromatography technology	Drissi R (2015)	1
NEDD8	0	KRT1	3	affinity chromatography technology	Bennett EJ (2010)	1
MCM2	3	GRB2	2	affinity chromatography technology	Drissi R (2015)	1
EED	1	KRT19	0	affinity chromatography technology	Cao Q (2014)	1
CUL3	17	KRT5	1	affinity chromatography technology	Bennett EJ (2010)	1
KRT10	7	PRSS1	0	biochemical	Wan C (2015)	1
EED	1	KRT1	3	affinity chromatography technology	Cao Q (2014)	1
FN1	17	EPS15	1	affinity chromatography technology	Humphries JD (2009)	1
CBL	7	KRT10	7	affinity chromatography technology	Brehme M (2009)	1
NEDD8	0	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010)	3
DCUN1D1	0	HNRNPA1	1	affinity chromatography technology	Bennett EJ (2010)	1
CYLD	2	KRT19	0	affinity chromatography technology	Elliott PR (2016)	1
RC3H1	6	KRT2	0	affinity chromatography technology	Murakawa Y (2015)	1
NEDD8	0	EWSR1	2	affinity chromatography technology	Bennett EJ (2010)	1
EGFR	5	KRT2	0	affinity chromatography technology	Yao Z (2017)	1
SFN	1	CBL	7	affinity chromatography technology	Subramanian RR (2001)	1
CUL3	17	KRT13	2	affinity chromatography technology	Bennett EJ (2010)	1
CUL1	7	EIF4A3	1	affinity chromatography technology	Bennett EJ (2010)	1
SHC1	0	UBASH3B	4	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Li J (2013)	2
GRB2	2	KRT10	7	affinity chromatography technology	Brehme M (2009)	1
SFN	1	KRT1	3	affinity chromatography technology	Wilker EW (2007)	1
GRB2	2	PIK3R2	3	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bandyopadhyay S (2010), Brehme M (2009), Brehme M (2009), Bisson N (2011)	4
PAN2	3	KRT10	7	affinity chromatography technology	Bett JS (2013)	1
VCAM1	2	KRT10	7	affinity chromatography technology	Humphries JD (2009)	1
CUL2	3	KRT13	2	affinity chromatography technology	Bennett EJ (2010)	1
EGFR	5	KRT10	7	affinity chromatography technology	Yao Z (2017)	1
ADRB2	0	GRB2	2	affinity chromatography technology, pull down	Karoor V (1998), Karoor V (1998)	2
POU5F1	0	CUL4A	2	affinity chromatography technology	Oliviero G (2015)	1
CAND1	2	MCM2	3	affinity chromatography technology	Bennett EJ (2010)	1
FN1	17	KRT19	0	affinity chromatography technology	Humphries JD (2009)	1
EGFR	5	KRT1	3	affinity chromatography technology	Yao Z (2017)	1
COPS5	0	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), He F (2013), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	9
CAND1	2	KRT10	7	affinity chromatography technology	Bennett EJ (2010)	1
PAN2	3	KRT2	0	affinity chromatography technology	Bett JS (2013)	1
MCM5	1	MCM2	3	two hybrid, two hybrid, affinity chromatography technology, biochemical, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), DaFonseca CJ (2001), Havugimana PC (2012), Ramachandran N (2004), Wan C (2015), Drissi R (2015), Drissi R (2015), Huang J (2013), Lossaint G (2013)	10
NEDD8	0	KRT5	1	affinity chromatography technology	Bennett EJ (2010)	1
VCAM1	2	KRT2	0	affinity chromatography technology	Humphries JD (2009)	1
CUL3	17	EWSR1	2	affinity chromatography technology	Bennett EJ (2010)	1
MCM2	3	KRT5	1	affinity chromatography technology	Drissi R (2015)	1
CRK	0	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, pull down, two hybrid	Gesbert F (1998), Husson H (1997), Ingham RJ (1996), Ingham RJ (1996), Delehanty LL (2003), Garcia-Guzman M (2000), Garcia-Guzman M (2000), Barber DL (1997), Buday L (1996), Sawasdikosol S (1996), Sawasdikosol S (1996), Thien CB (1997), van Leeuwen JE (1999), Ribon V (1996), Lottin-Divoux S (2006), Reedquist KA (1996), Brehme M (2009), Brehme M (2009), Ota S (1998), Peterson ME (2008), Liu BA (2012), Fukazawa T (1996), Umehara H (2002), Grossmann A (2015)	24
INPPL1	6	PIK3R2	3	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009)	2
SHC1	0	KRT13	2	affinity chromatography technology	Brehme M (2009)	1
CUL5	1	CUL2	3	affinity chromatography technology	Bennett EJ (2010)	1
UBASH3B	4	KRT5	1	affinity chromatography technology	Brehme M (2009)	1
INPPL1	6	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009), Brehme M (2009), Bisson N (2011)	4
FN1	17	CAND1	2	affinity chromatography technology	Humphries JD (2009)	1
RPS6KB2	3	EWSR1	2	affinity chromatography technology	Roy R (2014)	1
CUL1	7	CAND1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Min KW (2003), Min KW (2003), Menon S (2008), Chew EH (2007), Min KW (2005), Min KW (2005), Min KW (2005), Hwang JW (2003), Hwang JW (2003), Mao X (2011), Chua YS (2011), Chua YS (2011), Tron AE (2012), Zheng J (2002), Zheng J (2002), Bornstein G (2006), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), He YJ (2006), Emberley ED (2012), Choo YY (2011), Jonason JH (2007), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Liu J (2002), Liu J (2002), Liu J (2002), Liu J (2002), Korzeniewski N (2012), Pierce NW (2013), Kim AY (2008), Zhang S (2016), Tikhmyanova N (2017), Tikhmyanova N (2017), Reitsma JM (2017), Reitsma JM (2017)	41
FN1	17	AP2M1	5	affinity chromatography technology	Humphries JD (2009)	1
MAGOH	0	EIF4A3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Chan CC (2004), Chan CC (2004), Singh G (2012), Singh G (2012), Singh G (2012), Singh G (2012), Barbosa I (2012)	7
COPS5	0	KRT5	1	affinity chromatography technology	Bennett EJ (2010)	1
MAGOH	0	KRT5	1	affinity chromatography technology	Singh G (2012)	1
TRAF6	0	KRT10	7	affinity chromatography technology	Yu J (2016)	1
HNRNPA1	1	KRT10	7	affinity chromatography technology	Roy R (2014)	1
KRT1	3	KRT5	1	biochemical	Wan C (2015)	1
CUL2	3	KRT2	0	affinity chromatography technology	Bennett EJ (2010)	1
INPPL1	6	KRT10	7	affinity chromatography technology	Brehme M (2009)	1
KRT1	3	PRSS1	0	biochemical	Wan C (2015)	1
CUL4A	2	NEDD8	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Angers S (2006), Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Olma MH (2009)	7
KRT5	1	KRT31	0	two hybrid	Rolland T (2014)	1
CUL3	17	CAND1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Min KW (2003), Chua YS (2011), Chua YS (2011), Tron AE (2012), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Schumacher FR (2015), Schumacher FR (2015), Lo SC (2006), Lo SC (2006)	12
FN1	17	KRT1	3	affinity chromatography technology	Humphries JD (2009)	1
COPS5	0	NEDD8	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Sowa ME (2009), Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Birol M (2014)	5
NEDD8	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Wimuttisuk W (2007)	4
UBASH3B	4	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	de Castro RO (2012), Li J (2013), Li J (2013)	3
COPS5	0	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Sowa ME (2009), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Pick E (2012)	7
GRB2	2	KRT19	0	affinity chromatography technology	Brehme M (2009)	1
CUL3	17	EIF4A3	1	affinity chromatography technology	Bennett EJ (2010)	1
RPS6KB2	3	KRT2	0	affinity chromatography technology	Roy R (2014)	1
PIK3R2	3	CRK	0	affinity chromatography technology, affinity chromatography technology, two hybrid	Brehme M (2009), Brehme M (2009), Grossmann A (2015)	3
KRT2	0	KRT31	0	two hybrid	Rolland T (2014)	1
EPS15	1	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	van Delft S (1997), Sigismund S (2005), Bertelsen V (2011), Parachoniak CA (2009), Parachoniak CA (2009), Hoeller D (2006)	6
KRT5	1	KRT38	4	two hybrid	Rolland T (2014)	1
ADRB2	0	KRT5	1	affinity chromatography technology	Roy SJ (2013)	1
SFN	1	KRT10	7	affinity chromatography technology	Wilker EW (2007)	1